EA201790920A1 - Титрованные экстракты cynara scolymus и их применения - Google Patents

Титрованные экстракты cynara scolymus и их применения

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Publication number
EA201790920A1
EA201790920A1 EA201790920A EA201790920A EA201790920A1 EA 201790920 A1 EA201790920 A1 EA 201790920A1 EA 201790920 A EA201790920 A EA 201790920A EA 201790920 A EA201790920 A EA 201790920A EA 201790920 A1 EA201790920 A1 EA 201790920A1
Authority
EA
Eurasian Patent Office
Prior art keywords
titrated
cynara scolymus
applications
extract
fractions
Prior art date
Application number
EA201790920A
Other languages
English (en)
Inventor
Валентино Меркати
Original Assignee
Абока С.П.А. Сосиета' Агрикола
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Абока С.П.А. Сосиета' Агрикола filed Critical Абока С.П.А. Сосиета' Агрикола
Publication of EA201790920A1 publication Critical patent/EA201790920A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к титрованному экстракту Cynara scolymus, к титрованным фракциям экстракта Cynara scolymus или к титрованным смесям указанного экстракта с одной или несколькими из указанных титрованных фракций или смесей указанных фракций, а также к композициям и наборам, содержащим их, для предупреждения и/или лечения патологического состояния, характеризуемого конститутивной активацией фактора транскрипции STAT3.
EA201790920A 2014-11-25 2015-11-24 Титрованные экстракты cynara scolymus и их применения EA201790920A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM20140685 2014-11-25
PCT/IB2015/059073 WO2016083992A1 (en) 2014-11-25 2015-11-24 Titled extracts of cynara scolymus and uses thereof

Publications (1)

Publication Number Publication Date
EA201790920A1 true EA201790920A1 (ru) 2017-09-29

Family

ID=52273397

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201790915A EA201790915A1 (ru) 2014-11-25 2015-11-24 Титрованные экстракты cynara scolymus для применения в лечении мезотелиомы
EA201790920A EA201790920A1 (ru) 2014-11-25 2015-11-24 Титрованные экстракты cynara scolymus и их применения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201790915A EA201790915A1 (ru) 2014-11-25 2015-11-24 Титрованные экстракты cynara scolymus для применения в лечении мезотелиомы

Country Status (11)

Country Link
US (2) US20170340689A1 (ru)
EP (2) EP3223840A1 (ru)
JP (2) JP2017535617A (ru)
CN (2) CN106999525A (ru)
AU (2) AU2015352042B2 (ru)
BR (1) BR112017010910A2 (ru)
CA (2) CA2967749A1 (ru)
EA (2) EA201790915A1 (ru)
HK (1) HK1244228A1 (ru)
MX (2) MX2017006806A (ru)
WO (2) WO2016083993A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107496399B (zh) * 2017-08-21 2020-05-05 四川九章生物科技有限公司 一种具有抗肿瘤药物功效的联合用药物
IT201800005721A1 (it) * 2018-05-25 2019-11-25 Nuove composizioni per il trattamento di leiomiomi uterini
CN112479881B (zh) * 2020-11-18 2022-07-29 湖南朗林生物资源股份有限公司 一种朝鲜蓟提取物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627376A1 (de) * 1996-07-06 1998-01-08 Aar Pharma Adler Apotheke Verwendung von Artischocken-(Cynara)-Extrakten
DE10164893B4 (de) * 2001-08-08 2008-08-28 Divapharma Chur Ag Verfahren zur Herstellung von Artischockenblätterextrakten und so erhaltene Artischockenblätterextrakte
ITMI20051347A1 (it) * 2005-07-14 2007-01-15 Indena Spa Estratti di cynara scolimus loro uso e formulazioni che li contengono
PT103839B (pt) * 2007-09-28 2008-10-23 Ecbio Investigacao E Desenvolv Composições farmacêuticas contendo a enzima ciprosina, uma peptidase aspártica de cynara cardunculus, e a sua inclusão em formulações antitumurais
ITRM20130312A1 (it) * 2013-05-29 2014-11-30 Aboca Spa Societa Agricola Estratto di cynara spp. e suoi usi.

Also Published As

Publication number Publication date
BR112017010910A2 (pt) 2018-02-06
WO2016083993A1 (en) 2016-06-02
EP3223840A1 (en) 2017-10-04
JP2018501304A (ja) 2018-01-18
CN106999596A (zh) 2017-08-01
WO2016083992A1 (en) 2016-06-02
CA2967749A1 (en) 2016-06-02
AU2015352041A1 (en) 2017-06-01
MX2017006806A (es) 2018-01-18
AU2015352041B2 (en) 2018-08-23
AU2015352042B2 (en) 2018-06-21
CN106999525A (zh) 2017-08-01
HK1244228A1 (zh) 2018-08-03
AU2015352042A1 (en) 2017-06-01
MX2017006807A (es) 2018-01-18
EA201790915A1 (ru) 2017-11-30
EP3223839A1 (en) 2017-10-04
CA2967746A1 (en) 2016-06-02
US20170340688A1 (en) 2017-11-30
JP2017535617A (ja) 2017-11-30
US20170340689A1 (en) 2017-11-30

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