WO2000050904A8 - Testkit zur analytik der faktor-viii-spaltenden protease - Google Patents

Testkit zur analytik der faktor-viii-spaltenden protease

Info

Publication number
WO2000050904A8
WO2000050904A8 PCT/AT2000/000049 AT0000049W WO0050904A8 WO 2000050904 A8 WO2000050904 A8 WO 2000050904A8 AT 0000049 W AT0000049 W AT 0000049W WO 0050904 A8 WO0050904 A8 WO 0050904A8
Authority
WO
WIPO (PCT)
Prior art keywords
von willebrand
willebrand factor
splitting
test kit
analysing
Prior art date
Application number
PCT/AT2000/000049
Other languages
English (en)
French (fr)
Other versions
WO2000050904A1 (de
Inventor
Helena E Gerritsen
Miha Furlan
Peter Turecek
Katalin Varadi
Juergen Siekmann
Bernhard Laemmle
Hans-Peter Schwarz
Original Assignee
Baxter Ag
Helena E Gerritsen
Miha Furlan
Peter Turecek
Katalin Varadi
Juergen Siekmann
Bernhard Laemmle
Schwarz Hans Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag, Helena E Gerritsen, Miha Furlan, Peter Turecek, Katalin Varadi, Juergen Siekmann, Bernhard Laemmle, Schwarz Hans Peter filed Critical Baxter Ag
Priority to AU31336/00A priority Critical patent/AU756563B2/en
Priority to CA002362483A priority patent/CA2362483A1/en
Priority to EP00908814A priority patent/EP1155328A1/de
Publication of WO2000050904A1 publication Critical patent/WO2000050904A1/de
Publication of WO2000050904A8 publication Critical patent/WO2000050904A8/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Beschrieben wird ein Testkit zur Analytik der von Willebrand Faktor-spaltenden Protease und zur Differentialdiagnostik zwischen Patienten mit thrombotisch thrombozytopenischer Purpura und Patienten mit hämolytisch-urämischem Syndrom, bestehend aus einer von Willebrand Faktor-Standardpräparation, die frei von von Willebrand Faktor-spaltender Aktivität ist, als Substrat für die von Willebrand Faktor-spaltende Aktivität in einer Probe oder im Patientenplasma und einem System zur quantitativen Bestimmung der Bindung von von Willebrand Faktor an Collagen, sowie ein Verfahren zum Nachweis eines erworbenen oder kongenitalen Mangels der von Willebrand Faktor-spaltenden Protease.
PCT/AT2000/000049 1999-02-25 2000-02-23 Testkit zur analytik der faktor-viii-spaltenden protease WO2000050904A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU31336/00A AU756563B2 (en) 1999-02-25 2000-02-23 Test kit for analysing factor VIII-splitting protease
CA002362483A CA2362483A1 (en) 1999-02-25 2000-02-23 Test kit for analysing factor viii-splitting protease
EP00908814A EP1155328A1 (de) 1999-02-25 2000-02-23 Testkit zur analytik der faktor-viii-spaltenden protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT13299 1999-02-25
ATGM132/99 1999-02-25

Publications (2)

Publication Number Publication Date
WO2000050904A1 WO2000050904A1 (de) 2000-08-31
WO2000050904A8 true WO2000050904A8 (de) 2001-04-12

Family

ID=3482389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2000/000049 WO2000050904A1 (de) 1999-02-25 2000-02-23 Testkit zur analytik der faktor-viii-spaltenden protease

Country Status (4)

Country Link
EP (1) EP1155328A1 (de)
AU (1) AU756563B2 (de)
CA (1) CA2362483A1 (de)
WO (1) WO2000050904A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20213920U1 (de) 2002-07-03 2003-01-16 Böhm, Martina, 60439 Frankfurt Diagnostikum zum Nachweis der den von Willebrand-Faktorspaltenden Aktivität von ADAMTS13
US7763430B2 (en) * 2003-04-22 2010-07-27 Baxter International Inc. Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies
US7780831B2 (en) 2003-07-07 2010-08-24 The University Of North Carolina At Chapel Hill Assays for detection of von willebrand factor (vWF) multimers and for degradation of vWF by agents such as ADAMTS13 and related methods
ES2373989T3 (es) 2006-01-31 2012-02-10 Mitsubishi Chemical Medience Corporation Procedimiento para la determinación del estado de un síndrome de coagulación intravascular diseminada.
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
EP4279607A1 (de) 2022-05-20 2023-11-22 Siemens Healthcare Diagnostics Products GmbH Enzym-verstärkter adamts-13 aktivitätstest

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6068838A (en) * 1996-04-29 2000-05-30 Baxter Aktiengesellschaft Purified multimerase
AT403853B (de) * 1996-07-04 1998-06-25 Immuno Ag Verfahren zur bestimmung der aktivität eines adhäsionsproteins

Also Published As

Publication number Publication date
AU3133600A (en) 2000-09-14
EP1155328A1 (de) 2001-11-21
CA2362483A1 (en) 2000-08-31
AU756563B2 (en) 2003-01-16
WO2000050904A1 (de) 2000-08-31

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