IL146939A0 - Induction of pharmacological stress with adenosine receptor agonists - Google Patents
Induction of pharmacological stress with adenosine receptor agonistsInfo
- Publication number
- IL146939A0 IL146939A0 IL14693900A IL14693900A IL146939A0 IL 146939 A0 IL146939 A0 IL 146939A0 IL 14693900 A IL14693900 A IL 14693900A IL 14693900 A IL14693900 A IL 14693900A IL 146939 A0 IL146939 A0 IL 146939A0
- Authority
- IL
- Israel
- Prior art keywords
- induction
- receptor agonists
- adenosine receptor
- pharmacological stress
- pharmacological
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/336,198 US6322771B1 (en) | 1999-06-18 | 1999-06-18 | Induction of pharmacological stress with adenosine receptor agonists |
PCT/US2000/016029 WO2000078774A2 (en) | 1999-06-18 | 2000-06-12 | Induction of pharmacological stress with adenosine receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IL146939A0 true IL146939A0 (en) | 2002-08-14 |
Family
ID=23314994
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14693900A IL146939A0 (en) | 1999-06-18 | 2000-06-12 | Induction of pharmacological stress with adenosine receptor agonists |
IL146939A IL146939A (en) | 1999-06-18 | 2001-12-05 | Pharmacological strain induction with adenosine receptor agonists |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL146939A IL146939A (en) | 1999-06-18 | 2001-12-05 | Pharmacological strain induction with adenosine receptor agonists |
Country Status (22)
Country | Link |
---|---|
US (1) | US6322771B1 (xx) |
EP (1) | EP1194440B1 (xx) |
JP (1) | JP4890705B2 (xx) |
KR (1) | KR100683607B1 (xx) |
AR (1) | AR030151A1 (xx) |
AT (1) | ATE289317T1 (xx) |
AU (1) | AU5605100A (xx) |
BR (1) | BR0011725A (xx) |
CA (1) | CA2375374C (xx) |
DE (1) | DE60018185T2 (xx) |
DK (1) | DK1194440T3 (xx) |
ES (1) | ES2233401T3 (xx) |
HU (1) | HU229005B1 (xx) |
IL (2) | IL146939A0 (xx) |
MX (1) | MXPA01013213A (xx) |
MY (1) | MY126794A (xx) |
NO (1) | NO322229B1 (xx) |
NZ (1) | NZ516169A (xx) |
PT (1) | PT1194440E (xx) |
TW (1) | TW585870B (xx) |
WO (1) | WO2000078774A2 (xx) |
ZA (1) | ZA200200342B (xx) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7378400B2 (en) * | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
US6403567B1 (en) | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
WO2001062979A2 (en) | 2000-02-23 | 2001-08-30 | Cv Therapeutics, Inc. | Dentification of partial agonists of the a2a adenosine receptor |
US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6716444B1 (en) | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6663662B2 (en) | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
WO2003029264A2 (en) * | 2001-10-01 | 2003-04-10 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
EP1465634B1 (en) | 2001-12-12 | 2014-10-22 | The Government of the United States of America, as represented by the Secretary Department of Health and Human Services | Methods for using adenosine receptor inhibitors to enhance immune response and inflammation |
AUPR977701A0 (en) * | 2001-12-28 | 2002-01-24 | Austral Ships Pty Ltd | Seagoing vessels |
US20030224455A1 (en) * | 2002-05-28 | 2003-12-04 | Mariapia Abbracchio | Method for the diagnosis of heart diseases |
US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
US7683037B2 (en) * | 2002-07-29 | 2010-03-23 | Gilead Palo Alto, Inc. | Myocardial perfusion imaging method |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
WO2004082639A2 (en) * | 2003-03-19 | 2004-09-30 | Baylor College Of Medicine | Detecting coronary artery disease with bnp during stress testing |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
US20050033044A1 (en) | 2003-05-19 | 2005-02-10 | Bristol-Myers Squibb Pharma Company | Methods for preparing 2-alkynyladenosine derivatives |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
US20070166227A1 (en) * | 2004-02-10 | 2007-07-19 | Shuang Liu | Crowned dithiocarbamate metal complexes and methods for their use |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
NZ553288A (en) * | 2004-08-02 | 2010-12-24 | Univ Virginia | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
WO2006028618A1 (en) * | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
WO2006023272A1 (en) * | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
US20060079479A1 (en) * | 2004-10-13 | 2006-04-13 | Italo Biaggioni | Methods of inducing vasodilation |
US7655636B2 (en) * | 2004-10-20 | 2010-02-02 | Gilead Palo Alto, Inc. | Use of A2A adenosine receptor agonists |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0500785D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
MY144906A (en) | 2005-10-21 | 2011-11-30 | Novartis Ag | Human antibodies against il13 and therapeutic uses |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
JP5326156B2 (ja) | 2006-02-03 | 2013-10-30 | ギリアード サイエンシーズ, インコーポレイテッド | A2a−アデノシンレセプターアゴニストおよびその多形体の調製方法 |
WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
WO2007107598A1 (en) | 2006-03-21 | 2007-09-27 | Heinrich-Heine-Universität Düsseldorf | Phosphorylated a2a receptor agonists |
GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
MY146645A (en) | 2006-04-21 | 2012-09-14 | Novartis Ag | Purine derivatives for use as adenosin a2a receptor agonists |
GB0607951D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
US8188063B2 (en) | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
WO2008063712A1 (en) * | 2006-06-22 | 2008-05-29 | Cv Therapeutics, Inc. | Use of a2a adenosine receptor agonists in the treatment of ischemia |
US7811549B2 (en) * | 2006-07-05 | 2010-10-12 | Adenobio N.V. | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects |
EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
RU2459626C2 (ru) * | 2006-09-01 | 2012-08-27 | Гайлид Сайэнсиз, Инк. | Способы и композиции, повышающие переносимость пациентом методов визуализации миокарда |
US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
EP1903044A1 (en) | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
KR20090073121A (ko) | 2006-09-29 | 2009-07-02 | 노파르티스 아게 | Pi3k 지질 키나제 억제제로서의 피라졸로피리미딘 |
EP2066232A1 (en) * | 2006-09-29 | 2009-06-10 | Cv Therapeutics, Inc. | Methods for myocardial imaging in patients having a history of pulmonary disease |
JP2010508315A (ja) | 2006-10-30 | 2010-03-18 | ノバルティス アーゲー | 抗炎症剤としてのヘテロ環式化合物 |
MX2009007071A (es) * | 2007-01-03 | 2009-10-13 | Cv Therapeutics Inc | Elaboracion de imagen de perfusion del miocardio. |
US20080219927A1 (en) * | 2007-01-18 | 2008-09-11 | Thakur Ajit B | Adenosine derivative formulations for medical imaging |
JP2008266143A (ja) * | 2007-04-16 | 2008-11-06 | Santen Pharmaceut Co Ltd | アデノシン誘導体を有効成分として含有する緑内障治療剤 |
US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
EA201001129A1 (ru) | 2008-01-11 | 2011-02-28 | Новартис Аг | Пиримидины в качестве ингибиторов киназы |
US20090185973A1 (en) * | 2008-01-22 | 2009-07-23 | Adenobio N.V. | Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects |
SI2306971T1 (sl) * | 2008-07-03 | 2015-07-31 | University Of Virginia Patent Foundation | Dozirna enota Apadenoson-a |
US20100086483A1 (en) * | 2008-09-29 | 2010-04-08 | Gilead Palo Alto, Inc. | Method of multidetector computed tomagraphy |
SI2391366T1 (sl) | 2009-01-29 | 2013-01-31 | Novartis Ag | Substituirani benzimidazoli za zdravljenje astrocitomov |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
AU2010283806A1 (en) | 2009-08-12 | 2012-03-01 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
MX2012002066A (es) | 2009-08-17 | 2012-03-29 | Intellikine Inc | Compuestos heterociclicos y usos de los mismos. |
EP2467383A1 (en) | 2009-08-20 | 2012-06-27 | Novartis AG | Heterocyclic oxime compounds |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
JP5808826B2 (ja) | 2011-02-23 | 2015-11-10 | インテリカイン, エルエルシー | 複素環化合物およびその使用 |
MA34969B1 (fr) | 2011-02-25 | 2014-03-01 | Irm Llc | Composes et compositions en tant qu inibiteurs de trk |
US11129911B2 (en) | 2011-05-05 | 2021-09-28 | Cedars-Sinai Medical Center | Assessment of coronary heart disease with carbon dioxide |
EP2704577A4 (en) * | 2011-05-05 | 2014-10-15 | Cedars Sinai Medical Center | EVALUATION OF A CORONARY HEART DISEASE WITH CARBON DIOXIDE |
MX339302B (es) | 2011-09-15 | 2016-05-19 | Novartis Ag | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. |
CA2856803A1 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
WO2013114204A1 (en) | 2012-02-03 | 2013-08-08 | Adenobio N.V. | A method of using adenosine and dipyridamole for pharmacologic stress testing, with specific compositions, unit dosage forms and kits |
EP2834246B1 (en) | 2012-04-03 | 2021-07-28 | Novartis AG | Combination products with tyrosine kinase inhibitors and their use |
US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
EP2879683B1 (en) * | 2012-08-01 | 2020-01-22 | Lewis and Clark Pharmaceuticals, Inc. | N-alkyl-alkynyladenosine-5-uronamide compounds as agonists of a2a receptor |
WO2014151147A1 (en) | 2013-03-15 | 2014-09-25 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
US10471094B2 (en) | 2013-08-05 | 2019-11-12 | Cedars-Sinai Medical Center | Methods for reducing ischemia-reperfusion injury via targeted control of blood gases |
WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
KR20170036037A (ko) | 2014-07-31 | 2017-03-31 | 노파르티스 아게 | 조합 요법 |
US20200078400A1 (en) | 2016-12-03 | 2020-03-12 | Juno Therapeutics, Inc. | Methods for determining car-t cells dosing |
MA46961A (fr) | 2016-12-03 | 2019-10-09 | Juno Therapeutics Inc | Procédés de modulation de lymphocytes t modifiés par car |
CN110249046A (zh) | 2016-12-05 | 2019-09-17 | 朱诺治疗学股份有限公司 | 用于过继细胞疗法的工程化细胞的产生 |
US11413310B2 (en) | 2017-06-02 | 2022-08-16 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
JP2020526194A (ja) | 2017-06-29 | 2020-08-31 | ジュノー セラピューティクス インコーポレイテッド | 免疫療法薬と関連する毒性を評価するためのマウスモデル |
WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
AU2018360800A1 (en) | 2017-11-01 | 2020-05-14 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen (BCMA) |
US11623961B2 (en) | 2017-11-01 | 2023-04-11 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for B-cell maturation antigen |
KR20200116081A (ko) | 2017-12-01 | 2020-10-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포의 투약 및 조절 방법 |
MA51184A (fr) | 2017-12-15 | 2020-10-21 | Juno Therapeutics Inc | Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés |
EP3873943A2 (en) | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
JP2022506598A (ja) | 2018-11-01 | 2022-01-17 | ジュノー セラピューティクス インコーポレイテッド | Gタンパク質共役受容体クラスcグループ5メンバーd(gprc5d)に特異的なキメラ抗原受容体 |
CA3120118A1 (en) | 2018-11-16 | 2020-05-22 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
PT3886875T (pt) | 2018-11-30 | 2024-06-27 | Juno Therapeutics Inc | Métodos para tratamento utilizando terapia celular adotiva |
CN113365660A (zh) | 2019-01-29 | 2021-09-07 | 朱诺治疗学股份有限公司 | 对受体酪氨酸激酶样孤儿受体1(ror1)具特异性的抗体及嵌合抗原受体 |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
CN115916223A (zh) | 2020-04-10 | 2023-04-04 | 朱诺治疗学股份有限公司 | 与用靶向b细胞成熟抗原的嵌合抗原受体工程化的细胞疗法相关的方法和用途 |
WO2023250400A1 (en) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
US20240041929A1 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
WO2024129778A2 (en) | 2022-12-13 | 2024-06-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for baff-r and cd19 and methods and uses thereof |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892777A (en) | 1968-05-01 | 1975-07-01 | Hoffmann La Roche | Substituted benzylethylenedicarbamates |
CH608236A5 (xx) | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
US4193926A (en) | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
DK159431C (da) | 1984-05-10 | 1991-03-18 | Byk Gulden Lomberg Chem Fab | 6-phenyl-3(2h)-pyridazinoner, fremgangsmaade til fremstilling deraf, laegemidler indeholdende disse samt anvendelse af forbindelserne til fremstilling af laegemidler |
GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
US4824660A (en) | 1985-06-06 | 1989-04-25 | Paul S. Angello | Method of determining the viability of tissue in an organism |
US5231086A (en) | 1985-09-24 | 1993-07-27 | Item Development Aktiebolag | Continuous administration adenosine to increase myocardial blood flow |
JPS6299395A (ja) | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
US5096906A (en) | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
US4965271A (en) | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
US5272153A (en) | 1986-12-31 | 1993-12-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
US5298508A (en) | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
US5070877A (en) | 1988-08-11 | 1991-12-10 | Medco Research, Inc. | Novel method of myocardial imaging |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
USRE36494E (en) | 1990-02-20 | 2000-01-11 | Discovery Therapeutics, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
US6004945A (en) | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
US5124455A (en) | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
US5189027A (en) | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
JP3053908B2 (ja) * | 1991-06-28 | 2000-06-19 | ヤマサ醤油株式会社 | 2‐アルキニルアデノシン誘導体 |
IL99368A (en) | 1991-09-02 | 1996-01-19 | Teva Pharma | Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine |
US5278150A (en) | 1992-04-24 | 1994-01-11 | Whitby Research, Inc. | 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions |
IT1254915B (it) * | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
WO1994023723A1 (en) | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
US5665754A (en) | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
WO1995011681A1 (en) | 1993-10-29 | 1995-05-04 | Merck & Co., Inc. | Human adenosine receptor antagonists |
US5877180A (en) | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
US5661153A (en) | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
GB9415529D0 (en) | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
US5854081A (en) | 1996-06-20 | 1998-12-29 | The University Of Patent Foundation | Stable expression of human A2B adenosine receptors, and assays employing the same |
SK138799A3 (en) | 1997-04-18 | 2001-01-18 | Searle & Co | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
EP1014995A4 (en) | 1997-06-18 | 2005-02-16 | Aderis Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSES CONSECUTIVE TO REVASCULARIZATION INTERVENTIONS |
US5998386A (en) | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
US6020339A (en) | 1997-10-03 | 2000-02-01 | Merck & Co., Inc. | Aryl furan derivatives as PDE IV inhibitors |
US6034089A (en) | 1997-10-03 | 2000-03-07 | Merck & Co., Inc. | Aryl thiophene derivatives as PDE IV inhibitors |
AU4675699A (en) | 1998-06-08 | 1999-12-30 | Epigenesis Pharmaceuticals, Inc. | Composition and method for prevention and treatment of cardiopulmonary and renal failure or damage associated with ischemia, endotoxin release, ards or brought about by administration of certain drugs |
UA72912C2 (uk) | 1999-02-01 | 2005-05-16 | Юніверсіті Оф Вірджінія Патент Фаундейшн | Композиція для лікування запальної реакції |
-
1999
- 1999-06-18 US US09/336,198 patent/US6322771B1/en not_active Expired - Lifetime
-
2000
- 2000-06-12 AU AU56051/00A patent/AU5605100A/en not_active Abandoned
- 2000-06-12 CA CA2375374A patent/CA2375374C/en not_active Expired - Fee Related
- 2000-06-12 HU HU0202094A patent/HU229005B1/hu not_active IP Right Cessation
- 2000-06-12 ES ES00941335T patent/ES2233401T3/es not_active Expired - Lifetime
- 2000-06-12 KR KR1020017016107A patent/KR100683607B1/ko not_active IP Right Cessation
- 2000-06-12 MX MXPA01013213A patent/MXPA01013213A/es active IP Right Grant
- 2000-06-12 IL IL14693900A patent/IL146939A0/xx active IP Right Grant
- 2000-06-12 WO PCT/US2000/016029 patent/WO2000078774A2/en active IP Right Grant
- 2000-06-12 JP JP2001504939A patent/JP4890705B2/ja not_active Expired - Fee Related
- 2000-06-12 DK DK00941335T patent/DK1194440T3/da active
- 2000-06-12 BR BR0011725-0A patent/BR0011725A/pt not_active Application Discontinuation
- 2000-06-12 PT PT00941335T patent/PT1194440E/pt unknown
- 2000-06-12 NZ NZ516169A patent/NZ516169A/xx not_active IP Right Cessation
- 2000-06-12 DE DE60018185T patent/DE60018185T2/de not_active Expired - Lifetime
- 2000-06-12 AT AT00941335T patent/ATE289317T1/de not_active IP Right Cessation
- 2000-06-12 EP EP00941335A patent/EP1194440B1/en not_active Expired - Lifetime
- 2000-06-14 TW TW089111546A patent/TW585870B/zh not_active IP Right Cessation
- 2000-06-16 MY MYPI20002713 patent/MY126794A/en unknown
- 2000-06-16 AR ARP000103042A patent/AR030151A1/es not_active Application Discontinuation
-
2001
- 2001-12-05 IL IL146939A patent/IL146939A/en not_active IP Right Cessation
- 2001-12-06 NO NO20015974A patent/NO322229B1/no not_active IP Right Cessation
-
2002
- 2002-01-15 ZA ZA200200342A patent/ZA200200342B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0202094A3 (en) | 2005-02-28 |
ES2233401T3 (es) | 2005-06-16 |
AU5605100A (en) | 2001-01-09 |
KR100683607B1 (ko) | 2007-02-20 |
NO20015974L (no) | 2002-02-14 |
PT1194440E (pt) | 2005-05-31 |
ATE289317T1 (de) | 2005-03-15 |
JP2003502433A (ja) | 2003-01-21 |
NO20015974D0 (no) | 2001-12-06 |
DE60018185D1 (de) | 2005-03-24 |
US6322771B1 (en) | 2001-11-27 |
DK1194440T3 (da) | 2005-05-30 |
HU229005B1 (en) | 2013-07-29 |
EP1194440B1 (en) | 2005-02-16 |
JP4890705B2 (ja) | 2012-03-07 |
CA2375374A1 (en) | 2000-12-28 |
WO2000078774A2 (en) | 2000-12-28 |
MY126794A (en) | 2006-10-31 |
WO2000078774A3 (en) | 2001-07-12 |
CA2375374C (en) | 2010-03-23 |
KR20020033640A (ko) | 2002-05-07 |
NO322229B1 (no) | 2006-08-28 |
NZ516169A (en) | 2004-12-24 |
DE60018185T2 (de) | 2005-06-30 |
TW585870B (en) | 2004-05-01 |
EP1194440A2 (en) | 2002-04-10 |
BR0011725A (pt) | 2002-03-26 |
AR030151A1 (es) | 2003-08-13 |
ZA200200342B (en) | 2003-04-30 |
IL146939A (en) | 2006-08-20 |
HUP0202094A2 (en) | 2002-10-28 |
MXPA01013213A (es) | 2002-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL146939A0 (en) | Induction of pharmacological stress with adenosine receptor agonists | |
PL341091A1 (en) | Agonists of adenosine receptor a1 | |
IL135964A0 (en) | Adenosine a1 receptor agonists | |
IL147198A0 (en) | N-pyrazole a2a receptor agonists | |
IL147195A0 (en) | C-pyrazole a2a receptor agonists | |
EP1085869A4 (en) | SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS | |
PT1192170E (pt) | Agonistas de receptor a2a de propargilfenileter | |
HUP0203371A3 (en) | Adenosine receptor antagonists and methods of making and using the same | |
IL148366A0 (en) | Selective antagonists of a2b adenosine receptors | |
EP1224155A4 (en) | NEW BICYCLIC CANNABINOID AGONISTS FOR THE CANNABINOID RECEPTOR | |
IL127947A0 (en) | Pharmaceutical use of adenosine agonists | |
IL146471A0 (en) | Orally active a1 adenosine receptor agonists | |
GB2362684B (en) | Crack injector system | |
IL148409A0 (en) | Formulations for parenteral use of estramustine phosphate with improved pharmacological properties | |
TW364420U (en) | Improvement on structure of sleeve with adjustable angles | |
PL342213A1 (en) | Pharmacological preparation | |
TW412998U (en) | Structure of cup with heat-insulating effects | |
AU3128700A (en) | Combinations of dopamine receptor antagonists with dopamine agonists | |
GB9817179D0 (en) | Spiropiperidine derivatives as melanocortin receptor agonists | |
TW364419U (en) | Structure of sleeve with adjustable angles | |
HK1048803A1 (en) | β 2-ADRENERGIC RECEPTOR AGONISTS | |
SI1235787T1 (en) | $g(b)2-ADRENERGIC RECEPTOR AGONISTS | |
GB9800454D0 (en) | Antagonists of gonadatropin releasing hormone | |
TW412999U (en) | Improved structure of thermal cup | |
PL344600A1 (en) | Adenosine a3 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |