BR112017002489B1 - Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico - Google Patents

Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico Download PDF

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BR112017002489B1
BR112017002489B1 BR112017002489-6A BR112017002489A BR112017002489B1 BR 112017002489 B1 BR112017002489 B1 BR 112017002489B1 BR 112017002489 A BR112017002489 A BR 112017002489A BR 112017002489 B1 BR112017002489 B1 BR 112017002489B1
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sample
instrument
sensor
excitation
energy
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BR112017002489-6A
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English (en)
Portuguese (pt)
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BR112017002489A2 (pt
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Jonathan M. Rothberg
Ali Kabiri
Jason W. Sickler
Brett J. Gyarfas
Jeremy Lackey
Gerard Schmid
Paul E. Glenn
Lawrence C. West
Benjamin Cipriany
Keith G. Fife
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Quantum-Si Incorporated
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/04—Batch operation; multisample devices
    • G01N2201/0446—Multicell plate, sequential
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
BR112017002489-6A 2014-08-08 2015-08-07 Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico BR112017002489B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462035242P 2014-08-08 2014-08-08
US62/035,242 2014-08-08
PCT/US2015/044378 WO2016023010A1 (en) 2014-08-08 2015-08-07 Optical system and assay chip for probing, detecting, and analyzing molecules

Publications (2)

Publication Number Publication Date
BR112017002489A2 BR112017002489A2 (pt) 2017-12-05
BR112017002489B1 true BR112017002489B1 (pt) 2023-02-14

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BR112017002489-6A BR112017002489B1 (pt) 2014-08-08 2015-08-07 Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico

Country Status (10)

Country Link
US (4) US9921157B2 (enExample)
EP (2) EP3194933B1 (enExample)
JP (1) JP6812341B2 (enExample)
KR (2) KR102472061B1 (enExample)
CN (1) CN106796175B (enExample)
AU (1) AU2015300778B2 (enExample)
BR (1) BR112017002489B1 (enExample)
CA (1) CA2957543A1 (enExample)
MX (1) MX383892B (enExample)
WO (1) WO2016023010A1 (enExample)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8933526B2 (en) * 2009-07-15 2015-01-13 First Solar, Inc. Nanostructured functional coatings and devices
CA3248042A1 (en) 2012-05-18 2025-10-31 Rebellion Photonics, Inc. Divided-aperture infra-red spectral imaging system for chemical detection
US9599508B2 (en) 2012-05-18 2017-03-21 Rebellion Photonics, Inc. Divided-aperture infra-red spectral imaging system
CA3040684C (en) 2012-08-20 2023-02-07 Hod Finkelstein Method and system for fluorescence lifetime based sequencing
EP2945742B1 (en) 2013-01-18 2024-07-10 Biomeme, Inc. Analytic device
CA2938783A1 (en) * 2013-04-18 2014-10-23 Ripon Kumar DEY Method of fabricating nano-scale structures and nano-scale structures fabricated using the method
JP5808021B2 (ja) * 2013-07-16 2015-11-10 国立大学法人名古屋大学 電子親和力の低下処理装置に用いられる活性化容器及びキット、該キットを含む電子親和力の低下処理装置、フォトカソード電子ビーム源、並びに、フォトカソード電子ビーム源を含む電子銃、自由電子レーザー加速器、透過型電子顕微鏡、走査型電子顕微鏡、電子線ホログラフィー顕微鏡、電子線描画装置、電子線回折装置及び電子線検査装置
GB201319438D0 (en) * 2013-11-04 2013-12-18 Univ Lancaster Waveguide
EP2871452B1 (en) 2013-11-12 2019-05-01 Rebellion Photonics, Inc. Divided-aperture infra-red spectral imaging system
JP6673843B2 (ja) 2013-11-17 2020-03-25 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子をプローブし、検出し、分析するための光学システム及びアッセイ・チップ
US11290662B2 (en) 2014-05-01 2022-03-29 Rebellion Photonics, Inc. Mobile gas and chemical imaging camera
US20170026588A1 (en) 2014-05-01 2017-01-26 Rebellion Photonics, Inc. Dual-band divided-aperture infra-red spectral imaging system
US10458905B2 (en) 2014-07-07 2019-10-29 Rebellion Photonics, Inc. Gas leak emission quantification with a gas cloud imager
CA2957546A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
EP3194935B1 (en) 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
MX383892B (es) 2014-08-08 2025-03-14 Quantum Si Inc Sistema optico y circuito integrado de valoración para sondear, detectar y analizar moleculas.
JP6179682B2 (ja) * 2015-01-22 2017-08-16 株式会社村田製作所 空隙配置構造体およびその製造方法
US9995859B2 (en) 2015-04-14 2018-06-12 California Institute Of Technology Conformal optical metasurfaces
KR102696246B1 (ko) * 2015-05-20 2024-08-20 퀀텀-에스아이 인코포레이티드 펄스 레이저 및 바이오분석 시스템
EP4375631A3 (en) 2015-05-29 2024-07-31 Rebellion Photonics, Inc. Hydrogen sulfide imaging system
US10324029B2 (en) * 2015-08-18 2019-06-18 Tokushima University Concentration measurement device
WO2017034995A1 (en) * 2015-08-21 2017-03-02 California Institute Of Technology Planar diffractive device with matching diffraction spectrum
US9927477B1 (en) * 2015-09-09 2018-03-27 Cpg Technologies, Llc Object identification system and method
US10097281B1 (en) 2015-11-18 2018-10-09 Hypres, Inc. System and method for cryogenic optoelectronic data link
US10352856B2 (en) * 2015-12-14 2019-07-16 Massachusetts Institute Of Technology Apparatus and methods for spectroscopy and broadband light emission using two-dimensional plasmon fields
US10670782B2 (en) 2016-01-22 2020-06-02 California Institute Of Technology Dispersionless and dispersion-controlled optical dielectric metasurfaces
US10441174B2 (en) 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
FI20165148A (fi) * 2016-02-25 2017-08-26 Arcdia Int Oy Ltd Kaksoisfotoniviritteistä fluoresenssia hyödyntävä bioaffiniteettimääritysmenetelmä
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
SG11201809171VA (en) * 2016-04-22 2018-11-29 Illumina Inc Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
MX2018014856A (es) 2016-06-01 2019-03-07 Quantum Si Inc Llamador de pulso y llamador de base.
MX394779B (es) 2016-06-01 2025-03-24 Quantum Si Inc Dispositivo integrado para detectar y analizar moléculas.
JP6771147B2 (ja) * 2016-06-22 2020-10-21 パナソニックＩｐマネジメント株式会社 浴光システム及び携帯端末
US11124827B2 (en) * 2016-06-23 2021-09-21 Roche Sequencing Solutions, Inc. Period-to-period analysis of AC signals from nanopore sequencing
US11373278B2 (en) * 2016-09-30 2022-06-28 University Of Utah Research Foundation Lensless imaging device
EP3305170B1 (en) 2016-10-04 2020-12-02 ams AG Fluorescence lifetime sensor module and method of determining a fluorescence lifetime using a sensor module
CA3041100A1 (en) 2016-10-21 2018-04-26 Rebellion Photonics, Inc. Gas imaging system
US10375327B2 (en) 2016-10-21 2019-08-06 Rebellion Photonics, Inc. Mobile gas and chemical imaging camera
JP6775223B2 (ja) * 2016-10-27 2020-10-28 シャープ株式会社 蛍光検査システム、分子検査方法及び蛍光検査方法
CN110088667B (zh) 2016-12-16 2023-05-23 宽腾矽公司 紧密的光束整形及操纵总成
US10731209B2 (en) 2016-12-19 2020-08-04 Quantum-Si Incorporated Loading molecules into sample wells for analysis
TWI836905B (zh) * 2016-12-22 2024-03-21 美商寬騰矽公司 具有直接合併像素之整合式光電偵測器
US11041806B2 (en) * 2017-01-10 2021-06-22 Photoswitch Biosciences, Inc. Systems and methods for detection
CN207396531U (zh) 2017-01-31 2018-05-22 杭州探真纳米科技有限公司 一种悬臂末端纳米探针
WO2018156795A1 (en) 2017-02-22 2018-08-30 Rebellion Photonics, Inc. Systems and methods for monitoring remote installations
WO2018175341A1 (en) * 2017-03-20 2018-09-27 Complete Genomics, Inc. Biosensors for biological or chemical analysis and methods of manufacturing the same
US10379288B2 (en) * 2017-04-07 2019-08-13 Lijie Qiao Method and device having a saturable absorber for filtering
US10488651B2 (en) 2017-04-10 2019-11-26 California Institute Of Technology Tunable elastic dielectric metasurface lenses
AU2018261007B2 (en) 2017-05-05 2024-09-26 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
JP7072847B2 (ja) * 2017-05-12 2022-05-23 公立大学法人大阪 被検出物質の検出キットおよびそれを備えた検出システム、ならびに、被検出物質の検出キットの製造方法
US20180364223A1 (en) * 2017-06-16 2018-12-20 Krista Michelle Fretes Portable single-molecule bio-sensing device
AU2018282868B2 (en) * 2017-06-16 2023-10-19 Duke University Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation
CN107463727B (zh) * 2017-06-27 2021-01-19 浙江大学 基于向量式有限元和fpga的混合试验方法
US10222350B2 (en) * 2017-07-12 2019-03-05 International Business Machines Corporation High sensitivity force gauge with parallel dipole line trap system
TW201915473A (zh) 2017-07-24 2019-04-16 美商寬騰矽公司 手持，大量平行之生物光電裝置
WO2019023146A1 (en) * 2017-07-24 2019-01-31 Quantum-Si Incorporated PHOTONIC STRUCTURES WITH OPTICAL RELEASE
EP3438649B1 (en) * 2017-07-31 2020-03-11 Vestel Elektronik Sanayi ve Ticaret A.S. Identification tag and method of identifying an object
CN107332106B (zh) * 2017-08-01 2019-10-15 复旦大学 全硅分布式反馈激光器
WO2019036055A2 (en) 2017-08-18 2019-02-21 Ignite Biosciences, Inc. METHODS OF SELECTING BINDING REAGENTS
CN111356768A (zh) 2017-09-15 2020-06-30 生米公司 用于自动化样品处理的方法和系统
US10811772B2 (en) * 2017-09-18 2020-10-20 The United States Of America As Represented By The Secretary Of The Army Concentric, co-located and interleaved dual band antenna array
EP4379331A3 (en) 2017-11-09 2024-07-31 Rebellion Photonics, Inc. Window obscuration sensors for mobile gas and chemical imaging cameras
EP3724352A4 (en) 2017-12-15 2021-09-01 Biomeme, Inc. PORTABLE DEVICES AND METHODS FOR ANALYZING SAMPLES
CN109932316A (zh) * 2017-12-18 2019-06-25 长光华大基因测序设备（长春）有限公司 基因测序光学装置
NL2020615B1 (en) 2017-12-26 2019-07-02 Illumina Inc Image sensor structure
CN111512155B (zh) 2017-12-28 2022-07-05 豪夫迈·罗氏有限公司 测量和去除来自交流信号驱动的纳米孔dna测序系统的随机信号中的噪声
JP6987889B2 (ja) 2018-01-08 2022-01-05 イルミナ インコーポレイテッド 半導体ベースの検出を用いた高スループットシーケンシング
JP2021509578A (ja) * 2018-01-08 2021-04-01 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ サブミクロンスケール反応チャンバの動電学的ローディングのためのシステムおよび方法
EP3743918A1 (en) 2018-01-26 2020-12-02 Quantum-Si Incorporated Machine learning enabled pulse and base calling for sequencing devices
NL2021357A (en) * 2018-01-31 2018-08-16 Asml Netherlands Bv Two-dimensional diffraction grating
GB201802597D0 (en) * 2018-02-16 2018-04-04 Vision Rt Ltd A calibration object for calibrating a patient monitoring system
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CN109085224B (zh) * 2018-08-27 2023-11-03 浙江大学 用于细胞表面区域atp检测的敏感微电极
US20200072752A1 (en) * 2018-08-29 2020-03-05 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors
CN110910888B (zh) * 2018-09-17 2022-06-14 中国移动通信集团设计院有限公司 语音识别装置及方法
US10796191B2 (en) * 2018-09-26 2020-10-06 Stmicroelectronics Sa Device and method for processing a histogram of arrival times in an optical sensor
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
WO2020106889A1 (en) 2018-11-20 2020-05-28 Nautilus Biotechnology, Inc. Design and selection of affinity reagents
CN109603942B (zh) * 2019-02-15 2021-12-24 京东方科技集团股份有限公司 微流控装置和微流控方法
EP3924723A1 (en) * 2019-03-05 2021-12-22 Quantum-Si Incorporated Optical absorption filter for an integrated device
WO2020191193A1 (en) * 2019-03-21 2020-09-24 Biomeme, Inc. Multi-function analytic devices
CA3135206A1 (en) 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
US12313627B2 (en) 2019-05-01 2025-05-27 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CN113994192B (zh) 2019-05-17 2023-12-05 上海芯像生物科技有限公司 用于分子检测和感测的分析系统
US11011366B2 (en) * 2019-06-06 2021-05-18 Kla Corporation Broadband ultraviolet illumination sources
US11085878B2 (en) 2019-06-18 2021-08-10 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
CN110229747A (zh) * 2019-06-18 2019-09-13 京东方科技集团股份有限公司 基因测序芯片、设备及制备方法
US11009611B2 (en) 2019-06-18 2021-05-18 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
BR112021025529A2 (pt) 2019-06-19 2022-04-12 Quantum Si Inc Supressor de nanoestrutura óptica para um dispositi-vo integrado e métodos relacionados
WO2020264546A1 (en) 2019-06-28 2020-12-30 Illumina Cambridge Limited Flowcells with linear waveguides
CA3144668A1 (en) 2019-06-28 2020-12-30 Quantum-Si Incorporated Optical and electrical secondary path rejection
AU2020326781A1 (en) 2019-08-08 2022-03-17 Quantum-Si Incorporated Increased emission collection efficiency in integrated optical devices
EP3779408A1 (de) * 2019-08-15 2021-02-17 optek-Danulat GmbH Messvorrichtung und verfahren zur bestimmung einer stoffkonzentration
AU2020364058A1 (en) 2019-10-11 2022-05-26 Quantum-Si Incorporated Surface modification in the vapor phase
FR3102848B1 (fr) * 2019-10-30 2021-11-19 Commissariat Energie Atomique Dispositif d'excitation et de détection de photoluminescence
TW202137577A (zh) 2019-10-31 2021-10-01 美商寬騰矽公司 具有增強汲極之像素
CN111123428B (zh) * 2019-12-24 2022-03-08 中国科学院苏州生物医学工程技术研究所 一种零模波导孔孔壁的修饰方法及零模波导孔结构
CN111123429B (zh) * 2019-12-24 2022-03-08 中国科学院苏州生物医学工程技术研究所 涂覆有锚定物质的零模波导孔的制备方法及波导孔结构
EP4088351A1 (en) 2020-01-14 2022-11-16 Quantum-si Incorporated Amplitude-modulated laser
US11885744B2 (en) 2020-01-14 2024-01-30 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
US11408032B2 (en) * 2020-01-17 2022-08-09 Element Biosciences, Inc. Tube lens design for improved depth-of-field
WO2021168155A1 (en) * 2020-02-18 2021-08-26 Pacific Biosciences Of California, Inc. Highly multiplexed nucleic acid sequencing systems
JP2023515682A (ja) 2020-03-02 2023-04-13 クアンタム－エスアイ インコーポレイテッド 多次元信号解析用集積センサ
CN113686939A (zh) * 2020-03-20 2021-11-23 上海芯像生物科技有限公司 用于分子检测和感测的高通量分析系统
KR20220162170A (ko) * 2020-04-06 2022-12-07 레어사이트 잉크 이미징 시스템들 및 스펙트럼 에지 검출을 위한 광학 트레인들
EP3901612B1 (en) * 2020-04-23 2024-06-12 Sensirion AG Integrated particulate matter sensor with cavity
CN111551531B (zh) * 2020-05-19 2023-04-18 北京金诺美科技股份有限公司 一种荧光激发系统及实时荧光定量pcr仪
CA3178563C (en) * 2020-05-20 2024-02-27 Kevin Flanagan Extended solid angle turbidity sensor
US11555994B2 (en) * 2020-05-22 2023-01-17 The Texas A&M University System Wide-field deep UV Raman microscope
AU2021288692A1 (en) 2020-06-11 2023-02-02 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
US20230304932A1 (en) * 2020-07-23 2023-09-28 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
EP4213989A4 (en) 2020-09-18 2025-01-15 Biomeme, Inc. Portable devices and methods for analyzing samples
EP4217711A4 (en) 2020-10-22 2024-07-03 Quantum-si Incorporated Integrated circuit with sequentially-coupled charge storage and associated techniques
US20220128456A1 (en) * 2020-10-23 2022-04-28 Quantum-Si Incorporated Systems and methods for sample process scaling
WO2022115873A1 (en) 2020-11-30 2022-06-02 Gentroma Inc. Semiconductor nanosensing device with multilayer graphene sheet for sequencing or sensing nucleic acids
CN116848397A (zh) 2020-12-15 2023-10-03 宽腾矽公司 通过单分子动力学进行分子条形码分析
WO2022159663A1 (en) 2021-01-21 2022-07-28 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
CN112986206B (zh) * 2021-05-20 2021-07-30 北京百奥纳芯生物科技有限公司 一种检测基因芯片杂交结果的方法
CN113640327B (zh) * 2021-06-03 2023-07-25 中国工程物理研究院材料研究所 一种大曲率微小件表面多层金属薄膜的无损检测方法
CN113433104A (zh) * 2021-07-05 2021-09-24 夏晓艺 基于等离子体增强的单分子检测模块、防伪标签及应用
EP4373968A4 (en) 2021-07-21 2025-05-14 Element Biosciences, Inc. Optical systems for nucleic acid sequencing and methods therefor
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
WO2023049073A1 (en) 2021-09-22 2023-03-30 Nautilus Biotechnology, Inc. Methods and systems for determining polypeptide interactions
WO2023070093A1 (en) 2021-10-22 2023-04-27 Illumina, Inc. Semiconductor light sensing
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US11662526B1 (en) * 2021-12-09 2023-05-30 Visera Technologies Company Ltd. Optical structure
KR102578658B1 (ko) 2021-12-10 2023-09-14 한국세라믹기술원 미소 충전 샘플링에 의한 ｐｅｂ 유도 에너지 분석 방법
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
CN114879243B (zh) * 2022-04-13 2023-04-25 中国科学院近代物理研究所 一种基于光子计数的束流光谱检测装置及方法
TWI830229B (zh) * 2022-05-11 2024-01-21 國立成功大學 微型檢測機及其檢測模組
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
US12146833B2 (en) * 2022-10-14 2024-11-19 Toyota Motor Engineering & Manufacturing North America, Inc. Chiral sensing with harmonic generation from a metasurface fabricated on a SOI wafer
EP4375644A1 (en) * 2022-11-22 2024-05-29 Gnothis Holding AG Fingerprint analysis of single molecule events
EP4382614A1 (en) * 2022-12-06 2024-06-12 Gnothis Holding AG High yield support
EP4630816A1 (en) 2022-12-09 2025-10-15 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
WO2024130000A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
US20240344116A1 (en) 2023-03-24 2024-10-17 Nautilus Subsidiary, Inc. Transfer of nanoparticles to array surfaces
CN116106263B (zh) * 2023-04-07 2023-06-16 成都甄识科技有限公司 一种高灵敏度高品质因数的超表面局域等离激元传感器
US20240369405A1 (en) * 2023-05-03 2024-11-07 Tomphyzx. Llc Optical probe for measuring photon density
US12498319B2 (en) * 2023-05-12 2025-12-16 Redshift Bioanalytics, Inc. Matched optical filter
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20240411078A1 (en) * 2023-06-08 2024-12-12 Ii-Vi Delaware, Inc. Polarizer, diffraction grating and meta surface fabrication via ion implantation
US12444022B2 (en) * 2023-06-30 2025-10-14 Fei Company Focus stacking applications for sample preparation
CN117042425B (zh) * 2023-07-03 2024-08-09 成都飞机工业（集团）有限责任公司 一种吸波型频率选择表面电磁屏蔽结构
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025128588A1 (en) 2023-12-11 2025-06-19 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
US20250205706A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
CN117608082B (zh) * 2024-01-23 2024-05-03 江苏金视传奇科技有限公司 压缩成像系统、压缩成像方法
WO2025160569A1 (en) * 2024-01-26 2025-07-31 Pumpkinseed Technologies, Inc. Methods and systems for nucleic acid sequence determination
US20250298016A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
JPH05281041A (ja) * 1992-03-31 1993-10-29 Omron Corp 分光器
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US6456326B2 (en) 1994-01-28 2002-09-24 California Institute Of Technology Single chip camera device having double sampling operation
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
DE69505370T2 (de) 1994-05-27 1999-04-01 Novartis Ag, Basel Verfahren und sensor zum nachweis abklingend angeregter lumineszenz
JPH0815590A (ja) * 1994-06-29 1996-01-19 Olympus Optical Co Ltd 光学要素位置決め装置
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5990506A (en) 1996-03-20 1999-11-23 California Institute Of Technology Active pixel sensors with substantially planarized color filtering elements
US5929986A (en) * 1996-08-26 1999-07-27 Kaiser Optical Systems, Inc. Synchronous spectral line imaging methods and apparatus
WO1998022799A2 (de) 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
CN1251609A (zh) 1997-02-12 2000-04-26 尤金·Y·查恩 分析聚合物的方法和产品
AU743025B2 (en) 1997-03-12 2002-01-17 Applera Corporation DNA polymerases having improved labeled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) * 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
US6232103B1 (en) 1998-03-23 2001-05-15 Invitrogen Corporation Methods useful for nucleic acid sequencing using modified nucleotides comprising phenylboronic acid
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
EP1082458A1 (en) 1998-05-01 2001-03-14 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
EP1141409B2 (en) 1998-12-14 2009-05-27 Pacific Biosciences of California, Inc. A kit and methods for nucleic acid sequencing of single molecules by polymerase synthesis
EP1159453B1 (en) 1999-03-10 2008-05-28 ASM Scientific, Inc. A method for direct nucleic acid sequencing
EP1681357A3 (en) 1999-05-19 2006-07-26 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
US6331438B1 (en) * 1999-11-24 2001-12-18 Iowa State University Research Foundation, Inc. Optical sensors and multisensor arrays containing thin film electroluminescent devices
EP1285290A1 (en) 2000-04-28 2003-02-26 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
AU2001268291A1 (en) 2000-06-07 2001-12-17 Li-Cor, Inc. Charge-switch nucleotides
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
AU2001286963A1 (en) 2000-08-30 2002-03-13 University Of Rochester Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element
AU2001284681A1 (en) 2000-09-11 2002-03-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
AU2002258997A1 (en) 2001-04-24 2002-11-05 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
DK1421213T3 (da) 2001-08-29 2010-06-07 Ge Healthcare Bio Sciences Mærkede nukleosidpolyphosphater
US7727722B2 (en) 2001-08-29 2010-06-01 General Electric Company Ligation amplification
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
WO2003025132A2 (en) 2001-09-14 2003-03-27 Invitrogen Corporation Dna polymerases and mutants thereof
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6924887B2 (en) 2002-03-27 2005-08-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
US6768122B2 (en) * 2002-06-04 2004-07-27 National Taiwan University Multiphoton excitation microscope for biochip fluorescence assay
US7244961B2 (en) * 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US7393640B2 (en) 2003-02-05 2008-07-01 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides with new linkers
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
JP4268461B2 (ja) * 2003-06-24 2009-05-27 浜松ホトニクス株式会社 時間分解測定装置
WO2005073407A1 (en) * 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
US20050074784A1 (en) * 2003-10-07 2005-04-07 Tuan Vo-Dinh Integrated biochip with continuous sampling and processing (CSP) system
US7002688B2 (en) * 2003-10-16 2006-02-21 Pria Diagnostics, Inc. Multilens optical assembly for a diagnostic device
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
EP1716254B1 (en) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Methods for analyzing polynucleotide sequences
US8128871B2 (en) * 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US20060062531A1 (en) 2004-09-17 2006-03-23 Stephen Turner Fabrication of optical confinements
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
WO2006055521A2 (en) 2004-11-16 2006-05-26 Helicos Biosciences Corporation Tirf single molecule analysis and method of sequencing nucleic acids
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
JP2008546424A (ja) 2005-06-28 2008-12-25 アジェンコート パーソナル ジェノミクス コーポレイション 修飾ポリヌクレオチドを作製する方法および配列決定する方法
WO2007015168A2 (en) 2005-07-01 2007-02-08 Dako Denmark A/S Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
JP2009519041A (ja) 2005-12-12 2009-05-14 アメリカ合衆国 核酸配列決定のためのプローブおよび使用方法
CA2633524A1 (en) 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
ATE518010T1 (de) 2005-12-22 2011-08-15 Pacific Biosciences California Aktive oberflächengekoppelte polymerasen
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20070188736A1 (en) * 2006-02-16 2007-08-16 Fouquet Julie E Obtaining measurement and baseline signals for evaluating assay test strips
JP4782593B2 (ja) * 2006-03-13 2011-09-28 株式会社日立製作所 光検出装置
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
EP3936857B1 (en) 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP5395323B2 (ja) * 2006-09-29 2014-01-22 ブレインビジョン株式会社 固体撮像素子
US20100096561A1 (en) * 2006-10-05 2010-04-22 Koninklijke Philips Electronics N.V. Methods and systems for detection with front irradiation
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
EP1925929A1 (en) * 2006-11-27 2008-05-28 Koninklijke Philips Electronics N.V. Multivariate detection of molecules in bioassay
US8821799B2 (en) * 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
ATE509265T1 (de) 2007-03-22 2011-05-15 Univ Strasbourg Etablissement Public A Caractere Scient Culturel Et Professionel Gerät zur sortierung und konzentration elektromagnetischer energie und vorrichtung mit mindestens einem derartigen gerät
ATE548643T1 (de) 2007-03-30 2012-03-15 Pacific Biosciences California System und verfahren zur verstärkung von fluoreszenzsignalen
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
US20110165652A1 (en) 2008-01-14 2011-07-07 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
CA2714630A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. Cis reactive oxygen quenchers integrated into linkers
AU2009215193A1 (en) 2008-02-12 2009-08-20 Pacific Biosciences Of California, Inc. Compositions and methods for use in analytical reactions
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
AU2009223702B2 (en) 2008-03-13 2013-08-22 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
WO2009120374A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
WO2009120372A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
WO2009145820A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
EP2274446B1 (en) 2008-03-31 2015-09-09 Pacific Biosciences of California, Inc. Two slow-step polymerase enzyme systems and methods
AU2009251881B2 (en) 2008-03-31 2015-03-26 Pacific Biosciences Of California, Inc Single molecule loading methods and compositions
CA2735979A1 (en) 2008-09-05 2010-03-11 Pacific Biosciences Of California, Inc. Engineering polymerases and reaction conditions for modified incorporation properties
CA3063032A1 (en) 2008-09-16 2010-03-25 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
WO2010036287A1 (en) 2008-09-24 2010-04-01 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8247216B2 (en) 2008-09-30 2012-08-21 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
EP2182523B1 (en) 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
JP2010161629A (ja) * 2009-01-08 2010-07-22 Fujifilm Corp 固体撮像素子及びその駆動方法並びに撮像装置
CA2750874A1 (en) 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Hybridization linkers
US20100255487A1 (en) 2009-03-27 2010-10-07 Life Technologies Corporation Methods and apparatus for single molecule sequencing using energy transfer detection
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
WO2011040971A2 (en) 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US9579402B2 (en) 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
WO2011090745A1 (en) 2009-12-29 2011-07-28 Life Technologies Corporation Single molecule detection and sequencing using fluorescence lifetime imaging
US9410891B2 (en) 2010-02-19 2016-08-09 Pacific Biosciences Of California, Inc. Optics collection and detection system and method
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
JP5021054B2 (ja) * 2010-05-25 2012-09-05 キヤノン株式会社 屈折率分布計測方法および屈折率分布計測装置
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
JP2012047719A (ja) * 2010-07-28 2012-03-08 Furukawa Electric Advanced Engineering Co Ltd マルチ光測定装置、マルチ光測定方法、マルチ光スイッチ
WO2012129242A2 (en) 2011-03-23 2012-09-27 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US8773665B1 (en) * 2011-04-01 2014-07-08 Emcore Corporation Compact fiber optic gyroscope
WO2013024637A1 (ja) * 2011-08-12 2013-02-21 オリンパス株式会社 蛍光粒子の検出方法
WO2013031365A1 (ja) * 2011-08-30 2013-03-07 オリンパス株式会社 標的粒子の検出方法
IN2014DN03441A (enExample) * 2011-09-30 2015-06-05 Life Technologies Corp
WO2013063382A2 (en) 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method
US9606060B2 (en) 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP2814953B1 (en) 2012-02-15 2017-06-07 Pacific Biosciences Of California, Inc. Polymerase enzyme substrates with protein shield
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
CA3040684C (en) * 2012-08-20 2023-02-07 Hod Finkelstein Method and system for fluorescence lifetime based sequencing
US9772322B2 (en) * 2012-10-25 2017-09-26 Hamamatsu Photonics K.K. Cell observation device, and cell observation method
EP2936222B1 (en) 2012-12-18 2019-07-03 Pacific Biosciences Of California, Inc. An optical analytical device
JP6673843B2 (ja) 2013-11-17 2020-03-25 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子をプローブし、検出し、分析するための光学システム及びアッセイ・チップ
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
MX383892B (es) 2014-08-08 2025-03-14 Quantum Si Inc Sistema optico y circuito integrado de valoración para sondear, detectar y analizar moleculas.
CA2957546A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
EP3194935B1 (en) 2014-08-08 2018-10-31 Quantum-si Incorporated Integrated device for temporal binning of received photons
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
CN113064236B (zh) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统

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