BG64600B1 - Кетолиди от класа на 15-членни лактами с антибактериална активност - Google Patents

Кетолиди от класа на 15-членни лактами с антибактериална активност Download PDF

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Publication number
BG64600B1
BG64600B1 BG104913A BG10491300A BG64600B1 BG 64600 B1 BG64600 B1 BG 64600B1 BG 104913 A BG104913 A BG 104913A BG 10491300 A BG10491300 A BG 10491300A BG 64600 B1 BG64600 B1 BG 64600B1
Authority
BG
Bulgaria
Prior art keywords
group
hydrogen
compound
formula
ketone
Prior art date
Application number
BG104913A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104913A (en
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Zeljko Kelneric
Original Assignee
Pliva, Farmaceutska Industrija, Dionicko Drustvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva, Farmaceutska Industrija, Dionicko Drustvo filed Critical Pliva, Farmaceutska Industrija, Dionicko Drustvo
Publication of BG104913A publication Critical patent/BG104913A/xx
Publication of BG64600B1 publication Critical patent/BG64600B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
BG104913A 1998-04-06 2000-11-06 Кетолиди от класа на 15-членни лактами с антибактериална активност BG64600B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides

Publications (2)

Publication Number Publication Date
BG104913A BG104913A (en) 2001-08-31
BG64600B1 true BG64600B1 (bg) 2005-08-31

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104913A BG64600B1 (bg) 1998-04-06 2000-11-06 Кетолиди от класа на 15-членни лактами с антибактериална активност

Country Status (27)

Country Link
US (1) US6110965A (pl)
EP (1) EP1070077B1 (pl)
JP (1) JP2002510701A (pl)
KR (1) KR100600463B1 (pl)
CN (1) CN1141312C (pl)
AR (1) AR019261A1 (pl)
AT (1) ATE241638T1 (pl)
AU (1) AU3046499A (pl)
BG (1) BG64600B1 (pl)
BR (1) BR9910115A (pl)
CA (1) CA2327775C (pl)
DE (1) DE69908338T2 (pl)
DK (1) DK1070077T3 (pl)
EE (1) EE04283B1 (pl)
ES (1) ES2200512T3 (pl)
HK (1) HK1036457A1 (pl)
HR (1) HRP980189B1 (pl)
HU (1) HUP0101817A3 (pl)
IL (2) IL138837A0 (pl)
NO (1) NO317982B1 (pl)
PL (1) PL193742B1 (pl)
PT (1) PT1070077E (pl)
RU (1) RU2211222C2 (pl)
SI (1) SI1070077T1 (pl)
SK (1) SK284169B6 (pl)
UA (1) UA70941C2 (pl)
WO (1) WO1999051616A1 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
DE60138876D1 (de) * 2000-03-28 2009-07-16 Sandoz Ag Geschmackmaskierte granulierte teilchen
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
EA200400214A1 (ru) * 2001-08-21 2004-06-24 Пфайзер Продактс Инк. Азитромицин в виде разовой дозы
CA2476423A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1482957A4 (en) 2002-02-15 2006-07-19 Merckle Gmbh ANTIBIOTIC CONJUGATES
US20040005641A1 (en) 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
PL375162A1 (pl) 2002-07-08 2005-11-28 Pliva-Istrazivacki Institut D.O.O. Nowe związki oraz kompozycje jako nośniki dla steroidowych/niesteroidowych cząsteczek o aktywności przeciwzapalnej, przeciwnowotworowej i przeciwwirusowej
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005030227A1 (en) * 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
KR20070105993A (ko) 2005-01-13 2007-10-31 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. 소염 활성을 갖는 마크로라이드
US7547679B2 (en) 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
US8124744B2 (en) * 2006-05-01 2012-02-28 Taisho Pharmaceutical Co., Ltd. Macrolide derivatives
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
TW201038277A (en) * 2009-01-30 2010-11-01 Glaxosmithkline Zagreb Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CA2820451C (en) * 2010-12-09 2017-12-12 Wockhardt Limited Ketolide compounds
SG11202105227QA (en) * 2018-11-19 2021-06-29 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof
US20230250124A1 (en) * 2019-10-29 2023-08-10 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328334A (en) * 1979-04-02 1982-05-04 Pliva Pharmaceutical And Chemical Works 11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well as a process for their preparation
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
BE892357A (fr) * 1981-03-06 1982-07-01 Pliva Pharm & Chem Works Nouveaux derives de l'erythromycine a, procede pour leur preparation et leur utilisation comme substances anti-bacteriennes
EP0507595A1 (en) * 1991-04-05 1992-10-07 Merck & Co. Inc. 8A-aza-8A-homoerythromycin lactams
FR2697524A1 (fr) * 1992-11-05 1994-05-06 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
DE69403963T2 (de) * 1993-05-19 1997-11-20 Pfizer Zwischenprodukt für azithromycin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328334A (en) * 1979-04-02 1982-05-04 Pliva Pharmaceutical And Chemical Works 11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well as a process for their preparation
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
BE892357A (fr) * 1981-03-06 1982-07-01 Pliva Pharm & Chem Works Nouveaux derives de l'erythromycine a, procede pour leur preparation et leur utilisation comme substances anti-bacteriennes
EP0507595A1 (en) * 1991-04-05 1992-10-07 Merck & Co. Inc. 8A-aza-8A-homoerythromycin lactams
FR2697524A1 (fr) * 1992-11-05 1994-05-06 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Also Published As

Publication number Publication date
RU2211222C2 (ru) 2003-08-27
HK1036457A1 (en) 2002-01-04
EP1070077A1 (en) 2001-01-24
EE200000587A (et) 2002-04-15
DE69908338D1 (de) 2003-07-03
KR100600463B1 (ko) 2006-07-13
KR20010034754A (ko) 2001-04-25
CN1301268A (zh) 2001-06-27
CA2327775A1 (en) 1999-10-14
DE69908338T2 (de) 2004-04-08
NO317982B1 (no) 2005-01-17
JP2002510701A (ja) 2002-04-09
BG104913A (en) 2001-08-31
AR019261A1 (es) 2002-02-13
HRP980189B1 (en) 2004-04-30
PL343441A1 (en) 2001-08-13
BR9910115A (pt) 2000-12-26
HRP980189A2 (en) 2000-12-31
IL138837A0 (en) 2001-10-31
SK15022000A3 (sk) 2001-03-12
CA2327775C (en) 2007-08-07
WO1999051616A1 (en) 1999-10-14
IL138837A (en) 2006-10-05
UA70941C2 (uk) 2004-11-15
US6110965A (en) 2000-08-29
PT1070077E (pt) 2003-10-31
PL193742B1 (pl) 2007-03-30
EE04283B1 (et) 2004-04-15
DK1070077T3 (da) 2003-09-22
NO20005015D0 (no) 2000-10-05
ES2200512T3 (es) 2004-03-01
SI1070077T1 (en) 2004-02-29
CN1141312C (zh) 2004-03-10
ATE241638T1 (de) 2003-06-15
HUP0101817A2 (hu) 2001-11-28
SK284169B6 (sk) 2004-10-05
NO20005015L (no) 2000-12-04
AU3046499A (en) 1999-10-25
HUP0101817A3 (en) 2003-07-28
EP1070077B1 (en) 2003-05-28

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