IL267565A - Binding polypeptides and methods for their preparation - Google Patents

Binding polypeptides and methods for their preparation

Info

Publication number
IL267565A
IL267565A IL267565A IL26756519A IL267565A IL 267565 A IL267565 A IL 267565A IL 267565 A IL267565 A IL 267565A IL 26756519 A IL26756519 A IL 26756519A IL 267565 A IL267565 A IL 267565A
Authority
IL
Israel
Prior art keywords
making
methods
same
binding polypeptides
polypeptides
Prior art date
Application number
IL267565A
Other languages
English (en)
Hebrew (he)
Other versions
IL267565B1 (en
Original Assignee
Visterra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visterra Inc filed Critical Visterra Inc
Publication of IL267565A publication Critical patent/IL267565A/en
Publication of IL267565B1 publication Critical patent/IL267565B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1093General methods of preparing gene libraries, not provided for in other subgroups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL267565A 2016-12-23 2017-12-22 Production methods for binding polypeptides containing covalently linked heavy chains and light chains IL267565B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662438712P 2016-12-23 2016-12-23
PCT/US2017/068204 WO2018119402A1 (en) 2016-12-23 2017-12-22 Binding polypeptides and methods of making the same

Publications (2)

Publication Number Publication Date
IL267565A true IL267565A (en) 2019-08-29
IL267565B1 IL267565B1 (en) 2024-10-01

Family

ID=61054491

Family Applications (1)

Application Number Title Priority Date Filing Date
IL267565A IL267565B1 (en) 2016-12-23 2017-12-22 Production methods for binding polypeptides containing covalently linked heavy chains and light chains

Country Status (15)

Country Link
US (2) US11820979B2 (es)
EP (1) EP3559028A1 (es)
JP (2) JP7360324B2 (es)
KR (2) KR20240133790A (es)
CN (1) CN110366557B (es)
AU (1) AU2017382367A1 (es)
BR (1) BR112019013096A2 (es)
CA (1) CA3045696A1 (es)
CL (2) CL2019001757A1 (es)
CO (1) CO2019006663A2 (es)
IL (1) IL267565B1 (es)
MX (1) MX2019007356A (es)
MY (1) MY201744A (es)
RU (1) RU2019123063A (es)
WO (1) WO2018119402A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019204226A1 (en) * 2018-04-16 2019-10-24 University Of Massachusetts Compositions and methods for improved gene editing
CN109161572B (zh) * 2018-07-05 2021-11-12 中国海洋大学 单链环状核酸及其制备方法和应用

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
EP0768377A1 (en) 1988-09-02 1997-04-16 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8905669D0 (en) 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ アンティボディー テクノロジー リミティド 特異的な結合ペアーの構成員の製造方法
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5612205A (en) 1990-08-29 1997-03-18 Genpharm International, Incorporated Homologous recombination in mammalian cells
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
DK1279731T3 (da) 1991-03-01 2007-09-24 Dyax Corp Fremgangsmåde til udvikling af bindende miniproteiner
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
EP2192131A1 (en) 1992-08-21 2010-06-02 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
AU3399797A (en) 1996-06-17 1998-01-07 Biodynamics Associates Method and kits for preparing multicomponent nucleic acid constructs
US20020086330A1 (en) 2000-01-31 2002-07-04 Rosen Craig A. Nucleic acids, proteins, and antibodies
AU2001232204A1 (en) 2000-02-22 2001-09-03 Ahuva Nissim Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
KR101135134B1 (ko) * 2003-09-18 2012-04-13 심포젠 에이/에스 관심있는 서열을 결합시키는 방법
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
US20060199191A1 (en) 2004-12-13 2006-09-07 Demian Obregon Methods and compositions for the synthesis of RNA and DNA
CN101370832B (zh) 2005-12-02 2014-07-02 健泰科生物技术公司 结合多肽及其用途
ATE521704T1 (de) * 2007-03-01 2011-09-15 Symphogen As Verfahren zur klonierung verwandter antikörper
JP5726417B2 (ja) * 2007-03-01 2015-06-03 シムフォゲン・アクティーゼルスカブSymphogen A/S 組み換え抗上皮成長因子受容体抗体組成物
US8691730B2 (en) 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
SI2274008T1 (sl) 2008-03-27 2014-08-29 Zymogenetics, Inc. Sestavki in metode za zaviranje PDGFRBETA in VEGF-A
US20110275063A1 (en) * 2008-07-11 2011-11-10 President And Fellows Of Harvard College Systems and methods of droplet-based selection
EP2331689A4 (en) 2008-08-29 2012-10-31 Symphogen As METHOD OF CLONING AVIAN ORIGIN ANTIBODIES
US8497071B2 (en) 2009-06-29 2013-07-30 California Institute Of Technology Isolation of unknown rearranged T-cell receptors from single cells
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione
EP2510127B1 (en) * 2009-12-07 2015-06-10 Prognosys Biosciences, Inc. Peptide display arrays
CN103003697A (zh) 2010-05-17 2013-03-27 得克萨斯系统大学董事会 来自动物的单克隆抗体的快速分离
US9146241B2 (en) 2011-11-23 2015-09-29 Board Of Regents, The University Of Texas System Proteomic identification of antibodies
JP6173911B2 (ja) * 2010-09-10 2017-08-09 メディミューン リミテド 抗体誘導体
WO2012083225A2 (en) 2010-12-16 2012-06-21 Gigagen, Inc. System and methods for massively parallel analysis of nycleic acids in single cells
SG10201900183VA (en) 2011-04-28 2019-05-30 Univ Leland Stanford Junior Identification of polynucleotides associated with a sample
US20140243234A1 (en) 2011-08-03 2014-08-28 Texas Biomedical Research Institute Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
JP2015500655A (ja) 2011-12-21 2015-01-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 同起源の抗体可変領域遺伝子セグメントをクローニングおよび発現させるための迅速な方法
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
EP2626433B1 (en) 2012-02-09 2017-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for linking nucleic acids in a microsome from endoplasmatic reticuli
DK2861760T3 (da) * 2012-06-15 2020-03-09 Univ Texas Sekventering med høj kapacitet af flere udskrifter af en enkelt celle
EP2861761A1 (en) 2012-06-15 2015-04-22 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
WO2014043813A1 (en) 2012-09-19 2014-03-27 British Columbia Cancer Agency Branch Immune repertoire profiling
US9816088B2 (en) 2013-03-15 2017-11-14 Abvitro Llc Single cell bar-coding for antibody discovery
CA2906218A1 (en) 2013-03-15 2014-09-18 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
RU2578009C2 (ru) 2013-05-08 2016-03-20 Закрытое акционерное общество "ЕВРОГЕН" Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
EP3041934A1 (en) * 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimeric polynucleotides
GB201402591D0 (en) 2014-02-14 2014-04-02 Memo Therapeutics Ag Method for recovering two or more genes, or gene products, encoding an immunoreceptor
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
GB201407852D0 (en) * 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
EP3146079B1 (en) 2014-05-22 2019-01-30 The University Of British Columbia Methods for determining lymphocyte receptor chain pairs
CA2961210A1 (en) 2014-09-15 2016-03-24 Abvitro, Inc. High-throughput nucleotide library sequencing
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
MX2017013471A (es) 2015-04-27 2018-08-01 Abvitro Llc Metodo de secuenciamiento, determinacion, apareamiento y validacion de agentes terapeuticos y antigenos especificos de enfermedades.
US9422547B1 (en) 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires

Also Published As

Publication number Publication date
US11820979B2 (en) 2023-11-21
CL2019001757A1 (es) 2019-11-29
US20240141334A1 (en) 2024-05-02
RU2019123063A3 (es) 2021-11-29
CA3045696A1 (en) 2018-06-28
BR112019013096A2 (pt) 2019-12-17
US20180201926A1 (en) 2018-07-19
CN110366557A (zh) 2019-10-22
IL267565B1 (en) 2024-10-01
JP2023169422A (ja) 2023-11-29
CO2019006663A2 (es) 2019-06-28
AU2017382367A1 (en) 2019-06-13
JP7360324B2 (ja) 2023-10-12
KR20240133790A (ko) 2024-09-04
EP3559028A1 (en) 2019-10-30
MY201744A (en) 2024-03-15
CN110366557B (zh) 2024-04-09
WO2018119402A1 (en) 2018-06-28
MX2019007356A (es) 2019-09-05
KR20190111036A (ko) 2019-10-01
JP2020511117A (ja) 2020-04-16
RU2019123063A (ru) 2021-01-26
CL2022000454A1 (es) 2023-03-24
KR102702552B1 (ko) 2024-09-03

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