IL131270A - Compounds and method for preparing substituted 4-phenyl-4-cyanocylohexanoic acids - Google Patents

Compounds and method for preparing substituted 4-phenyl-4-cyanocylohexanoic acids

Info

Publication number
IL131270A
IL131270A IL13127098A IL13127098A IL131270A IL 131270 A IL131270 A IL 131270A IL 13127098 A IL13127098 A IL 13127098A IL 13127098 A IL13127098 A IL 13127098A IL 131270 A IL131270 A IL 131270A
Authority
IL
Israel
Prior art keywords
cyanocylohexanoic
phenyl
acids
compounds
preparing substituted
Prior art date
Application number
IL13127098A
Other languages
English (en)
Other versions
IL131270A0 (en
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Priority to IL15095498A priority Critical patent/IL150954A/xx
Priority to IL15095798A priority patent/IL150957A/xx
Priority to IL15095598A priority patent/IL150955A0/xx
Priority to IL15095698A priority patent/IL150956A0/xx
Priority to IL15626598A priority patent/IL156265A0/xx
Publication of IL131270A0 publication Critical patent/IL131270A0/xx
Publication of IL131270A publication Critical patent/IL131270A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
IL13127098A 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocylohexanoic acids IL131270A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL15095498A IL150954A (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL15095798A IL150957A (en) 1997-02-12 1998-02-12 Process for enriching cis-4-cyano -4- ( 3 - cyclopentyloxy -4- methoxyphenyl) - r-cyclohexanecarboxylic acid from mixtures of cis and trans form
IL15095598A IL150955A0 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4 cyanocyclohexanoic acids
IL15095698A IL150956A0 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL15626598A IL156265A0 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cycanocyclohexanoic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12
PCT/US1998/002749 WO1998034584A2 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
IL131270A0 IL131270A0 (en) 2001-01-28
IL131270A true IL131270A (en) 2005-05-17

Family

ID=21895265

Family Applications (7)

Application Number Title Priority Date Filing Date
IL13127098A IL131270A (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocylohexanoic acids
IL150955A IL150955A (en) 1997-02-12 2002-07-29 Compounds and Method for Preparation of Acids 4 - Phenyl - 4 - Transformed Cyanocyclohexane
IL16618405A IL166184A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618805A IL166188A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618505A IL166185A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618605A IL166186A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618705A IL166187A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Family Applications After (6)

Application Number Title Priority Date Filing Date
IL150955A IL150955A (en) 1997-02-12 2002-07-29 Compounds and Method for Preparation of Acids 4 - Phenyl - 4 - Transformed Cyanocyclohexane
IL16618405A IL166184A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618805A IL166188A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618505A IL166185A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618605A IL166186A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
IL16618705A IL166187A0 (en) 1997-02-12 2005-01-06 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Country Status (38)

Country Link
US (1) US6337408B1 (pt)
EP (1) EP1023279B8 (pt)
JP (4) JP3786971B2 (pt)
KR (1) KR100412008B1 (pt)
CN (2) CN1301982C (pt)
AP (1) AP1215A (pt)
AR (2) AR012550A1 (pt)
AT (2) ATE237603T1 (pt)
AU (1) AU725484B2 (pt)
BG (1) BG63541B1 (pt)
BR (1) BR9808637A (pt)
CA (1) CA2279951A1 (pt)
CO (1) CO4950534A1 (pt)
CY (1) CY2478B1 (pt)
DE (3) DE69836928T2 (pt)
DK (2) DK1524268T3 (pt)
DZ (1) DZ2423A1 (pt)
EA (1) EA001783B1 (pt)
ES (3) ES2246373T3 (pt)
HK (1) HK1037613A1 (pt)
HU (1) HUP0001801A3 (pt)
ID (1) ID23527A (pt)
IL (7) IL131270A (pt)
MA (1) MA24471A1 (pt)
MY (1) MY118813A (pt)
NO (1) NO993863L (pt)
NZ (1) NZ337084A (pt)
OA (1) OA11144A (pt)
PL (1) PL193366B1 (pt)
PT (2) PT1524268E (pt)
SI (2) SI1524268T1 (pt)
SK (1) SK108899A3 (pt)
TR (1) TR199901920T2 (pt)
TW (1) TW442455B (pt)
UA (1) UA58533C2 (pt)
UY (2) UY24882A1 (pt)
WO (1) WO1998034584A2 (pt)
ZA (1) ZA981125B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67753C2 (uk) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
UY26268A1 (es) * 1999-08-06 2001-01-31 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
GB9920152D0 (en) 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
EP0634930A4 (en) * 1992-04-02 1995-02-22 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases.

Also Published As

Publication number Publication date
JP2004269546A (ja) 2004-09-30
JP4093967B2 (ja) 2008-06-04
HK1037613A1 (en) 2002-02-15
IL166184A0 (en) 2006-01-15
EP1023279A2 (en) 2000-08-02
IL150955A (en) 2006-07-05
IL131270A0 (en) 2001-01-28
IL166188A0 (en) 2006-01-15
DE69831022D1 (de) 2005-09-01
HUP0001801A3 (en) 2001-12-28
BG103651A (en) 2000-02-29
IL166186A0 (en) 2006-01-15
AR012550A1 (es) 2000-11-08
SI1524268T1 (sl) 2007-04-30
ES2280008T3 (es) 2007-09-01
NZ337084A (en) 2001-04-27
DE69813596T2 (de) 2004-02-12
PL193366B1 (pl) 2007-02-28
SI1295869T1 (sl) 2005-12-31
OA11144A (en) 2003-04-17
EA199900735A1 (ru) 2000-02-28
JP2001510482A (ja) 2001-07-31
EA001783B1 (ru) 2001-08-27
NO993863D0 (no) 1999-08-11
AU725484B2 (en) 2000-10-12
AP9901618A0 (en) 1999-09-30
PT1524268E (pt) 2007-03-30
KR100412008B1 (ko) 2003-12-24
AP1215A (en) 2003-10-14
EP1023279B1 (en) 2003-04-16
NO993863L (no) 1999-08-11
ATE300517T1 (de) 2005-08-15
DE69836928D1 (de) 2007-03-08
IL166185A0 (en) 2006-01-15
JP2004149546A (ja) 2004-05-27
WO1998034584A3 (en) 1998-11-19
BR9808637A (pt) 2000-07-04
US6337408B1 (en) 2002-01-08
CA2279951A1 (en) 1998-08-13
TW442455B (en) 2001-06-23
UY24882A1 (es) 2001-08-27
JP2004292460A (ja) 2004-10-21
DE69831022T2 (de) 2006-04-20
UY25127A1 (es) 1998-11-27
KR20000070927A (ko) 2000-11-25
ZA981125B (en) 1998-08-21
CN1246855A (zh) 2000-03-08
UA58533C2 (uk) 2003-08-15
MA24471A1 (fr) 1998-10-01
ES2246373T3 (es) 2006-02-16
MY118813A (en) 2005-01-31
PT1023279E (pt) 2003-08-29
EP1023279A4 (en) 2000-10-04
SK108899A3 (en) 2000-01-18
WO1998034584A2 (en) 1998-08-13
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
DE69813596D1 (de) 2003-05-22
DE69836928T2 (de) 2007-11-08
CO4950534A1 (es) 2000-09-01
CN1301982C (zh) 2007-02-28
DK1524268T3 (da) 2007-05-14
TR199901920T2 (xx) 1999-11-22
JP4053023B2 (ja) 2008-02-27
PL335031A1 (en) 2000-03-27
IL166187A0 (en) 2006-01-15
ID23527A (id) 2000-04-27
BG63541B1 (bg) 2002-04-30
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
JP4053024B2 (ja) 2008-02-27
ES2196551T3 (es) 2003-12-16
JP3786971B2 (ja) 2006-06-21
HUP0001801A2 (hu) 2000-10-28
ATE237603T1 (de) 2003-05-15
AU6654498A (en) 1998-08-26
AR050308A2 (es) 2006-10-18
DK1023279T3 (da) 2003-07-21

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees