BG62332B1 - Съединение с формула 4-[/2-бензотиазолил/метиламино]-алфа-[/3,4-дифлуорофенокси/метил]-1-пиперидинетанол, методи занеговото получаване и използване, както и фармацевтични състави стова съединение и методи за получаването им - Google Patents

Съединение с формула 4-[/2-бензотиазолил/метиламино]-алфа-[/3,4-дифлуорофенокси/метил]-1-пиперидинетанол, методи занеговото получаване и използване, както и фармацевтични състави стова съединение и методи за получаването им Download PDF

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Publication number
BG62332B1
BG62332B1 BG98068A BG9806893A BG62332B1 BG 62332 B1 BG62332 B1 BG 62332B1 BG 98068 A BG98068 A BG 98068A BG 9806893 A BG9806893 A BG 9806893A BG 62332 B1 BG62332 B1 BG 62332B1
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BG
Bulgaria
Prior art keywords
formula
compound
preparation
optionally
reaction
Prior art date
Application number
BG98068A
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Bulgarian (bg)
English (en)
Other versions
BG98068A (bg
Inventor
Raymond A. Stokbroekx
Gilbert A. Grauwels
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG98068A publication Critical patent/BG98068A/bg
Publication of BG62332B1 publication Critical patent/BG62332B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Paper (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
BG98068A 1991-02-25 1993-08-24 Съединение с формула 4-[/2-бензотиазолил/метиламино]-алфа-[/3,4-дифлуорофенокси/метил]-1-пиперидинетанол, методи занеговото получаване и използване, както и фармацевтични състави стова съединение и методи за получаването им BG62332B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65964591A 1991-02-25 1991-02-25
PCT/EP1992/000356 WO1992014731A1 (en) 1991-02-25 1992-02-14 4-[(2-BENZOTHIAZOLYL)METHYLAMINO]-α-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINEETHANOL

Publications (2)

Publication Number Publication Date
BG98068A BG98068A (bg) 1994-06-30
BG62332B1 true BG62332B1 (bg) 1999-08-31

Family

ID=24646210

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98068A BG62332B1 (bg) 1991-02-25 1993-08-24 Съединение с формула 4-[/2-бензотиазолил/метиламино]-алфа-[/3,4-дифлуорофенокси/метил]-1-пиперидинетанол, методи занеговото получаване и използване, както и фармацевтични състави стова съединение и методи за получаването им

Country Status (36)

Country Link
US (2) US5434168A (ru)
EP (2) EP0573473B1 (ru)
JP (1) JP2825652B2 (ru)
KR (1) KR0165901B1 (ru)
CN (3) CN1033454C (ru)
AT (1) ATE131478T1 (ru)
AU (1) AU649788B2 (ru)
BG (1) BG62332B1 (ru)
CA (1) CA2104000A1 (ru)
CY (1) CY1924A (ru)
CZ (1) CZ284705B6 (ru)
DE (1) DE69206787T2 (ru)
DK (1) DK0573473T3 (ru)
DZ (1) DZ1560A1 (ru)
EE (1) EE02983B1 (ru)
ES (1) ES2083737T3 (ru)
FI (1) FI933719A (ru)
GR (1) GR3018692T3 (ru)
HK (1) HK172296A (ru)
HU (2) HUT67695A (ru)
IE (1) IE69567B1 (ru)
IL (3) IL113837A (ru)
LV (1) LV11689B (ru)
MA (1) MA22447A1 (ru)
MX (1) MX9200777A (ru)
NO (1) NO300591B1 (ru)
NZ (2) NZ248437A (ru)
PL (1) PL168791B1 (ru)
RO (1) RO112959B1 (ru)
RU (2) RU2106348C1 (ru)
SK (1) SK278705B6 (ru)
TN (1) TNSN92017A1 (ru)
TW (1) TW218016B (ru)
WO (1) WO1992014731A1 (ru)
ZA (1) ZA921341B (ru)
ZW (1) ZW1992A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (ru) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
HUT77362A (hu) * 1994-10-14 1998-03-30 Janssen Pharmaceutica N.V. Sabeluzolt tartalmazó vizes orális szuszpenziók és eljárás előállításukra
PL320296A1 (en) * 1994-11-24 1997-09-15 Janssen Pharmaceutica Nv Intravenal lubeluzole solutions
JPH10501823A (ja) * 1995-04-10 1998-02-17 バクスター、インターナショナル、インコーポレイテッド クモ膜下出血の治療における架橋ヘモグロビンの使用
AU7298296A (en) * 1995-10-25 1997-05-15 Janssen Pharmaceutica N.V. Lubeluzole n-oxide
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
GB9815785D0 (en) * 1998-07-20 1998-09-16 Cerebrus Ltd Chemical compounds
DE60020556T2 (de) * 1999-05-12 2005-10-27 Neurosearch A/S Ionenkanal modulierende mittel

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963732A (en) * 1973-05-30 1976-06-15 Tiberio Bruzzese Process for preparing dihydroxydiphenylmethane derivatives
US4310658A (en) * 1980-06-18 1982-01-12 Allied Corporation Production of polyester thermally stabilized with an oxirane
US4861785A (en) * 1984-12-03 1989-08-29 Janssen Pharmaceutica N.V. Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4689330A (en) * 1985-04-15 1987-08-25 Janssen Pharmaceutica N.V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4717760A (en) * 1986-07-10 1988-01-05 The Dow Chemical Company Fluorinated tris-epoxides based on triphenyl methane
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol

Also Published As

Publication number Publication date
AU649788B2 (en) 1994-06-02
GR3018692T3 (en) 1996-04-30
HU211560A9 (en) 1995-12-28
KR0165901B1 (en) 1999-01-15
PL168791B1 (pl) 1996-04-30
BG98068A (bg) 1994-06-30
IE69567B1 (en) 1996-10-02
LV11689B (en) 1997-08-20
MX9200777A (es) 1992-08-01
CA2104000A1 (en) 1992-08-26
JPH06505012A (ja) 1994-06-09
NO933010D0 (no) 1993-08-24
US5434168A (en) 1995-07-18
DE69206787D1 (de) 1996-01-25
FI933719A0 (fi) 1993-08-24
TW218016B (ru) 1993-12-21
CS51292A3 (en) 1992-09-16
CN1043609C (zh) 1999-06-16
HU9302395D0 (en) 1993-11-29
RU2094434C1 (ru) 1997-10-27
CZ284705B6 (cs) 1999-02-17
JP2825652B2 (ja) 1998-11-18
US5675027A (en) 1997-10-07
ZA921341B (en) 1993-08-24
NZ248437A (en) 1994-07-26
IE920575A1 (en) 1992-08-26
TNSN92017A1 (fr) 1993-06-08
CN1064865A (zh) 1992-09-30
EP0573473B1 (en) 1995-12-13
IL113837A0 (en) 1995-08-31
CY1924A (en) 1997-03-07
CN1113437A (zh) 1995-12-20
IL113837A (en) 1996-05-14
DE69206787T2 (de) 1996-06-05
EP0573473A1 (en) 1993-12-15
ES2083737T3 (es) 1996-04-16
ATE131478T1 (de) 1995-12-15
FI933719A (fi) 1993-08-24
LV11689A (lv) 1997-02-20
NZ241592A (en) 1994-07-26
HUT67695A (en) 1995-04-28
AU1208592A (en) 1992-09-15
EE02983B1 (et) 1997-04-15
EP0501552A1 (en) 1992-09-02
IL100952A (en) 1995-12-31
ZW1992A1 (en) 1993-09-22
SK278705B6 (sk) 1998-01-14
WO1992014731A1 (en) 1992-09-03
CN1033454C (zh) 1996-12-04
RU95112519A (ru) 1997-04-20
CN1117048A (zh) 1996-02-21
DZ1560A1 (fr) 2002-02-17
MA22447A1 (fr) 1992-10-01
IL100952A0 (en) 1992-11-15
NO933010L (no) 1993-08-24
HK172296A (en) 1996-09-20
RU2106348C1 (ru) 1998-03-10
RO112959B1 (ro) 1998-02-27
DK0573473T3 (da) 1996-01-29
NO300591B1 (no) 1997-06-23

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