EE04283B1 - 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis - Google Patents

15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis

Info

Publication number
EE04283B1
EE04283B1 EEP200000587A EEP200000587A EE04283B1 EE 04283 B1 EE04283 B1 EE 04283B1 EE P200000587 A EEP200000587 A EE P200000587A EE P200000587 A EEP200000587 A EE P200000587A EE 04283 B1 EE04283 B1 EE 04283B1
Authority
EE
Estonia
Prior art keywords
ketoazalides
preparation
treatment
pharmaceutical composition
composition containing
Prior art date
Application number
EEP200000587A
Other languages
English (en)
Inventor
Lazarevski Gorjana
Kobrehel Gabrijela
Kelneric Zeljko
Original Assignee
PLIVA, farmaceutska industrija, dionicko dru�tvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PLIVA, farmaceutska industrija, dionicko dru�tvo filed Critical PLIVA, farmaceutska industrija, dionicko dru�tvo
Publication of EE200000587A publication Critical patent/EE200000587A/et
Publication of EE04283B1 publication Critical patent/EE04283B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
EEP200000587A 1998-04-06 1999-04-02 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis EE04283B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (2)

Publication Number Publication Date
EE200000587A EE200000587A (et) 2002-04-15
EE04283B1 true EE04283B1 (et) 2004-04-15

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000587A EE04283B1 (et) 1998-04-06 1999-04-02 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis

Country Status (27)

Country Link
US (1) US6110965A (et)
EP (1) EP1070077B1 (et)
JP (1) JP2002510701A (et)
KR (1) KR100600463B1 (et)
CN (1) CN1141312C (et)
AR (1) AR019261A1 (et)
AT (1) ATE241638T1 (et)
AU (1) AU3046499A (et)
BG (1) BG64600B1 (et)
BR (1) BR9910115A (et)
CA (1) CA2327775C (et)
DE (1) DE69908338T2 (et)
DK (1) DK1070077T3 (et)
EE (1) EE04283B1 (et)
ES (1) ES2200512T3 (et)
HK (1) HK1036457A1 (et)
HR (1) HRP980189B1 (et)
HU (1) HUP0101817A3 (et)
IL (2) IL138837A0 (et)
NO (1) NO317982B1 (et)
PL (1) PL193742B1 (et)
PT (1) PT1070077E (et)
RU (1) RU2211222C2 (et)
SI (1) SI1070077T1 (et)
SK (1) SK284169B6 (et)
UA (1) UA70941C2 (et)
WO (1) WO1999051616A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
KR20030011797A (ko) * 2000-03-28 2003-02-11 바이오케미 게젤샤프트 엠베하 맛이 차폐된 과립형 입자
GB0025688D0 (en) 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
CZ2004232A3 (cs) * 2001-08-21 2005-10-12 Pfizer Products Inc. Jednorázová dávka azithromycinu
EP1483579A4 (en) 2002-02-15 2006-07-12 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THE PREPARATION AND USE OF CONJUGATES, FORMULATION AND PHARMACEUTICAL APPLICATIONS OBTAINED FROM SUCH CONJUGATES
AU2003219770B2 (en) 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7271154B2 (en) 2002-02-15 2007-09-18 Merckle Gmbh Antibiotic conjugates
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
PT1851236E (pt) 2005-01-13 2010-10-25 Glaxosmithkline Zagreb Macrólidos com actividade anti-inflamatória
EP1879903A1 (en) 2005-05-10 2008-01-23 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Ether linked macrolides useful for the treatment of microbial infections
US8124744B2 (en) * 2006-05-01 2012-02-28 Taisho Pharmaceutical Co., Ltd. Macrolide derivatives
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
MA32997B1 (fr) * 2009-01-30 2012-01-02 Glaxo Group Ltd Macrolide anti-inflammatoire
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
PL2673285T3 (pl) * 2010-12-09 2017-12-29 Wockhardt Limited Związki ketolidowe
MX2021005423A (es) * 2018-11-19 2021-09-08 Zikani Therapeutics Inc Macrolidos de 13 miembros sustituidos con c10-alquileno y usos de los mismos.
EP4051289A4 (en) * 2019-10-29 2024-03-27 Hikal Limited ESSENTIALLY PURE CLARITHROMYCIN 9-OXIME AND ITS PRODUCTION

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
ATE154806T1 (de) * 1993-05-19 1997-07-15 Pfizer Zwischenprodukt für azithromycin

Also Published As

Publication number Publication date
PL343441A1 (en) 2001-08-13
BG64600B1 (bg) 2005-08-31
DE69908338T2 (de) 2004-04-08
IL138837A0 (en) 2001-10-31
WO1999051616A1 (en) 1999-10-14
CN1301268A (zh) 2001-06-27
HUP0101817A2 (hu) 2001-11-28
CN1141312C (zh) 2004-03-10
PT1070077E (pt) 2003-10-31
NO20005015D0 (no) 2000-10-05
AR019261A1 (es) 2002-02-13
CA2327775A1 (en) 1999-10-14
JP2002510701A (ja) 2002-04-09
UA70941C2 (uk) 2004-11-15
PL193742B1 (pl) 2007-03-30
BG104913A (en) 2001-08-31
EP1070077A1 (en) 2001-01-24
KR100600463B1 (ko) 2006-07-13
ATE241638T1 (de) 2003-06-15
EE200000587A (et) 2002-04-15
BR9910115A (pt) 2000-12-26
ES2200512T3 (es) 2004-03-01
NO20005015L (no) 2000-12-04
EP1070077B1 (en) 2003-05-28
HRP980189A2 (en) 2000-12-31
RU2211222C2 (ru) 2003-08-27
SI1070077T1 (en) 2004-02-29
DE69908338D1 (de) 2003-07-03
SK15022000A3 (sk) 2001-03-12
AU3046499A (en) 1999-10-25
HK1036457A1 (en) 2002-01-04
HUP0101817A3 (en) 2003-07-28
CA2327775C (en) 2007-08-07
KR20010034754A (ko) 2001-04-25
US6110965A (en) 2000-08-29
HRP980189B1 (en) 2004-04-30
DK1070077T3 (da) 2003-09-22
NO317982B1 (no) 2005-01-17
IL138837A (en) 2006-10-05
SK284169B6 (sk) 2004-10-05

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090402