ES2126597T5 - Sistema de sondas que permite efectuar la tipificacion hla dr, y procedimiento de tipificacion que utiliza dichas sondas. - Google Patents
Sistema de sondas que permite efectuar la tipificacion hla dr, y procedimiento de tipificacion que utiliza dichas sondas.Info
- Publication number
- ES2126597T5 ES2126597T5 ES92916146T ES92916146T ES2126597T5 ES 2126597 T5 ES2126597 T5 ES 2126597T5 ES 92916146 T ES92916146 T ES 92916146T ES 92916146 T ES92916146 T ES 92916146T ES 2126597 T5 ES2126597 T5 ES 2126597T5
- Authority
- ES
- Spain
- Prior art keywords
- probes
- typification
- procedure
- allows
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000523 sample Substances 0.000 title abstract 8
- 102000006354 HLA-DR Antigens Human genes 0.000 abstract 2
- 108010058597 HLA-DR Antigens Proteins 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Tests Of Electronic Circuits (AREA)
- Testing Or Measuring Of Semiconductors Or The Like (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Polyamides (AREA)
- Graft Or Block Polymers (AREA)
Abstract
LOS POLIMEROS INJERTADOS CON UNA FUNCIONALIDAD AMINA REACTIVA SE PREPARAN A BASE DE:<br /><br /> A) PROPORCIONAR UN POLIMERO TERMOPLASTICO QUE CONTENGA POR LO MENOS UNA FUNCIONALIDAD ELECTROFILICA SUFICIENTE COMO PARA REACCIONAR CON GRUPOS AMINO PRIMARIOS; Y<br /><br /> B) HACERLO REACCIONAR POR FUSION CON UN COMPUESTO QUIMICO QUE CONTENGA UNA AMINA PRIMARIA Y UNA AMINA SECUNDARIA, EN DONDE LA AMINA SECUNDARIA TENGA UNA REACTIVIDAD APROXIMADAMENTE IGUAL O MENOR QUE LA AMINA PRIMARIA. MEDIANTE LA UTILIZACION DE UNA DIAMINA SELECCIONADA QUE CONTENGA COMPUESTOS QUIMICOS, SE EVITA ESENCIALMENTE LA FORMACION DE ENLACES EN CRUZ. SE DESCRIBE EL USO DEL POLIMERO INJERTADO COMO MODIFICADOR Y COMPATIBILIZADOR DE COMPOSICIONES DE POLIMEROS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9109058A FR2679252B1 (fr) | 1991-07-17 | 1991-07-17 | Systeme de sondes permettant d'effectuer le typage hla dr, et procede de typage utilisant lesdites sondes. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2126597T3 ES2126597T3 (es) | 1999-04-01 |
| ES2126597T5 true ES2126597T5 (es) | 2002-11-01 |
Family
ID=9415244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92916146T Expired - Lifetime ES2126597T5 (es) | 1991-07-17 | 1992-07-17 | Sistema de sondas que permite efectuar la tipificacion hla dr, y procedimiento de tipificacion que utiliza dichas sondas. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0549776B9 (es) |
| JP (1) | JPH06501622A (es) |
| AT (1) | ATE174064T1 (es) |
| AU (1) | AU659866B2 (es) |
| CA (1) | CA2091775C (es) |
| DE (1) | DE69227756T3 (es) |
| DK (1) | DK0549776T4 (es) |
| ES (1) | ES2126597T5 (es) |
| FR (1) | FR2679252B1 (es) |
| WO (1) | WO1993002213A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976789A (en) * | 1991-07-17 | 1999-11-02 | Bio Merieux | System of probes enabling HLA-DR typing to be performed, and typing method using said probes |
| FR2749308B1 (fr) * | 1996-06-03 | 1998-07-24 | Bio Merieux | Sondes nucleotidiques et procede pour determiner le typage hla dqb1 |
| AU6223098A (en) * | 1997-02-14 | 1998-09-08 | Medical Research Council | Method of determining susceptibility to late-onset alzheimer's disease and dementia with lewy bodies |
| FR2793808B1 (fr) * | 1999-05-20 | 2003-09-19 | Biomerieux Sa | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie |
| FR2793809B1 (fr) * | 1999-05-20 | 2006-07-28 | Biomerieux Sa | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie et amplification adaptee a un tel procede |
| DE10032529A1 (de) * | 2000-06-30 | 2002-02-07 | Epigenomics Ag | Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC) |
| GB0016836D0 (en) * | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (1) |
| EP1536021A1 (en) * | 2003-11-27 | 2005-06-01 | Consortium National de Recherche en Genomique (CNRG) | Method for HLA typing |
| JP6734011B2 (ja) * | 2014-06-06 | 2020-08-05 | 古河電気工業株式会社 | 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用試験片及び生体分子検出用標識試薬 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5310893A (en) * | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
| US6194561B1 (en) * | 1986-03-13 | 2001-02-27 | Roche Molecular Systems, Inc. | Characterization and detection of sequences associated with autoimmune diseases |
| US4965189A (en) * | 1986-07-01 | 1990-10-23 | University Of Massachusetts Medical School | Probes for the determination of the proclivity for development of autoimmune diseases |
| JPH03164180A (ja) * | 1989-08-10 | 1991-07-16 | Noboru Kashiwagi | 新規なdna塩基配列およびその用途 |
| GB9002625D0 (en) * | 1990-02-06 | 1990-04-04 | Univ Singapore | Human leukocyte antigen typing |
| US5387505A (en) * | 1990-05-04 | 1995-02-07 | Eastman Kodak Company | Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage |
| EP0466367B1 (en) † | 1990-06-28 | 1995-08-23 | Wakunaga Seiyaku Kabushiki Kaisha | Process for detecting nucleic acid |
| JP2560160B2 (ja) † | 1990-08-20 | 1996-12-04 | 社団法人北里研究所 | 新規なdna塩基配列およびその用途 |
| AU656161B2 (en) † | 1990-12-06 | 1995-01-27 | F. Hoffmann-La Roche Ag | Methods and reagents for HLA DRbeta DNA typing |
| WO1993009245A1 (en) † | 1991-10-31 | 1993-05-13 | University Of Pittsburgh | Reverse dot blot hybridization using tandem head-to-tail monomers containing probes synthesized by staggered complementary primers |
-
1991
- 1991-07-17 FR FR9109058A patent/FR2679252B1/fr not_active Expired - Fee Related
-
1992
- 1992-07-17 JP JP5502642A patent/JPH06501622A/ja active Pending
- 1992-07-17 AU AU23885/92A patent/AU659866B2/en not_active Ceased
- 1992-07-17 DE DE69227756T patent/DE69227756T3/de not_active Expired - Fee Related
- 1992-07-17 DK DK92916146T patent/DK0549776T4/da active
- 1992-07-17 AT AT92916146T patent/ATE174064T1/de not_active IP Right Cessation
- 1992-07-17 EP EP92916146A patent/EP0549776B9/fr not_active Expired - Lifetime
- 1992-07-17 WO PCT/FR1992/000702 patent/WO1993002213A1/fr not_active Ceased
- 1992-07-17 ES ES92916146T patent/ES2126597T5/es not_active Expired - Lifetime
- 1992-07-17 CA CA002091775A patent/CA2091775C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2388592A (en) | 1993-02-23 |
| CA2091775C (fr) | 2003-02-25 |
| DK0549776T3 (da) | 1999-08-16 |
| WO1993002213A1 (fr) | 1993-02-04 |
| FR2679252A1 (fr) | 1993-01-22 |
| EP0549776B2 (fr) | 2002-03-27 |
| DE69227756T2 (de) | 1999-07-29 |
| ES2126597T3 (es) | 1999-04-01 |
| DK0549776T4 (da) | 2002-07-29 |
| DE69227756T3 (de) | 2002-11-21 |
| ATE174064T1 (de) | 1998-12-15 |
| JPH06501622A (ja) | 1994-02-24 |
| AU659866B2 (en) | 1995-06-01 |
| FR2679252B1 (fr) | 1993-12-10 |
| DE69227756D1 (de) | 1999-01-14 |
| EP0549776B1 (fr) | 1998-12-02 |
| CA2091775A1 (fr) | 1993-01-18 |
| EP0549776B9 (fr) | 2003-03-12 |
| EP0549776A1 (fr) | 1993-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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