EA201290173A1 - Антитела против эндоглина - Google Patents

Антитела против эндоглина

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Publication number
EA201290173A1
EA201290173A1 EA201290173A EA201290173A EA201290173A1 EA 201290173 A1 EA201290173 A1 EA 201290173A1 EA 201290173 A EA201290173 A EA 201290173A EA 201290173 A EA201290173 A EA 201290173A EA 201290173 A1 EA201290173 A1 EA 201290173A1
Authority
EA
Eurasian Patent Office
Prior art keywords
humanized
antibodies
endoglin
aspect relates
another aspect
Prior art date
Application number
EA201290173A
Other languages
English (en)
Other versions
EA025174B1 (ru
Inventor
Чарльз Теуэр
Максимилиано Васкес
Original Assignee
Тракон Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тракон Фармасьютикалз, Инк. filed Critical Тракон Фармасьютикалз, Инк.
Publication of EA201290173A1 publication Critical patent/EA201290173A1/ru
Publication of EA025174B1 publication Critical patent/EA025174B1/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

Настоящее изобретение относится к композициям гуманизированных и гуманизированных/деиммунизи-рованных антител против эндоглина и их антигенсвязывающих фрагментов. Один из аспектов относится к антителам, имеющим одну или более модификаций по меньшей мере в одном аминокислотном остатке по меньшей мере одного из каркасных участков вариабельной области тяжелой цепи, вариабельной области легкой цепи или их обеих. Другой аспект относится к антителам, которые связывают эндоглин и ингибируют ангиогенез. Другой аспект относится к деиммунизации гуманизированных антител для уменьшения иммуногенности. Другой аспект относится к применению гуманизированных и гуманизированных/деиммунизированных антител, которые связывают эндоглин, для детекции, диагностики или лечения заболевания или состояния, ассоциированного с эндоглином, ангиогенезом или их комбинацией.
EA201290173A 2009-09-30 2010-09-29 Антитела против эндоглина EA025174B1 (ru)

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US12/751,907 US8221753B2 (en) 2009-09-30 2010-03-31 Endoglin antibodies
PCT/US2010/050759 WO2011041441A1 (en) 2009-09-30 2010-09-29 Endoglin antibodies

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