BR0011725A - Método para diagnosticar estenose arterial coronária em um mamìfero, e, composto - Google Patents
Método para diagnosticar estenose arterial coronária em um mamìfero, e, compostoInfo
- Publication number
- BR0011725A BR0011725A BR0011725-0A BR0011725A BR0011725A BR 0011725 A BR0011725 A BR 0011725A BR 0011725 A BR0011725 A BR 0011725A BR 0011725 A BR0011725 A BR 0011725A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- coronary artery
- mammal
- artery stenosis
- diagnose coronary
- Prior art date
Links
- 201000000057 Coronary Stenosis Diseases 0.000 title abstract 2
- 206010011089 Coronary artery stenosis Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 206010060965 Arterial stenosis Diseases 0.000 abstract 1
- 239000003379 purinergic P1 receptor agonist Substances 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/336,198 US6322771B1 (en) | 1999-06-18 | 1999-06-18 | Induction of pharmacological stress with adenosine receptor agonists |
| PCT/US2000/016029 WO2000078774A2 (en) | 1999-06-18 | 2000-06-12 | Induction of pharmacological stress with adenosine receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011725A true BR0011725A (pt) | 2002-03-26 |
Family
ID=23314994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011725-0A BR0011725A (pt) | 1999-06-18 | 2000-06-12 | Método para diagnosticar estenose arterial coronária em um mamìfero, e, composto |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6322771B1 (https=) |
| EP (1) | EP1194440B1 (https=) |
| JP (1) | JP4890705B2 (https=) |
| KR (1) | KR100683607B1 (https=) |
| AR (1) | AR030151A1 (https=) |
| AT (1) | ATE289317T1 (https=) |
| AU (1) | AU5605100A (https=) |
| BR (1) | BR0011725A (https=) |
| CA (1) | CA2375374C (https=) |
| DE (1) | DE60018185T2 (https=) |
| DK (1) | DK1194440T3 (https=) |
| ES (1) | ES2233401T3 (https=) |
| HU (1) | HU229005B1 (https=) |
| IL (2) | IL146939A0 (https=) |
| MX (1) | MXPA01013213A (https=) |
| MY (1) | MY126794A (https=) |
| NO (1) | NO322229B1 (https=) |
| NZ (1) | NZ516169A (https=) |
| PT (1) | PT1194440E (https=) |
| TW (1) | TW585870B (https=) |
| WO (1) | WO2000078774A2 (https=) |
| ZA (1) | ZA200200342B (https=) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7378400B2 (en) * | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
| US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
| USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
| US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
| US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
| AU2001238665A1 (en) * | 2000-02-23 | 2001-09-03 | Cv Therapeutics, Inc. | Method of identifying partial agonists of the a2a receptor |
| US6716444B1 (en) | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| US6663662B2 (en) | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
| US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
| EP1434782A2 (en) * | 2001-10-01 | 2004-07-07 | University of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
| EP1465634B1 (en) | 2001-12-12 | 2014-10-22 | The Government of the United States of America, as represented by the Secretary Department of Health and Human Services | Methods for using adenosine receptor inhibitors to enhance immune response and inflammation |
| AUPR977701A0 (en) * | 2001-12-28 | 2002-01-24 | Austral Ships Pty Ltd | Seagoing vessels |
| US20030224455A1 (en) * | 2002-05-28 | 2003-12-04 | Mariapia Abbracchio | Method for the diagnosis of heart diseases |
| US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
| JP2005538190A (ja) * | 2002-07-29 | 2005-12-15 | シーブイ・セラピューティクス・インコーポレイテッド | 心筋潅流イメージング |
| US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
| US20040243010A1 (en) * | 2003-03-19 | 2004-12-02 | Zoghbi William A. | Use of BNP during stress testing for the detection and risk stratification of individuals with suspected coronary artery disease |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| US20050033044A1 (en) * | 2003-05-19 | 2005-02-10 | Bristol-Myers Squibb Pharma Company | Methods for preparing 2-alkynyladenosine derivatives |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| US20070166227A1 (en) * | 2004-02-10 | 2007-07-19 | Shuang Liu | Crowned dithiocarbamate metal complexes and methods for their use |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| AU2005267706B2 (en) * | 2004-08-02 | 2011-12-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
| US7576069B2 (en) * | 2004-08-02 | 2009-08-18 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
| US7442687B2 (en) * | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
| US20060079479A1 (en) * | 2004-10-13 | 2006-04-13 | Italo Biaggioni | Methods of inducing vasodilation |
| CN101076343A (zh) * | 2004-10-20 | 2007-11-21 | Cv医药有限公司 | A2a腺苷受体激动剂的应用 |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0500785D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| RU2421464C2 (ru) | 2005-10-21 | 2011-06-20 | Новартис Аг | Человеческие антитела к il-13 и их терапевтическое применение |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| WO2007092372A1 (en) | 2006-02-03 | 2007-08-16 | Cv Therapeutics, Inc. | Process for preparing an a2a-adenosine receptor agonist and its polymorphs |
| WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| WO2007107598A1 (en) | 2006-03-21 | 2007-09-27 | Heinrich-Heine-Universität Düsseldorf | Phosphorylated a2a receptor agonists |
| GB0607951D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| EP2322525B1 (en) | 2006-04-21 | 2013-09-18 | Novartis AG | Purine derivatives for use as adenosin A2A receptor agonists |
| US8188063B2 (en) | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| JP2009541354A (ja) * | 2006-06-22 | 2009-11-26 | シーブイ・セラピューティクス・インコーポレイテッド | 虚血の治療におけるa2aアデノシン受容体アゴニストの使用 |
| US7811549B2 (en) * | 2006-07-05 | 2010-10-12 | Adenobio N.V. | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects |
| EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| WO2008028140A1 (en) * | 2006-09-01 | 2008-03-06 | Cv Therapeutics, Inc. | Methods and compositions for increasing patient tolerability during myocardial imaging methods |
| US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
| EP1903044A1 (en) | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| US20080170990A1 (en) * | 2006-09-29 | 2008-07-17 | Cv Therapeutics, Inc. | Methods for Myocardial Imaging in Patients Having a History of Pulmonary Disease |
| WO2008037477A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as p13k lipid kinase inhibitors |
| CN101522682A (zh) | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
| WO2008086096A2 (en) * | 2007-01-03 | 2008-07-17 | Cv Therapeutics, Inc. | Myocardial perfusion imaging |
| WO2008088816A1 (en) * | 2007-01-18 | 2008-07-24 | Pgxhealth, Llc | Adenosine derivative formulations for medical imaging |
| JP2008266143A (ja) * | 2007-04-16 | 2008-11-06 | Santen Pharmaceut Co Ltd | アデノシン誘導体を有効成分として含有する緑内障治療剤 |
| US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| MX2010007604A (es) | 2008-01-11 | 2010-08-02 | Novartis Ag | Pirimidinas como inhibidores de cinasa. |
| WO2009092516A2 (en) * | 2008-01-22 | 2009-07-30 | Adenobio N.V. | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects |
| CN102119023B (zh) * | 2008-07-03 | 2014-04-09 | 弗吉尼亚大学专利基金会 | 阿帕地松单位剂量 |
| MX2011003168A (es) * | 2008-09-29 | 2011-05-19 | Gilead Sciences Inc | Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples. |
| PT2391366E (pt) | 2009-01-29 | 2013-02-05 | Novartis Ag | Benzimidazoles substituídos para o tratamento de astrocitomas |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| JP5781510B2 (ja) | 2009-08-12 | 2015-09-24 | ノバルティス アーゲー | ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用 |
| PE20121148A1 (es) | 2009-08-17 | 2012-09-07 | Intellikine Llc | Compuestos heterociclicos y usos de los mismos |
| JP5775871B2 (ja) | 2009-08-20 | 2015-09-09 | ノバルティス アーゲー | ヘテロ環式オキシム化合物 |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
| WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| US11439309B2 (en) | 2011-05-05 | 2022-09-13 | Cedars-Sinai Medical Center | Assessment of coronary heart disease with carbon dioxide |
| US11129911B2 (en) | 2011-05-05 | 2021-09-28 | Cedars-Sinai Medical Center | Assessment of coronary heart disease with carbon dioxide |
| EA026655B1 (ru) | 2011-09-15 | 2017-05-31 | Новартис Аг | 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ |
| CA2856803A1 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
| CA2863685C (en) | 2012-02-03 | 2020-10-13 | Adenobio N.V. | A method of using adenosine and dipyridamole for pharmacologic stress testing, with specific compositions, unit dosage forms and kits |
| JP2015512425A (ja) | 2012-04-03 | 2015-04-27 | ノバルティス アーゲー | チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用 |
| IN2015DN00538A (https=) * | 2012-08-01 | 2015-06-26 | Lewis And Clark Pharmaceuticals Inc | |
| US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
| EP2968340A4 (en) | 2013-03-15 | 2016-08-10 | Intellikine Llc | COMBINING KINASE INHIBITORS AND USES THEREOF |
| WO2015021078A1 (en) | 2013-08-05 | 2015-02-12 | Cedars-Sinai Medical Center | Methods for reducing ischemia-reperfusion injury |
| WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| ES2831416T3 (es) | 2014-07-31 | 2021-06-08 | Novartis Ag | Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR |
| AU2017368332A1 (en) | 2016-12-03 | 2019-06-13 | Juno Therapeutics, Inc. | Methods for modulation of CAR-T cells |
| BR112019011065A2 (pt) | 2016-12-03 | 2019-10-01 | Juno Therapeutics Inc | métodos para determinação da dosagem de células t car |
| AU2017370644A1 (en) | 2016-12-05 | 2019-06-13 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| EP3644721A1 (en) | 2017-06-29 | 2020-05-06 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| AU2018358067A1 (en) | 2017-11-01 | 2020-05-07 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for B-cell maturation antigen |
| JP7447006B2 (ja) | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体 |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| US20210198372A1 (en) | 2017-12-01 | 2021-07-01 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| WO2019118937A1 (en) | 2017-12-15 | 2019-06-20 | Juno Therapeutics, Inc. | Anti-cct5 binding molecules and methods of use thereof |
| KR20210113169A (ko) | 2018-11-01 | 2021-09-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | Β세포 성숙 항원에 특이적인 키메라 항원 수용체를 이용한 치료 방법 |
| MA54079A (fr) | 2018-11-01 | 2021-09-08 | Juno Therapeutics Inc | Récepteurs antigéniques chimériques spécifiques du gprc5d (élément d du groupe 5 de classe c des récepteurs couplés à la protéine g) |
| KR20210104713A (ko) | 2018-11-16 | 2021-08-25 | 주노 쎄러퓨티크스 인코퍼레이티드 | B 세포 악성 종양 치료를 위한 조작된 t 세포 투약 방법 |
| PL3886875T3 (pl) | 2018-11-30 | 2024-09-09 | Juno Therapeutics, Inc. | Metody leczenia z wykorzystaniem adoptywnej terapii komórkowej |
| CA3123303A1 (en) | 2019-01-29 | 2020-08-06 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1) |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
| KR20230009386A (ko) | 2020-04-10 | 2023-01-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | B-세포 성숙 항원을 표적화하는 키메라 항원 수용체로 조작된 세포 요법 관련 방법 및 용도 |
| EP4543923A1 (en) | 2022-06-22 | 2025-04-30 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
| CA3263560A1 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | GPRC5D AND BCMA SPECIFIC CHIMERICAL ANTIGENIC RECEPTORS |
| CN120712102A (zh) | 2022-12-13 | 2025-09-26 | 朱诺治疗学股份有限公司 | 对baff-r和cd19具特异性的嵌合抗原受体及其方法和用途 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892777A (en) | 1968-05-01 | 1975-07-01 | Hoffmann La Roche | Substituted benzylethylenedicarbamates |
| CH608236A5 (https=) | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
| US4193926A (en) | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| DK159431C (da) | 1984-05-10 | 1991-03-18 | Byk Gulden Lomberg Chem Fab | 6-phenyl-3(2h)-pyridazinoner, fremgangsmaade til fremstilling deraf, laegemidler indeholdende disse samt anvendelse af forbindelserne til fremstilling af laegemidler |
| GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| US4824660A (en) | 1985-06-06 | 1989-04-25 | Paul S. Angello | Method of determining the viability of tissue in an organism |
| US5231086A (en) | 1985-09-24 | 1993-07-27 | Item Development Aktiebolag | Continuous administration adenosine to increase myocardial blood flow |
| JPS6299395A (ja) | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
| US5096906A (en) | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
| US4965271A (en) | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5272153A (en) | 1986-12-31 | 1993-12-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5298508A (en) | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
| US5070877A (en) | 1988-08-11 | 1991-12-10 | Medco Research, Inc. | Novel method of myocardial imaging |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
| USRE36494E (en) | 1990-02-20 | 2000-01-11 | Discovery Therapeutics, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
| US6004945A (en) | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| US5124455A (en) | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
| US5189027A (en) | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
| ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| JP3053908B2 (ja) * | 1991-06-28 | 2000-06-19 | ヤマサ醤油株式会社 | 2‐アルキニルアデノシン誘導体 |
| IL99368A (en) | 1991-09-02 | 1996-01-19 | Teva Pharma | Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine |
| US5278150A (en) | 1992-04-24 | 1994-01-11 | Whitby Research, Inc. | 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions |
| IT1254915B (it) | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
| WO1994023723A1 (en) | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| US5665754A (en) | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| WO1995011681A1 (en) | 1993-10-29 | 1995-05-04 | Merck & Co., Inc. | Human adenosine receptor antagonists |
| US5877180A (en) | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| US5661153A (en) | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
| GB9415529D0 (en) | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| US5854081A (en) | 1996-06-20 | 1998-12-29 | The University Of Patent Foundation | Stable expression of human A2B adenosine receptors, and assays employing the same |
| EA199900837A1 (ru) | 1997-04-18 | 2000-10-30 | Дж.Д.Сирл Энд Ко. | Способ применения ингибиторов циклооксигеназы-2 для предупреждения сердечно-сосудистых расстройств |
| EP1014995A4 (en) | 1997-06-18 | 2005-02-16 | Aderis Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSES CONSECUTIVE TO REVASCULARIZATION INTERVENTIONS |
| US5998386A (en) | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
| US6020339A (en) | 1997-10-03 | 2000-02-01 | Merck & Co., Inc. | Aryl furan derivatives as PDE IV inhibitors |
| US6034089A (en) | 1997-10-03 | 2000-03-07 | Merck & Co., Inc. | Aryl thiophene derivatives as PDE IV inhibitors |
| EP1011608A4 (en) | 1998-06-08 | 2002-05-15 | Epigenesis Pharmaceuticals Inc | COMPOSITION AND METHOD FOR THE PREVENTION AND TREATMENT OF HEART AND NEUTRAL FAILURE OR DAMAGE RELATED TO ISCHEMIA, ENDOTOXIN RELEASE, ARDS OR CALLED BY THE ADDITION OF SPECIFIC MEDICINES |
| CA2361614C (en) | 1999-02-01 | 2008-08-26 | University Of Virginia Patent Foundation | Compositions for treating inflammatory response |
-
1999
- 1999-06-18 US US09/336,198 patent/US6322771B1/en not_active Expired - Lifetime
-
2000
- 2000-06-12 JP JP2001504939A patent/JP4890705B2/ja not_active Expired - Fee Related
- 2000-06-12 KR KR1020017016107A patent/KR100683607B1/ko not_active Expired - Fee Related
- 2000-06-12 DK DK00941335T patent/DK1194440T3/da active
- 2000-06-12 PT PT00941335T patent/PT1194440E/pt unknown
- 2000-06-12 WO PCT/US2000/016029 patent/WO2000078774A2/en not_active Ceased
- 2000-06-12 NZ NZ516169A patent/NZ516169A/xx not_active IP Right Cessation
- 2000-06-12 BR BR0011725-0A patent/BR0011725A/pt not_active Application Discontinuation
- 2000-06-12 MX MXPA01013213A patent/MXPA01013213A/es active IP Right Grant
- 2000-06-12 AT AT00941335T patent/ATE289317T1/de not_active IP Right Cessation
- 2000-06-12 CA CA2375374A patent/CA2375374C/en not_active Expired - Fee Related
- 2000-06-12 AU AU56051/00A patent/AU5605100A/en not_active Abandoned
- 2000-06-12 EP EP00941335A patent/EP1194440B1/en not_active Expired - Lifetime
- 2000-06-12 HU HU0202094A patent/HU229005B1/hu not_active IP Right Cessation
- 2000-06-12 DE DE60018185T patent/DE60018185T2/de not_active Expired - Lifetime
- 2000-06-12 IL IL14693900A patent/IL146939A0/xx active IP Right Grant
- 2000-06-12 ES ES00941335T patent/ES2233401T3/es not_active Expired - Lifetime
- 2000-06-14 TW TW089111546A patent/TW585870B/zh not_active IP Right Cessation
- 2000-06-16 AR ARP000103042A patent/AR030151A1/es not_active Application Discontinuation
- 2000-06-16 MY MYPI20002713 patent/MY126794A/en unknown
-
2001
- 2001-12-05 IL IL146939A patent/IL146939A/en not_active IP Right Cessation
- 2001-12-06 NO NO20015974A patent/NO322229B1/no not_active IP Right Cessation
-
2002
- 2002-01-15 ZA ZA200200342A patent/ZA200200342B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0202094A2 (en) | 2002-10-28 |
| DK1194440T3 (da) | 2005-05-30 |
| MXPA01013213A (es) | 2002-06-04 |
| NO20015974D0 (no) | 2001-12-06 |
| NZ516169A (en) | 2004-12-24 |
| JP2003502433A (ja) | 2003-01-21 |
| HUP0202094A3 (en) | 2005-02-28 |
| PT1194440E (pt) | 2005-05-31 |
| DE60018185D1 (de) | 2005-03-24 |
| KR100683607B1 (ko) | 2007-02-20 |
| ATE289317T1 (de) | 2005-03-15 |
| CA2375374A1 (en) | 2000-12-28 |
| WO2000078774A3 (en) | 2001-07-12 |
| CA2375374C (en) | 2010-03-23 |
| TW585870B (en) | 2004-05-01 |
| KR20020033640A (ko) | 2002-05-07 |
| EP1194440A2 (en) | 2002-04-10 |
| IL146939A (en) | 2006-08-20 |
| US6322771B1 (en) | 2001-11-27 |
| MY126794A (en) | 2006-10-31 |
| AR030151A1 (es) | 2003-08-13 |
| AU5605100A (en) | 2001-01-09 |
| JP4890705B2 (ja) | 2012-03-07 |
| NO322229B1 (no) | 2006-08-28 |
| NO20015974L (no) | 2002-02-14 |
| EP1194440B1 (en) | 2005-02-16 |
| WO2000078774A2 (en) | 2000-12-28 |
| ES2233401T3 (es) | 2005-06-16 |
| HU229005B1 (en) | 2013-07-29 |
| DE60018185T2 (de) | 2005-06-30 |
| ZA200200342B (en) | 2003-04-30 |
| IL146939A0 (en) | 2002-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0011725A (pt) | Método para diagnosticar estenose arterial coronária em um mamìfero, e, composto | |
| ES2186844T3 (es) | Agentes de diagnostico para la diabetes. | |
| DE60214594D1 (de) | Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar) | |
| BRPI9912227A (pt) | método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método. | |
| ES2135966T3 (es) | Polimerizacion de olefinas. | |
| PE134199A1 (es) | Inhibicion de la oxidacion de lipoproteinas | |
| FR2687679B1 (fr) | Oligothionucleotides. | |
| ES2055424T3 (es) | Derivados de n-fenilbenzamida con actividad anti-ulcera y anti-alergia y un metodo para su preparacion. | |
| ATE272841T1 (de) | Versuchsanordnung mit erweiterter bandbreite | |
| DE69920759D1 (de) | Lastmessung | |
| BR9916281A (pt) | Complexo de metaloceno, processo para prepararo mesmo, e, uso de um complexo de metaloceno | |
| MX247325B (es) | Procedimiento para la obtencion de derivados de triazolintiona. | |
| BR9815867A (pt) | Fita para ser montada em uma peça de trabalho, e, processo para a produção de uma fita | |
| AR006058A1 (es) | Procedimientos para preparar compuestos de dicianoacetato y de 1,2-pirazol-5-amino-3-substituido | |
| DE50002968D1 (de) | Zeilen-OCT als optischer Sensor für die Mess- und Medizintechnik | |
| ES2192244T3 (es) | Procedimiento para la hidrogenacion de metalocenos. | |
| BR9406223A (pt) | Método para determinar em uma amostra a atividade funcional de um componente da coagulação sanguinea método para diagnosticar um disturbio da coagulação/anticoagulação sanguinea preparado de anticorpo linhagem celular uso de fator v subunidades ou fragmentos do mesmo tendo atividade anticoagulante na forma de cofator par apc prepraro de plasma embalado plasma deficiente em atividade anticoagulante de fator v como cofator para apc uso do preparado de anticorpo preparado de proteina s preparado de | |
| ATE346981T1 (de) | Verlegeverfahren für eine zerlegbare brücke | |
| ATE229968T1 (de) | Diagnostisches mittel zur glykostoffwechselfunktion | |
| NO20005751D0 (no) | Merkede analoger av glutamin og lysin | |
| ES2191962T3 (es) | Procedimiento para la obtencion de metalocenos. | |
| BR0010882A (pt) | Agonistas receptores de adenosina a1 oralmente ativos e processo para uso de tal composição | |
| ES2126597T5 (es) | Sistema de sondas que permite efectuar la tipificacion hla dr, y procedimiento de tipificacion que utiliza dichas sondas. | |
| ES2311459T3 (es) | Diagnostico de restenosis. | |
| BR9917543A (pt) | Processo e sonda de medição |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O,11,10,25 E 37 DA LPI |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |