BR112012001491B1 - Preparação terapêutica para tratar dermatite e uso de uma preparação terapêutica - Google Patents
Preparação terapêutica para tratar dermatite e uso de uma preparação terapêutica Download PDFInfo
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- BR112012001491B1 BR112012001491B1 BR112012001491-9A BR112012001491A BR112012001491B1 BR 112012001491 B1 BR112012001491 B1 BR 112012001491B1 BR 112012001491 A BR112012001491 A BR 112012001491A BR 112012001491 B1 BR112012001491 B1 BR 112012001491B1
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- dermatitis
- erythema
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| CN104367925A (zh) * | 2014-11-07 | 2015-02-25 | 济南高达信息技术有限公司 | 一种治疗红皮病的中药洗剂及其制备方法 |
| CN107709352A (zh) * | 2015-05-29 | 2018-02-16 | Igisu株式会社 | 环肽以及含有该环肽的药物、外用剂和化妆品 |
| US10675243B2 (en) * | 2015-06-19 | 2020-06-09 | Global Health Solutions Llc | Petrolatum-based compositions comprising cationic biocides |
| EP3330280A4 (en) * | 2015-07-31 | 2019-06-12 | Igisu Co., Ltd. | CYCLIC PEPTIDE CNP AND MEDICINE, PREPARATION FOR EXTERNAL USE AND COSMETIC PRODUCT, CONTAINING ALL OF SAID CYCLIC PEPTIDE |
| CN105617360B (zh) * | 2015-12-04 | 2018-12-21 | 中国农业大学 | C-型钠肽在制备外用避孕药和精子功能检测试剂中的应用 |
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| KR20190005199A (ko) | 2016-05-05 | 2019-01-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| US20200030411A1 (en) * | 2016-09-21 | 2020-01-30 | Agency For Science, Technology And Research | Methods and Compositions for Inhibiting Skin Inflammation and Determining Cancer Susceptibility |
| JP7125862B2 (ja) * | 2018-05-29 | 2022-08-25 | 小林製薬株式会社 | 外用組成物 |
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Family Cites Families (44)
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|---|---|---|---|---|
| US5114923A (en) | 1988-05-31 | 1992-05-19 | California Biotechnology Inc. | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
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| WO2005094890A1 (ja) | 2004-03-31 | 2005-10-13 | Kazuwa Nakao | 身長増加用組成物 |
| JP4825667B2 (ja) | 2004-03-31 | 2011-11-30 | 一和 中尾 | 関節炎症治療剤又は予防剤 |
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| CA2660294C (en) | 2006-08-08 | 2017-08-29 | Mayo Foundation For Medical Education And Research | Diuretic and natriuretic polypeptides |
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| JP5010913B2 (ja) | 2006-12-31 | 2012-08-29 | 寿子 小出 | 心房利尿ホルモンファミリー分子を活性物質として含有する組織再生製剤また該製剤をもちいる組織再生方法、および心房利尿ホルモンファミリー分子を活性物質として含有する発毛、増毛、育毛剤および皮膚組織修復改善剤また該製剤を用いる発毛、増毛、育毛促進方法および皮膚組織修復改善方法 |
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| ITPG20090061A1 (it) | 2009-11-27 | 2011-05-28 | Andrea Marcantonini | Impianto mobile per la produzione di calcestruzzo |
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