DE69908338D1 - 15-gliedrige ketolid-lactame mit antibakterieller wirkung - Google Patents

15-gliedrige ketolid-lactame mit antibakterieller wirkung

Info

Publication number
DE69908338D1
DE69908338D1 DE69908338T DE69908338T DE69908338D1 DE 69908338 D1 DE69908338 D1 DE 69908338D1 DE 69908338 T DE69908338 T DE 69908338T DE 69908338 T DE69908338 T DE 69908338T DE 69908338 D1 DE69908338 D1 DE 69908338D1
Authority
DE
Germany
Prior art keywords
ketolid
lactame
piece
antibacterial effect
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69908338T
Other languages
English (en)
Other versions
DE69908338T2 (de
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Zeljko Kelneric
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutika dd
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutika dd, Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutika dd
Publication of DE69908338D1 publication Critical patent/DE69908338D1/de
Application granted granted Critical
Publication of DE69908338T2 publication Critical patent/DE69908338T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69908338T 1998-04-06 1999-04-02 15-gliedrige ketolid-lactame mit antibakterieller wirkung Expired - Lifetime DE69908338T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HR980189 1998-04-06
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (2)

Publication Number Publication Date
DE69908338D1 true DE69908338D1 (de) 2003-07-03
DE69908338T2 DE69908338T2 (de) 2004-04-08

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69908338T Expired - Lifetime DE69908338T2 (de) 1998-04-06 1999-04-02 15-gliedrige ketolid-lactame mit antibakterieller wirkung

Country Status (27)

Country Link
US (1) US6110965A (de)
EP (1) EP1070077B1 (de)
JP (1) JP2002510701A (de)
KR (1) KR100600463B1 (de)
CN (1) CN1141312C (de)
AR (1) AR019261A1 (de)
AT (1) ATE241638T1 (de)
AU (1) AU3046499A (de)
BG (1) BG64600B1 (de)
BR (1) BR9910115A (de)
CA (1) CA2327775C (de)
DE (1) DE69908338T2 (de)
DK (1) DK1070077T3 (de)
EE (1) EE04283B1 (de)
ES (1) ES2200512T3 (de)
HK (1) HK1036457A1 (de)
HR (1) HRP980189B1 (de)
HU (1) HUP0101817A3 (de)
IL (2) IL138837A0 (de)
NO (1) NO317982B1 (de)
PL (1) PL193742B1 (de)
PT (1) PT1070077E (de)
RU (1) RU2211222C2 (de)
SI (1) SI1070077T1 (de)
SK (1) SK284169B6 (de)
UA (1) UA70941C2 (de)
WO (1) WO1999051616A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
DE60138876D1 (de) * 2000-03-28 2009-07-16 Sandoz Ag Geschmackmaskierte granulierte teilchen
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
EA200400214A1 (ru) * 2001-08-21 2004-06-24 Пфайзер Продактс Инк. Азитромицин в виде разовой дозы
CA2476423A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1482957A4 (de) 2002-02-15 2006-07-19 Merckle Gmbh Antibiotische konjugate
US20040005641A1 (en) 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
PL375162A1 (en) 2002-07-08 2005-11-28 Pliva-Istrazivacki Institut D.O.O. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005030227A1 (en) * 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
KR20070105993A (ko) 2005-01-13 2007-10-31 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. 소염 활성을 갖는 마크로라이드
US7547679B2 (en) 2005-05-10 2009-06-16 Glaxosmithkline Istrazivacki Center Zagreb D.O.O Ether linked macrolides useful for the treatment of microbial infections
US8124744B2 (en) * 2006-05-01 2012-02-28 Taisho Pharmaceutical Co., Ltd. Macrolide derivatives
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
TW201038277A (en) * 2009-01-30 2010-11-01 Glaxosmithkline Zagreb Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CA2820451C (en) * 2010-12-09 2017-12-12 Wockhardt Limited Ketolide compounds
SG11202105227QA (en) * 2018-11-19 2021-06-29 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof
US20230250124A1 (en) * 2019-10-29 2023-08-10 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
EP0549040A1 (de) * 1991-12-20 1993-06-30 Merck & Co. Inc. Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
DE69403963T2 (de) * 1993-05-19 1997-11-20 Pfizer Zwischenprodukt für azithromycin

Also Published As

Publication number Publication date
BG64600B1 (bg) 2005-08-31
RU2211222C2 (ru) 2003-08-27
HK1036457A1 (en) 2002-01-04
EP1070077A1 (de) 2001-01-24
EE200000587A (et) 2002-04-15
KR100600463B1 (ko) 2006-07-13
KR20010034754A (ko) 2001-04-25
CN1301268A (zh) 2001-06-27
CA2327775A1 (en) 1999-10-14
DE69908338T2 (de) 2004-04-08
NO317982B1 (no) 2005-01-17
JP2002510701A (ja) 2002-04-09
BG104913A (en) 2001-08-31
AR019261A1 (es) 2002-02-13
HRP980189B1 (en) 2004-04-30
PL343441A1 (en) 2001-08-13
BR9910115A (pt) 2000-12-26
HRP980189A2 (en) 2000-12-31
IL138837A0 (en) 2001-10-31
SK15022000A3 (sk) 2001-03-12
CA2327775C (en) 2007-08-07
WO1999051616A1 (en) 1999-10-14
IL138837A (en) 2006-10-05
UA70941C2 (uk) 2004-11-15
US6110965A (en) 2000-08-29
PT1070077E (pt) 2003-10-31
PL193742B1 (pl) 2007-03-30
EE04283B1 (et) 2004-04-15
DK1070077T3 (da) 2003-09-22
NO20005015D0 (no) 2000-10-05
ES2200512T3 (es) 2004-03-01
SI1070077T1 (en) 2004-02-29
CN1141312C (zh) 2004-03-10
ATE241638T1 (de) 2003-06-15
HUP0101817A2 (hu) 2001-11-28
SK284169B6 (sk) 2004-10-05
NO20005015L (no) 2000-12-04
AU3046499A (en) 1999-10-25
HUP0101817A3 (en) 2003-07-28
EP1070077B1 (de) 2003-05-28

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