BG64668B1 - Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда - Google Patents
Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда Download PDFInfo
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- BG64668B1 BG64668B1 BG103884A BG10388499A BG64668B1 BG 64668 B1 BG64668 B1 BG 64668B1 BG 103884 A BG103884 A BG 103884A BG 10388499 A BG10388499 A BG 10388499A BG 64668 B1 BG64668 B1 BG 64668B1
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- BG
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- Prior art keywords
- antide
- nicotinamide
- solubility
- peptide
- pharmaceutical composition
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Classifications
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Immunology (AREA)
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- Reproductive Health (AREA)
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- Zoology (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97108593A EP0880968A1 (en) | 1997-05-28 | 1997-05-28 | Pharmaceutical compositions of peptides having low solubility in physiological medium |
| EP97121246A EP0880969A1 (en) | 1997-05-28 | 1997-12-03 | Pharmaceutical compositions of peptides having low solubility in physiological medium |
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| Publication Number | Publication Date |
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| BG103884A BG103884A (en) | 2000-07-31 |
| BG64668B1 true BG64668B1 (bg) | 2005-11-30 |
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| BG103884A BG64668B1 (bg) | 1997-05-28 | 1999-11-15 | Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда |
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| EP (2) | EP0880969A1 (pt) |
| JP (1) | JP2002502384A (pt) |
| KR (1) | KR100552546B1 (pt) |
| CN (1) | CN1159062C (pt) |
| AR (1) | AR012868A1 (pt) |
| AT (1) | ATE252909T1 (pt) |
| AU (1) | AU743152B2 (pt) |
| BG (1) | BG64668B1 (pt) |
| BR (1) | BR9809708A (pt) |
| CA (1) | CA2291765A1 (pt) |
| CZ (1) | CZ298825B6 (pt) |
| DE (1) | DE69819322T2 (pt) |
| DK (1) | DK0984788T3 (pt) |
| EA (1) | EA002227B1 (pt) |
| EE (1) | EE04001B1 (pt) |
| ES (1) | ES2210772T3 (pt) |
| HK (1) | HK1029928A1 (pt) |
| IL (2) | IL133176A0 (pt) |
| NO (1) | NO323697B1 (pt) |
| NZ (1) | NZ500777A (pt) |
| PL (1) | PL192647B1 (pt) |
| PT (1) | PT984788E (pt) |
| SI (1) | SI0984788T1 (pt) |
| SK (1) | SK284640B6 (pt) |
| TR (1) | TR199902865T2 (pt) |
| WO (1) | WO1998053844A1 (pt) |
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| US8343186B2 (en) | 2004-04-06 | 2013-01-01 | Arthrex, Inc. | Fully threaded suture anchor with transverse anchor pin |
| EP1064934A1 (en) * | 1999-06-30 | 2001-01-03 | Applied Research Systems ARS Holding N.V. | GRF-containing lyophilized pharmaceutical composition |
| CA2380423A1 (en) * | 2000-05-17 | 2001-11-22 | Bionebraska, Inc. | Peptide pharmaceutical formulations |
| US20040229334A1 (en) * | 2003-05-15 | 2004-11-18 | Mendoza Christine B. | Process for manufacture of nematode-extracted anticoagulant protein (NAP) |
| CN101678083A (zh) * | 2007-04-04 | 2010-03-24 | 瑟瑞技术公司 | Ghrh分子的药物制剂 |
| US20150157619A1 (en) | 2012-07-10 | 2015-06-11 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation for injection |
| US9072919B2 (en) | 2012-10-12 | 2015-07-07 | L'oreal S.A. | Synergistic antioxidant cosmetic compositions containing at least one of baicalin and taxifolin, at least one of caffeine and nicotinamide, at least one of vitamin C and resveratrol and ferulic acid |
| US9018177B2 (en) | 2012-10-12 | 2015-04-28 | L'oreal S.A. | Cosmetic compositions for increasing bioavailability of the active compounds baicalin and/or vitamin C |
| US9023826B2 (en) | 2012-10-12 | 2015-05-05 | L'oreal S.A. | Compositions containing adenosine and the hydrotropes caffeine and nicotinamide for cosmetic use |
| US9107853B2 (en) | 2012-10-12 | 2015-08-18 | L'oreal S.A. | Compositions containing phenolic compounds and hydrotropes for cosmetic use |
| ES2768323T5 (es) * | 2012-10-12 | 2023-03-08 | Oreal | Composiciones cosméticas que contienen al menos un hidrótropo y al menos un compuesto activo |
| US9669242B2 (en) * | 2013-07-01 | 2017-06-06 | L'oreal | Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use |
| JP6634758B2 (ja) * | 2015-09-25 | 2020-01-22 | ニプロ株式会社 | 液体組成物及び凍結乾燥製剤 |
| EP3416666B1 (en) | 2016-02-16 | 2021-10-27 | Strongbridge Dublin Limited | Pharmaceutical compostions of water soluble veldoreotide with poor solubility in physiological conditions and methods for production |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0105759A2 (en) * | 1982-10-04 | 1984-04-18 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| EP0377665A1 (en) * | 1987-08-24 | 1990-07-18 | Univ Texas | EFFECTIVE HORMONE ANTAGONISTS WITH LUTENIZATION HORMONE RELEASE RELEASING A NEGLIGIBLE QUANTITY OF HISTAMINE. |
| EP0649655A1 (en) * | 1993-10-15 | 1995-04-26 | Takeda Chemical Industries, Ltd. | Injectable solutions containing anti-ulcer benzimidazoles and amides |
| WO1996010417A1 (en) * | 1994-10-04 | 1996-04-11 | Novo Nordisk A/S | PREPARATIONS CONTAINING AspB28 HUMAN INSULIN AND NICOTINAMIDE |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| JP3122128B2 (ja) * | 1989-12-21 | 2001-01-09 | ノボ ノルディスク アクティーゼルスカブ | ペプチド製剤 |
| CA2070061C (en) * | 1991-06-07 | 2004-02-10 | Shigeyuki Takama | Physiologically active polypeptide-containing pharmaceutical composition |
| US5487898A (en) * | 1991-08-26 | 1996-01-30 | Abbott Laboratories | Compositions and method for the sublingual or buccal administration therapeutic agents |
| WO1993003751A1 (en) * | 1991-08-26 | 1993-03-04 | Abbott Laboratories | Compositions and methods for the sublingual or buccal administration of therapeutic agents |
| US5446025A (en) * | 1992-06-12 | 1995-08-29 | Abbott Laboratories | Formulations and method of the percutaneous administration of leuprolide |
| JP2944419B2 (ja) * | 1993-05-10 | 1999-09-06 | ノバルティス アクチエンゲゼルシャフト | 持続性遊離組成物中の薬理学的活性成分の安定 |
| KR100236393B1 (ko) * | 1996-02-02 | 1999-12-15 | 나까니시 히로유끼 | 사람성장호르몬을 함유하는 의약제제 |
-
1997
- 1997-12-03 EP EP97121246A patent/EP0880969A1/en not_active Withdrawn
-
1998
- 1998-05-26 DE DE69819322T patent/DE69819322T2/de not_active Expired - Fee Related
- 1998-05-26 JP JP50021999A patent/JP2002502384A/ja not_active Withdrawn
- 1998-05-26 NZ NZ500777A patent/NZ500777A/en unknown
- 1998-05-26 DK DK98930729T patent/DK0984788T3/da active
- 1998-05-26 SK SK1597-99A patent/SK284640B6/sk unknown
- 1998-05-26 AT AT98930729T patent/ATE252909T1/de not_active IP Right Cessation
- 1998-05-26 SI SI9830555T patent/SI0984788T1/xx unknown
- 1998-05-26 EP EP98930729A patent/EP0984788B1/en not_active Expired - Lifetime
- 1998-05-26 WO PCT/EP1998/003079 patent/WO1998053844A1/en active IP Right Grant
- 1998-05-26 BR BR9809708-3A patent/BR9809708A/pt not_active Application Discontinuation
- 1998-05-26 ES ES98930729T patent/ES2210772T3/es not_active Expired - Lifetime
- 1998-05-26 CN CNB988054671A patent/CN1159062C/zh not_active Expired - Fee Related
- 1998-05-26 EA EA199901089A patent/EA002227B1/ru not_active IP Right Cessation
- 1998-05-26 IL IL13317698A patent/IL133176A0/xx not_active IP Right Cessation
- 1998-05-26 CZ CZ0423199A patent/CZ298825B6/cs not_active IP Right Cessation
- 1998-05-26 PL PL336982A patent/PL192647B1/pl unknown
- 1998-05-26 KR KR1019997010204A patent/KR100552546B1/ko not_active IP Right Cessation
- 1998-05-26 TR TR1999/02865T patent/TR199902865T2/xx unknown
- 1998-05-26 CA CA002291765A patent/CA2291765A1/en not_active Abandoned
- 1998-05-26 PT PT98930729T patent/PT984788E/pt unknown
- 1998-05-26 AU AU81062/98A patent/AU743152B2/en not_active Ceased
- 1998-05-26 EE EEP199900545A patent/EE04001B1/xx not_active IP Right Cessation
- 1998-05-27 AR ARP980102454A patent/AR012868A1/es active IP Right Grant
-
1999
- 1999-11-15 BG BG103884A patent/BG64668B1/bg unknown
- 1999-11-24 NO NO19995763A patent/NO323697B1/no unknown
- 1999-11-28 IL IL133176A patent/IL133176A/en unknown
- 1999-11-29 US US09/451,013 patent/US6331520B1/en not_active Expired - Fee Related
-
2001
- 2001-02-02 HK HK01100764A patent/HK1029928A1/xx not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0105759A2 (en) * | 1982-10-04 | 1984-04-18 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| EP0377665A1 (en) * | 1987-08-24 | 1990-07-18 | Univ Texas | EFFECTIVE HORMONE ANTAGONISTS WITH LUTENIZATION HORMONE RELEASE RELEASING A NEGLIGIBLE QUANTITY OF HISTAMINE. |
| EP0649655A1 (en) * | 1993-10-15 | 1995-04-26 | Takeda Chemical Industries, Ltd. | Injectable solutions containing anti-ulcer benzimidazoles and amides |
| WO1996010417A1 (en) * | 1994-10-04 | 1996-04-11 | Novo Nordisk A/S | PREPARATIONS CONTAINING AspB28 HUMAN INSULIN AND NICOTINAMIDE |
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