BG64050B1 - Метод за получаване на аминопроизводни на алкилоксифуранон, съединения, получени по този метод, и тяхното използване - Google Patents

Метод за получаване на аминопроизводни на алкилоксифуранон, съединения, получени по този метод, и тяхното използване Download PDF

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Publication number
BG64050B1
BG64050B1 BG104073A BG10407300A BG64050B1 BG 64050 B1 BG64050 B1 BG 64050B1 BG 104073 A BG104073 A BG 104073A BG 10407300 A BG10407300 A BG 10407300A BG 64050 B1 BG64050 B1 BG 64050B1
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BG
Bulgaria
Prior art keywords
formula
acid
compounds
compound
salt
Prior art date
Application number
BG104073A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104073A (en
Inventor
Raphael Bouchet
Francis Brion
Colette Colladant
Jacques Lagouardat
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of BG104073A publication Critical patent/BG104073A/xx
Publication of BG64050B1 publication Critical patent/BG64050B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG104073A 1997-07-15 2000-01-12 Метод за получаване на аминопроизводни на алкилоксифуранон, съединения, получени по този метод, и тяхното използване BG64050B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number Publication Date
BG104073A BG104073A (en) 2001-05-31
BG64050B1 true BG64050B1 (bg) 2003-11-28

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104073A BG64050B1 (bg) 1997-07-15 2000-01-12 Метод за получаване на аминопроизводни на алкилоксифуранон, съединения, получени по този метод, и тяхното използване

Country Status (34)

Country Link
US (1) US6235899B1 (et)
EP (1) EP0998470B1 (et)
JP (1) JP4450987B2 (et)
KR (1) KR100519691B1 (et)
CN (1) CN100363355C (et)
AP (1) AP1071A (et)
AR (1) AR015924A1 (et)
AT (1) ATE239713T1 (et)
AU (1) AU744272B2 (et)
BG (1) BG64050B1 (et)
BR (1) BR9810896A (et)
CA (1) CA2296742C (et)
CZ (1) CZ295312B6 (et)
DE (1) DE69814395T2 (et)
DK (1) DK0998470T3 (et)
EA (1) EA002883B1 (et)
EE (1) EE03873B1 (et)
ES (1) ES2197489T3 (et)
FR (1) FR2766188B1 (et)
HR (1) HRP20000027B1 (et)
HU (1) HU230148B1 (et)
ID (1) ID23784A (et)
IL (1) IL134031A (et)
ME (1) ME01708B (et)
NO (1) NO324508B1 (et)
NZ (1) NZ502338A (et)
PL (1) PL200820B1 (et)
PT (1) PT998470E (et)
RS (1) RS49832B (et)
SK (1) SK284168B6 (et)
TR (1) TR200000117T2 (et)
UA (1) UA66364C2 (et)
WO (1) WO1999003852A1 (et)
ZA (1) ZA986203B (et)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) * 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
AU5369201A (en) * 2000-04-24 2001-11-07 Vertex Pharma Process and intermediates for making substituted aspartic acid acetals
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
JPWO2002055478A1 (ja) * 2001-01-16 2004-05-13 鐘淵化学工業株式会社 光学活性アミノラクトン誘導体の製造法およびその中間体
CN102161656B (zh) 2004-02-27 2013-02-20 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
CN103467459A (zh) 2004-03-12 2013-12-25 弗特克斯药品有限公司 制备化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
KR100519691B1 (ko) 2005-10-13
PL338035A1 (en) 2000-09-25
CZ295312B6 (cs) 2005-07-13
JP2001510191A (ja) 2001-07-31
AR015924A1 (es) 2001-05-30
NO20000182L (no) 2000-03-07
HUP0003857A3 (en) 2002-08-28
ZA986203B (en) 1999-08-18
CZ200065A3 (cs) 2000-07-12
HUP0003857A2 (hu) 2001-04-28
ATE239713T1 (de) 2003-05-15
YU1500A (sh) 2002-10-18
BR9810896A (pt) 2000-09-26
NZ502338A (en) 2001-09-28
WO1999003852A1 (fr) 1999-01-28
HU230148B1 (hu) 2015-09-28
ES2197489T3 (es) 2004-01-01
KR20010021834A (ko) 2001-03-15
CN1269795A (zh) 2000-10-11
DE69814395T2 (de) 2003-12-11
FR2766188A1 (fr) 1999-01-22
ME01708B (me) 2008-08-07
CN100363355C (zh) 2008-01-23
AU8633398A (en) 1999-02-10
ID23784A (id) 2000-05-11
AP1071A (en) 2002-05-20
SK284168B6 (sk) 2004-10-05
BG104073A (en) 2001-05-31
IL134031A0 (en) 2001-04-30
IL134031A (en) 2004-06-01
US6235899B1 (en) 2001-05-22
AP2000001732A0 (en) 2000-03-31
NO324508B1 (no) 2007-11-05
FR2766188B1 (fr) 2000-02-11
EP0998470B1 (fr) 2003-05-07
CA2296742A1 (fr) 1999-01-28
JP4450987B2 (ja) 2010-04-14
UA66364C2 (uk) 2004-05-17
PL200820B1 (pl) 2009-02-27
RS49832B (sr) 2008-08-07
TR200000117T2 (tr) 2000-07-21
EE200000024A (et) 2000-10-16
HRP20000027B1 (en) 2006-07-31
EA002883B1 (ru) 2002-10-31
HRP20000027A2 (en) 2000-10-31
AU744272B2 (en) 2002-02-21
SK302000A3 (en) 2000-11-07
EP0998470A1 (fr) 2000-05-10
EA200000127A1 (ru) 2000-08-28
DK0998470T3 (da) 2003-09-01
EE03873B1 (et) 2002-10-15
NO20000182D0 (no) 2000-01-14
DE69814395D1 (de) 2003-06-12
CA2296742C (fr) 2009-12-08
PT998470E (pt) 2003-09-30

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