ATE131478T1 - 4-((2-benzothiazolyl)methylamino>-alpha-(3,4- difluorphenoxy)methyl-1-piperidenethanol - Google Patents

4-((2-benzothiazolyl)methylamino>-alpha-(3,4- difluorphenoxy)methyl-1-piperidenethanol

Info

Publication number
ATE131478T1
ATE131478T1 AT92905117T AT92905117T ATE131478T1 AT E131478 T1 ATE131478 T1 AT E131478T1 AT 92905117 T AT92905117 T AT 92905117T AT 92905117 T AT92905117 T AT 92905117T AT E131478 T1 ATE131478 T1 AT E131478T1
Authority
AT
Austria
Prior art keywords
piperidenethanol
difluorphenoxy
benzothiazolyl
methylamino
alpha
Prior art date
Application number
AT92905117T
Other languages
English (en)
Inventor
Raymond Antoine Stokbroekx
Gilbert Arthur Jules Grauwels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE131478T1 publication Critical patent/ATE131478T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Paper (AREA)
AT92905117T 1991-02-25 1992-02-14 4-((2-benzothiazolyl)methylamino>-alpha-(3,4- difluorphenoxy)methyl-1-piperidenethanol ATE131478T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65964591A 1991-02-25 1991-02-25

Publications (1)

Publication Number Publication Date
ATE131478T1 true ATE131478T1 (de) 1995-12-15

Family

ID=24646210

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92905117T ATE131478T1 (de) 1991-02-25 1992-02-14 4-((2-benzothiazolyl)methylamino>-alpha-(3,4- difluorphenoxy)methyl-1-piperidenethanol

Country Status (36)

Country Link
US (2) US5434168A (de)
EP (2) EP0501552A1 (de)
JP (1) JP2825652B2 (de)
KR (1) KR0165901B1 (de)
CN (3) CN1033454C (de)
AT (1) ATE131478T1 (de)
AU (1) AU649788B2 (de)
BG (1) BG62332B1 (de)
CA (1) CA2104000A1 (de)
CY (1) CY1924A (de)
CZ (1) CZ284705B6 (de)
DE (1) DE69206787T2 (de)
DK (1) DK0573473T3 (de)
DZ (1) DZ1560A1 (de)
EE (1) EE02983B1 (de)
ES (1) ES2083737T3 (de)
FI (1) FI933719A (de)
GR (1) GR3018692T3 (de)
HK (1) HK172296A (de)
HU (2) HUT67695A (de)
IE (1) IE69567B1 (de)
IL (3) IL113837A (de)
LV (1) LV11689B (de)
MA (1) MA22447A1 (de)
MX (1) MX9200777A (de)
NO (1) NO300591B1 (de)
NZ (2) NZ241592A (de)
PL (1) PL168791B1 (de)
RO (1) RO112959B1 (de)
RU (2) RU2106348C1 (de)
SK (1) SK278705B6 (de)
TN (1) TNSN92017A1 (de)
TW (1) TW218016B (de)
WO (1) WO1992014731A1 (de)
ZA (1) ZA921341B (de)
ZW (1) ZW1992A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (de) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
CN1160348A (zh) * 1994-10-14 1997-09-24 詹森药业有限公司 口服沙贝鲁唑悬浮液
PL320296A1 (en) * 1994-11-24 1997-09-15 Janssen Pharmaceutica Nv Intravenal lubeluzole solutions
WO1996032130A1 (en) * 1995-04-10 1996-10-17 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
EP0843674A1 (de) * 1995-10-25 1998-05-27 Janssen Pharmaceutica N.V. Lubezole n-oxide
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
GB9815785D0 (en) * 1998-07-20 1998-09-16 Cerebrus Ltd Chemical compounds
AU4537500A (en) * 1999-05-12 2000-12-05 Neurosearch A/S Ion channel modulating agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963732A (en) * 1973-05-30 1976-06-15 Tiberio Bruzzese Process for preparing dihydroxydiphenylmethane derivatives
US4310658A (en) * 1980-06-18 1982-01-12 Allied Corporation Production of polyester thermally stabilized with an oxirane
US4861785A (en) * 1984-12-03 1989-08-29 Janssen Pharmaceutica N.V. Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
US4689330A (en) * 1985-04-15 1987-08-25 Janssen Pharmaceutica N.V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
US4717760A (en) * 1986-07-10 1988-01-05 The Dow Chemical Company Fluorinated tris-epoxides based on triphenyl methane
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol

Also Published As

Publication number Publication date
DZ1560A1 (fr) 2002-02-17
JP2825652B2 (ja) 1998-11-18
HUT67695A (en) 1995-04-28
CN1033454C (zh) 1996-12-04
CY1924A (en) 1997-03-07
US5434168A (en) 1995-07-18
CN1064865A (zh) 1992-09-30
HU9302395D0 (en) 1993-11-29
HU211560A9 (en) 1995-12-28
SK278705B6 (sk) 1998-01-14
US5675027A (en) 1997-10-07
DE69206787D1 (de) 1996-01-25
IE920575A1 (en) 1992-08-26
CN1043609C (zh) 1999-06-16
PL168791B1 (pl) 1996-04-30
AU1208592A (en) 1992-09-15
IL100952A0 (en) 1992-11-15
TNSN92017A1 (fr) 1993-06-08
RO112959B1 (ro) 1998-02-27
JPH06505012A (ja) 1994-06-09
NO933010D0 (no) 1993-08-24
CN1117048A (zh) 1996-02-21
NZ248437A (en) 1994-07-26
NO300591B1 (no) 1997-06-23
RU95112519A (ru) 1997-04-20
IL113837A (en) 1996-05-14
HK172296A (en) 1996-09-20
IL113837A0 (en) 1995-08-31
EP0573473B1 (de) 1995-12-13
FI933719A0 (fi) 1993-08-24
LV11689B (en) 1997-08-20
RU2094434C1 (ru) 1997-10-27
CS51292A3 (en) 1992-09-16
DK0573473T3 (da) 1996-01-29
NZ241592A (en) 1994-07-26
ZA921341B (en) 1993-08-24
MX9200777A (es) 1992-08-01
ES2083737T3 (es) 1996-04-16
BG98068A (bg) 1994-06-30
FI933719A (fi) 1993-08-24
BG62332B1 (bg) 1999-08-31
TW218016B (de) 1993-12-21
CA2104000A1 (en) 1992-08-26
CN1113437A (zh) 1995-12-20
AU649788B2 (en) 1994-06-02
IL100952A (en) 1995-12-31
EE02983B1 (et) 1997-04-15
DE69206787T2 (de) 1996-06-05
EP0573473A1 (de) 1993-12-15
IE69567B1 (en) 1996-10-02
EP0501552A1 (de) 1992-09-02
ZW1992A1 (en) 1993-09-22
MA22447A1 (fr) 1992-10-01
NO933010L (no) 1993-08-24
LV11689A (lv) 1997-02-20
KR0165901B1 (en) 1999-01-15
CZ284705B6 (cs) 1999-02-17
WO1992014731A1 (en) 1992-09-03
RU2106348C1 (ru) 1998-03-10
GR3018692T3 (en) 1996-04-30

Similar Documents

Publication Publication Date Title
DE69008366T2 (de) 2-Aminopyrimidinon-Derivate.
DK0580502T3 (da) 3-(hydroxybenzylidenyl)-indolin-2-oner og farmaceutiske sammensætninger indeholdende disse
ATE131478T1 (de) 4-((2-benzothiazolyl)methylamino>-alpha-(3,4- difluorphenoxy)methyl-1-piperidenethanol
FI913433A0 (fi) Foerfarande foer foerhindrande eller begraensande av skada vid aoterstroemning av blod genom ett organ eller en vaevnad.
RU93053624A (ru) 4-[(2-БЕНЗОТИАЗОЛИЛ)МЕТИЛАМИНО] -α- [(3,4-ДИФТОРОФЕНОКСИ)МЕТИЛ]-1-ПИПЕРИДИНЭТАНОЛ, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ
NO910904L (no) Fremgangsmaate for fremstilling av en substituert aminforbindelse.
DK0398427T3 (da) Antirhinovirale pyridazinaminer
PT91613A (pt) Process for the preparation of antihypertensive 3-piperidinyl-indazole derivatives
AU5511394A (en) New (cyclohexyl)alkene compounds, processes for preparing them and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee