HRP980189B1 - Novel 15-membered lactams ketolides - Google Patents

Novel 15-membered lactams ketolides

Info

Publication number
HRP980189B1
HRP980189B1 HR980189A HRP980189A HRP980189B1 HR P980189 B1 HRP980189 B1 HR P980189B1 HR 980189 A HR980189 A HR 980189A HR P980189 A HRP980189 A HR P980189A HR P980189 B1 HRP980189 B1 HR P980189B1
Authority
HR
Croatia
Prior art keywords
ketolides
novel
membered lactams
lactams
membered
Prior art date
Application number
HR980189A
Other languages
English (en)
Inventor
Gorjana Lazarevski
Gabrijela Kobrehel
Aeeljko Kelneric
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Priority to HR980189A priority Critical patent/HRP980189B1/xx
Priority to US09/127,764 priority patent/US6110965A/en
Priority to UA2000106059A priority patent/UA70941C2/uk
Priority to AT99911955T priority patent/ATE241638T1/de
Priority to PCT/HR1999/000004 priority patent/WO1999051616A1/en
Priority to JP2000542337A priority patent/JP2002510701A/ja
Priority to RU2000128042/04A priority patent/RU2211222C2/ru
Priority to DE69908338T priority patent/DE69908338T2/de
Priority to HU0101817A priority patent/HUP0101817A3/hu
Priority to KR1020007011140A priority patent/KR100600463B1/ko
Priority to AU30464/99A priority patent/AU3046499A/en
Priority to BR9910115-7A priority patent/BR9910115A/pt
Priority to PL99343441A priority patent/PL193742B1/pl
Priority to ES99911955T priority patent/ES2200512T3/es
Priority to EP99911955A priority patent/EP1070077B1/en
Priority to DK99911955T priority patent/DK1070077T3/da
Priority to IL13883799A priority patent/IL138837A0/xx
Priority to CNB998063568A priority patent/CN1141312C/zh
Priority to CA002327775A priority patent/CA2327775C/en
Priority to SK1502-2000A priority patent/SK284169B6/sk
Priority to PT99911955T priority patent/PT1070077E/pt
Priority to EEP200000587A priority patent/EE04283B1/xx
Priority to SI9930366T priority patent/SI1070077T1/xx
Priority to ARP990101519A priority patent/AR019261A1/es
Priority to IL138837A priority patent/IL138837A/en
Priority to NO20005015A priority patent/NO317982B1/no
Priority to BG104913A priority patent/BG64600B1/bg
Publication of HRP980189A2 publication Critical patent/HRP980189A2/hr
Priority to HK01107415A priority patent/HK1036457A1/xx
Publication of HRP980189B1 publication Critical patent/HRP980189B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HR980189A 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides HRP980189B1 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides
US09/127,764 US6110965A (en) 1998-04-06 1998-07-31 Ketolides from the class of 15-membered lactams
UA2000106059A UA70941C2 (uk) 1998-04-06 1999-02-04 Кетоліди класу 15-членних лактамів, спосіб їх одержання та фармацевтична композиція з антибактеріальною активністю
ES99911955T ES2200512T3 (es) 1998-04-06 1999-04-02 Cetolidas de lactama con 15 elementos dotados de actividad antimicrobiana.
IL13883799A IL138837A0 (en) 1998-04-06 1999-04-02 15-membered lactam ketolides with antibacterial activity
JP2000542337A JP2002510701A (ja) 1998-04-06 1999-04-02 １５員ラクタム系からの新規なケトライド
RU2000128042/04A RU2211222C2 (ru) 1998-04-06 1999-04-02 Новые кетоазолиды и способ их получения
DE69908338T DE69908338T2 (de) 1998-04-06 1999-04-02 15-gliedrige ketolid-lactame mit antibakterieller wirkung
HU0101817A HUP0101817A3 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides and pharmaceutical compositions comprising them with antibacterial activity
KR1020007011140A KR100600463B1 (ko) 1998-04-06 1999-04-02 항균 활성을 갖는 15-원 락탐 케톨라이드
AU30464/99A AU3046499A (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity
BR9910115-7A BR9910115A (pt) 1998-04-06 1999-04-02 Cetolìdeos da classe dos lactamas de 5 elementos
PL99343441A PL193742B1 (pl) 1998-04-06 1999-04-02 Związek z klasy antybiotyków makrolidowych erytromycyty A, sposób jego wytwarzania, kompozycja farmaceutyczna i zastosowanie
AT99911955T ATE241638T1 (de) 1998-04-06 1999-04-02 15-gliedrige ketolid-lactame mit antibakterieller wirkung
EP99911955A EP1070077B1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity
DK99911955T DK1070077T3 (da) 1998-04-06 1999-04-02 15-Leddede ketolid-lactamer med antibakteriel virkning
PCT/HR1999/000004 WO1999051616A1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity
CNB998063568A CN1141312C (zh) 1998-04-06 1999-04-02 抗细菌活性的15元内酰胺类酮内酯
CA002327775A CA2327775C (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity
SK1502-2000A SK284169B6 (sk) 1998-04-06 1999-04-02 15-členná laktámová ketolidová zlúčenina s antibakteriálnou účinnosťou, spôsob jej prípravy, farmaceutická kompozícia s jej obsahom a jej použitie
PT99911955T PT1070077E (pt) 1998-04-06 1999-04-02 Cetolidos de lactama com 15 membros que possuem actividade antibacteriana
EEP200000587A EE04283B1 (et) 1998-04-06 1999-04-02 15-lülilised ketoasaliidid, meetod nende valmistamiseks ning neid sisaldav farmatseutiline kompositsioon kasutamiseks bakternakkuste ravis
SI9930366T SI1070077T1 (en) 1998-04-06 1999-04-02 15-membered lactams ketolides with antibacterial activity
ARP990101519A AR019261A1 (es) 1998-04-06 1999-04-05 Cetoazalido de la clase de lactamas de 15 miembros, su uso, procedimiento para prepararlo , y una composicion farmaceutica util para el tratamiento de infecciones bacterianas en seres humanos y animales
IL138837A IL138837A (en) 1998-04-06 2000-10-03 Derivatives of 6-O-methyl-A8-Aza-A8-homo- and 6-O-methyl-A9-aza-A9-homoarthromycin A, their preparation and antibacterial preparations containing them
NO20005015A NO317982B1 (no) 1998-04-06 2000-10-05 15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner
BG104913A BG64600B1 (bg) 1998-04-06 2000-11-06 Кетолиди от класа на 15-членни лактами с антибактериална активност
HK01107415A HK1036457A1 (en) 1998-04-06 2001-10-24 15-membered lactams ketolides with antibacterial activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides

Publications (2)

Publication Number Publication Date
HRP980189A2 HRP980189A2 (en) 2000-12-31
HRP980189B1 true HRP980189B1 (en) 2004-04-30

Family

ID=10946724

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980189A HRP980189B1 (en) 1998-04-06 1998-04-06 Novel 15-membered lactams ketolides

Country Status (27)

Country Link
US (1) US6110965A (pl)
EP (1) EP1070077B1 (pl)
JP (1) JP2002510701A (pl)
KR (1) KR100600463B1 (pl)
CN (1) CN1141312C (pl)
AR (1) AR019261A1 (pl)
AT (1) ATE241638T1 (pl)
AU (1) AU3046499A (pl)
BG (1) BG64600B1 (pl)
BR (1) BR9910115A (pl)
CA (1) CA2327775C (pl)
DE (1) DE69908338T2 (pl)
DK (1) DK1070077T3 (pl)
EE (1) EE04283B1 (pl)
ES (1) ES2200512T3 (pl)
HK (1) HK1036457A1 (pl)
HR (1) HRP980189B1 (pl)
HU (1) HUP0101817A3 (pl)
IL (2) IL138837A0 (pl)
NO (1) NO317982B1 (pl)
PL (1) PL193742B1 (pl)
PT (1) PT1070077E (pl)
RU (1) RU2211222C2 (pl)
SI (1) SI1070077T1 (pl)
SK (1) SK284169B6 (pl)
UA (1) UA70941C2 (pl)
WO (1) WO1999051616A1 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US20030099715A1 (en) * 2000-03-28 2003-05-29 Schwarz Franz Xaver Granulated particles with masked taste
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
OA12845A (en) * 2001-08-21 2006-09-15 Pfizer Prod Inc Single dose azithromycin for treating respiratory infections.
CA2476448A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
AU2003264917A1 (en) 2002-07-08 2004-01-23 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
AU2006215315B2 (en) 2005-01-13 2012-02-16 Glaxo Group Limited Macrolides with anti-inflammatory activity
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
CN103193840A (zh) * 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
WO2009007988A1 (en) * 2007-07-11 2009-01-15 Alembic Limited Process for the preparation of 6-o-methylerythromycin a 9-oxime
AU2010209732B2 (en) * 2009-01-30 2012-12-20 Glaxo Group Limited Anti-inflammatory macrolide
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
EP3216798A3 (en) * 2010-12-09 2017-10-25 Wockhardt Limited Ketolide compounds
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途
WO2021084411A1 (en) * 2019-10-29 2021-05-06 Hikal Limited Substantially pure clarithromycin 9-oxime and its preparation thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin

Also Published As

Publication number Publication date
RU2211222C2 (ru) 2003-08-27
EE04283B1 (et) 2004-04-15
AR019261A1 (es) 2002-02-13
PL193742B1 (pl) 2007-03-30
EP1070077A1 (en) 2001-01-24
PT1070077E (pt) 2003-10-31
PL343441A1 (en) 2001-08-13
WO1999051616A1 (en) 1999-10-14
DE69908338T2 (de) 2004-04-08
AU3046499A (en) 1999-10-25
SK284169B6 (sk) 2004-10-05
SK15022000A3 (sk) 2001-03-12
US6110965A (en) 2000-08-29
KR20010034754A (ko) 2001-04-25
IL138837A0 (en) 2001-10-31
HK1036457A1 (en) 2002-01-04
HUP0101817A3 (en) 2003-07-28
BG64600B1 (bg) 2005-08-31
BR9910115A (pt) 2000-12-26
NO20005015L (no) 2000-12-04
JP2002510701A (ja) 2002-04-09
HRP980189A2 (en) 2000-12-31
BG104913A (en) 2001-08-31
EE200000587A (et) 2002-04-15
ATE241638T1 (de) 2003-06-15
KR100600463B1 (ko) 2006-07-13
NO317982B1 (no) 2005-01-17
UA70941C2 (uk) 2004-11-15
EP1070077B1 (en) 2003-05-28
CA2327775C (en) 2007-08-07
DE69908338D1 (de) 2003-07-03
NO20005015D0 (no) 2000-10-05
DK1070077T3 (da) 2003-09-22
CN1301268A (zh) 2001-06-27
ES2200512T3 (es) 2004-03-01
CN1141312C (zh) 2004-03-10
CA2327775A1 (en) 1999-10-14
SI1070077T1 (en) 2004-02-29
HUP0101817A2 (hu) 2001-11-28
IL138837A (en) 2006-10-05

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,

PPPP Transfer of rights

Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20080331

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20090407