BRPI0015283A - processo para monitorar a eficácia de um processo de purificação. - Google Patents
processo para monitorar a eficácia de um processo de purificação.Info
- Publication number
- BRPI0015283A BRPI0015283A BRPI0015283A BRPI0015283A BRPI0015283A BR PI0015283 A BRPI0015283 A BR PI0015283A BR PI0015283 A BRPI0015283 A BR PI0015283A BR PI0015283 A BRPI0015283 A BR PI0015283A BR PI0015283 A BRPI0015283 A BR PI0015283A
- Authority
- BR
- Brazil
- Prior art keywords
- effectiveness
- sample
- human tpa
- wild
- monitoring
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 abstract 2
- 241000699802 Cricetulus griseus Species 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000011210 chromatographic step Methods 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9726—Tissue plasminogen activator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16360799P | 1999-11-04 | 1999-11-04 | |
PCT/US2000/030252 WO2001032915A2 (en) | 1999-11-04 | 2000-11-01 | Reversed-phase hplc assay for plasminogen activators |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0015283A true BRPI0015283A (pt) | 2002-07-02 |
BRPI0015283B1 BRPI0015283B1 (pt) | 2015-03-17 |
BRPI0015283B8 BRPI0015283B8 (pt) | 2021-07-06 |
Family
ID=22590762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0015283 BRPI0015283B8 (pt) | 1999-11-04 | 2000-11-01 | Processo para monitorar a eficácia de um processo de purificação. |
Country Status (24)
Country | Link |
---|---|
US (2) | US6593097B1 (pt) |
EP (1) | EP1226269B1 (pt) |
JP (1) | JP4659320B2 (pt) |
KR (1) | KR100649043B1 (pt) |
CN (1) | CN1167808C (pt) |
AT (1) | ATE243263T1 (pt) |
AU (1) | AU781023B2 (pt) |
BR (1) | BRPI0015283B8 (pt) |
CA (1) | CA2384756C (pt) |
CZ (1) | CZ302023B6 (pt) |
DE (1) | DE60003449T2 (pt) |
DK (1) | DK1226269T3 (pt) |
ES (1) | ES2200973T3 (pt) |
HK (1) | HK1046158B (pt) |
HU (1) | HU226202B1 (pt) |
IL (1) | IL149006A0 (pt) |
MX (1) | MXPA02004401A (pt) |
NO (1) | NO329876B1 (pt) |
NZ (1) | NZ518187A (pt) |
PL (1) | PL204011B1 (pt) |
PT (1) | PT1226269E (pt) |
SI (1) | SI1226269T1 (pt) |
WO (1) | WO2001032915A2 (pt) |
ZA (1) | ZA200202687B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE391789T1 (de) | 1999-12-10 | 2008-04-15 | Invitrogen Corp | Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen |
AU2715302A (en) | 2000-12-08 | 2002-06-18 | Invitrogen Corp | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US6972327B1 (en) * | 2001-05-08 | 2005-12-06 | Immunex Corporation | Regeneration of chromatography material |
EP1885488B1 (en) * | 2005-05-24 | 2015-07-08 | GE Healthcare Bio-Sciences AB | Regeneration of a chromatography matrix |
KR100701265B1 (ko) * | 2006-01-16 | 2007-04-02 | 대한민국 | 재조합 사람 조직형 플라스미노겐 활성인자 발현벡터 및 플라스미노겐 활성인자를 소변으로 분비하는 형질전환돼지 생산방법 |
CN101511387A (zh) * | 2006-09-08 | 2009-08-19 | 惠氏公司 | 使用亲和色谱法纯化蛋白质的精氨酸洗涤液 |
JP2010507384A (ja) * | 2006-10-27 | 2010-03-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤のプロファイリング方法 |
CN101539550B (zh) * | 2009-04-28 | 2012-05-23 | 李绍平 | 用于多糖的定性与定量分析方法 |
EP3592858A1 (en) | 2017-03-09 | 2020-01-15 | Universität des Saarlandes | Means and methods for lignin pyrolysis |
CN108333281A (zh) * | 2018-02-08 | 2018-07-27 | 吉林大学 | 一种测定重组人粒细胞集落刺激因子二硫键组成的方法 |
CN108918749B (zh) * | 2018-07-17 | 2020-05-05 | 北京赛升药业股份有限公司 | 一种蛇毒纤溶酶的反相hplc检测方法 |
CN114426962A (zh) * | 2021-12-21 | 2022-05-03 | 佛山汉腾生物科技有限公司 | t-PA纯化方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI831484L (fi) | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
US5120535A (en) * | 1986-11-26 | 1992-06-09 | Oncogen | Oncostatin M and novel compositions having anti-neoplastic activity |
US5411864A (en) * | 1987-11-05 | 1995-05-02 | Genentech, Inc. | Method of purifying recombinant proteins from corresponding host cell proteins |
GB8919803D0 (en) * | 1989-09-01 | 1989-10-18 | Ciba Geigy | Pharmaceutical compositions |
DE10199044I2 (de) | 1992-06-03 | 2006-02-09 | Genentech Inc | Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung |
US5753702A (en) * | 1996-05-22 | 1998-05-19 | University Of Vermont | Arachidonic acid metabolite, 16-hete |
-
2000
- 2000-11-01 US US09/703,695 patent/US6593097B1/en not_active Expired - Lifetime
- 2000-11-01 DK DK00978343T patent/DK1226269T3/da active
- 2000-11-01 WO PCT/US2000/030252 patent/WO2001032915A2/en active IP Right Grant
- 2000-11-01 PL PL355389A patent/PL204011B1/pl unknown
- 2000-11-01 IL IL14900600A patent/IL149006A0/xx active IP Right Grant
- 2000-11-01 KR KR1020027005727A patent/KR100649043B1/ko active IP Right Grant
- 2000-11-01 CN CNB008153434A patent/CN1167808C/zh not_active Expired - Lifetime
- 2000-11-01 JP JP2001535595A patent/JP4659320B2/ja not_active Expired - Lifetime
- 2000-11-01 BR BRPI0015283 patent/BRPI0015283B8/pt not_active IP Right Cessation
- 2000-11-01 MX MXPA02004401A patent/MXPA02004401A/es active IP Right Grant
- 2000-11-01 CA CA2384756A patent/CA2384756C/en not_active Expired - Lifetime
- 2000-11-01 HU HU0202973A patent/HU226202B1/hu unknown
- 2000-11-01 PT PT00978343T patent/PT1226269E/pt unknown
- 2000-11-01 AT AT00978343T patent/ATE243263T1/de active
- 2000-11-01 DE DE60003449T patent/DE60003449T2/de not_active Expired - Lifetime
- 2000-11-01 ES ES00978343T patent/ES2200973T3/es not_active Expired - Lifetime
- 2000-11-01 NZ NZ518187A patent/NZ518187A/xx not_active IP Right Cessation
- 2000-11-01 CZ CZ20021196A patent/CZ302023B6/cs not_active IP Right Cessation
- 2000-11-01 EP EP00978343A patent/EP1226269B1/en not_active Expired - Lifetime
- 2000-11-01 SI SI200030178T patent/SI1226269T1/xx unknown
- 2000-11-01 AU AU15816/01A patent/AU781023B2/en not_active Expired
-
2002
- 2002-04-05 ZA ZA200202687A patent/ZA200202687B/en unknown
- 2002-05-03 NO NO20022122A patent/NO329876B1/no not_active IP Right Cessation
- 2002-10-28 HK HK02107782.5A patent/HK1046158B/zh unknown
-
2003
- 2003-05-21 US US10/443,701 patent/US6828118B2/en not_active Expired - Lifetime
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/03/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/11/00, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 22A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2694 DE 23-08-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |