SK284169B6 - 15-členná laktámová ketolidová zlúčenina s antibakteriálnou účinnosťou, spôsob jej prípravy, farmaceutická kompozícia s jej obsahom a jej použitie - Google Patents

15-členná laktámová ketolidová zlúčenina s antibakteriálnou účinnosťou, spôsob jej prípravy, farmaceutická kompozícia s jej obsahom a jej použitie Download PDF

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Publication number
SK284169B6
SK284169B6 SK1502-2000A SK15022000A SK284169B6 SK 284169 B6 SK284169 B6 SK 284169B6 SK 15022000 A SK15022000 A SK 15022000A SK 284169 B6 SK284169 B6 SK 284169B6
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SK
Slovakia
Prior art keywords
group
formula
hydrogen
ketone
compound
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Application number
SK1502-2000A
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English (en)
Slovak (sk)
Other versions
SK15022000A3 (sk
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
�eljko KELNERI�
Original Assignee
Pliva, Farmaceutska Industrija, Dioni�Ko Dru�Tvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva, Farmaceutska Industrija, Dioni�Ko Dru�Tvo filed Critical Pliva, Farmaceutska Industrija, Dioni�Ko Dru�Tvo
Publication of SK15022000A3 publication Critical patent/SK15022000A3/sk
Publication of SK284169B6 publication Critical patent/SK284169B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
SK1502-2000A 1998-04-06 1999-04-02 15-členná laktámová ketolidová zlúčenina s antibakteriálnou účinnosťou, spôsob jej prípravy, farmaceutická kompozícia s jej obsahom a jej použitie SK284169B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity

Publications (2)

Publication Number Publication Date
SK15022000A3 SK15022000A3 (sk) 2001-03-12
SK284169B6 true SK284169B6 (sk) 2004-10-05

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1502-2000A SK284169B6 (sk) 1998-04-06 1999-04-02 15-členná laktámová ketolidová zlúčenina s antibakteriálnou účinnosťou, spôsob jej prípravy, farmaceutická kompozícia s jej obsahom a jej použitie

Country Status (27)

Country Link
US (1) US6110965A (pl)
EP (1) EP1070077B1 (pl)
JP (1) JP2002510701A (pl)
KR (1) KR100600463B1 (pl)
CN (1) CN1141312C (pl)
AR (1) AR019261A1 (pl)
AT (1) ATE241638T1 (pl)
AU (1) AU3046499A (pl)
BG (1) BG64600B1 (pl)
BR (1) BR9910115A (pl)
CA (1) CA2327775C (pl)
DE (1) DE69908338T2 (pl)
DK (1) DK1070077T3 (pl)
EE (1) EE04283B1 (pl)
ES (1) ES2200512T3 (pl)
HK (1) HK1036457A1 (pl)
HR (1) HRP980189B1 (pl)
HU (1) HUP0101817A3 (pl)
IL (2) IL138837A0 (pl)
NO (1) NO317982B1 (pl)
PL (1) PL193742B1 (pl)
PT (1) PT1070077E (pl)
RU (1) RU2211222C2 (pl)
SI (1) SI1070077T1 (pl)
SK (1) SK284169B6 (pl)
UA (1) UA70941C2 (pl)
WO (1) WO1999051616A1 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US20030099715A1 (en) * 2000-03-28 2003-05-29 Schwarz Franz Xaver Granulated particles with masked taste
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
OA12845A (en) * 2001-08-21 2006-09-15 Pfizer Prod Inc Single dose azithromycin for treating respiratory infections.
CA2476448A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
AU2003264917A1 (en) 2002-07-08 2004-01-23 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
AU2006215315B2 (en) 2005-01-13 2012-02-16 Glaxo Group Limited Macrolides with anti-inflammatory activity
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
CN103193840A (zh) * 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
AU2010209732B2 (en) * 2009-01-30 2012-12-20 Glaxo Group Limited Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
EP3216798A3 (en) * 2010-12-09 2017-10-25 Wockhardt Limited Ketolide compounds
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途
WO2021084411A1 (en) * 2019-10-29 2021-05-06 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin

Also Published As

Publication number Publication date
RU2211222C2 (ru) 2003-08-27
EE04283B1 (et) 2004-04-15
AR019261A1 (es) 2002-02-13
PL193742B1 (pl) 2007-03-30
EP1070077A1 (en) 2001-01-24
PT1070077E (pt) 2003-10-31
PL343441A1 (en) 2001-08-13
WO1999051616A1 (en) 1999-10-14
DE69908338T2 (de) 2004-04-08
AU3046499A (en) 1999-10-25
SK15022000A3 (sk) 2001-03-12
US6110965A (en) 2000-08-29
KR20010034754A (ko) 2001-04-25
IL138837A0 (en) 2001-10-31
HRP980189B1 (en) 2004-04-30
HK1036457A1 (en) 2002-01-04
HUP0101817A3 (en) 2003-07-28
BG64600B1 (bg) 2005-08-31
BR9910115A (pt) 2000-12-26
NO20005015L (no) 2000-12-04
JP2002510701A (ja) 2002-04-09
HRP980189A2 (en) 2000-12-31
BG104913A (en) 2001-08-31
EE200000587A (et) 2002-04-15
ATE241638T1 (de) 2003-06-15
KR100600463B1 (ko) 2006-07-13
NO317982B1 (no) 2005-01-17
UA70941C2 (uk) 2004-11-15
EP1070077B1 (en) 2003-05-28
CA2327775C (en) 2007-08-07
DE69908338D1 (de) 2003-07-03
NO20005015D0 (no) 2000-10-05
DK1070077T3 (da) 2003-09-22
CN1301268A (zh) 2001-06-27
ES2200512T3 (es) 2004-03-01
CN1141312C (zh) 2004-03-10
CA2327775A1 (en) 1999-10-14
SI1070077T1 (en) 2004-02-29
HUP0101817A2 (hu) 2001-11-28
IL138837A (en) 2006-10-05

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20090402