CL2019001757A1 - Polipéptidos de unión y métodos para fabricarlos. - Google Patents

Polipéptidos de unión y métodos para fabricarlos.

Info

Publication number
CL2019001757A1
CL2019001757A1 CL2019001757A CL2019001757A CL2019001757A1 CL 2019001757 A1 CL2019001757 A1 CL 2019001757A1 CL 2019001757 A CL2019001757 A CL 2019001757A CL 2019001757 A CL2019001757 A CL 2019001757A CL 2019001757 A1 CL2019001757 A1 CL 2019001757A1
Authority
CL
Chile
Prior art keywords
methods
making
binding polypeptides
polypeptides
molecules
Prior art date
Application number
CL2019001757A
Other languages
English (en)
Spanish (es)
Inventor
Gregory Babcock
Zachary Shriver
Luke Robinson
Original Assignee
Visterra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visterra Inc filed Critical Visterra Inc
Publication of CL2019001757A1 publication Critical patent/CL2019001757A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1093General methods of preparing gene libraries, not provided for in other subgroups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CL2019001757A 2016-12-23 2019-06-21 Polipéptidos de unión y métodos para fabricarlos. CL2019001757A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662438712P 2016-12-23 2016-12-23

Publications (1)

Publication Number Publication Date
CL2019001757A1 true CL2019001757A1 (es) 2019-11-29

Family

ID=61054491

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019001757A CL2019001757A1 (es) 2016-12-23 2019-06-21 Polipéptidos de unión y métodos para fabricarlos.
CL2022000454A CL2022000454A1 (es) 2016-12-23 2022-02-24 Polipéptidos de unión y métodos para fabricarlos (divisional de la solicitud no.201901757)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2022000454A CL2022000454A1 (es) 2016-12-23 2022-02-24 Polipéptidos de unión y métodos para fabricarlos (divisional de la solicitud no.201901757)

Country Status (15)

Country Link
US (2) US11820979B2 (enExample)
EP (1) EP3559028A1 (enExample)
JP (2) JP7360324B2 (enExample)
KR (2) KR102702552B1 (enExample)
CN (1) CN110366557B (enExample)
AU (1) AU2017382367B2 (enExample)
BR (1) BR112019013096A2 (enExample)
CA (1) CA3045696A1 (enExample)
CL (2) CL2019001757A1 (enExample)
CO (1) CO2019006663A2 (enExample)
IL (2) IL315727A (enExample)
MX (1) MX2019007356A (enExample)
MY (1) MY201744A (enExample)
RU (1) RU2019123063A (enExample)
WO (1) WO2018119402A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3781677A4 (en) * 2018-04-16 2022-01-19 University of Massachusetts COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING
CN109161572B (zh) * 2018-07-05 2021-11-12 中国海洋大学 单链环状核酸及其制备方法和应用
EP3876956A4 (en) 2018-11-08 2022-12-28 The Regents of The University of California SYSTEMS AND METHODS FOR TARGETING CANCER CELLS

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP1541682A3 (en) 1988-09-02 2005-07-06 Dyax Corp. Generation and selection of recombinant varied binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8905669D0 (en) 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ アンティボディー テクノロジー リミティド 特異的な結合ペアーの構成員の製造方法
WO1992003917A1 (en) 1990-08-29 1992-03-19 Genpharm International Homologous recombination in mammalian cells
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
DE69233769D1 (de) 1991-03-01 2009-09-24 Dyax Corp Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
EP1498427B1 (en) 1992-08-21 2009-12-16 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
IL127624A0 (en) 1996-06-17 1999-10-28 Biodynamics Associates Method and kits for preparing multicomponent nucleic acid constructs
US20020086330A1 (en) * 2000-01-31 2002-07-04 Rosen Craig A. Nucleic acids, proteins, and antibodies
AU2001232204A1 (en) 2000-02-22 2001-09-03 Ahuva Nissim Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
KR101135134B1 (ko) * 2003-09-18 2012-04-13 심포젠 에이/에스 관심있는 서열을 결합시키는 방법
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
US20060199191A1 (en) 2004-12-13 2006-09-07 Demian Obregon Methods and compositions for the synthesis of RNA and DNA
CN101370832B (zh) * 2005-12-02 2014-07-02 健泰科生物技术公司 结合多肽及其用途
MX338151B (es) * 2007-03-01 2016-04-05 Symphogen As Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.
CA2677771A1 (en) 2007-03-01 2008-09-04 Symphogen A/S Method for cloning cognate antibodies
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP5933894B2 (ja) 2007-09-14 2016-06-15 アディマブ, エルエルシー 合理的に設計された、合成抗体ライブラリおよびその使用
SI2274008T1 (sl) * 2008-03-27 2014-08-29 Zymogenetics, Inc. Sestavki in metode za zaviranje PDGFRBETA in VEGF-A
WO2010005593A1 (en) * 2008-07-11 2010-01-14 President And Fellows Of Harvard College Systems and methods of droplet-based selection
WO2010022738A1 (en) * 2008-08-29 2010-03-04 Symphogen A/S Method for cloning avian-derived antibodies
JP5829606B2 (ja) 2009-06-29 2015-12-09 カリフォルニア・インスティテュート・オブ・テクノロジーCalifornia Institute Oftechnology 単一細胞からの未知の再配列されたt細胞受容体の単離
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione
JP2013512691A (ja) * 2009-12-07 2013-04-18 プログノシス バイオサイエンシズ インコーポレイテッド ペプチド提示アレイ
WO2011146514A2 (en) 2010-05-17 2011-11-24 The Board Of Regents Of The University Of Texas System Rapid isolation of monoclonal antibodies from animals
WO2012032181A2 (en) * 2010-09-10 2012-03-15 Allozyne, Inc Novel antibody derivatives
US20140057799A1 (en) 2010-12-16 2014-02-27 Gigagen System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells
EP3421592B1 (en) 2011-04-28 2023-09-13 The Board of Trustees of the Leland Stanford Junior University Identification of polynucleotides associated with a sample
EP2739733B1 (en) 2011-08-03 2017-11-22 Texas Biomedical Research Insitute Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
CA2887880A1 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Proteomic identification of antibodies
EP2794652B1 (en) * 2011-12-21 2017-11-15 F. Hoffmann-La Roche AG Rapid method for cloning and expression of cognate antibody variable region gene segments
EP2809783A2 (en) 2012-02-02 2014-12-10 Invenra, Inc. High throughput screen for biologically active polypeptides
EP2626433B1 (en) * 2012-02-09 2017-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for linking nucleic acids in a microsome from endoplasmatic reticuli
WO2013188872A1 (en) * 2012-06-15 2013-12-19 The Board Of Regents Of The University Of Texas System High throughput sequencing of multiple transcripts of a single cell
CA2876209A1 (en) 2012-06-15 2013-12-19 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
WO2014043813A1 (en) 2012-09-19 2014-03-27 British Columbia Cancer Agency Branch Immune repertoire profiling
WO2014144495A1 (en) 2013-03-15 2014-09-18 Abvitro, Inc. Single cell bar-coding for antibody discovery
SG11201506991VA (en) 2013-03-15 2015-10-29 Adaptive Biotechnologies Corp Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
RU2578009C2 (ru) 2013-05-08 2016-03-20 Закрытое акционерное общество "ЕВРОГЕН" Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
AU2014315287A1 (en) * 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
GB201402591D0 (en) 2014-02-14 2014-04-02 Memo Therapeutics Ag Method for recovering two or more genes, or gene products, encoding an immunoreceptor
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
GB201407852D0 (en) * 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
CA2947320C (en) 2014-05-22 2023-03-14 The University Of British Columbia Methods for determining lymphocyte receptor chain pairs
WO2016044227A1 (en) 2014-09-15 2016-03-24 Abvitro, Inc. High-throughput nucleotide library sequencing
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
WO2016176322A1 (en) 2015-04-27 2016-11-03 Abvitro Llc Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
US9422547B1 (en) 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires
WO2017180738A1 (en) * 2016-04-12 2017-10-19 Medimmune, Llc Immune repertoire mining

Also Published As

Publication number Publication date
AU2017382367A1 (en) 2019-06-13
JP7360324B2 (ja) 2023-10-12
IL315727A (en) 2024-11-01
EP3559028A1 (en) 2019-10-30
MY201744A (en) 2024-03-15
CL2022000454A1 (es) 2023-03-24
CN110366557A (zh) 2019-10-22
WO2018119402A1 (en) 2018-06-28
CA3045696A1 (en) 2018-06-28
IL267565A (en) 2019-08-29
JP2023169422A (ja) 2023-11-29
CO2019006663A2 (es) 2019-06-28
MX2019007356A (es) 2019-09-05
JP2020511117A (ja) 2020-04-16
KR20240133790A (ko) 2024-09-04
CN110366557B (zh) 2024-04-09
US11820979B2 (en) 2023-11-21
IL267565B2 (en) 2025-02-01
RU2019123063A3 (enExample) 2021-11-29
US20180201926A1 (en) 2018-07-19
IL267565B1 (en) 2024-10-01
RU2019123063A (ru) 2021-01-26
US20240141334A1 (en) 2024-05-02
AU2017382367B2 (en) 2024-11-21
KR102702552B1 (ko) 2024-09-03
KR20190111036A (ko) 2019-10-01
BR112019013096A2 (pt) 2019-12-17

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