BR112012007318A2 - anticorpos de endoglina. - Google Patents

anticorpos de endoglina.

Info

Publication number
BR112012007318A2
BR112012007318A2 BR112012007318A BR112012007318A BR112012007318A2 BR 112012007318 A2 BR112012007318 A2 BR 112012007318A2 BR 112012007318 A BR112012007318 A BR 112012007318A BR 112012007318 A BR112012007318 A BR 112012007318A BR 112012007318 A2 BR112012007318 A2 BR 112012007318A2
Authority
BR
Brazil
Prior art keywords
antibodies
humanized
endoglin
another aspect
bind
Prior art date
Application number
BR112012007318A
Other languages
English (en)
Other versions
BR112012007318B1 (pt
Inventor
Charles Theuer
Maximiliano Vasquez
Original Assignee
Tracon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tracon Pharmaceuticals Inc filed Critical Tracon Pharmaceuticals Inc
Publication of BR112012007318A2 publication Critical patent/BR112012007318A2/pt
Publication of BR112012007318B1 publication Critical patent/BR112012007318B1/pt

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

anticorpos de endoglina. o presente pedido refere-se a composições de humanizados e humanizada/deimunized anti-endoglina anticorpos e de ligação ao antígeno seus fragmentos. um aspecto refere-se a anticorpos que possuem uma ou mais modificações em pelo menos um resíduo de aminoácido de pelo menos uma das regiões de estrutura da cadeia pesada variável, a variável da cadeia leve, ou ambos. outro aspecto refere-se a anticorpos que se ligam endoglina e inibir a angiogênese. outro aspecto refere-se à deimmunization de anticorpos humanizados para reduzir a imunogenicidade. outro aspecto refere-se à utilização de anticorpos humanizados e humanizada/deimmunized que se ligam endoglina para a detecção, diagnóstico ou tratamento de uma doença ou condição associada com endoglina, angiogénese ou uma combinação destes.
BR112012007318-4A 2009-09-30 2010-09-29 Anticorpo ou fragmento de ligação de antígeno do mesmo, composição e uso de um anticorpo ou fragmento de ligação de antígeno BR112012007318B1 (pt)

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US12/751,907 US8221753B2 (en) 2009-09-30 2010-03-31 Endoglin antibodies
US12/751,907 2010-03-31
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