ES2107528T3 - Ensayos de la actividad de la amilina. - Google Patents
Ensayos de la actividad de la amilina.Info
- Publication number
- ES2107528T3 ES2107528T3 ES92904180T ES92904180T ES2107528T3 ES 2107528 T3 ES2107528 T3 ES 2107528T3 ES 92904180 T ES92904180 T ES 92904180T ES 92904180 T ES92904180 T ES 92904180T ES 2107528 T3 ES2107528 T3 ES 2107528T3
- Authority
- ES
- Spain
- Prior art keywords
- rise
- amylin
- lactate
- simulate
- amyline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE PRESENTAN METODOS PARA SU USO EN LA IDENTIFICACION O EN EL ENSAYO DE COMPUESTOS QUE PUEDAN INHIBIR O SIMULAR LA CAPACIDAD DE LA AMILINA DE PROVOCAR HIPERLACTEMIA Y / O HIPERGLUCEMIA EN MODELOS BIOLOGICOS VIVOS. TAMBIEN SE PRESENTAN METODOS PARA SU USO EN LA EVALUACION DE LA POTENCIA DE LOS COMPUESTOS CONOCIDOS O SOSPECHOSOS DE ESTIMULAR CUALQUIERA O AMBAS DE ESTAS ACCIONES DE LA AMILINA. LA FIGURA MUESTRA LA RESPUESTA DE LA GLUCOSA DEL PLASMA DE RATAS INOCULADAS CON SOMATOSTATINA MAS AMILINA (CIRCULO ABIERTO), CON UN PEPTIDO DE CONTROL (CUADRADO ABIERTO), O CON PENTOLAMINA (TRIANGULO ABIERTO).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/640,478 US5234906A (en) | 1991-01-10 | 1991-01-10 | Hyperglycemic compositions |
US66652791A | 1991-03-08 | 1991-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2107528T3 true ES2107528T3 (es) | 1997-12-01 |
Family
ID=27093565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92904180T Expired - Lifetime ES2107528T3 (es) | 1991-01-10 | 1992-01-10 | Ensayos de la actividad de la amilina. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6048514A (es) |
EP (1) | EP0525149B1 (es) |
JP (1) | JP2818296B2 (es) |
AT (1) | ATE155689T1 (es) |
CA (1) | CA2077265A1 (es) |
DE (1) | DE69221040T2 (es) |
DK (1) | DK0525149T3 (es) |
ES (1) | ES2107528T3 (es) |
GR (1) | GR3024812T3 (es) |
WO (1) | WO1992011863A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU222249B1 (hu) | 1991-03-08 | 2003-05-28 | Amylin Pharmaceuticals Inc. | Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
ES2232811T3 (es) * | 1992-05-15 | 2005-06-01 | Amylin Pharmaceuticals, Inc. | Pruebas sobre anticuerpos para la amilina. |
WO1994018571A1 (en) * | 1993-02-12 | 1994-08-18 | Amylin Pharmaceuticals, Inc. | Mcf-7 binding site assays |
US6936584B1 (en) | 1998-02-13 | 2005-08-30 | Amylin Pharmaceuticals, Inc. | Mixed amylin activity compounds |
US20040038861A1 (en) * | 2001-11-26 | 2004-02-26 | Cooper Garth J. S. | Methods and compositions for normalizing lipid levels in mammalian tissues |
US20040142393A1 (en) * | 2002-08-01 | 2004-07-22 | Cooper Garth James Smith | Methods of use of compounds with preptin function |
US7339347B2 (en) * | 2003-08-11 | 2008-03-04 | Reserve Power Cell, Llc | Apparatus and method for reliably supplying electrical energy to an electrical system |
EP1719447A1 (de) * | 2005-05-07 | 2006-11-08 | F. Hoffmann-La Roche AG | Verfahren und Vorrichtung zur Bestimmung der Glucose-Konzentration in Gewebflüssigkeit |
CN101808615B (zh) * | 2007-08-24 | 2013-05-15 | 巴斯夫欧洲公司 | 包含苯并三唑和部花青的混合物 |
JP6358942B2 (ja) * | 2014-12-05 | 2018-07-18 | 沢井製薬株式会社 | エンドトキシンの測定用試薬及びエンドトキシンの測定方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8316032D0 (en) * | 1983-06-11 | 1983-07-13 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
US5280014A (en) * | 1988-01-11 | 1994-01-18 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
US5266561A (en) * | 1988-01-11 | 1993-11-30 | Amylin Pharmaceuticals, Inc. | Treatment of type 2 diabetes mellitus |
US5260275A (en) * | 1990-08-14 | 1993-11-09 | Amylin Pharmaceuticals, Inc. | Hypoglycemics |
US5321008A (en) * | 1991-01-10 | 1994-06-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions |
US5234906A (en) * | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
US5376638A (en) * | 1992-09-01 | 1994-12-27 | Amylin Pharmaceuticals, Inc. | Methods for treating renin-related disorders with amylin antagonists |
-
1992
- 1992-01-10 DK DK92904180.4T patent/DK0525149T3/da active
- 1992-01-10 ES ES92904180T patent/ES2107528T3/es not_active Expired - Lifetime
- 1992-01-10 CA CA002077265A patent/CA2077265A1/en not_active Abandoned
- 1992-01-10 EP EP92904180A patent/EP0525149B1/en not_active Expired - Lifetime
- 1992-01-10 JP JP4504502A patent/JP2818296B2/ja not_active Expired - Fee Related
- 1992-01-10 WO PCT/US1992/000185 patent/WO1992011863A1/en active IP Right Grant
- 1992-01-10 AT AT92904180T patent/ATE155689T1/de not_active IP Right Cessation
- 1992-01-10 DE DE69221040T patent/DE69221040T2/de not_active Expired - Fee Related
-
1995
- 1995-04-14 US US08/422,747 patent/US6048514A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 GR GR970402446T patent/GR3024812T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0525149T3 (da) | 1997-12-01 |
JPH05505625A (ja) | 1993-08-19 |
WO1992011863A1 (en) | 1992-07-23 |
ATE155689T1 (de) | 1997-08-15 |
US6048514A (en) | 2000-04-11 |
EP0525149A1 (en) | 1993-02-03 |
EP0525149B1 (en) | 1997-07-23 |
DE69221040T2 (de) | 1997-11-13 |
EP0525149A4 (en) | 1993-08-25 |
GR3024812T3 (en) | 1998-01-30 |
JP2818296B2 (ja) | 1998-10-30 |
DE69221040D1 (de) | 1997-09-04 |
CA2077265A1 (en) | 1992-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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