BR112022008730A2 - Epítopo de antígeno de superfície de células t reguladoras e um anticorpo que se liga especificamente ao mesmo - Google Patents
Epítopo de antígeno de superfície de células t reguladoras e um anticorpo que se liga especificamente ao mesmoInfo
- Publication number
- BR112022008730A2 BR112022008730A2 BR112022008730A BR112022008730A BR112022008730A2 BR 112022008730 A2 BR112022008730 A2 BR 112022008730A2 BR 112022008730 A BR112022008730 A BR 112022008730A BR 112022008730 A BR112022008730 A BR 112022008730A BR 112022008730 A2 BR112022008730 A2 BR 112022008730A2
- Authority
- BR
- Brazil
- Prior art keywords
- regulatory
- antibody
- specifically binds
- cells
- surface antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 210000003289 regulatory T cell Anatomy 0.000 title abstract 3
- 102000016844 Immunoglobulin-like domains Human genes 0.000 abstract 1
- 108050006430 Immunoglobulin-like domains Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000004901 leucine-rich repeat Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
EPÍTOPO DE ANTÍGENO DE SUPERFÍCIE DE CÉLULAS T REGULADORAS E UM ANTICORPO QUE SE LIGA ESPECIFICAMENTE AO MESMO A presente invenção se refere a um epítopo da proteína Lrig-1 (domínios semelhantes à imunoglobulina 1 e repetições ricas em leucina), que é um antígeno presente na superfície de uma célula T reguladora, e um anticorpo ou fragmento de ligação a antígeno que se liga especificamente ao mesmo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190142251 | 2019-11-08 | ||
PCT/KR2020/015656 WO2021091359A1 (ko) | 2019-11-08 | 2020-11-09 | 조절 t 세포 표면 항원의 에피토프 및 이에 특이적으로 결합하는 항체 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022008730A2 true BR112022008730A2 (pt) | 2022-07-19 |
Family
ID=75848106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022008730A BR112022008730A2 (pt) | 2019-11-08 | 2020-11-09 | Epítopo de antígeno de superfície de células t reguladoras e um anticorpo que se liga especificamente ao mesmo |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP4056586A4 (pt) |
JP (1) | JP2023500248A (pt) |
KR (1) | KR102488967B1 (pt) |
CN (1) | CN114929733A (pt) |
AU (1) | AU2020380072A1 (pt) |
BR (1) | BR112022008730A2 (pt) |
CA (1) | CA3156600A1 (pt) |
WO (1) | WO2021091359A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3882266A4 (en) * | 2018-10-17 | 2022-07-27 | Good T Cells, Inc. | LRIG-1 PROTEIN SPECIFIC BINDING MOLECULE AND USE THEREOF |
WO2023287212A1 (ko) * | 2021-07-16 | 2023-01-19 | 주식회사 굳티셀 | 조절 t 세포 표면 항원의 에피토프 및 이에 특이적으로 결합하는 항체 |
CN118591619A (zh) * | 2021-11-24 | 2024-09-03 | 雷格细胞股份有限公司 | 人诱导性调节性t细胞及其制作方法 |
WO2024155098A1 (ko) * | 2023-01-17 | 2024-07-25 | 주식회사 굳티셀 | 조절 t 세포 표면 항원 및 이에 특이적으로 결합하는 항체 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180116925A (ko) * | 2017-04-18 | 2018-10-26 | 주식회사 굳티셀 | 암 또는 면역 질환의 예방 또는 치료용 약학 조성물 |
AU2018256237A1 (en) * | 2017-04-18 | 2019-12-05 | Good T Cells, Inc. | Binding molecule specific for Lrig-1 protein and use thereof |
KR20180116924A (ko) * | 2017-04-18 | 2018-10-26 | 주식회사 굳티셀 | 면역 세포 표면 단백질의 항원 결정기인 폴리펩티드 |
CN112040959A (zh) * | 2018-02-23 | 2020-12-04 | 真和制药有限公司 | 通过阻断vista和其结合伴侣的相互作用治疗癌症 |
KR101959237B1 (ko) * | 2018-02-26 | 2019-03-20 | 주식회사 굳티셀 | 조절자 T 세포에 특이적으로 존재하는 새로운 표면단백질 Lrig-1의 용도 |
WO2019209078A1 (ko) * | 2018-04-26 | 2019-10-31 | 주식회사 굳티셀 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
-
2020
- 2020-11-09 CA CA3156600A patent/CA3156600A1/en active Pending
- 2020-11-09 EP EP20885858.9A patent/EP4056586A4/en active Pending
- 2020-11-09 AU AU2020380072A patent/AU2020380072A1/en active Pending
- 2020-11-09 KR KR1020200148886A patent/KR102488967B1/ko active IP Right Grant
- 2020-11-09 WO PCT/KR2020/015656 patent/WO2021091359A1/ko unknown
- 2020-11-09 CN CN202080077856.2A patent/CN114929733A/zh active Pending
- 2020-11-09 JP JP2022525129A patent/JP2023500248A/ja active Pending
- 2020-11-09 BR BR112022008730A patent/BR112022008730A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
CA3156600A1 (en) | 2021-05-14 |
KR20210056280A (ko) | 2021-05-18 |
JP2023500248A (ja) | 2023-01-05 |
EP4056586A4 (en) | 2024-04-10 |
CN114929733A (zh) | 2022-08-19 |
KR102488967B1 (ko) | 2023-01-16 |
AU2020380072A1 (en) | 2022-05-19 |
EP4056586A1 (en) | 2022-09-14 |
WO2021091359A1 (ko) | 2021-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022008730A2 (pt) | Epítopo de antígeno de superfície de células t reguladoras e um anticorpo que se liga especificamente ao mesmo | |
BR112018015670A2 (pt) | construtos de anticorpo biespecíficos envolvendo células t | |
CL2018002490A1 (es) | Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123. (divisional solicitud 201701866) | |
EA202092825A1 (ru) | Анти-sirpa антитела и способы их применения | |
BR112018011100A2 (pt) | anticorpo, composição, construto de ácido nucleico, vetor de expressão, célula hospedeira, método para tratamento de um indivíduo que tem um câncer, kit de partes, e, uso de um anticorpo ou de uma composição. | |
CO2020014773A2 (es) | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación | |
EA201890302A1 (ru) | Химерные рецепторы антигенов на основе однодоменных антител и способы их применения | |
BR112018076260A2 (pt) | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina | |
BR112019010595A2 (pt) | anticorpo ou fragmento de ligação ao antígeno do mesmo, combinação de moléculas de ácido nucleico isoladas, composição farmacêutica, kit, e, método para selecionar um composto. | |
MX2020004674A (es) | Anticuerpos contra alfa-sinucleina y usos de los mismos. | |
BR112023003511A2 (pt) | Anticorpo biespecífico calr-cd3 mutante anticlivado e composição farmacêutica | |
BR112021026089A2 (pt) | Fragmentos de ligação ao antígeno de cd3 e composições compreendendo os mesmos | |
BR112021021281A2 (pt) | Anticorpo monoclonal que se liga especificamente ao gitr | |
CY1121169T1 (el) | Αντισωμα που δεσμευει ενα γραμμικο επιτοπο ανθρωπινου ρ53 και διαγνωστικες εφαρμογες αυτου | |
BR112021023897A2 (pt) | Anticorpo ou receptor de antígeno quimérico que visa claudina18.2 | |
BR112022001693A2 (pt) | Construtos de proteína de ligação ao antígeno e usos dos mesmos | |
BR112017021026A2 (pt) | novos métodos para seleção de epítopo. | |
PE20181199A1 (es) | Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano | |
EA201791691A1 (ru) | ОДНОДОМЕННЫЕ АНТИТЕЛА, НАПРАВЛЕННЫЕ НА CD1d | |
BR112021025077A2 (pt) | Anticorpos anti-sortilina para uso em terapia | |
BR112019009765A2 (pt) | anticorpo de ligação à anidrase carbônica e uso do mesmo | |
BR112017007877A2 (pt) | anticorpo ou fragmento do mesmo, epítopo em ccr6 humana solúvel, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo ou fragmento do mesmo, composição e imunoconjugado | |
BR112022013403A2 (pt) | Anticorpos anti-tigit, anticorpos multiespecíficos que compreendem os mesmos e métodos de uso dos mesmos | |
BR112022011037A2 (pt) | Anticorpos ddr1 novos e usos dos mesmos | |
BR112016019739A2 (pt) | novo anticorpo de anti-presepsina |