CL2019001757A1 - Polipéptidos de unión y métodos para fabricarlos. - Google Patents

Polipéptidos de unión y métodos para fabricarlos.

Info

Publication number
CL2019001757A1
CL2019001757A1 CL2019001757A CL2019001757A CL2019001757A1 CL 2019001757 A1 CL2019001757 A1 CL 2019001757A1 CL 2019001757 A CL2019001757 A CL 2019001757A CL 2019001757 A CL2019001757 A CL 2019001757A CL 2019001757 A1 CL2019001757 A1 CL 2019001757A1
Authority
CL
Chile
Prior art keywords
methods
making
binding polypeptides
polypeptides
molecules
Prior art date
Application number
CL2019001757A
Other languages
English (en)
Inventor
Gregory Babcock
Zachary Shriver
Luke Robinson
Original Assignee
Visterra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visterra Inc filed Critical Visterra Inc
Publication of CL2019001757A1 publication Critical patent/CL2019001757A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBEN LOS POLIPÉPTIDOS, TAL COMO MOLÉCULAS DE ANTICUERPO Y MOLÉCULAS DE TCR, Y MÉTODOS PARA FABRICAR LAS MISMAS. LOS POLIPÉPTIDOS PUEDEN USARSE PARA TRATAR, PREVENIR, Y/O DIAGNOSTICAR TRASTORNOS.
CL2019001757A 2016-12-23 2019-06-21 Polipéptidos de unión y métodos para fabricarlos. CL2019001757A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662438712P 2016-12-23 2016-12-23

Publications (1)

Publication Number Publication Date
CL2019001757A1 true CL2019001757A1 (es) 2019-11-29

Family

ID=61054491

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019001757A CL2019001757A1 (es) 2016-12-23 2019-06-21 Polipéptidos de unión y métodos para fabricarlos.
CL2022000454A CL2022000454A1 (es) 2016-12-23 2022-02-24 Polipéptidos de unión y métodos para fabricarlos (divisional de la solicitud no.201901757)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2022000454A CL2022000454A1 (es) 2016-12-23 2022-02-24 Polipéptidos de unión y métodos para fabricarlos (divisional de la solicitud no.201901757)

Country Status (15)

Country Link
US (2) US11820979B2 (es)
EP (1) EP3559028A1 (es)
JP (2) JP7360324B2 (es)
KR (1) KR20190111036A (es)
CN (1) CN110366557B (es)
AU (1) AU2017382367A1 (es)
BR (1) BR112019013096A2 (es)
CA (1) CA3045696A1 (es)
CL (2) CL2019001757A1 (es)
CO (1) CO2019006663A2 (es)
IL (1) IL267565A (es)
MX (1) MX2019007356A (es)
MY (1) MY201744A (es)
RU (1) RU2019123063A (es)
WO (1) WO2018119402A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11981892B2 (en) * 2018-04-16 2024-05-14 University Of Massachusetts Compositions and methods for improved gene editing
CN109161572B (zh) * 2018-07-05 2021-11-12 中国海洋大学 单链环状核酸及其制备方法和应用

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0768377A1 (en) 1988-09-02 1997-04-16 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8905669D0 (en) 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
ATE164395T1 (de) 1990-12-03 1998-04-15 Genentech Inc Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
DK1820858T3 (da) 1991-03-01 2009-11-02 Dyax Corp Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf
CA2108147C (en) 1991-04-10 2009-01-06 Angray Kang Heterodimeric receptor libraries using phagemids
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
DE69334305D1 (de) 1992-08-21 2010-01-28 Univ Bruxelles Immunoglobuline ohne leichte Ketten
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
CA2258570A1 (en) 1996-06-17 1997-12-24 Biodynamics Associates Method and kits for preparing multicomponent nucleic acid constructs
US20020086330A1 (en) 2000-01-31 2002-07-04 Rosen Craig A. Nucleic acids, proteins, and antibodies
WO2001062908A2 (en) 2000-02-22 2001-08-30 Ahuva Nissim Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
US20060199191A1 (en) 2004-12-13 2006-09-07 Demian Obregon Methods and compositions for the synthesis of RNA and DNA
CN101370832B (zh) 2005-12-02 2014-07-02 健泰科生物技术公司 结合多肽及其用途
CA2676049C (en) * 2007-03-01 2018-04-10 Symphogen A/S Recombinant anti-epidermal growth factor receptor antibody compositions
SI2121920T1 (sl) 2007-03-01 2011-12-30 Symphogen As Postopek za kloniranje sorodnih protiteles
AU2008298603B2 (en) 2007-09-14 2015-04-30 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2604279A1 (en) * 2008-03-27 2013-06-19 ZymoGenetics, Inc. Compositions and methods for inhibiting PDGFRBETA and VEGF-A
US20110275063A1 (en) * 2008-07-11 2011-11-10 President And Fellows Of Harvard College Systems and methods of droplet-based selection
KR20110058861A (ko) * 2008-08-29 2011-06-01 심포젠 에이/에스 조류 유래 항체의 클로닝 방법
JP5829606B2 (ja) 2009-06-29 2015-12-09 カリフォルニア・インスティテュート・オブ・テクノロジーＣａｌｉｆｏｒｎｉａ Ｉｎｓｔｉｔｕｔｅ Ｏｆｔｅｃｈｎｏｌｏｇｙ 単一細胞からの未知の再配列されたｔ細胞受容体の単離
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione
EP2510127B1 (en) * 2009-12-07 2015-06-10 Prognosys Biosciences, Inc. Peptide display arrays
AU2011256290B2 (en) 2010-05-17 2014-06-12 The Board Of Regents Of The University Of Texas System Rapid isolation of monoclonal antibodies from animals
CN103261222B (zh) * 2010-09-10 2017-07-28 医疗免疫有限公司 抗体衍生物
US20140057799A1 (en) 2010-12-16 2014-02-27 Gigagen System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells
SI3418380T1 (sl) 2011-04-28 2022-10-28 The Board Of Trustees Of The Leland Stanford Junior University Identifikacija polinukleotidov, povezanih z vzorcem
WO2013020087A2 (en) 2011-08-03 2013-02-07 Texas Biomedical Research Insitute Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
WO2013078455A2 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Proteomic identification of antibodies
CN109810188A (zh) * 2011-12-21 2019-05-28 弗·哈夫曼-拉罗切有限公司 用于克隆和表达关联抗体可变区基因区段的快速方法
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
EP2626433B1 (en) 2012-02-09 2017-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for linking nucleic acids in a microsome from endoplasmatic reticuli
CA2876209A1 (en) 2012-06-15 2013-12-19 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
JP6558830B2 (ja) * 2012-06-15 2019-08-14 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 複数転写産物のハイスループットシークエンシング
WO2014043813A1 (en) 2012-09-19 2014-03-27 British Columbia Cancer Agency Branch Immune repertoire profiling
CA2906076A1 (en) 2013-03-15 2014-09-18 Abvitro, Inc. Single cell bar-coding for antibody discovery
US20160024493A1 (en) 2013-03-15 2016-01-28 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
RU2578009C2 (ru) 2013-05-08 2016-03-20 Закрытое акционерное общество "ЕВРОГЕН" Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
EP3041934A1 (en) * 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimeric polynucleotides
GB201402591D0 (en) 2014-02-14 2014-04-02 Memo Therapeutics Ag Method for recovering two or more genes, or gene products, encoding an immunoreceptor
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
GB201407852D0 (en) * 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
EP3146079B1 (en) 2014-05-22 2019-01-30 The University Of British Columbia Methods for determining lymphocyte receptor chain pairs
ES2895750T3 (es) 2014-09-15 2022-02-22 Abvitro Llc Secuenciación de alto rendimiento de colecciones de nucleótidos
ES2784343T3 (es) 2014-10-29 2020-09-24 Adaptive Biotechnologies Corp Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
EP3289082A4 (en) 2015-04-27 2018-09-12 AbVitro LLC Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
US9422547B1 (en) 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires

Also Published As

Publication number Publication date
US20240141334A1 (en) 2024-05-02
CN110366557A (zh) 2019-10-22
KR20190111036A (ko) 2019-10-01
JP2023169422A (ja) 2023-11-29
RU2019123063A3 (es) 2021-11-29
MY201744A (en) 2024-03-15
BR112019013096A2 (pt) 2019-12-17
US11820979B2 (en) 2023-11-21
IL267565A (en) 2019-08-29
EP3559028A1 (en) 2019-10-30
WO2018119402A1 (en) 2018-06-28
MX2019007356A (es) 2019-09-05
CN110366557B (zh) 2024-04-09
RU2019123063A (ru) 2021-01-26
CO2019006663A2 (es) 2019-06-28
AU2017382367A1 (en) 2019-06-13
JP2020511117A (ja) 2020-04-16
CL2022000454A1 (es) 2023-03-24
JP7360324B2 (ja) 2023-10-12
US20180201926A1 (en) 2018-07-19
CA3045696A1 (en) 2018-06-28

Similar Documents

Publication Publication Date Title
CO2019000931A2 (es) Polipéptidos modificados y usos de los mismos
CL2018000194A1 (es) Compuestos de piridina
GT201700081A (es) Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
CR20180013A (es) Anticuerpos anti-tau y métodos de uso.
CU24481B1 (es) Moléculas de anticuerpo que se unen a lag-3
UY35967A (es) Moléculas de anticuerpo que se unen a pd-1 y usos de las mismas
CR20160347A (es) Moléculas de anticuerpo que se unen a tim-3 y usos de las mismas
BR112017013176A2 (pt) receptores de antígenos quiméricos e métodos para usá-los
CR20190271A (es) Anticuerpos antitau y métodos de uso
MY197345A (en) Antibody molecules to april and uses thereof
BR112016022841A2 (pt) cadeia j modificada
EA202090632A1 (ru) Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов
BR112019006865A2 (pt) caspases induzíveis e métodos para uso
DK3142785T3 (da) Fremgangsmåde til fremstilling af alkenoler og anvendelse deraf til fremstilling af 1,3-butadien
PE20180171A1 (es) Neutralizacion del virus chikungunya mediada por anticuerpos
CL2019002605A1 (es) Formulaciones que contienen proteínas de unión pd-1 y métodos de fabricación de las mismas.
EA201792612A1 (ru) 6-аминохинолин-3-карбонитрилы в качестве модуляторов cot
EA201691473A1 (ru) Биспецифические анти-il-13/il-17 антитела и их применение
CR20150585A (es) Anticuerpos anti-igf-1r con abolición de la unión al fcrn y su utilización en el tratamiento de enfermedades oculares vasculares
CL2022000454A1 (es) Polipéptidos de unión y métodos para fabricarlos (divisional de la solicitud no.201901757)
DK3342909T3 (da) Højtydende polyphenylensulfid-fiberstruktur, fremgangsmåde til fremstilling derfor og anvendelse deraf
EA202191471A1 (ru) Противовоспалительные полипептиды
EA201790920A1 (ru) Титрованные экстракты cynara scolymus и их применения
UY37763A (es) 2,5-dibromopiridina y procesos para prepararla
AR104081A1 (es) Moléculas de anticuerpo que se unen a pd-l1 y sus usos