BR0014514A - Enzimas da via de destinação lisossomal - Google Patents
Enzimas da via de destinação lisossomalInfo
- Publication number
- BR0014514A BR0014514A BR0014514-9A BR0014514A BR0014514A BR 0014514 A BR0014514 A BR 0014514A BR 0014514 A BR0014514 A BR 0014514A BR 0014514 A BR0014514 A BR 0014514A
- Authority
- BR
- Brazil
- Prior art keywords
- route via
- via enzymes
- lysosomal
- lysosomal route
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1223—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04045—N-Acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (3.1.4.45)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"ENZIMAS DA VIA DE DESTINAçãO LISOSSOMAL". As enzimas da via de destinação lisossomal GlcNAc-fosfotransferase e fosfodiéster <244>-GlcNAcase são recuperadas e usadas para produzir hidrolases lisossomais altamente fosforiladas que podem ser usadas para tratar doenças de armazenamento lisossomal. Geralmente, as moléculas de ácido nucléico que codificam as enzimas são incorporadas em vetores de expressão que são usados para transfectar células hospedeiras que expressam as enzimas. As enzimas expressas são recuperadas e usadas para tratar hidrolases lisossomais com estruturas com alto teor de manose. As hidrolases lisossomais resultantes possuem oligossacarídeos ligados à asparagina que são altamente fosforilados com manose fosfato. Os hidrolases lisossomais altamente fosforiladas são facilmente introduzidas na célula e no lisossoma durante procedimentos de terapia de reposição enzimática.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15383199P | 1999-09-14 | 1999-09-14 | |
PCT/US2000/021970 WO2001019955A2 (en) | 1999-09-14 | 2000-09-14 | Lysosomal targeting pathway enzymes |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014514A true BR0014514A (pt) | 2002-07-23 |
Family
ID=22548927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014514-9A BR0014514A (pt) | 1999-09-14 | 2000-09-14 | Enzimas da via de destinação lisossomal |
Country Status (10)
Country | Link |
---|---|
US (8) | US6642038B1 (pt) |
EP (1) | EP1224266B1 (pt) |
JP (1) | JP2003509043A (pt) |
AT (1) | ATE373086T1 (pt) |
AU (1) | AU783224B2 (pt) |
BR (1) | BR0014514A (pt) |
CA (1) | CA2383217C (pt) |
DE (1) | DE60036395T2 (pt) |
MX (1) | MXPA02002901A (pt) |
WO (1) | WO2001019955A2 (pt) |
Families Citing this family (152)
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US5939279A (en) | 1997-09-18 | 1999-08-17 | The Board Of Trustees Of The University Of Arkansas | Inhibition of bacterial binding by high-mannose oligosaccharides |
AU2306499A (en) * | 1997-12-18 | 1999-07-05 | Human Genome Sciences, Inc. | 110 human secreted proteins |
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US6800472B2 (en) * | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
-
2000
- 2000-08-10 US US09/636,060 patent/US6642038B1/en not_active Expired - Lifetime
- 2000-08-10 US US09/635,872 patent/US6534300B1/en not_active Expired - Lifetime
- 2000-08-10 US US09/636,077 patent/US6537785B1/en not_active Expired - Lifetime
- 2000-09-14 AU AU73303/00A patent/AU783224B2/en not_active Expired
- 2000-09-14 WO PCT/US2000/021970 patent/WO2001019955A2/en active IP Right Grant
- 2000-09-14 MX MXPA02002901A patent/MXPA02002901A/es unknown
- 2000-09-14 JP JP2001523727A patent/JP2003509043A/ja active Pending
- 2000-09-14 DE DE60036395T patent/DE60036395T2/de not_active Expired - Lifetime
- 2000-09-14 EP EP00961335A patent/EP1224266B1/en not_active Expired - Lifetime
- 2000-09-14 BR BR0014514-9A patent/BR0014514A/pt not_active IP Right Cessation
- 2000-09-14 CA CA2383217A patent/CA2383217C/en not_active Expired - Lifetime
- 2000-09-14 AT AT00961335T patent/ATE373086T1/de not_active IP Right Cessation
-
2001
- 2001-07-02 US US09/895,072 patent/US6861242B2/en not_active Expired - Lifetime
- 2001-11-09 US US09/986,552 patent/US6670165B2/en not_active Expired - Lifetime
-
2003
- 2003-09-09 US US10/657,280 patent/US7067127B2/en not_active Expired - Lifetime
-
2005
- 2005-08-09 US US11/199,233 patent/US7371366B2/en not_active Expired - Lifetime
-
2008
- 2008-02-27 US US12/038,018 patent/US20080176285A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6537785B1 (en) | 2003-03-25 |
AU783224B2 (en) | 2005-10-06 |
US6642038B1 (en) | 2003-11-04 |
JP2003509043A (ja) | 2003-03-11 |
CA2383217A1 (en) | 2001-03-22 |
EP1224266B1 (en) | 2007-09-12 |
ATE373086T1 (de) | 2007-09-15 |
US6534300B1 (en) | 2003-03-18 |
EP1224266A2 (en) | 2002-07-24 |
US20020025550A1 (en) | 2002-02-28 |
US20050089869A1 (en) | 2005-04-28 |
EP1224266A4 (en) | 2003-05-28 |
US20060073498A1 (en) | 2006-04-06 |
DE60036395T2 (de) | 2008-06-12 |
MXPA02002901A (es) | 2003-10-14 |
US6670165B2 (en) | 2003-12-30 |
DE60036395D1 (de) | 2007-10-25 |
WO2001019955A3 (en) | 2001-10-04 |
US7371366B2 (en) | 2008-05-13 |
US6861242B2 (en) | 2005-03-01 |
US7067127B2 (en) | 2006-06-27 |
US20020150981A1 (en) | 2002-10-17 |
US20080176285A1 (en) | 2008-07-24 |
AU7330300A (en) | 2001-04-17 |
CA2383217C (en) | 2013-11-19 |
WO2001019955A2 (en) | 2001-03-22 |
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