DE69709127D1 - Verfahren zur herstellung von iohexol - Google Patents

Verfahren zur herstellung von iohexol

Info

Publication number
DE69709127D1
DE69709127D1 DE69709127T DE69709127T DE69709127D1 DE 69709127 D1 DE69709127 D1 DE 69709127D1 DE 69709127 T DE69709127 T DE 69709127T DE 69709127 T DE69709127 T DE 69709127T DE 69709127 D1 DE69709127 D1 DE 69709127D1
Authority
DE
Germany
Prior art keywords
iohexol
producing
producing iohexol
triiodophthalamide
dihydroxypropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69709127T
Other languages
English (en)
Other versions
DE69709127T2 (de
Inventor
Dick Malthe-Sorenssen
Einar Ingvoldstad
Espen Myrbraten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of DE69709127D1 publication Critical patent/DE69709127D1/de
Application granted granted Critical
Publication of DE69709127T2 publication Critical patent/DE69709127T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Saccharide Compounds (AREA)
DE69709127T 1996-08-29 1997-08-29 Verfahren zur herstellung von iohexol Expired - Lifetime DE69709127T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9618056.7A GB9618056D0 (en) 1996-08-29 1996-08-29 Process
PCT/GB1997/002332 WO1998008804A1 (en) 1996-08-29 1997-08-29 Process for iohexol manufacture

Publications (2)

Publication Number Publication Date
DE69709127D1 true DE69709127D1 (de) 2002-01-24
DE69709127T2 DE69709127T2 (de) 2002-08-14

Family

ID=10799120

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709127T Expired - Lifetime DE69709127T2 (de) 1996-08-29 1997-08-29 Verfahren zur herstellung von iohexol

Country Status (26)

Country Link
US (2) US5948940A (de)
EP (1) EP0925275B1 (de)
JP (1) JP3780002B2 (de)
KR (1) KR100517588B1 (de)
CN (1) CN1120148C (de)
AT (1) ATE210631T1 (de)
AU (1) AU723184B2 (de)
BG (1) BG63663B1 (de)
BR (1) BR9711381A (de)
CA (1) CA2265047A1 (de)
CZ (1) CZ295058B6 (de)
DE (1) DE69709127T2 (de)
EE (1) EE9900082A (de)
ES (1) ES2173476T3 (de)
GB (1) GB9618056D0 (de)
HK (1) HK1020722A1 (de)
HU (1) HU229253B1 (de)
IL (1) IL128715A (de)
IN (1) IN186429B (de)
NO (1) NO322795B1 (de)
NZ (1) NZ334817A (de)
PL (1) PL190151B1 (de)
PT (1) PT925275E (de)
SK (1) SK26499A3 (de)
TR (1) TR199900405T2 (de)
WO (1) WO1998008804A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US6262303B1 (en) * 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
NO20033058D0 (no) * 2003-07-03 2003-07-03 Amersham Health As Prosess
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20053676D0 (no) 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
US8445725B2 (en) 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
CA2940698A1 (en) * 2014-03-04 2015-09-11 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same
CN110054569B (zh) * 2019-05-17 2022-05-17 浙江海洲制药有限公司 一种制备碘海醇的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1548594A (en) * 1922-05-27 1925-08-04 Helios Machine Company Motion-converting mechanism
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
NO160918C (no) * 1982-10-01 1989-06-14 Nyegaard & Co As Trijodbenzen-derivater og radiologiske preparater inneholdende disse.
EP0108638B1 (de) * 1982-11-08 1986-07-16 NYEGAARD & CO. A/S Röntgenkontrastmittel
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5371278A (en) * 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process

Also Published As

Publication number Publication date
NZ334817A (en) 2000-09-29
BG103289A (en) 2000-01-31
GB9618056D0 (en) 1996-10-09
HK1020722A1 (en) 2000-05-19
WO1998008804A1 (en) 1998-03-05
PL331706A1 (en) 1999-08-02
BG63663B1 (bg) 2002-08-30
EP0925275A1 (de) 1999-06-30
KR20000035945A (ko) 2000-06-26
IL128715A0 (en) 2000-01-31
PT925275E (pt) 2002-05-31
NO990889D0 (no) 1999-02-25
NO990889L (no) 1999-02-25
ATE210631T1 (de) 2001-12-15
IN186429B (de) 2001-09-01
CZ66999A3 (cs) 1999-08-11
PL190151B1 (pl) 2005-11-30
HUP9904325A3 (en) 2000-06-28
AU4123697A (en) 1998-03-19
CA2265047A1 (en) 1998-03-05
CN1120148C (zh) 2003-09-03
NO322795B1 (no) 2006-12-11
SK26499A3 (en) 1999-08-06
CZ295058B6 (cs) 2005-05-18
US6153796A (en) 2000-11-28
IL128715A (en) 2002-08-14
KR100517588B1 (ko) 2005-09-29
AU723184B2 (en) 2000-08-17
BR9711381A (pt) 1999-08-17
HU229253B1 (en) 2013-10-28
EE9900082A (et) 1999-10-15
ES2173476T3 (es) 2002-10-16
CN1228763A (zh) 1999-09-15
US5948940A (en) 1999-09-07
DE69709127T2 (de) 2002-08-14
JP2000517312A (ja) 2000-12-26
HUP9904325A2 (hu) 2000-04-28
EP0925275B1 (de) 2001-12-12
TR199900405T2 (xx) 1999-06-21
JP3780002B2 (ja) 2006-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO