PT998470E - Processo de preparacao de derivados aminados de alquiloxifuranona compostos provenientes desse processo e utilizacao desses compostos - Google Patents

Processo de preparacao de derivados aminados de alquiloxifuranona compostos provenientes desse processo e utilizacao desses compostos

Info

Publication number
PT998470E
PT998470E PT98937591T PT98937591T PT998470E PT 998470 E PT998470 E PT 998470E PT 98937591 T PT98937591 T PT 98937591T PT 98937591 T PT98937591 T PT 98937591T PT 998470 E PT998470 E PT 998470E
Authority
PT
Portugal
Prior art keywords
compounds
alkyloxifuranone
aminox
derivatives
preparation
Prior art date
Application number
PT98937591T
Other languages
English (en)
Inventor
Francis Brion
Colette Colladant
Jacques Lagouardat
Raphael Bouchet
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PT998470E publication Critical patent/PT998470E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00Separation of optically-active compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60Two oxygen atoms, e.g. succinic anhydride
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT98937591T 1997-07-15 1998-07-09 Processo de preparacao de derivados aminados de alquiloxifuranona compostos provenientes desse processo e utilizacao desses compostos PT998470E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes

Publications (1)

Publication Number Publication Date
PT998470E true PT998470E (pt) 2003-09-30

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98937591T PT998470E (pt) 1997-07-15 1998-07-09 Processo de preparacao de derivados aminados de alquiloxifuranona compostos provenientes desse processo e utilizacao desses compostos

Country Status (34)

Country Link
US (1) US6235899B1 (pt)
EP (1) EP0998470B1 (pt)
JP (1) JP4450987B2 (pt)
KR (1) KR100519691B1 (pt)
CN (1) CN100363355C (pt)
AP (1) AP1071A (pt)
AR (1) AR015924A1 (pt)
AT (1) ATE239713T1 (pt)
AU (1) AU744272B2 (pt)
BG (1) BG64050B1 (pt)
BR (1) BR9810896A (pt)
CA (1) CA2296742C (pt)
CZ (1) CZ295312B6 (pt)
DE (1) DE69814395T2 (pt)
DK (1) DK0998470T3 (pt)
EA (1) EA002883B1 (pt)
EE (1) EE03873B1 (pt)
ES (1) ES2197489T3 (pt)
FR (1) FR2766188B1 (pt)
HR (1) HRP20000027B1 (pt)
HU (1) HU230148B1 (pt)
ID (1) ID23784A (pt)
IL (1) IL134031A (pt)
ME (1) ME01708B (pt)
NO (1) NO324508B1 (pt)
NZ (1) NZ502338A (pt)
PL (1) PL200820B1 (pt)
PT (1) PT998470E (pt)
RS (1) RS49832B (pt)
SK (1) SK284168B6 (pt)
TR (1) TR200000117T2 (pt)
UA (1) UA66364C2 (pt)
WO (1) WO1999003852A1 (pt)
ZA (1) ZA986203B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
ES2347133T3 (es) 2000-04-24 2010-10-26 Vertex Pharmaceuticals Incorporated Procedimiento e intermedios para preparar acetales de acido aspartico sustituidos.
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
WO2002055478A1 (fr) * 2001-01-16 2002-07-18 Kaneka Corporation Procede de preparation de derives d'aminolactone optiquement actifs et intermediaires de ces derives
JP2007525503A (ja) 2004-02-27 2007-09-06 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼインヒビターおよびそれらの使用
WO2005090334A2 (en) 2004-03-12 2005-09-29 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
CZ200065A3 (cs) 2000-07-12
DK0998470T3 (da) 2003-09-01
CA2296742A1 (fr) 1999-01-28
ZA986203B (en) 1999-08-18
UA66364C2 (uk) 2004-05-17
TR200000117T2 (tr) 2000-07-21
CN1269795A (zh) 2000-10-11
JP2001510191A (ja) 2001-07-31
KR100519691B1 (ko) 2005-10-13
BG104073A (en) 2001-05-31
DE69814395T2 (de) 2003-12-11
NO324508B1 (no) 2007-11-05
EP0998470A1 (fr) 2000-05-10
NZ502338A (en) 2001-09-28
US6235899B1 (en) 2001-05-22
BR9810896A (pt) 2000-09-26
RS49832B (sr) 2008-08-07
ATE239713T1 (de) 2003-05-15
ID23784A (id) 2000-05-11
EA002883B1 (ru) 2002-10-31
AP2000001732A0 (en) 2000-03-31
HUP0003857A2 (hu) 2001-04-28
AP1071A (en) 2002-05-20
AU744272B2 (en) 2002-02-21
CN100363355C (zh) 2008-01-23
EE03873B1 (et) 2002-10-15
PL338035A1 (en) 2000-09-25
HRP20000027A2 (en) 2000-10-31
HRP20000027B1 (en) 2006-07-31
NO20000182L (no) 2000-03-07
IL134031A0 (en) 2001-04-30
SK302000A3 (en) 2000-11-07
CZ295312B6 (cs) 2005-07-13
FR2766188B1 (fr) 2000-02-11
EA200000127A1 (ru) 2000-08-28
ME01708B (me) 2008-08-07
FR2766188A1 (fr) 1999-01-22
CA2296742C (fr) 2009-12-08
DE69814395D1 (de) 2003-06-12
HU230148B1 (hu) 2015-09-28
IL134031A (en) 2004-06-01
AU8633398A (en) 1999-02-10
YU1500A (sh) 2002-10-18
NO20000182D0 (no) 2000-01-14
AR015924A1 (es) 2001-05-30
KR20010021834A (ko) 2001-03-15
EP0998470B1 (fr) 2003-05-07
HUP0003857A3 (en) 2002-08-28
JP4450987B2 (ja) 2010-04-14
EE200000024A (et) 2000-10-16
SK284168B6 (sk) 2004-10-05
PL200820B1 (pl) 2009-02-27
ES2197489T3 (es) 2004-01-01
BG64050B1 (bg) 2003-11-28
WO1999003852A1 (fr) 1999-01-28

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