BRPI0006823B8 - composição farmacêutica estabilizada, preparação de injeção, e kit comercial - Google Patents

composição farmacêutica estabilizada, preparação de injeção, e kit comercial

Info

Publication number
BRPI0006823B8
BRPI0006823B8 BRPI0006823A BRPI0006823A BRPI0006823B8 BR PI0006823 B8 BRPI0006823 B8 BR PI0006823B8 BR PI0006823 A BRPI0006823 A BR PI0006823A BR PI0006823 A BRPI0006823 A BR PI0006823A BR PI0006823 B8 BRPI0006823 B8 BR PI0006823B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
injection preparation
commercial kit
stabilized pharmaceutical
stabilized
Prior art date
Application number
BRPI0006823A
Other languages
English (en)
Portuguese (pt)
Inventor
Kasai Akihiro
Otomo Kazumi
Sawai Seiji
Original Assignee
Astellas Pharma Inc
Fujisawa Pharmaceutical Co
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16210881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0006823(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astellas Pharma Inc, Fujisawa Pharmaceutical Co, Yamanouchi Pharmaceutical Co Ltd filed Critical Astellas Pharma Inc
Publication of BRPI0006823B1 publication Critical patent/BRPI0006823B1/pt
Publication of BRPI0006823B8 publication Critical patent/BRPI0006823B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
BRPI0006823A 1999-07-01 2000-06-29 composição farmacêutica estabilizada, preparação de injeção, e kit comercial BRPI0006823B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPHEI11-187713 1999-07-01
JP18771399 1999-07-01
PCT/JP2000/004381 WO2001002002A1 (en) 1999-07-01 2000-06-29 Stabilized pharmaceutical composition in lyophilized form

Publications (2)

Publication Number Publication Date
BRPI0006823B1 BRPI0006823B1 (pt) 2020-01-07
BRPI0006823B8 true BRPI0006823B8 (pt) 2021-05-25

Family

ID=16210881

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0006823A BRPI0006823B8 (pt) 1999-07-01 2000-06-29 composição farmacêutica estabilizada, preparação de injeção, e kit comercial
BR0006823-3A BR0006823A (pt) 1999-07-01 2000-06-29 Composição farmacêutica estabilizada, uso de composto de polipeptìdeo cìclico, preparação de injeção e pacote comercial

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0006823-3A BR0006823A (pt) 1999-07-01 2000-06-29 Composição farmacêutica estabilizada, uso de composto de polipeptìdeo cìclico, preparação de injeção e pacote comercial

Country Status (28)

Country Link
US (2) US6774104B1 (cg-RX-API-DMAC7.html)
EP (1) EP1107777B1 (cg-RX-API-DMAC7.html)
JP (2) JP3381722B2 (cg-RX-API-DMAC7.html)
KR (1) KR100454784B1 (cg-RX-API-DMAC7.html)
CN (2) CN1179748C (cg-RX-API-DMAC7.html)
AR (1) AR024634A1 (cg-RX-API-DMAC7.html)
AT (1) ATE280583T1 (cg-RX-API-DMAC7.html)
AU (1) AU752265B2 (cg-RX-API-DMAC7.html)
BR (2) BRPI0006823B8 (cg-RX-API-DMAC7.html)
CA (1) CA2341568C (cg-RX-API-DMAC7.html)
CZ (1) CZ295720B6 (cg-RX-API-DMAC7.html)
DE (1) DE60015279T2 (cg-RX-API-DMAC7.html)
ES (1) ES2225161T3 (cg-RX-API-DMAC7.html)
HK (1) HK1040057B (cg-RX-API-DMAC7.html)
HU (1) HU229089B1 (cg-RX-API-DMAC7.html)
ID (1) ID29468A (cg-RX-API-DMAC7.html)
IL (2) IL141455A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA01000601A (cg-RX-API-DMAC7.html)
NO (1) NO330353B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ510290A (cg-RX-API-DMAC7.html)
OA (1) OA11601A (cg-RX-API-DMAC7.html)
PL (1) PL200141B1 (cg-RX-API-DMAC7.html)
PT (1) PT1107777E (cg-RX-API-DMAC7.html)
RU (1) RU2251411C2 (cg-RX-API-DMAC7.html)
TR (1) TR200100609T1 (cg-RX-API-DMAC7.html)
TW (1) TWI233805B (cg-RX-API-DMAC7.html)
WO (1) WO2001002002A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200101589B (cg-RX-API-DMAC7.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
ITMI20021040A1 (it) * 2002-05-16 2003-11-17 Novuspharma Spa Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale
KR101016595B1 (ko) * 2002-07-31 2011-02-22 센주 세이야꾸 가부시키가이샤 수성액제 및 광안정화된 수성액제
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
US7119061B2 (en) * 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
PT1565201T (pt) * 2002-11-18 2019-02-05 Vicuron Pharmaceuticals Llc Métodos de administração de dalbavancina para o tratamento de infeções bacterianas
CN100515422C (zh) * 2004-03-04 2009-07-22 卫材R&D管理有限公司 含有苄脒衍生物的组合物及苄脒衍生物的稳定化方法
WO2005111033A2 (en) * 2004-05-19 2005-11-24 Neurosearch A/S Novel azabicyclic aryl derivatives
WO2006053383A1 (en) * 2004-11-22 2006-05-26 Anadis Ltd Bioactive compositions
KR101307999B1 (ko) 2004-12-01 2013-09-12 니폰 조키 세야쿠 가부시키가이샤 건조물 및 그 제조방법
KR20080028942A (ko) * 2005-07-20 2008-04-02 교와 메덱스 가부시키가이샤 생체 시료 중의 펩티드의 안정화 방법
CN1962852B (zh) * 2006-11-27 2011-11-09 西北农林科技大学 红景天多糖在制备抗冻剂中的新用途及其产品和制备方法
CN102614492B (zh) * 2011-01-31 2013-12-11 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的液体药用组合物
CN102614491B (zh) 2011-01-31 2014-04-16 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的药用组合物及其制备方法和用途
BR112014029108B1 (pt) * 2012-05-22 2022-02-08 Paion Uk Limited Composições que compreendem benzodiazepinas de curta ação, uso de uma mistura de pelo menos um dissacarídeo e pelo menos uma dextrana e método de preparação de uma composição farmacêutica
ES3026983T3 (en) 2013-03-15 2025-06-12 Merck Sharp & Dohme Llc Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
CN103330932B (zh) * 2013-04-26 2015-12-23 江苏豪森药业股份有限公司 一种米卡芬净或其盐的药物组合物
CN103330933B (zh) * 2013-04-26 2015-08-05 江苏豪森药业股份有限公司 含有米卡芬净或其盐的药物组合物
DK3003298T3 (da) * 2013-06-05 2024-06-17 Univ British Columbia Antifibrogene forbindelser, fremgangsmåder og anvendelser deraf
AU2014233637A1 (en) 2013-09-09 2015-03-26 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
KR101611349B1 (ko) 2014-04-14 2016-04-12 신우철 안정성이 개선된 밀크씨슬 엑스의 제형
US20170190742A1 (en) * 2014-05-29 2017-07-06 Shanghai Techwell Biopharmaceutical Co., Ltd. Composition of cyclic peptide compound, preparation method for same, and uses thereof
WO2016088863A1 (ja) * 2014-12-05 2016-06-09 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法
WO2016107890A1 (en) 2014-12-31 2016-07-07 Galenicum Health S.L. Stable pharmaceutical compositions comprising micafungin
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
WO2018112330A1 (en) 2016-12-16 2018-06-21 Baxter International Inc. Micafungin compositions
WO2019005829A1 (en) * 2017-06-26 2019-01-03 Wayne State University METHODS AND COMPOSITIONS RELATING TO CANCER DEPENDENT ON HORMONE RECEPTORS
RU2666148C1 (ru) * 2017-10-05 2018-09-06 Общество с ограниченной ответственностью "Новые Антибиотики" Способ получения водорастворимой лиофилизированной формы соли бис(2-тио-4,6-диоксо-1,2,3,4,5,6-гексагидропиримидин-5-ил)-(4-нитрофенил)метана
EP3485873A1 (en) 2017-11-17 2019-05-22 Cadila Healthcare Limited Stable pharmaceutical injectable compositions of micafungin

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03193735A (ja) 1989-12-22 1991-08-23 Shionogi & Co Ltd グリコペプチド系抗生物質の安定化組成物
JPH03240727A (ja) 1990-02-15 1991-10-28 Toyo Jozo Co Ltd ニューモシスチス・カリニ肺炎治療剤
IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
JP3193735B2 (ja) 1991-07-24 2001-07-30 株式会社リコー カラー画像形成装置の搬送装置
RU2095081C1 (ru) * 1991-12-13 1997-11-10 Акционерное общество "Биофа" Фармацевтическая композиция антивирусного действия
JPH0651641A (ja) 1992-07-30 1994-02-25 Olympus Optical Co Ltd 湿式現像装置
JPH06172204A (ja) * 1992-12-09 1994-06-21 Asahi Chem Ind Co Ltd アクレアシン類含有リポソーム製剤およびその製造法
JP3240727B2 (ja) 1993-02-25 2001-12-25 ソニー株式会社 偏平型陰極線管の画像歪補正装置
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
IL109615A (en) * 1993-05-17 2000-12-06 Fujisawa Pharmaceutical Co Cyclic polypeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
DE122008000025I2 (de) 1994-10-07 2011-02-17 Astellas Pharma Inc Zyklische hexapeptide mit antibiotischer aktivität
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
EP1854877B1 (en) * 1996-03-08 2012-02-08 Astellas Pharma Inc. Process for the deacylation of cyclic lipopeptides
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
JPH09301997A (ja) 1996-05-17 1997-11-25 Yamanouchi Pharmaceut Co Ltd 新規環状ペプチド系化合物
FR2755857B1 (fr) * 1996-11-19 1998-12-24 Rhone Poulenc Rorer Sa Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
JPH10279498A (ja) * 1997-04-07 1998-10-20 Nippon Shinyaku Co Ltd 慢性関節リウマチ治療剤
JP3544847B2 (ja) * 1998-01-16 2004-07-21 三菱電機株式会社 光学的情報再生方法および装置
KR20010112302A (ko) * 1999-03-03 2001-12-20 피터 지. 스트링거 제약학적 경구용 ｅｃｂ 조제물 및 조성물의 제조 방법
HK1040062A1 (zh) * 1999-03-03 2002-05-24 Eli Lilly And Company 含有成胶束表面活性剂的棘白菌素药物配方
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent

Also Published As

Publication number Publication date
HK1040057B (zh) 2005-08-05
JP2002363097A (ja) 2002-12-18
HK1080724A1 (zh) 2006-05-04
ES2225161T3 (es) 2005-03-16
CA2341568C (en) 2011-10-25
ZA200101589B (en) 2002-09-02
ATE280583T1 (de) 2004-11-15
EP1107777A1 (en) 2001-06-20
CN1315865A (zh) 2001-10-03
PL346297A1 (en) 2002-01-28
NZ510290A (en) 2003-07-25
NO20010893D0 (no) 2001-02-22
AR024634A1 (es) 2002-10-16
BR0006823A (pt) 2001-06-05
MXPA01000601A (es) 2002-04-08
AU5572200A (en) 2001-01-22
HK1040057A1 (en) 2002-05-24
WO2001002002A1 (en) 2001-01-11
IL141455A (en) 2006-12-31
KR100454784B1 (ko) 2004-11-05
EP1107777B1 (en) 2004-10-27
CN1636591A (zh) 2005-07-13
RU2251411C2 (ru) 2005-05-10
HU229089B1 (en) 2013-07-29
JP2003503462A (ja) 2003-01-28
OA11601A (en) 2004-07-30
CZ20011186A3 (cs) 2001-09-12
NO20010893L (no) 2001-04-24
BRPI0006823B1 (pt) 2020-01-07
PL200141B1 (pl) 2008-12-31
HUP0103740A2 (hu) 2002-02-28
CN100352495C (zh) 2007-12-05
CA2341568A1 (en) 2001-01-11
CZ295720B6 (cs) 2005-10-12
HUP0103740A3 (en) 2002-08-28
DE60015279D1 (de) 2004-12-02
US7112565B2 (en) 2006-09-26
DE60015279T2 (de) 2005-05-25
TR200100609T1 (tr) 2001-07-23
JP4691866B2 (ja) 2011-06-01
AU752265B2 (en) 2002-09-12
CN1179748C (zh) 2004-12-15
ID29468A (id) 2001-08-30
TWI233805B (en) 2005-06-11
KR20010072903A (ko) 2001-07-31
NO330353B1 (no) 2011-04-04
JP3381722B2 (ja) 2003-03-04
US6774104B1 (en) 2004-08-10
US20040157769A1 (en) 2004-08-12
IL141455A0 (en) 2002-03-10
PT1107777E (pt) 2005-01-31

Similar Documents

Publication Publication Date Title
BRPI0006823B8 (pt) composição farmacêutica estabilizada, preparação de injeção, e kit comercial
BR0213877A (pt) Compostos orgânicos
BR0111639A (pt) Uso de uma molécula de ácido oligodeoxinucléico, e composição farmacêutica contendo a mesma
TR200003256T2 (tr) P-38 mapkinaz engelleyicileri olan pirazol türevleri
BR0108679A (pt) Novos compostos
BR0014136A (pt) Composto, uso do mesmo, métodos para a preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica
BR0312560A (pt) Novas espiropiperidinas ou espiropirrolidinas tricìclicas
TR200200778T2 (tr) Pirazol türevleri.
BR0306150A (pt) Composto, uso de um composto, e, composição farmacêutica
EA199900242A1 (ru) Аралкил- и аралкилиден-гетероциклические лактамы и имиды
TR200201874T2 (tr) Proteaz inhibitörleri olarak yeni bileşikler ve bileşimler.
TR199901578T2 (xx) Klaritromisin form 0 kristali
DE69932424D1 (de) Melanocortin 1 rezeptorselektive verbindungen
NO20021859D0 (no) Nye digosakkarider, deres fremstilling samt farmasöytiske preparater
BR9712140A (pt) Agentes e processos para inibir a produção de citoquina, a adesão de cédulas e a produção de tnf - alfa e uso de um composto.
BR0016133A (pt) Composto, formulação farmacêutica, e, uso de um composto
NO20020176D0 (no) Sykliske peptidderivater som inhibitorer for intergrin <alfa>v<beta>6
IL163625A0 (en) Alkoxy-pyridine derivatives and pharmaceutical compositions containing the same
BR0209452A (pt) Composto de cefem, processo para sua preparação, composição farmacêutica e uso do composto
HUP0103203A2 (hu) Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények
WO2001072263A3 (de) Verwendung von ectoin oder ectoin-derivaten zum schutz der stressprotein in der haut
BR0302496A (pt) Composições farmacêuticas com atividade antibiótica
BR0212353A (pt) Composto, composição farmacêutica, e, uso de um composto
TR200200125T2 (tr) Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar.
BR0208169A (pt) Composto quìmicos