BR0111464A - Composição farmacêutica na forma de dosagem unitária, e, método de tratamento de um paciente com nefropatia diabética - Google Patents
Composição farmacêutica na forma de dosagem unitária, e, método de tratamento de um paciente com nefropatia diabéticaInfo
- Publication number
- BR0111464A BR0111464A BR0111464-6A BR0111464A BR0111464A BR 0111464 A BR0111464 A BR 0111464A BR 0111464 A BR0111464 A BR 0111464A BR 0111464 A BR0111464 A BR 0111464A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetic nephropathy
- patient
- pharmaceutical composition
- dosage form
- unit dosage
- Prior art date
Links
- 208000007342 Diabetic Nephropathies Diseases 0.000 title abstract 3
- 208000033679 diabetic kidney disease Diseases 0.000 title abstract 3
- 239000002552 dosage form Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 2
- 108010088751 Albumins Proteins 0.000 abstract 2
- 230000029142 excretion Effects 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- GRYSXUXXBDSYRT-WOUKDFQISA-N (2r,3r,4r,5r)-2-(hydroxymethyl)-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol Chemical compound C1=NC=2C(NC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OC GRYSXUXXBDSYRT-WOUKDFQISA-N 0.000 abstract 1
- 206010027525 Microalbuminuria Diseases 0.000 abstract 1
- 229920000439 Sulodexide Polymers 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 229960003491 sulodexide Drugs 0.000 abstract 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA NA FORMA DE DOSAGEM UNITáRIA, E, MéTODO DE TRATAMENTO DE UM PACIENTE COM NEFROPATIA DIABéTICA". A presente invenção proporciona formulações orais de Sulodexida para o tratamento de nefropatia diabética em pacientes com diabetes melitus tanto dependente de insulina quanto não dependente de insulina. São proporcionadas formulações orais contendo doses adaptadas para administração para obter uma redução na excreção de albumina em pacientes tanto com microalbuminúria quanto com macroalbuminúria e para produzir melhoria duradoura na taxa de excreção de albumina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20990700P | 2000-06-07 | 2000-06-07 | |
PCT/US2001/018411 WO2001093850A2 (en) | 2000-06-07 | 2001-06-06 | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0111464A true BR0111464A (pt) | 2003-05-06 |
Family
ID=22780806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0111464-6A BR0111464A (pt) | 2000-06-07 | 2001-06-06 | Composição farmacêutica na forma de dosagem unitária, e, método de tratamento de um paciente com nefropatia diabética |
Country Status (21)
Country | Link |
---|---|
US (2) | US7259152B2 (pt) |
EP (1) | EP1292315B1 (pt) |
JP (1) | JP2003535129A (pt) |
KR (1) | KR100815287B1 (pt) |
AT (1) | ATE409042T1 (pt) |
AU (2) | AU2001265388B2 (pt) |
BR (1) | BR0111464A (pt) |
CA (1) | CA2411243A1 (pt) |
CY (1) | CY1108595T1 (pt) |
DE (1) | DE60135911D1 (pt) |
DK (1) | DK1292315T3 (pt) |
ES (1) | ES2309070T3 (pt) |
HU (1) | HUP0301408A2 (pt) |
IL (2) | IL153074A0 (pt) |
MX (1) | MXPA02011708A (pt) |
NO (1) | NO20025849D0 (pt) |
NZ (1) | NZ522963A (pt) |
PL (1) | PL201658B1 (pt) |
PT (1) | PT1292315E (pt) |
RU (1) | RU2003100081A (pt) |
WO (1) | WO2001093850A2 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100417A2 (en) * | 2001-06-12 | 2002-12-19 | Keryx Biopharmaceuticals Inc. | Use of glycosaminoglycans for the treatment of hiv-associated nephropathy |
AU2006244446A1 (en) * | 2005-05-05 | 2006-11-16 | Keryx Biopharmaceuticals, Inc. | Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy |
EP1968561B8 (en) * | 2005-12-22 | 2010-10-20 | Kiacta Sàrl | Treatment of diabetic nephropathy |
CN101730529A (zh) * | 2006-12-22 | 2010-06-09 | 贝鲁斯健康(国际)有限公司 | 用于治疗代谢疾病和糖尿病的方法、化合物和组合物 |
CN101632686A (zh) * | 2008-04-04 | 2010-01-27 | 马斯特里赫特大学 | 糖胺聚糖用于修复糖萼的用途 |
IT1401253B1 (it) | 2010-04-23 | 2013-07-18 | Uni Degli Studi Carlo Bo Urbino | Uso del sulodexide per la riduzione delle metalloproteinasi di matrice. |
FR3071283B1 (fr) * | 2017-09-21 | 2022-07-29 | Fineheart | Pompe cardiaque equipee d'une turbine a pales internes |
Family Cites Families (38)
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US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
DE2426586A1 (de) | 1973-06-14 | 1975-01-09 | Opocrin Srl | Verfahren zur herstellung von glukuronil-glukosamin-glykan-sulfaten mit antilipaemischer wirkung |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
IT1163772B (it) | 1983-07-13 | 1987-04-08 | Baldacci Lab Spa | Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5413645A (en) | 1986-04-25 | 1995-05-09 | Weirton Steel Corporation | Light-cage composite-coated flat-rolled steel manufacture and product |
US5672334A (en) | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
US4945086A (en) | 1988-05-03 | 1990-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Smooth muscle cell growth inhibitor |
IT1234508B (it) | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
US5380716A (en) | 1988-12-15 | 1995-01-10 | Glycomed, Inc. | Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation |
US5272261A (en) | 1989-01-11 | 1993-12-21 | Merrell Dow Pharmaceuticals Inc. | Preparation of sulfated polysaccharide fractions |
IT1234826B (it) | 1989-01-30 | 1992-05-29 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5378829A (en) | 1990-04-23 | 1995-01-03 | Akzo N.V. | Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
ATE148713T1 (de) | 1990-07-24 | 1997-02-15 | Seikagaku Kogyo Co Ltd | Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor |
US5073643A (en) | 1990-08-30 | 1991-12-17 | Polyset Corporation | High yield synthesis of hydroxyl-containing cationic photoinitiators |
IT1242604B (it) | 1990-11-13 | 1994-05-16 | Alfa Wassermann Spa | Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono. |
IT1245761B (it) * | 1991-01-30 | 1994-10-14 | Alfa Wassermann Spa | Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. |
IT1245907B (it) | 1991-05-17 | 1994-10-25 | Alfa Wassermann Spa | Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
IT1260137B (it) | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato |
IT1260136B (it) | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
IT1264102B1 (it) | 1993-03-29 | 1996-09-10 | Alfa Wassermann Spa | Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali |
IT1264101B1 (it) | 1993-03-29 | 1996-09-10 | Alfa Wassermann Spa | Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 |
IT1270846B (it) | 1993-05-10 | 1997-05-13 | Alfa Wassermann Spa | Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica. |
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-
2001
- 2001-06-04 US US09/873,234 patent/US7259152B2/en not_active Expired - Lifetime
- 2001-06-06 RU RU2003100081/15A patent/RU2003100081A/ru not_active Application Discontinuation
- 2001-06-06 CA CA002411243A patent/CA2411243A1/en not_active Abandoned
- 2001-06-06 WO PCT/US2001/018411 patent/WO2001093850A2/en active IP Right Grant
- 2001-06-06 AU AU2001265388A patent/AU2001265388B2/en not_active Ceased
- 2001-06-06 DK DK01939923T patent/DK1292315T3/da active
- 2001-06-06 PT PT01939923T patent/PT1292315E/pt unknown
- 2001-06-06 NZ NZ522963A patent/NZ522963A/en not_active IP Right Cessation
- 2001-06-06 MX MXPA02011708A patent/MXPA02011708A/es active IP Right Grant
- 2001-06-06 AU AU6538801A patent/AU6538801A/xx active Pending
- 2001-06-06 HU HU0301408A patent/HUP0301408A2/hu unknown
- 2001-06-06 BR BR0111464-6A patent/BR0111464A/pt not_active Application Discontinuation
- 2001-06-06 JP JP2002501423A patent/JP2003535129A/ja active Pending
- 2001-06-06 PL PL359346A patent/PL201658B1/pl unknown
- 2001-06-06 IL IL15307401A patent/IL153074A0/xx unknown
- 2001-06-06 DE DE60135911T patent/DE60135911D1/de not_active Expired - Lifetime
- 2001-06-06 ES ES01939923T patent/ES2309070T3/es not_active Expired - Lifetime
- 2001-06-06 KR KR1020027016731A patent/KR100815287B1/ko active IP Right Grant
- 2001-06-06 AT AT01939923T patent/ATE409042T1/de active
- 2001-06-06 EP EP01939923A patent/EP1292315B1/en not_active Expired - Lifetime
-
2002
- 2002-11-25 IL IL153074A patent/IL153074A/en not_active IP Right Cessation
- 2002-12-05 NO NO20025849A patent/NO20025849D0/no not_active Application Discontinuation
-
2007
- 2007-07-19 US US11/880,274 patent/US20080045476A1/en not_active Abandoned
-
2008
- 2008-11-26 CY CY20081101363T patent/CY1108595T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1108595T1 (el) | 2014-04-09 |
IL153074A0 (en) | 2003-06-24 |
PL359346A1 (en) | 2004-08-23 |
US20020065233A1 (en) | 2002-05-30 |
CA2411243A1 (en) | 2001-12-13 |
ATE409042T1 (de) | 2008-10-15 |
PT1292315E (pt) | 2008-10-16 |
NZ522963A (en) | 2004-11-26 |
US20080045476A1 (en) | 2008-02-21 |
MXPA02011708A (es) | 2004-05-17 |
WO2001093850B1 (en) | 2003-02-20 |
DK1292315T3 (da) | 2008-11-17 |
US7259152B2 (en) | 2007-08-21 |
NO20025849L (no) | 2002-12-05 |
EP1292315B1 (en) | 2008-09-24 |
ES2309070T3 (es) | 2008-12-16 |
IL153074A (en) | 2008-07-08 |
HUP0301408A2 (hu) | 2003-11-28 |
JP2003535129A (ja) | 2003-11-25 |
AU6538801A (en) | 2001-12-17 |
PL201658B1 (pl) | 2009-04-30 |
KR100815287B1 (ko) | 2008-03-19 |
KR20030031493A (ko) | 2003-04-21 |
EP1292315A2 (en) | 2003-03-19 |
DE60135911D1 (de) | 2008-11-06 |
AU2001265388B2 (en) | 2006-12-14 |
WO2001093850A2 (en) | 2001-12-13 |
NO20025849D0 (no) | 2002-12-05 |
WO2001093850A3 (en) | 2002-08-22 |
RU2003100081A (ru) | 2004-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |