NO317982B1 - 15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner - Google Patents
15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner Download PDFInfo
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- NO317982B1 NO317982B1 NO20005015A NO20005015A NO317982B1 NO 317982 B1 NO317982 B1 NO 317982B1 NO 20005015 A NO20005015 A NO 20005015A NO 20005015 A NO20005015 A NO 20005015A NO 317982 B1 NO317982 B1 NO 317982B1
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- 150000001875 compounds Chemical class 0.000 title claims description 33
- 238000002360 preparation method Methods 0.000 title claims description 12
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- 208000022362 bacterial infectious disease Diseases 0.000 title claims description 7
- 238000000034 method Methods 0.000 title description 17
- 230000008569 process Effects 0.000 title description 6
- 239000003835 ketolide antibiotic agent Substances 0.000 title description 3
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- 238000011065 in-situ storage Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002596 lactones Chemical group 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- OHZZTXYKLXZFSZ-UHFFFAOYSA-I manganese(3+) 5,10,15-tris(1-methylpyridin-1-ium-4-yl)-20-(1-methylpyridin-4-ylidene)porphyrin-22-ide pentachloride Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Mn+3].C1=CN(C)C=CC1=C1C(C=C2)=NC2=C(C=2C=C[N+](C)=CC=2)C([N-]2)=CC=C2C(C=2C=C[N+](C)=CC=2)=C(C=C2)N=C2C(C=2C=C[N+](C)=CC=2)=C2N=C1C=C2 OHZZTXYKLXZFSZ-UHFFFAOYSA-I 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 238000006140 methanolysis reaction Methods 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- YGXCETJZBDTKRY-DZCVGBHJSA-N pristinamycin IA Chemical compound N([C@@H]1C(=O)N[C@@H](C(N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(=CC=2)N(C)C)C(=O)N2CCC(=O)C[C@H]2C(=O)N[C@H](C(=O)O[C@@H]1C)C=1C=CC=CC=1)=O)CC)C(=O)C1=NC=CC=C1O YGXCETJZBDTKRY-DZCVGBHJSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000006485 reductive methylation reaction Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR980189A HRP980189B1 (en) | 1998-04-06 | 1998-04-06 | Novel 15-membered lactams ketolides |
| PCT/HR1999/000004 WO1999051616A1 (en) | 1998-04-06 | 1999-04-02 | 15-membered lactams ketolides with antibacterial activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20005015D0 NO20005015D0 (no) | 2000-10-05 |
| NO20005015L NO20005015L (no) | 2000-12-04 |
| NO317982B1 true NO317982B1 (no) | 2005-01-17 |
Family
ID=10946724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005015A NO317982B1 (no) | 1998-04-06 | 2000-10-05 | 15-ring-laktamketolidforbindelse, fremgangsmate for fremstilling derav, samt anvendelse av forbindelsen for fremstilling av en farmasoytisk blanding og farmasoytisk preparat for behandling av bakterielle infeksjoner |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6110965A (pl) |
| EP (1) | EP1070077B1 (pl) |
| JP (1) | JP2002510701A (pl) |
| KR (1) | KR100600463B1 (pl) |
| CN (1) | CN1141312C (pl) |
| AR (1) | AR019261A1 (pl) |
| AT (1) | ATE241638T1 (pl) |
| AU (1) | AU3046499A (pl) |
| BG (1) | BG64600B1 (pl) |
| BR (1) | BR9910115A (pl) |
| CA (1) | CA2327775C (pl) |
| DE (1) | DE69908338T2 (pl) |
| DK (1) | DK1070077T3 (pl) |
| EE (1) | EE04283B1 (pl) |
| ES (1) | ES2200512T3 (pl) |
| HK (1) | HK1036457A1 (pl) |
| HR (1) | HRP980189B1 (pl) |
| HU (1) | HUP0101817A3 (pl) |
| IL (2) | IL138837A0 (pl) |
| NO (1) | NO317982B1 (pl) |
| PL (1) | PL193742B1 (pl) |
| PT (1) | PT1070077E (pl) |
| RU (1) | RU2211222C2 (pl) |
| SI (1) | SI1070077T1 (pl) |
| SK (1) | SK284169B6 (pl) |
| UA (1) | UA70941C2 (pl) |
| WO (1) | WO1999051616A1 (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP990116B1 (en) * | 1999-04-20 | 2007-10-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | NOVEL 8a AND 9a- 15-MEMBERED LACTAMES |
| MXPA02009587A (es) * | 2000-03-28 | 2003-05-14 | Biochemie Gmbh | Particulas granuladas con sabor enmascarado. |
| GB0025688D0 (en) * | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
| CZ2004232A3 (cs) * | 2001-08-21 | 2005-10-12 | Pfizer Products Inc. | Jednorázová dávka azithromycinu |
| US20040005641A1 (en) | 2002-02-15 | 2004-01-08 | Michael Burnet | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| WO2003070254A1 (en) | 2002-02-15 | 2003-08-28 | Sympore Gmbh | Antibiotic conjugates |
| US7579324B2 (en) | 2002-02-15 | 2009-08-25 | C-A-I-R Biosciences Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| US7091187B2 (en) | 2002-07-08 | 2006-08-15 | Pliva-Istrazivacki Institut D.O.O. | Compounds, compositions and methods for treatment of inflammatory diseases and conditions |
| WO2004005313A2 (en) | 2002-07-08 | 2004-01-15 | Pliva - Istrazivacki Institut D.O.O. | Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules |
| HRP20020779A2 (en) | 2002-09-27 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES |
| US7435805B2 (en) * | 2003-05-30 | 2008-10-14 | Glaxpsmithkline Istrazivacki | O-alkyl macrolide and azalide derivatives and regioselective process for their preparation |
| US7276487B2 (en) * | 2003-09-23 | 2007-10-02 | Enanta Pharmaceuticals, Inc. | 9a, 11-3C-bicyclic 9a-azalide derivatives |
| CN101142225B (zh) | 2005-01-13 | 2011-09-07 | 葛兰素集团有限公司 | 具有抗炎活性的大环内酯 |
| JP2008540503A (ja) | 2005-05-10 | 2008-11-20 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 細菌感染症の処置に有用なエーテル結合マクロライド |
| JP5126685B2 (ja) * | 2006-05-01 | 2013-01-23 | 大正製薬株式会社 | マクロライド誘導体 |
| WO2009007988A1 (en) * | 2007-07-11 | 2009-01-15 | Alembic Limited | Process for the preparation of 6-o-methylerythromycin a 9-oxime |
| CA2748847A1 (en) | 2009-01-30 | 2010-08-05 | Glaxo Group Limited | Anti-inflammatory macrolide |
| WO2011131749A1 (en) | 2010-04-23 | 2011-10-27 | Glaxo Group Limited | New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases |
| DK2673285T3 (en) * | 2010-12-09 | 2017-10-16 | Wockhardt Ltd | Ketolide compounds |
| CA3120148A1 (en) * | 2018-11-19 | 2020-05-28 | Zikani Therapeutics, Inc. | C10-alkylene substituted 13-membered macrolides and uses thereof |
| EP4051289A4 (en) * | 2019-10-29 | 2024-03-27 | Hikal Limited | ESSENTIALLY PURE CLARITHROMYCIN 9-OXIME AND ITS PRODUCTION |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43116B (en) * | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
| US4331803A (en) * | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| YU43006B (en) * | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
| JPS61103890A (ja) * | 1984-10-26 | 1986-05-22 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシンａ誘導体 |
| US5302705A (en) * | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| US5202434A (en) * | 1991-04-05 | 1993-04-13 | Merck & Co., Inc. | 8a-aza-8a-homoerythromycin lactams |
| CA2064985A1 (en) * | 1991-04-05 | 1992-10-06 | Robert R. Wilkening | 8a-aza-8a-homoertyhromycin cyclic lactams |
| EP0549040A1 (en) * | 1991-12-20 | 1993-06-30 | Merck & Co. Inc. | Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A |
| US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| ES2104386T3 (es) * | 1993-05-19 | 1997-10-01 | Pfizer | Compuesto intermedio para la acitromicina. |
-
1998
- 1998-04-06 HR HR980189A patent/HRP980189B1/xx not_active IP Right Cessation
- 1998-07-31 US US09/127,764 patent/US6110965A/en not_active Expired - Lifetime
-
1999
- 1999-02-04 UA UA2000106059A patent/UA70941C2/uk unknown
- 1999-04-02 CN CNB998063568A patent/CN1141312C/zh not_active Expired - Fee Related
- 1999-04-02 JP JP2000542337A patent/JP2002510701A/ja active Pending
- 1999-04-02 HU HU0101817A patent/HUP0101817A3/hu unknown
- 1999-04-02 EE EEP200000587A patent/EE04283B1/xx not_active IP Right Cessation
- 1999-04-02 SK SK1502-2000A patent/SK284169B6/sk not_active IP Right Cessation
- 1999-04-02 PL PL99343441A patent/PL193742B1/pl unknown
- 1999-04-02 PT PT99911955T patent/PT1070077E/pt unknown
- 1999-04-02 IL IL13883799A patent/IL138837A0/xx not_active IP Right Cessation
- 1999-04-02 DE DE69908338T patent/DE69908338T2/de not_active Expired - Lifetime
- 1999-04-02 KR KR1020007011140A patent/KR100600463B1/ko not_active IP Right Cessation
- 1999-04-02 SI SI9930366T patent/SI1070077T1/xx unknown
- 1999-04-02 DK DK99911955T patent/DK1070077T3/da active
- 1999-04-02 BR BR9910115-7A patent/BR9910115A/pt not_active Application Discontinuation
- 1999-04-02 AT AT99911955T patent/ATE241638T1/de not_active IP Right Cessation
- 1999-04-02 RU RU2000128042/04A patent/RU2211222C2/ru not_active IP Right Cessation
- 1999-04-02 WO PCT/HR1999/000004 patent/WO1999051616A1/en active IP Right Grant
- 1999-04-02 EP EP99911955A patent/EP1070077B1/en not_active Expired - Lifetime
- 1999-04-02 ES ES99911955T patent/ES2200512T3/es not_active Expired - Lifetime
- 1999-04-02 CA CA002327775A patent/CA2327775C/en not_active Expired - Fee Related
- 1999-04-02 AU AU30464/99A patent/AU3046499A/en not_active Abandoned
- 1999-04-05 AR ARP990101519A patent/AR019261A1/es active IP Right Grant
-
2000
- 2000-10-03 IL IL138837A patent/IL138837A/en unknown
- 2000-10-05 NO NO20005015A patent/NO317982B1/no unknown
- 2000-11-06 BG BG104913A patent/BG64600B1/bg unknown
-
2001
- 2001-10-24 HK HK01107415A patent/HK1036457A1/xx not_active IP Right Cessation
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