BR112017018834A2 - variantes de protoxina-ii e métodos de uso - Google Patents
variantes de protoxina-ii e métodos de usoInfo
- Publication number
- BR112017018834A2 BR112017018834A2 BR112017018834A BR112017018834A BR112017018834A2 BR 112017018834 A2 BR112017018834 A2 BR 112017018834A2 BR 112017018834 A BR112017018834 A BR 112017018834A BR 112017018834 A BR112017018834 A BR 112017018834A BR 112017018834 A2 BR112017018834 A2 BR 112017018834A2
- Authority
- BR
- Brazil
- Prior art keywords
- protoxin
- variants
- methods
- preparing
- relates
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Abstract
a presente invenção refere-se a variantes de protoxina-ii, polinucleotídeos que codificam as mesmas e métodos de preparo e uso dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562127339P | 2015-03-03 | 2015-03-03 | |
PCT/US2016/019549 WO2016140859A2 (en) | 2015-03-03 | 2016-02-25 | Protoxin-ii variants and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017018834A2 true BR112017018834A2 (pt) | 2018-04-17 |
Family
ID=56849056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017018834A BR112017018834A2 (pt) | 2015-03-03 | 2016-02-25 | variantes de protoxina-ii e métodos de uso |
Country Status (15)
Country | Link |
---|---|
US (3) | US20160257726A1 (pt) |
EP (1) | EP3265476A4 (pt) |
JP (2) | JP2018512123A (pt) |
KR (1) | KR20170120703A (pt) |
CN (1) | CN107531769A (pt) |
AR (1) | AR103838A1 (pt) |
AU (2) | AU2016226443B2 (pt) |
BR (1) | BR112017018834A2 (pt) |
CA (1) | CA2978435A1 (pt) |
HK (1) | HK1249118A1 (pt) |
IL (2) | IL254273A0 (pt) |
MA (1) | MA41642A (pt) |
MX (1) | MX2017011223A (pt) |
TW (1) | TW201706292A (pt) |
WO (1) | WO2016140859A2 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10414808B2 (en) | 2012-05-18 | 2019-09-17 | Janssen Biotech, Inc. | Huwentoxin-IV variants and methods of use |
WO2015051216A1 (en) | 2013-10-03 | 2015-04-09 | Janssen Biotech, Inc. | Protoxin-ii variants and methods of use |
KR20170097020A (ko) | 2014-12-23 | 2017-08-25 | 오토메드 피티와이 리미티드 | 딜리버리 장치, 시스템 및 관련 방법 |
MA41642A (fr) | 2015-03-03 | 2018-01-09 | Janssen Biotech Inc | Variants de protoxine ii et méthodes d'utilisation |
EP3277304B1 (en) * | 2015-04-02 | 2021-08-04 | Janssen Biotech, Inc. | Protoxin-ii variants and methods of use |
CN109369784B (zh) * | 2018-11-14 | 2019-08-30 | 青海芬陀利华生物科技有限公司 | PaTx-1毒素及其应用 |
CN109369785B (zh) * | 2018-11-14 | 2019-08-30 | 青海芬陀利华生物科技有限公司 | Ccotx1毒素及其应用 |
CN114957431B (zh) * | 2022-06-27 | 2023-06-20 | 四川丽妍工坊生物科技有限公司 | 一种皮肤抗皱多肽Cj2a2、制备方法及应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
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US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
RU2218407C2 (ru) | 1997-04-16 | 2003-12-10 | Юниджен Лэбораториз Инк. | Прямая экспрессия пептидов в культуральные среды |
IL120943A (en) | 1997-05-29 | 2004-03-28 | Univ Ben Gurion | A system for administering drugs through the skin |
EP1538206B1 (en) | 1997-09-16 | 2010-03-24 | Centocor, Inc. | Method for the complete chemical synthesis and assembly of genes and genomes |
US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
EP1348466A3 (en) | 2002-02-01 | 2003-10-29 | Inspire Pharmaceuticals, Inc. | Method for treating pain with adenosine-tetraphosphates |
US7659082B2 (en) | 2002-02-19 | 2010-02-09 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
CA2626584A1 (en) | 2005-11-04 | 2007-05-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of nav1.8 gene |
WO2007109324A2 (en) | 2006-03-21 | 2007-09-27 | Xenon Pharmaceuticals, Inc. | Potent and selective nav 1.7 sodium channel blockers |
US8283318B2 (en) | 2006-09-08 | 2012-10-09 | Mayo Foundation For Medical Education And Research | Aquaretic and natriuretic polypeptides lacking vasodilatory activity |
US7998980B2 (en) | 2006-09-15 | 2011-08-16 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
EP2081602A2 (en) | 2006-10-25 | 2009-07-29 | Amgen Inc. | Toxin peptide therapeutic agents |
CN102202677A (zh) | 2008-09-03 | 2011-09-28 | 阿尔伯维塔公司 | 治疗疼痛的活性剂和方法 |
WO2010104115A1 (ja) | 2009-03-10 | 2010-09-16 | 独立行政法人産業技術総合研究所 | 膜タンパク質を特異的に認識するポリペプチドの調製方法 |
JP5555891B2 (ja) | 2009-09-15 | 2014-07-23 | アロモネ プリクリニカル リミテッド | クモ毒から単離した新規ペプチド及びその使用 |
US9279003B2 (en) * | 2010-07-07 | 2016-03-08 | Purdue Pharma L.P. | Analogs of sodium channel peptide toxin |
CN101979411A (zh) | 2010-10-21 | 2011-02-23 | 湖南师范大学 | 虎纹捕鸟蛛蛋白酶抑制剂 |
JP2014507136A (ja) | 2011-01-18 | 2014-03-27 | アムジエン・インコーポレーテツド | NaV1.7ノックアウトマウスとそれらの使用 |
US10414808B2 (en) | 2012-05-18 | 2019-09-17 | Janssen Biotech, Inc. | Huwentoxin-IV variants and methods of use |
US9102751B2 (en) * | 2012-05-18 | 2015-08-11 | Janssen Biotech, Inc. | Huwentoxin-IV variants and methods of use |
WO2013173706A2 (en) | 2012-05-18 | 2013-11-21 | Janssen Biotech, Inc. | Huwentoxin-iv variants and methods of use |
WO2014016673A1 (en) | 2012-07-27 | 2014-01-30 | Purdue Pharma L.P. | Sodium channel blocking peptides and the use thereof |
US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
CN104065367B (zh) | 2013-03-20 | 2017-11-07 | 江苏多维科技有限公司 | 一种低功耗磁电阻开关传感器 |
WO2015051216A1 (en) * | 2013-10-03 | 2015-04-09 | Janssen Biotech, Inc. | Protoxin-ii variants and methods of use |
MA41642A (fr) | 2015-03-03 | 2018-01-09 | Janssen Biotech Inc | Variants de protoxine ii et méthodes d'utilisation |
EP3277304B1 (en) | 2015-04-02 | 2021-08-04 | Janssen Biotech, Inc. | Protoxin-ii variants and methods of use |
-
2016
- 2016-02-24 MA MA041642A patent/MA41642A/fr unknown
- 2016-02-25 EP EP16759288.0A patent/EP3265476A4/en not_active Withdrawn
- 2016-02-25 CA CA2978435A patent/CA2978435A1/en not_active Abandoned
- 2016-02-25 KR KR1020177027801A patent/KR20170120703A/ko not_active Application Discontinuation
- 2016-02-25 BR BR112017018834A patent/BR112017018834A2/pt not_active IP Right Cessation
- 2016-02-25 AU AU2016226443A patent/AU2016226443B2/en not_active Ceased
- 2016-02-25 JP JP2017546100A patent/JP2018512123A/ja not_active Ceased
- 2016-02-25 MX MX2017011223A patent/MX2017011223A/es unknown
- 2016-02-25 CN CN201680026028.XA patent/CN107531769A/zh active Pending
- 2016-02-25 WO PCT/US2016/019549 patent/WO2016140859A2/en active Application Filing
- 2016-03-01 TW TW105106183A patent/TW201706292A/zh unknown
- 2016-03-03 AR ARP160100558A patent/AR103838A1/es unknown
- 2016-03-03 US US15/060,158 patent/US20160257726A1/en not_active Abandoned
-
2017
- 2017-05-01 US US15/583,793 patent/US10995125B2/en active Active
- 2017-09-03 IL IL254273A patent/IL254273A0/en active IP Right Grant
-
2018
- 2018-07-05 HK HK18108700.4A patent/HK1249118A1/zh unknown
-
2021
- 2021-01-21 AU AU2021200400A patent/AU2021200400A1/en not_active Abandoned
- 2021-04-20 IL IL282482A patent/IL282482A/en unknown
- 2021-05-03 US US17/306,572 patent/US20210363204A1/en not_active Abandoned
-
2022
- 2022-02-28 JP JP2022029412A patent/JP2022071050A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2016140859A2 (en) | 2016-09-09 |
IL282482A (en) | 2021-06-30 |
AR103838A1 (es) | 2017-06-07 |
EP3265476A2 (en) | 2018-01-10 |
HK1249118A1 (zh) | 2018-10-26 |
US10995125B2 (en) | 2021-05-04 |
JP2018512123A (ja) | 2018-05-17 |
KR20170120703A (ko) | 2017-10-31 |
CN107531769A (zh) | 2018-01-02 |
JP2022071050A (ja) | 2022-05-13 |
US20170334959A1 (en) | 2017-11-23 |
AU2021200400A1 (en) | 2021-03-18 |
US20210363204A1 (en) | 2021-11-25 |
AU2016226443A1 (en) | 2017-09-21 |
EP3265476A4 (en) | 2018-08-22 |
TW201706292A (zh) | 2017-02-16 |
MX2017011223A (es) | 2018-06-20 |
WO2016140859A3 (en) | 2016-10-27 |
MA41642A (fr) | 2018-01-09 |
US20160257726A1 (en) | 2016-09-08 |
CA2978435A1 (en) | 2016-09-09 |
IL254273A0 (en) | 2017-10-31 |
AU2016226443B2 (en) | 2020-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2763 DE 19/12/2023. |