BG63541B1 - Съединения и метод за получаване на заместени 4-фенил-4- цианоциклохексаноени киселини - Google Patents

Съединения и метод за получаване на заместени 4-фенил-4- цианоциклохексаноени киселини Download PDF

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Publication number
BG63541B1
BG63541B1 BG103651A BG10365199A BG63541B1 BG 63541 B1 BG63541 B1 BG 63541B1 BG 103651 A BG103651 A BG 103651A BG 10365199 A BG10365199 A BG 10365199A BG 63541 B1 BG63541 B1 BG 63541B1
Authority
BG
Bulgaria
Prior art keywords
formula
hydrogen
optionally substituted
compound
alkyl
Prior art date
Application number
BG103651A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103651A (en
Inventor
Andrew Allen
Ann DIEDERICH
Li Liu
Wilford Mendelson
Kevin Webb
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of BG103651A publication Critical patent/BG103651A/xx
Publication of BG63541B1 publication Critical patent/BG63541B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
BG103651A 1997-02-12 1999-08-10 Съединения и метод за получаване на заместени 4-фенил-4- цианоциклохексаноени киселини BG63541B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12
PCT/US1998/002749 WO1998034584A2 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
BG103651A BG103651A (en) 2000-02-29
BG63541B1 true BG63541B1 (bg) 2002-04-30

Family

ID=21895265

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103651A BG63541B1 (bg) 1997-02-12 1999-08-10 Съединения и метод за получаване на заместени 4-фенил-4- цианоциклохексаноени киселини

Country Status (38)

Country Link
US (1) US6337408B1 (pt)
EP (1) EP1023279B8 (pt)
JP (4) JP3786971B2 (pt)
KR (1) KR100412008B1 (pt)
CN (2) CN1854131A (pt)
AP (1) AP1215A (pt)
AR (2) AR012550A1 (pt)
AT (2) ATE300517T1 (pt)
AU (1) AU725484B2 (pt)
BG (1) BG63541B1 (pt)
BR (1) BR9808637A (pt)
CA (1) CA2279951A1 (pt)
CO (1) CO4950534A1 (pt)
CY (1) CY2478B1 (pt)
DE (3) DE69836928T2 (pt)
DK (2) DK1023279T3 (pt)
DZ (1) DZ2423A1 (pt)
EA (1) EA001783B1 (pt)
ES (3) ES2196551T3 (pt)
HK (1) HK1037613A1 (pt)
HU (1) HUP0001801A3 (pt)
ID (1) ID23527A (pt)
IL (7) IL131270A (pt)
MA (1) MA24471A1 (pt)
MY (1) MY118813A (pt)
NO (1) NO993863L (pt)
NZ (1) NZ337084A (pt)
OA (1) OA11144A (pt)
PL (1) PL193366B1 (pt)
PT (2) PT1524268E (pt)
SI (2) SI1295869T1 (pt)
SK (1) SK108899A3 (pt)
TR (1) TR199901920T2 (pt)
TW (1) TW442455B (pt)
UA (1) UA58533C2 (pt)
UY (2) UY24882A1 (pt)
WO (1) WO1998034584A2 (pt)
ZA (1) ZA981125B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67753C2 (uk) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
ECSP003599A (es) * 1999-08-06 2002-03-25 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
US5602173A (en) * 1992-04-02 1997-02-11 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
CZ283425B6 (cs) * 1992-04-02 1998-04-15 Smithkline Beecham Corporation Fenylové deriváty a farmaceutické prostředky s jejich obsahem

Also Published As

Publication number Publication date
NZ337084A (en) 2001-04-27
TR199901920T2 (xx) 1999-11-22
DK1524268T3 (da) 2007-05-14
MY118813A (en) 2005-01-31
PT1023279E (pt) 2003-08-29
JP4053024B2 (ja) 2008-02-27
CN1301982C (zh) 2007-02-28
WO1998034584A2 (en) 1998-08-13
DE69813596T2 (de) 2004-02-12
IL150955A (en) 2006-07-05
CN1246855A (zh) 2000-03-08
ES2280008T3 (es) 2007-09-01
PT1524268E (pt) 2007-03-30
US6337408B1 (en) 2002-01-08
KR20000070927A (ko) 2000-11-25
AP1215A (en) 2003-10-14
SI1295869T1 (sl) 2005-12-31
JP2004292460A (ja) 2004-10-21
ZA981125B (en) 1998-08-21
EP1023279A2 (en) 2000-08-02
HUP0001801A2 (hu) 2000-10-28
ES2246373T3 (es) 2006-02-16
IL166184A0 (en) 2006-01-15
MA24471A1 (fr) 1998-10-01
KR100412008B1 (ko) 2003-12-24
IL166188A0 (en) 2006-01-15
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
DE69836928T2 (de) 2007-11-08
AR012550A1 (es) 2000-11-08
AP9901618A0 (en) 1999-09-30
PL335031A1 (en) 2000-03-27
NO993863D0 (no) 1999-08-11
ID23527A (id) 2000-04-27
BR9808637A (pt) 2000-07-04
EA199900735A1 (ru) 2000-02-28
NO993863L (no) 1999-08-11
JP2001510482A (ja) 2001-07-31
UY25127A1 (es) 1998-11-27
DE69831022D1 (de) 2005-09-01
HUP0001801A3 (en) 2001-12-28
JP2004149546A (ja) 2004-05-27
ATE237603T1 (de) 2003-05-15
AU6654498A (en) 1998-08-26
EP1023279A4 (en) 2000-10-04
IL166186A0 (en) 2006-01-15
IL131270A (en) 2005-05-17
OA11144A (en) 2003-04-17
TW442455B (en) 2001-06-23
DK1023279T3 (da) 2003-07-21
IL166187A0 (en) 2006-01-15
ES2196551T3 (es) 2003-12-16
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
PL193366B1 (pl) 2007-02-28
AU725484B2 (en) 2000-10-12
ATE300517T1 (de) 2005-08-15
JP4093967B2 (ja) 2008-06-04
WO1998034584A3 (en) 1998-11-19
JP3786971B2 (ja) 2006-06-21
EA001783B1 (ru) 2001-08-27
BG103651A (en) 2000-02-29
SI1524268T1 (sl) 2007-04-30
DE69831022T2 (de) 2006-04-20
UY24882A1 (es) 2001-08-27
EP1023279B1 (en) 2003-04-16
IL166185A0 (en) 2006-01-15
CO4950534A1 (es) 2000-09-01
UA58533C2 (uk) 2003-08-15
JP4053023B2 (ja) 2008-02-27
JP2004269546A (ja) 2004-09-30
AR050308A2 (es) 2006-10-18
DE69813596D1 (de) 2003-05-22
HK1037613A1 (en) 2002-02-15
SK108899A3 (en) 2000-01-18
IL131270A0 (en) 2001-01-28
DE69836928D1 (de) 2007-03-08
CA2279951A1 (en) 1998-08-13

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