BR0111061A - 1-aminoalquil-lactamas substituìdas e seu uso como antagonistas de receptor muscarìnico a61p 21/02 - Google Patents

1-aminoalquil-lactamas substituìdas e seu uso como antagonistas de receptor muscarìnico a61p 21/02

Info

Publication number
BR0111061A
BR0111061A BR0111061-6A BR0111061A BR0111061A BR 0111061 A BR0111061 A BR 0111061A BR 0111061 A BR0111061 A BR 0111061A BR 0111061 A BR0111061 A BR 0111061A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
lactams
aminoalkyl
substituted
muscarinic receptor
Prior art date
Application number
BR0111061-6A
Other languages
English (en)
Inventor
Charles Alois Dvorak
Lawrence Emerson Fisher
Keena Lynn Green
Ralph New Harris Iii
Hans Maag
Anthony Prince
David Bruce Repke
Russell Stephen Stabler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0111061A publication Critical patent/BR0111061A/pt

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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Abstract

"1-AMINOALQUIL-LACTAMAS SUBSTITUìDAS E SEU USO COMO ANTAGONISTAS DE RECEPTOR MUSCARìNICO". Esta invenção refere-se a compostos que são geralmente antagonistas de receptor M2/M3 muscarínico e que são representados pela Fórmula (I) em que um de X, Y ou Z é independentemente -S-, -O-, -CH^ 2^- ou >N-R^ 6^, os outros são -CH~ 2~-; m é um número inteiro de 0 a 3 inclusive; n é um número inteiro de 1 a 6 inclusive; R^ 4^ é (C~ 1-6~)-alquila; R^ 5^ é independentemente em cada ocorrência (C~ 1-6~)-alquila, (C~ 1-6~)-alquenila, (C~ 1-6~)-alquinila ou cicloalquila; e R^ 1^, R^ 2^ e R^ 3^ são hidrogênio ou substituintes especificados. Esses compostos são úteis para tratamento de doenças associadas a distúrbios do músculo liso.
BR0111061-6A 2000-05-25 2001-05-16 1-aminoalquil-lactamas substituìdas e seu uso como antagonistas de receptor muscarìnico a61p 21/02 BR0111061A (pt)

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US26757901P 2001-02-09 2001-02-09
PCT/EP2001/005584 WO2001090081A1 (en) 2000-05-25 2001-05-16 Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists

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US7361648B2 (en) 2008-04-22
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