BR0001773A - Processo para a preparação de 2-fenil-3-aminopiridina, derivados de fenila substituìda, dos mesmos e seus sais. - Google Patents
Processo para a preparação de 2-fenil-3-aminopiridina, derivados de fenila substituìda, dos mesmos e seus sais.Info
- Publication number
- BR0001773A BR0001773A BR0001773-6A BR0001773A BR0001773A BR 0001773 A BR0001773 A BR 0001773A BR 0001773 A BR0001773 A BR 0001773A BR 0001773 A BR0001773 A BR 0001773A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- phenyl
- aminopyridine
- salts
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- XTHJCITVHCRQRD-UHFFFAOYSA-N 2-phenylpyridin-3-amine Chemical compound NC1=CC=CN=C1C1=CC=CC=C1 XTHJCITVHCRQRD-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 8
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE 2-FENIL-3-AMINOPIRIDINA, DERIVADOS DE FENILA SUBSTITUìDA, DOS MESMOS E SEUS SAIS"<D>. Um processo para preparar 2-fenil-3-aminopiridina, e derivados de fenila substituída dos mesmos e seus sais. Um composto de fórmula é feito reagir com um composto da fórmula em um solvente inerte à reação na presença de uma base e de um catalisador de paládio para obter um composto de fórmula Preferencialmente, o composto de fórmula III ou VIII é preparado fazendo reagir um composto de fórmula com um composto da fórmula em um solvente inerte à reação. O composto de fórmula V é preferencialmente desprotegido em ácido aquoso para obter um sal do composto X. X, Y, Z, Ar, R¹, R², R³, R^ 4^ e R^ 5^ são como aqui definidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13455999P | 1999-05-17 | 1999-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0001773A true BR0001773A (pt) | 2001-01-02 |
Family
ID=22463902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0001773-6A BR0001773A (pt) | 1999-05-17 | 2000-05-16 | Processo para a preparação de 2-fenil-3-aminopiridina, derivados de fenila substituìda, dos mesmos e seus sais. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6316632B1 (pt) |
| EP (1) | EP1054002B1 (pt) |
| JP (1) | JP3837011B2 (pt) |
| KR (1) | KR100386226B1 (pt) |
| CN (1) | CN1216865C (pt) |
| AR (1) | AR020029A1 (pt) |
| AT (1) | ATE306474T1 (pt) |
| AU (1) | AU775947B2 (pt) |
| BR (1) | BR0001773A (pt) |
| CA (1) | CA2308817C (pt) |
| CZ (1) | CZ299474B6 (pt) |
| DE (1) | DE60023063T2 (pt) |
| DK (1) | DK1054002T3 (pt) |
| ES (1) | ES2248017T3 (pt) |
| HK (1) | HK1032397A1 (pt) |
| HU (1) | HUP0001928A3 (pt) |
| ID (1) | ID26061A (pt) |
| IL (1) | IL136105A (pt) |
| IN (1) | IN192341B (pt) |
| MX (1) | MXPA00004790A (pt) |
| PL (1) | PL198153B1 (pt) |
| RS (1) | RS49964B (pt) |
| RU (1) | RU2181120C2 (pt) |
| TR (1) | TR200001403A2 (pt) |
| TW (1) | TWI286133B (pt) |
| ZA (1) | ZA200002375B (pt) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
| US5364943A (en) * | 1991-11-27 | 1994-11-15 | Pfizer Inc. | Preparation of substituted piperidines |
| RU2105001C1 (ru) | 1991-03-26 | 1998-02-20 | Пфайзер Инк. | Способ получения замещенных 3-аминопиперидинов |
| RU2114848C1 (ru) | 1991-06-20 | 1998-07-10 | Пфайзер Инк. | Фторалкоксибензиламинные производные азотсодержащих гетероциклов, фармацевтическая композиция, способ ингибирования действия вещества р у млекопитающих |
| ATE199552T1 (de) | 1995-07-07 | 2001-03-15 | Pfizer | Substituierte benzolaktamverbindungen als substanz-p-antagonisten |
| TW340842B (en) | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| CA2273853A1 (en) | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating cognitive disorders |
| TW426667B (en) | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
-
2000
- 2000-04-03 RS YUP-196/00A patent/RS49964B/sr unknown
- 2000-04-07 CN CN001064517A patent/CN1216865C/zh not_active Expired - Fee Related
- 2000-04-11 AU AU27662/00A patent/AU775947B2/en not_active Ceased
- 2000-05-09 EP EP00303889A patent/EP1054002B1/en not_active Expired - Lifetime
- 2000-05-09 AT AT00303889T patent/ATE306474T1/de not_active IP Right Cessation
- 2000-05-09 ES ES00303889T patent/ES2248017T3/es not_active Expired - Lifetime
- 2000-05-09 DE DE60023063T patent/DE60023063T2/de not_active Expired - Fee Related
- 2000-05-09 JP JP2000136185A patent/JP3837011B2/ja not_active Expired - Fee Related
- 2000-05-09 DK DK00303889T patent/DK1054002T3/da active
- 2000-05-11 TW TW089109033A patent/TWI286133B/zh not_active IP Right Cessation
- 2000-05-11 IN IN506DE2000 patent/IN192341B/en unknown
- 2000-05-11 US US09/569,010 patent/US6316632B1/en not_active Expired - Fee Related
- 2000-05-12 IL IL136105A patent/IL136105A/en not_active IP Right Cessation
- 2000-05-15 AR ARP000102332A patent/AR020029A1/es active IP Right Grant
- 2000-05-15 ID IDP20000406A patent/ID26061A/id unknown
- 2000-05-15 ZA ZA200002375A patent/ZA200002375B/xx unknown
- 2000-05-15 CA CA002308817A patent/CA2308817C/en not_active Expired - Fee Related
- 2000-05-16 RU RU2000112354/04A patent/RU2181120C2/ru not_active IP Right Cessation
- 2000-05-16 KR KR10-2000-0025978A patent/KR100386226B1/ko not_active IP Right Cessation
- 2000-05-16 BR BR0001773-6A patent/BR0001773A/pt not_active Application Discontinuation
- 2000-05-16 CZ CZ20001800A patent/CZ299474B6/cs not_active IP Right Cessation
- 2000-05-16 MX MXPA00004790A patent/MXPA00004790A/es unknown
- 2000-05-16 HU HU0001928A patent/HUP0001928A3/hu unknown
- 2000-05-17 TR TR2000/01403A patent/TR200001403A2/xx unknown
- 2000-05-17 PL PL340157A patent/PL198153B1/pl unknown
-
2001
- 2001-04-24 HK HK01102898A patent/HK1032397A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8 E 13 DA LPI |
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| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |