NO20005015L - 15-ring-laktamketolider med antibakteriell aktivitet - Google Patents

15-ring-laktamketolider med antibakteriell aktivitet

Info

Publication number
NO20005015L
NO20005015L NO20005015A NO20005015A NO20005015L NO 20005015 L NO20005015 L NO 20005015L NO 20005015 A NO20005015 A NO 20005015A NO 20005015 A NO20005015 A NO 20005015A NO 20005015 L NO20005015 L NO 20005015L
Authority
NO
Norway
Prior art keywords
ketolides
antibacterial activity
ring lactam
lactam
ring
Prior art date
Application number
NO20005015A
Other languages
English (en)
Other versions
NO20005015D0 (no
NO317982B1 (no
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Zeljko Kelneric
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of NO20005015D0 publication Critical patent/NO20005015D0/no
Publication of NO20005015L publication Critical patent/NO20005015L/no
Publication of NO317982B1 publication Critical patent/NO317982B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO20005015A 1998-04-06 2000-10-05 15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner NO317982B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (3)

Publication Number Publication Date
NO20005015D0 NO20005015D0 (no) 2000-10-05
NO20005015L true NO20005015L (no) 2000-12-04
NO317982B1 NO317982B1 (no) 2005-01-17

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005015A NO317982B1 (no) 1998-04-06 2000-10-05 15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner

Country Status (26)

Country Link
US (1) US6110965A (no)
EP (1) EP1070077B1 (no)
JP (1) JP2002510701A (no)
KR (1) KR100600463B1 (no)
CN (1) CN1141312C (no)
AR (1) AR019261A1 (no)
AT (1) ATE241638T1 (no)
AU (1) AU3046499A (no)
BG (1) BG64600B1 (no)
BR (1) BR9910115A (no)
CA (1) CA2327775C (no)
DE (1) DE69908338T2 (no)
DK (1) DK1070077T3 (no)
EE (1) EE04283B1 (no)
ES (1) ES2200512T3 (no)
HR (1) HRP980189B1 (no)
HU (1) HUP0101817A3 (no)
IL (2) IL138837A0 (no)
NO (1) NO317982B1 (no)
PL (1) PL193742B1 (no)
PT (1) PT1070077E (no)
RU (1) RU2211222C2 (no)
SI (1) SI1070077T1 (no)
SK (1) SK284169B6 (no)
UA (1) UA70941C2 (no)
WO (1) WO1999051616A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
KR20030011797A (ko) * 2000-03-28 2003-02-11 바이오케미 게젤샤프트 엠베하 맛이 차폐된 과립형 입자
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
OA12845A (en) * 2001-08-21 2006-09-15 Pfizer Prod Inc Single dose azithromycin for treating respiratory infections.
NZ535354A (en) 2002-02-15 2008-01-31 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1482957A4 (en) 2002-02-15 2006-07-19 Merckle Gmbh ANTIBIOTIC CONJUGATES
EP1483579A4 (en) 2002-02-15 2006-07-12 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THE PREPARATION AND USE OF CONJUGATES, FORMULATION AND PHARMACEUTICAL APPLICATIONS OBTAINED FROM SUCH CONJUGATES
JP4790263B2 (ja) 2002-07-08 2011-10-12 グラクソ グループ リミテッド 炎症性の疾患および病態を治療する新規な化合物、組成物および方法
AU2003264917A1 (en) 2002-07-08 2004-01-23 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
RS51479B (sr) 2005-01-13 2011-04-30 Glaxo Group Limited Makrolidi sa anti-inflamatornim dejstvom
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
CN103193840A (zh) * 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
EA201101139A1 (ru) 2009-01-30 2012-03-30 Глэксо Груп Лимитед Противовоспалительный макролид
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN105669803A (zh) * 2010-12-09 2016-06-15 沃克哈特有限公司 酮内酯化合物
SG11202105227QA (en) * 2018-11-19 2021-06-29 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof
CA3156529A1 (en) * 2019-10-29 2021-05-06 Sudhir Nambiar Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5166967A (en) * 1990-08-27 1992-11-24 Fabian Carl E Markers for dental x-ray film and packets for simplified film mounting
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
ES2104386T3 (es) * 1993-05-19 1997-10-01 Pfizer Compuesto intermedio para la acitromicina.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) * 1995-12-08 2000-01-20 Руссель Юклаф Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция

Also Published As

Publication number Publication date
HUP0101817A2 (hu) 2001-11-28
DE69908338T2 (de) 2004-04-08
WO1999051616A1 (en) 1999-10-14
EE200000587A (et) 2002-04-15
SK284169B6 (sk) 2004-10-05
AU3046499A (en) 1999-10-25
HUP0101817A3 (en) 2003-07-28
EP1070077A1 (en) 2001-01-24
HK1036457A1 (en) 2002-01-04
BG64600B1 (bg) 2005-08-31
PL193742B1 (pl) 2007-03-30
BR9910115A (pt) 2000-12-26
PT1070077E (pt) 2003-10-31
RU2211222C2 (ru) 2003-08-27
CN1301268A (zh) 2001-06-27
CA2327775A1 (en) 1999-10-14
ES2200512T3 (es) 2004-03-01
PL343441A1 (en) 2001-08-13
EP1070077B1 (en) 2003-05-28
HRP980189B1 (en) 2004-04-30
CN1141312C (zh) 2004-03-10
NO20005015D0 (no) 2000-10-05
AR019261A1 (es) 2002-02-13
UA70941C2 (uk) 2004-11-15
JP2002510701A (ja) 2002-04-09
EE04283B1 (et) 2004-04-15
IL138837A (en) 2006-10-05
IL138837A0 (en) 2001-10-31
DK1070077T3 (da) 2003-09-22
CA2327775C (en) 2007-08-07
BG104913A (en) 2001-08-31
ATE241638T1 (de) 2003-06-15
NO317982B1 (no) 2005-01-17
SI1070077T1 (en) 2004-02-29
KR100600463B1 (ko) 2006-07-13
DE69908338D1 (de) 2003-07-03
US6110965A (en) 2000-08-29
KR20010034754A (ko) 2001-04-25
SK15022000A3 (sk) 2001-03-12
HRP980189A2 (en) 2000-12-31

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