BR112019013096A2 - polipeptídeos ligantes e métodos de preparo dos mesmos - Google Patents
polipeptídeos ligantes e métodos de preparo dos mesmos Download PDFInfo
- Publication number
- BR112019013096A2 BR112019013096A2 BR112019013096A BR112019013096A BR112019013096A2 BR 112019013096 A2 BR112019013096 A2 BR 112019013096A2 BR 112019013096 A BR112019013096 A BR 112019013096A BR 112019013096 A BR112019013096 A BR 112019013096A BR 112019013096 A2 BR112019013096 A2 BR 112019013096A2
- Authority
- BR
- Brazil
- Prior art keywords
- cell
- cdna
- sequence
- chain
- isolated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438712P | 2016-12-23 | 2016-12-23 | |
| PCT/US2017/068204 WO2018119402A1 (en) | 2016-12-23 | 2017-12-22 | Binding polypeptides and methods of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019013096A2 true BR112019013096A2 (pt) | 2019-12-17 |
Family
ID=61054491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019013096A BR112019013096A2 (pt) | 2016-12-23 | 2017-12-22 | polipeptídeos ligantes e métodos de preparo dos mesmos |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11820979B2 (enExample) |
| EP (1) | EP3559028A1 (enExample) |
| JP (2) | JP7360324B2 (enExample) |
| KR (2) | KR102702552B1 (enExample) |
| CN (1) | CN110366557B (enExample) |
| AU (1) | AU2017382367B2 (enExample) |
| BR (1) | BR112019013096A2 (enExample) |
| CA (1) | CA3045696A1 (enExample) |
| CL (2) | CL2019001757A1 (enExample) |
| CO (1) | CO2019006663A2 (enExample) |
| IL (2) | IL315727A (enExample) |
| MX (1) | MX2019007356A (enExample) |
| MY (1) | MY201744A (enExample) |
| RU (1) | RU2019123063A (enExample) |
| WO (1) | WO2018119402A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3781677A4 (en) * | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
| CN109161572B (zh) * | 2018-07-05 | 2021-11-12 | 中国海洋大学 | 单链环状核酸及其制备方法和应用 |
| EP3876956A4 (en) | 2018-11-08 | 2022-12-28 | The Regents of The University of California | SYSTEMS AND METHODS FOR TARGETING CANCER CELLS |
Family Cites Families (70)
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8905669D0 (en) | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
| WO1992003917A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International | Homologous recombination in mammalian cells |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| DE69233769D1 (de) | 1991-03-01 | 2009-09-24 | Dyax Corp | Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| US5851804A (en) | 1996-05-06 | 1998-12-22 | Apollon, Inc. | Chimeric kanamycin resistance gene |
| IL127624A0 (en) | 1996-06-17 | 1999-10-28 | Biodynamics Associates | Method and kits for preparing multicomponent nucleic acid constructs |
| US20020086330A1 (en) * | 2000-01-31 | 2002-07-04 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| AU2001232204A1 (en) | 2000-02-22 | 2001-09-03 | Ahuva Nissim | Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof |
| KR101135134B1 (ko) * | 2003-09-18 | 2012-04-13 | 심포젠 에이/에스 | 관심있는 서열을 결합시키는 방법 |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| US20060199191A1 (en) | 2004-12-13 | 2006-09-07 | Demian Obregon | Methods and compositions for the synthesis of RNA and DNA |
| CN101370832B (zh) * | 2005-12-02 | 2014-07-02 | 健泰科生物技术公司 | 结合多肽及其用途 |
| MX338151B (es) * | 2007-03-01 | 2016-04-05 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| CA2677771A1 (en) | 2007-03-01 | 2008-09-04 | Symphogen A/S | Method for cloning cognate antibodies |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| JP5933894B2 (ja) | 2007-09-14 | 2016-06-15 | アディマブ, エルエルシー | 合理的に設計された、合成抗体ライブラリおよびその使用 |
| SI2274008T1 (sl) * | 2008-03-27 | 2014-08-29 | Zymogenetics, Inc. | Sestavki in metode za zaviranje PDGFRBETA in VEGF-A |
| WO2010005593A1 (en) * | 2008-07-11 | 2010-01-14 | President And Fellows Of Harvard College | Systems and methods of droplet-based selection |
| WO2010022738A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
| JP5829606B2 (ja) | 2009-06-29 | 2015-12-09 | カリフォルニア・インスティテュート・オブ・テクノロジーCalifornia Institute Oftechnology | 単一細胞からの未知の再配列されたt細胞受容体の単離 |
| IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
| JP2013512691A (ja) * | 2009-12-07 | 2013-04-18 | プログノシス バイオサイエンシズ インコーポレイテッド | ペプチド提示アレイ |
| WO2011146514A2 (en) | 2010-05-17 | 2011-11-24 | The Board Of Regents Of The University Of Texas System | Rapid isolation of monoclonal antibodies from animals |
| WO2012032181A2 (en) * | 2010-09-10 | 2012-03-15 | Allozyne, Inc | Novel antibody derivatives |
| US20140057799A1 (en) | 2010-12-16 | 2014-02-27 | Gigagen | System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells |
| EP3421592B1 (en) | 2011-04-28 | 2023-09-13 | The Board of Trustees of the Leland Stanford Junior University | Identification of polynucleotides associated with a sample |
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| EP2794652B1 (en) * | 2011-12-21 | 2017-11-15 | F. Hoffmann-La Roche AG | Rapid method for cloning and expression of cognate antibody variable region gene segments |
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| CA2947320C (en) | 2014-05-22 | 2023-03-14 | The University Of British Columbia | Methods for determining lymphocyte receptor chain pairs |
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| WO2017180738A1 (en) * | 2016-04-12 | 2017-10-19 | Medimmune, Llc | Immune repertoire mining |
-
2017
- 2017-12-22 CN CN201780086589.3A patent/CN110366557B/zh active Active
- 2017-12-22 EP EP17835907.1A patent/EP3559028A1/en not_active Ceased
- 2017-12-22 US US15/852,718 patent/US11820979B2/en active Active
- 2017-12-22 JP JP2019533330A patent/JP7360324B2/ja active Active
- 2017-12-22 IL IL315727A patent/IL315727A/en unknown
- 2017-12-22 RU RU2019123063A patent/RU2019123063A/ru unknown
- 2017-12-22 CA CA3045696A patent/CA3045696A1/en active Pending
- 2017-12-22 KR KR1020197021677A patent/KR102702552B1/ko active Active
- 2017-12-22 WO PCT/US2017/068204 patent/WO2018119402A1/en not_active Ceased
- 2017-12-22 IL IL267565A patent/IL267565B2/en unknown
- 2017-12-22 MY MYPI2019003039A patent/MY201744A/en unknown
- 2017-12-22 BR BR112019013096A patent/BR112019013096A2/pt unknown
- 2017-12-22 MX MX2019007356A patent/MX2019007356A/es unknown
- 2017-12-22 AU AU2017382367A patent/AU2017382367B2/en active Active
- 2017-12-22 KR KR1020247029164A patent/KR20240133790A/ko active Pending
-
2019
- 2019-06-21 CO CONC2019/0006663A patent/CO2019006663A2/es unknown
- 2019-06-21 CL CL2019001757A patent/CL2019001757A1/es unknown
-
2022
- 2022-02-24 CL CL2022000454A patent/CL2022000454A1/es unknown
-
2023
- 2023-09-29 JP JP2023169621A patent/JP2023169422A/ja active Pending
- 2023-10-05 US US18/481,497 patent/US20240141334A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017382367A1 (en) | 2019-06-13 |
| JP7360324B2 (ja) | 2023-10-12 |
| IL315727A (en) | 2024-11-01 |
| EP3559028A1 (en) | 2019-10-30 |
| MY201744A (en) | 2024-03-15 |
| CL2022000454A1 (es) | 2023-03-24 |
| CN110366557A (zh) | 2019-10-22 |
| WO2018119402A1 (en) | 2018-06-28 |
| CA3045696A1 (en) | 2018-06-28 |
| IL267565A (en) | 2019-08-29 |
| JP2023169422A (ja) | 2023-11-29 |
| CO2019006663A2 (es) | 2019-06-28 |
| MX2019007356A (es) | 2019-09-05 |
| JP2020511117A (ja) | 2020-04-16 |
| CL2019001757A1 (es) | 2019-11-29 |
| KR20240133790A (ko) | 2024-09-04 |
| CN110366557B (zh) | 2024-04-09 |
| US11820979B2 (en) | 2023-11-21 |
| IL267565B2 (en) | 2025-02-01 |
| RU2019123063A3 (enExample) | 2021-11-29 |
| US20180201926A1 (en) | 2018-07-19 |
| IL267565B1 (en) | 2024-10-01 |
| RU2019123063A (ru) | 2021-01-26 |
| US20240141334A1 (en) | 2024-05-02 |
| AU2017382367B2 (en) | 2024-11-21 |
| KR102702552B1 (ko) | 2024-09-03 |
| KR20190111036A (ko) | 2019-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |