BR9406223A - Método para determinar em uma amostra a atividade funcional de um componente da coagulação sanguinea método para diagnosticar um disturbio da coagulação/anticoagulação sanguinea preparado de anticorpo linhagem celular uso de fator v subunidades ou fragmentos do mesmo tendo atividade anticoagulante na forma de cofator par apc prepraro de plasma embalado plasma deficiente em atividade anticoagulante de fator v como cofator para apc uso do preparado de anticorpo preparado de proteina s preparado de - Google Patents

Método para determinar em uma amostra a atividade funcional de um componente da coagulação sanguinea método para diagnosticar um disturbio da coagulação/anticoagulação sanguinea preparado de anticorpo linhagem celular uso de fator v subunidades ou fragmentos do mesmo tendo atividade anticoagulante na forma de cofator par apc prepraro de plasma embalado plasma deficiente em atividade anticoagulante de fator v como cofator para apc uso do preparado de anticorpo preparado de proteina s preparado de

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Publication number
BR9406223A
BR9406223A BR9406223A BR9406223A BR9406223A BR 9406223 A BR9406223 A BR 9406223A BR 9406223 A BR9406223 A BR 9406223A BR 9406223 A BR9406223 A BR 9406223A BR 9406223 A BR9406223 A BR 9406223A
Authority
BR
Brazil
Prior art keywords
protein
activity
prepared
factor
determining
Prior art date
Application number
BR9406223A
Other languages
English (en)
Inventor
Bjorn Dahlback
Original Assignee
Bjorn Dahlback
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26661641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9406223(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9300300A external-priority patent/SE9300300D0/xx
Priority claimed from SE9302457A external-priority patent/SE9302457D0/xx
Application filed by Bjorn Dahlback filed Critical Bjorn Dahlback
Publication of BR9406223A publication Critical patent/BR9406223A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96463—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
BR9406223A 1993-01-29 1994-01-28 Método para determinar em uma amostra a atividade funcional de um componente da coagulação sanguinea método para diagnosticar um disturbio da coagulação/anticoagulação sanguinea preparado de anticorpo linhagem celular uso de fator v subunidades ou fragmentos do mesmo tendo atividade anticoagulante na forma de cofator par apc prepraro de plasma embalado plasma deficiente em atividade anticoagulante de fator v como cofator para apc uso do preparado de anticorpo preparado de proteina s preparado de BR9406223A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300300A SE9300300D0 (sv) 1993-01-29 1993-01-29 A novel anticoagulant entity, antibodies reacting specifically with the entity, and diagnostic and therapeutic used of the entity
SE9302457A SE9302457D0 (sv) 1993-07-20 1993-07-20 A novel anticoagulant entity, antibodies reacting specifically with the enety, and diagnostic and therapeutic uses of the entity
PCT/SE1994/000070 WO1994017415A1 (en) 1993-01-29 1994-01-28 Novel anticoagulant cofactor activity

Publications (1)

Publication Number Publication Date
BR9406223A true BR9406223A (pt) 1996-01-09

Family

ID=26661641

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9406223A BR9406223A (pt) 1993-01-29 1994-01-28 Método para determinar em uma amostra a atividade funcional de um componente da coagulação sanguinea método para diagnosticar um disturbio da coagulação/anticoagulação sanguinea preparado de anticorpo linhagem celular uso de fator v subunidades ou fragmentos do mesmo tendo atividade anticoagulante na forma de cofator par apc prepraro de plasma embalado plasma deficiente em atividade anticoagulante de fator v como cofator para apc uso do preparado de anticorpo preparado de proteina s preparado de

Country Status (17)

Country Link
US (2) US7169572B1 (pt)
EP (1) EP0690991B2 (pt)
JP (1) JPH08506181A (pt)
AT (1) ATE168781T1 (pt)
AU (1) AU690535B2 (pt)
BR (1) BR9406223A (pt)
CA (1) CA2154080C (pt)
CZ (1) CZ184995A3 (pt)
DE (1) DE69411898T3 (pt)
DK (1) DK0690991T4 (pt)
ES (1) ES2119165T5 (pt)
FI (1) FI953565A0 (pt)
GR (1) GR3027697T3 (pt)
HU (1) HUT72191A (pt)
NZ (1) NZ261190A (pt)
PL (1) PL181102B1 (pt)
WO (1) WO1994017415A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT72191A (en) * 1993-01-29 1996-03-28 Dahlbaeck Novel anticoagulant cofactor activity
KR100384251B1 (ko) 1994-02-14 2003-09-19 리엑스 유니버시타이트 라이덴 활성화된단백질c에대한약한항응고반응및/또는혈전증과관련된유전자결함의존재를검색하는방법
DE4418635C2 (de) * 1994-05-27 1997-07-24 Immuno Ag Pharmazeutische Zusammensetzung zur Vorbeugung und Behandlung von Blutgerinnungsstörungen
DE4439756C2 (de) * 1994-11-09 2002-07-18 Dade Behring Marburg Gmbh Kalibrator zur Verwendung in Testverfahren zum Nachweis eines defekten Gerinnungsfaktors V
EP0711838B2 (de) * 1994-11-10 2007-06-20 Dade Behring Marburg GmbH Verfahren zum spezifischen Nachweis eines aktivierten Gerinnungsfaktors V mit einer erhöhten Stabilität gegenüber aktiviertem Protein C
US6867045B1 (en) * 1994-11-14 2005-03-15 The Scripps Research Institute Method for diagnosis of thrombotic disorders
ATE200710T1 (de) * 1994-12-23 2001-05-15 Diagnostic Reagents Ltd Verfahren zur diagnose von blutgerinnungsstörungen
US5874256A (en) * 1995-06-06 1999-02-23 Rijks Universiteit Leiden Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same
US5863896A (en) * 1995-11-09 1999-01-26 Immuno Ag Evaluation of substances for altering and for increasing APC response
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
DE19634312A1 (de) * 1996-08-24 1998-02-26 Behringwerke Ag Verfahren zur Herstellung von Faktor V-Mangelplasma und ein so erhaltenes Mangelplasma
EP1076698A2 (en) * 1998-05-14 2001-02-21 Battelle Memorial Institute Transgenic plant-derived human blood coagulation factors
FR2778923B1 (fr) * 1998-05-22 2000-08-18 Stago Diagnostica Compositions utiles comme controle pathologique dans une methode de detection d'une resistance a la proteine c activee, procede de preparation de ces compositions et utilisation dans ladite methode de detection
JP4377207B2 (ja) 2003-11-28 2009-12-02 シスメックス株式会社 血液凝固時間測定方法および血液凝固時間測定用試薬
US20100322921A1 (en) * 2006-10-16 2010-12-23 Rekha Bansal METHOD OF INHIBITING COAGULATION ACTIVATION WITH HUMAN ANTI-FACTOR Va ANTIBODIES AND USE THEREOF
US11650196B2 (en) * 2017-01-06 2023-05-16 Sony Corporation Blood coagulation system analysis apparatus, blood coagulation system analysis system, blood coagulation system analysis method, blood coagulation system analysis program, blood loss prediction apparatus, blood loss prediction system, blood loss prediction method, and blood loss prediction program

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Publication number Priority date Publication date Assignee Title
DE3330699A1 (de) 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
JPS60241900A (ja) 1984-05-16 1985-11-30 Nitto Boseki Co Ltd 新規な第Ｘａ因子活性測定用基質
DE3516579A1 (de) 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Gerinnungstest auf teststreifen
US4849403A (en) 1985-05-29 1989-07-18 Pentapharm Ag Protein C activator, methods of preparation and use thereof
DE3536903A1 (de) 1985-10-16 1987-04-16 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung von protein c
DE3607559A1 (de) 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US5200322A (en) * 1986-09-19 1993-04-06 Nippon Zoki Pharmaceutical Co., Ltd. Method for assaying protein C and measuring kit for the same
CA1339946C (en) 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5472850A (en) 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
US5055412A (en) 1989-03-21 1991-10-08 Proksch Gary J Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
IT1230744B (it) * 1989-07-07 1991-10-29 Instrumentation Lab Spa Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
WO1991001383A1 (en) 1989-07-14 1991-02-07 Michigan State University Method for diagnosing blood clotting disorders
SE464135B (sv) 1989-07-14 1991-03-11 Kabivitrum Ab Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
US5051357A (en) 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
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US5716795A (en) * 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
AU2870992A (en) * 1991-10-04 1993-05-03 Board Of Regents Of The University Of Nebraska, The A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
JP2562000B2 (ja) * 1991-11-13 1996-12-11 ダールベツク，ビヨルン 血液凝固疾患の診断方法
SE470274B (sv) 1991-11-13 1993-12-20 Bjoern Dahlbaeck Användning av en in vitro-metod för diagnos av blodkoagulationssjukdomar
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
HUT72191A (en) * 1993-01-29 1996-03-28 Dahlbaeck Novel anticoagulant cofactor activity
ATE213023T1 (de) * 1993-12-03 2002-02-15 Baxter Ag Test zur bestimmung der empfindlichkeit gegenüber aktiviertem protein c
DE4427785A1 (de) * 1994-08-08 1996-02-15 Behringwerke Ag Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
DE4439756C2 (de) * 1994-11-09 2002-07-18 Dade Behring Marburg Gmbh Kalibrator zur Verwendung in Testverfahren zum Nachweis eines defekten Gerinnungsfaktors V
US5705395A (en) * 1994-11-14 1998-01-06 The Scripps Research Institute Method for diagnosis of thrombotic disorders
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
US20030143759A1 (en) 1995-10-20 2003-07-31 Bjorn Dahlback Assays for determining anticoagulant cofactor activity
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism

Also Published As

Publication number Publication date
US20070212743A1 (en) 2007-09-13
ES2119165T5 (es) 2004-07-01
AU690535B2 (en) 1998-04-30
EP0690991A1 (en) 1996-01-10
DE69411898D1 (de) 1998-08-27
ATE168781T1 (de) 1998-08-15
CA2154080C (en) 2006-03-21
HU9502190D0 (en) 1995-09-28
CZ184995A3 (en) 1996-03-13
NZ261190A (en) 1997-12-19
CA2154080A1 (en) 1994-08-04
AU5982794A (en) 1994-08-15
DE69411898T2 (de) 1998-12-17
HUT72191A (en) 1996-03-28
DE69411898T3 (de) 2004-07-08
EP0690991B1 (en) 1998-07-22
US7169572B1 (en) 2007-01-30
PL181102B1 (pl) 2001-05-31
DK0690991T3 (da) 1999-02-01
DK0690991T4 (da) 2004-02-16
FI953565A (fi) 1995-07-26
GR3027697T3 (en) 1998-11-30
JPH08506181A (ja) 1996-07-02
EP0690991B2 (en) 2004-01-14
PL310050A1 (en) 1995-11-13
WO1994017415A1 (en) 1994-08-04
ES2119165T3 (es) 1998-10-01
FI953565A0 (fi) 1995-07-26

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B15K Others concerning applications: alteration of classification

Ipc: C12Q 1/56 (2006.01), A61K 38/36 (2006.0