BG63663B1 - Метод за получаване на йохексол - Google Patents

Метод за получаване на йохексол Download PDF

Info

Publication number
BG63663B1
BG63663B1 BG103289A BG10328999A BG63663B1 BG 63663 B1 BG63663 B1 BG 63663B1 BG 103289 A BG103289 A BG 103289A BG 10328999 A BG10328999 A BG 10328999A BG 63663 B1 BG63663 B1 BG 63663B1
Authority
BG
Bulgaria
Prior art keywords
yohexol
isopropanol
solvent
methoxyethanol
crude
Prior art date
Application number
BG103289A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103289A (en
Inventor
Dick Malthe-Sorenssen
Odd INGVOLDSTAD
Espen Myrbraten
Original Assignee
Nycomed Imaging A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging A/S filed Critical Nycomed Imaging A/S
Publication of BG103289A publication Critical patent/BG103289A/xx
Publication of BG63663B1 publication Critical patent/BG63663B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Saccharide Compounds (AREA)
BG103289A 1996-08-29 1999-03-26 Метод за получаване на йохексол BG63663B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9618056.7A GB9618056D0 (en) 1996-08-29 1996-08-29 Process
PCT/GB1997/002332 WO1998008804A1 (en) 1996-08-29 1997-08-29 Process for iohexol manufacture

Publications (2)

Publication Number Publication Date
BG103289A BG103289A (en) 2000-01-31
BG63663B1 true BG63663B1 (bg) 2002-08-30

Family

ID=10799120

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103289A BG63663B1 (bg) 1996-08-29 1999-03-26 Метод за получаване на йохексол

Country Status (26)

Country Link
US (2) US5948940A (zh)
EP (1) EP0925275B1 (zh)
JP (1) JP3780002B2 (zh)
KR (1) KR100517588B1 (zh)
CN (1) CN1120148C (zh)
AT (1) ATE210631T1 (zh)
AU (1) AU723184B2 (zh)
BG (1) BG63663B1 (zh)
BR (1) BR9711381A (zh)
CA (1) CA2265047A1 (zh)
CZ (1) CZ295058B6 (zh)
DE (1) DE69709127T2 (zh)
EE (1) EE9900082A (zh)
ES (1) ES2173476T3 (zh)
GB (1) GB9618056D0 (zh)
HK (1) HK1020722A1 (zh)
HU (1) HU229253B1 (zh)
IL (1) IL128715A (zh)
IN (1) IN186429B (zh)
NO (1) NO322795B1 (zh)
NZ (1) NZ334817A (zh)
PL (1) PL190151B1 (zh)
PT (1) PT925275E (zh)
SK (1) SK26499A3 (zh)
TR (1) TR199900405T2 (zh)
WO (1) WO1998008804A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US6262303B1 (en) * 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
ITMI20010773A1 (it) 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
NO20033058D0 (no) * 2003-07-03 2003-07-03 Amersham Health As Prosess
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20053676D0 (no) 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
WO2009091758A1 (en) * 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol
WO2015133651A1 (en) * 2014-03-04 2015-09-11 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same
CN110054569B (zh) * 2019-05-17 2022-05-17 浙江海洲制药有限公司 一种制备碘海醇的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1548594A (en) * 1922-05-27 1925-08-04 Helios Machine Company Motion-converting mechanism
CH608189A5 (zh) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DK162045C (da) * 1982-10-01 1992-02-10 Nyegaard & Co As Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser
NO161368C (no) * 1982-11-08 1989-08-09 Nyegaard & Co As Roentgenkontrastmidler samt radiologiske preparater derav.
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5371278A (en) * 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process

Also Published As

Publication number Publication date
TR199900405T2 (xx) 1999-06-21
JP2000517312A (ja) 2000-12-26
HK1020722A1 (en) 2000-05-19
HUP9904325A3 (en) 2000-06-28
US5948940A (en) 1999-09-07
PT925275E (pt) 2002-05-31
GB9618056D0 (en) 1996-10-09
KR100517588B1 (ko) 2005-09-29
CN1120148C (zh) 2003-09-03
US6153796A (en) 2000-11-28
ATE210631T1 (de) 2001-12-15
CZ295058B6 (cs) 2005-05-18
CN1228763A (zh) 1999-09-15
DE69709127T2 (de) 2002-08-14
IL128715A (en) 2002-08-14
HU229253B1 (en) 2013-10-28
AU4123697A (en) 1998-03-19
ES2173476T3 (es) 2002-10-16
NO322795B1 (no) 2006-12-11
NZ334817A (en) 2000-09-29
EP0925275A1 (en) 1999-06-30
CA2265047A1 (en) 1998-03-05
IN186429B (zh) 2001-09-01
KR20000035945A (ko) 2000-06-26
HUP9904325A2 (hu) 2000-04-28
PL190151B1 (pl) 2005-11-30
AU723184B2 (en) 2000-08-17
IL128715A0 (en) 2000-01-31
JP3780002B2 (ja) 2006-05-31
SK26499A3 (en) 1999-08-06
NO990889D0 (no) 1999-02-25
PL331706A1 (en) 1999-08-02
EE9900082A (et) 1999-10-15
BR9711381A (pt) 1999-08-17
EP0925275B1 (en) 2001-12-12
BG103289A (en) 2000-01-31
DE69709127D1 (de) 2002-01-24
CZ66999A3 (cs) 1999-08-11
WO1998008804A1 (en) 1998-03-05
NO990889L (no) 1999-02-25

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