BR112022017924A2 - Composições e métodos para imunoterapia de câncer npm1c-positivo - Google Patents

Composições e métodos para imunoterapia de câncer npm1c-positivo

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Publication number
BR112022017924A2
BR112022017924A2 BR112022017924A BR112022017924A BR112022017924A2 BR 112022017924 A2 BR112022017924 A2 BR 112022017924A2 BR 112022017924 A BR112022017924 A BR 112022017924A BR 112022017924 A BR112022017924 A BR 112022017924A BR 112022017924 A2 BR112022017924 A2 BR 112022017924A2
Authority
BR
Brazil
Prior art keywords
npm1c
methods
compositions
cancer immunotherapy
positive cancer
Prior art date
Application number
BR112022017924A
Other languages
English (en)
Portuguese (pt)
Inventor
Chen Jianzhu
Xie Guozhu
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of BR112022017924A2 publication Critical patent/BR112022017924A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Organic Chemistry (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
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  • Plant Pathology (AREA)
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  • Peptides Or Proteins (AREA)
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BR112022017924A 2020-03-10 2021-01-08 Composições e métodos para imunoterapia de câncer npm1c-positivo BR112022017924A2 (pt)

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US202062987612P 2020-03-10 2020-03-10
PCT/US2021/012701 WO2021183207A1 (en) 2020-03-10 2021-01-08 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER

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US (1) US11896619B2 (https=)
EP (1) EP4118112A1 (https=)
JP (1) JP7813235B2 (https=)
KR (1) KR20220167276A (https=)
CN (1) CN115485295A (https=)
AU (1) AU2021232853A1 (https=)
BR (1) BR112022017924A2 (https=)
CA (1) CA3173981A1 (https=)
IL (1) IL296241A (https=)
MX (1) MX2022011178A (https=)
WO (1) WO2021183207A1 (https=)

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JP2025514288A (ja) * 2022-04-27 2025-05-02 ザ チルドレンズ メディカル センター コーポレーション ヒト疾患の診断および治療標的としての突然変異体および誤局在細胞表面ヌクレオフォスミン１
CN119677779A (zh) * 2022-04-27 2025-03-21 儿童医学中心公司 抗核仁磷蛋白1抗体和抗体缀合物组合治疗

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