AR103838A1 - Variantes de protoxina-ii y métodos de uso - Google Patents

Variantes de protoxina-ii y métodos de uso

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Publication number
AR103838A1
AR103838A1 ARP160100558A ARP160100558A AR103838A1 AR 103838 A1 AR103838 A1 AR 103838A1 AR P160100558 A ARP160100558 A AR P160100558A AR P160100558 A ARP160100558 A AR P160100558A AR 103838 A1 AR103838 A1 AR 103838A1
Authority
AR
Argentina
Prior art keywords
menor
aproximadamente
protoxin
donde
variants
Prior art date
Application number
ARP160100558A
Other languages
English (en)
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of AR103838A1 publication Critical patent/AR103838A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente solicitud se refiere a variantes de Protoxina-II, polinucleótidos que las codifican y a métodos para prepara y usar lo anterior. Reivindicación 1: Una variante de Protoxina-II aislada, en donde la variante de Protoxina-II inhibe la actividad de Nav1.7 humano con un valor de lC₅₀ de aproximadamente 1 x 10⁻⁷ M ᵒ ᵐᵉⁿᵒʳ, ᵃᵖʳᵒˣⁱᵐᵃᵈᵃᵐᵉⁿᵗᵉ ¹ ˣ ¹⁰⁻⁸ M ᵒ ᵐᵉⁿᵒʳ, ᵃᵖʳᵒˣⁱᵐᵃᵈᵃᵐᵉⁿᵗᵉ ¹ ˣ ¹⁰⁻⁹ M ᵒ ᵐᵉⁿᵒʳ, ᵃᵖʳᵒˣⁱᵐᵃᵈᵃᵐᵉⁿᵗᵉ ¹ ˣ ¹⁰⁻¹⁰ M ᵒ ᵐᵉⁿᵒʳ, ᵃᵖʳᵒˣⁱᵐᵃᵈᵃᵐᵉⁿᵗᵉ ¹ ˣ ¹⁰⁻¹¹ M ᵒ ᵐᵉⁿᵒʳ ᵒ ᵃᵖʳᵒˣⁱᵐᵃᵈᵃᵐᵉⁿᵗᵉ ¹ ˣ ¹⁰⁻¹² M ᵒ ᵐᵉⁿᵒʳ, ᵉⁿ ᵈᵒⁿᵈᵉ ᵉˡ ᵛᵃˡᵒʳ ᵈᵉ ˡC₅₀ se mide con el uso de un ensayo de despolarización de membrana FLlPR® Tetra con el uso de transferencia de emergía por resonancia de fluorescencia (FRET) en presencia de 25 x 10⁻⁶ M ᵈᵉ ³⁻ᵛᵉʳᵃᵗʳᵒⁱˡᵛᵉʳᵃᶜᵉᵛⁱⁿᵃ ᵉⁿ ᶜéˡᵘˡᵃˢ HEK²⁹³ qᵘᵉ ᵉˣᵖʳᵉˢᵃⁿ ᵉˢᵗᵃᵇˡᵉᵐᵉⁿᵗᵉ Nᵃᵛ¹.⁷ ʰᵘᵐᵃⁿᵒ, ᵉⁿ ᵈᵒⁿᵈᵉ ˡᵃ ᵛᵃʳⁱᵃⁿᵗᵉ ᵈᵉ Pʳᵒᵗᵒˣⁱⁿᵃ⁻II ᵗⁱᵉⁿᵉ ᵘⁿᵃ ˢᵘˢᵗⁱᵗᵘᶜⁱóⁿ W⁷Q ʸ/ᵒ W³⁰L, ᵉⁿ ᵈᵒⁿᵈᵉ ˡᵒˢ ʳᵉˢⁱᵈᵘᵒˢ ˢᵉ ⁿᵘᵐᵉʳᵃⁿ ᵈᵉ ᵃᶜᵘᵉʳᵈᵒ ᶜᵒⁿ ˡᵃ ˢᵉᶜ. ᶜᵒⁿ ⁿúᵐ. ᵈᵉ ⁱᵈᵉⁿᵗ.: ¹.
ARP160100558A 2015-03-03 2016-03-03 Variantes de protoxina-ii y métodos de uso AR103838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562127339P 2015-03-03 2015-03-03

Publications (1)

Publication Number Publication Date
AR103838A1 true AR103838A1 (es) 2017-06-07

Family

ID=56849056

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100558A AR103838A1 (es) 2015-03-03 2016-03-03 Variantes de protoxina-ii y métodos de uso

Country Status (15)

Country Link
US (3) US20160257726A1 (es)
EP (1) EP3265476A4 (es)
JP (2) JP2018512123A (es)
KR (1) KR20170120703A (es)
CN (1) CN107531769A (es)
AR (1) AR103838A1 (es)
AU (2) AU2016226443B2 (es)
BR (1) BR112017018834A2 (es)
CA (1) CA2978435A1 (es)
HK (1) HK1249118A1 (es)
IL (2) IL254273A0 (es)
MA (1) MA41642A (es)
MX (1) MX2017011223A (es)
TW (1) TW201706292A (es)
WO (1) WO2016140859A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
MX2016004282A (es) 2013-10-03 2016-10-12 Janssen Biotech Inc Variantes de protoxina-ii y metodos de uso.
WO2016101031A1 (en) 2014-12-23 2016-06-30 Davoodi Pty Ltd Delivery apparatus, system and associated methods
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
WO2016161100A1 (en) * 2015-04-02 2016-10-06 Janssen Biotech, Inc. Protoxin-ii variants and methods of use
CN109369785B (zh) * 2018-11-14 2019-08-30 青海芬陀利华生物科技有限公司 Ccotx1毒素及其应用
CN109369784B (zh) * 2018-11-14 2019-08-30 青海芬陀利华生物科技有限公司 PaTx-1毒素及其应用
US11957542B2 (en) * 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device
CN114957431B (zh) * 2022-06-27 2023-06-20 四川丽妍工坊生物科技有限公司 一种皮肤抗皱多肽Cj2a2、制备方法及应用

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MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
WO2016161100A1 (en) 2015-04-02 2016-10-06 Janssen Biotech, Inc. Protoxin-ii variants and methods of use

Also Published As

Publication number Publication date
IL254273A0 (en) 2017-10-31
HK1249118A1 (zh) 2018-10-26
WO2016140859A3 (en) 2016-10-27
EP3265476A4 (en) 2018-08-22
TW201706292A (zh) 2017-02-16
IL282482A (en) 2021-06-30
AU2016226443B2 (en) 2020-10-22
US20170334959A1 (en) 2017-11-23
WO2016140859A2 (en) 2016-09-09
CN107531769A (zh) 2018-01-02
KR20170120703A (ko) 2017-10-31
JP2022071050A (ja) 2022-05-13
MX2017011223A (es) 2018-06-20
US10995125B2 (en) 2021-05-04
US20210363204A1 (en) 2021-11-25
US20160257726A1 (en) 2016-09-08
BR112017018834A2 (pt) 2018-04-17
CA2978435A1 (en) 2016-09-09
AU2016226443A1 (en) 2017-09-21
EP3265476A2 (en) 2018-01-10
MA41642A (fr) 2018-01-09
JP2018512123A (ja) 2018-05-17
AU2021200400A1 (en) 2021-03-18

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