RU93053624A - 4-[(2-БЕНЗОТИАЗОЛИЛ)МЕТИЛАМИНО] -α- [(3,4-ДИФТОРОФЕНОКСИ)МЕТИЛ]-1-ПИПЕРИДИНЭТАНОЛ, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ - Google Patents
4-[(2-БЕНЗОТИАЗОЛИЛ)МЕТИЛАМИНО] -α- [(3,4-ДИФТОРОФЕНОКСИ)МЕТИЛ]-1-ПИПЕРИДИНЭТАНОЛ, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЕЕ ПОЛУЧЕНИЯInfo
- Publication number
- RU93053624A RU93053624A RU93053624/04A RU93053624A RU93053624A RU 93053624 A RU93053624 A RU 93053624A RU 93053624/04 A RU93053624/04 A RU 93053624/04A RU 93053624 A RU93053624 A RU 93053624A RU 93053624 A RU93053624 A RU 93053624A
- Authority
- RU
- Russia
- Prior art keywords
- preparation
- diphotorophenoxy
- piperidinethanol
- benzothiazolyl
- methylamino
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title 2
- -1 2-BENZOTHIAZOLYL Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 206010033799 Paralysis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000703 anti-shock Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Изобретение относится к соединению формулы (I), рацемической смеси (S)-формы и кислотно-аддитивным солям его, обладающему свойствами против удара или паралича. В изобретении рассматриваются фармацевтические композиции, содержащие это соединение в качестве активного ингредиента, способ его получения и фармацевтических композиций.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65964591A | 1991-02-25 | 1991-02-25 | |
| US659645 | 1991-02-25 | ||
| PCT/EP1992/000356 WO1992014731A1 (en) | 1991-02-25 | 1992-02-14 | 4-[(2-BENZOTHIAZOLYL)METHYLAMINO]-α-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINEETHANOL |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95112519/04A Division RU2106348C1 (ru) | 1991-02-25 | 1992-02-14 | [(3,4-дифторфенокси)метил]-оксиран, его рацемическая смесь или энантиомерно чистая (s)-форма и способ его получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93053624A true RU93053624A (ru) | 1996-05-20 |
| RU2094434C1 RU2094434C1 (ru) | 1997-10-27 |
Family
ID=24646210
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9293053624A RU2094434C1 (ru) | 1991-02-25 | 1992-02-14 | 4-[(2-бензтиазолил)метиламино]-альфа-[(3,4-дифторфенокси)метил]-1-пиперидинэтанол в виде рацемической смеси или (s)-формы или его фармацевтически приемлемая соль присоединения кислоты, способ его получения, фармацевтическая композиция, проявляющая противоинфарктное действие на мозговую ткань |
| RU95112519/04A RU2106348C1 (ru) | 1991-02-25 | 1992-02-14 | [(3,4-дифторфенокси)метил]-оксиран, его рацемическая смесь или энантиомерно чистая (s)-форма и способ его получения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95112519/04A RU2106348C1 (ru) | 1991-02-25 | 1992-02-14 | [(3,4-дифторфенокси)метил]-оксиран, его рацемическая смесь или энантиомерно чистая (s)-форма и способ его получения |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US5434168A (ru) |
| EP (2) | EP0573473B1 (ru) |
| JP (1) | JP2825652B2 (ru) |
| KR (1) | KR0165901B1 (ru) |
| CN (3) | CN1033454C (ru) |
| AT (1) | ATE131478T1 (ru) |
| AU (1) | AU649788B2 (ru) |
| BG (1) | BG62332B1 (ru) |
| CA (1) | CA2104000A1 (ru) |
| CY (1) | CY1924A (ru) |
| CZ (1) | CZ284705B6 (ru) |
| DE (1) | DE69206787T2 (ru) |
| DK (1) | DK0573473T3 (ru) |
| DZ (1) | DZ1560A1 (ru) |
| EE (1) | EE02983B1 (ru) |
| ES (1) | ES2083737T3 (ru) |
| FI (1) | FI933719A (ru) |
| GR (1) | GR3018692T3 (ru) |
| HK (1) | HK172296A (ru) |
| HU (2) | HUT67695A (ru) |
| IE (1) | IE69567B1 (ru) |
| IL (3) | IL100952A (ru) |
| LV (1) | LV11689B (ru) |
| MA (1) | MA22447A1 (ru) |
| MX (1) | MX9200777A (ru) |
| NO (1) | NO300591B1 (ru) |
| NZ (2) | NZ248437A (ru) |
| PL (1) | PL168791B1 (ru) |
| RO (1) | RO112959B1 (ru) |
| RU (2) | RU2094434C1 (ru) |
| SK (1) | SK278705B6 (ru) |
| TN (1) | TNSN92017A1 (ru) |
| TW (1) | TW218016B (ru) |
| WO (1) | WO1992014731A1 (ru) |
| ZA (1) | ZA921341B (ru) |
| ZW (1) | ZW1992A1 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
| TW282469B (ru) * | 1993-06-11 | 1996-08-01 | Janssen Pharmaceutica Nv | |
| NZ295132A (en) * | 1994-10-14 | 1998-06-26 | Janssen Pharmaceutica Nv | Sabeluzole aqueous suspension having ph from 8 to 10 |
| EP0794777A1 (en) * | 1994-11-24 | 1997-09-17 | Janssen Pharmaceutica N.V. | Lubeluzole intravenous solutions |
| JPH10501823A (ja) * | 1995-04-10 | 1998-02-17 | バクスター、インターナショナル、インコーポレイテッド | クモ膜下出血の治療における架橋ヘモグロビンの使用 |
| IL123083A0 (en) * | 1995-10-25 | 1998-09-24 | Janssen Pharmaceutica Nv | Lubeluzole n-oxides their preparation and pharmaceutical compositions containing them |
| US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| US6242198B1 (en) | 1996-07-25 | 2001-06-05 | Cambridge Neuroscience, Inc. | Methods of treatment of eye trauma and disorders |
| US6756389B2 (en) | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| GB9815785D0 (en) * | 1998-07-20 | 1998-09-16 | Cerebrus Ltd | Chemical compounds |
| ATE296814T1 (de) * | 1999-05-12 | 2005-06-15 | Neurosearch As | Ionenkanal modulierende mittel |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3963732A (en) * | 1973-05-30 | 1976-06-15 | Tiberio Bruzzese | Process for preparing dihydroxydiphenylmethane derivatives |
| US4310658A (en) * | 1980-06-18 | 1982-01-12 | Allied Corporation | Production of polyester thermally stabilized with an oxirane |
| CA1260474A (en) * | 1984-12-03 | 1989-09-26 | Raymond A. Stokbroekx | Benzoxazol- and benzothiazolamine derivatives |
| US4861785A (en) * | 1984-12-03 | 1989-08-29 | Janssen Pharmaceutica N.V. | Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents |
| KR930005004B1 (ko) * | 1985-04-15 | 1993-06-11 | 쟈안센 파아마슈우티카 엔. 부이. | 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법 |
| US4689330A (en) * | 1985-04-15 | 1987-08-25 | Janssen Pharmaceutica N.V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
| US4749702A (en) * | 1985-04-15 | 1988-06-07 | Janssen Pharmaceutica N. V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
| US4717760A (en) * | 1986-07-10 | 1988-01-05 | The Dow Chemical Company | Fluorinated tris-epoxides based on triphenyl methane |
| JPH0643426B2 (ja) * | 1986-07-25 | 1994-06-08 | 東京田辺製薬株式会社 | イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
| ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
-
1992
- 1992-02-10 ZW ZW19/92A patent/ZW1992A1/xx unknown
- 1992-02-11 NZ NZ24843792A patent/NZ248437A/xx unknown
- 1992-02-11 NZ NZ24159292A patent/NZ241592A/en unknown
- 1992-02-12 CN CN92101908A patent/CN1033454C/zh not_active Expired - Fee Related
- 1992-02-14 HU HU9302395A patent/HUT67695A/hu unknown
- 1992-02-14 RU RU9293053624A patent/RU2094434C1/ru active
- 1992-02-14 ES ES92905117T patent/ES2083737T3/es not_active Expired - Lifetime
- 1992-02-14 EP EP92905117A patent/EP0573473B1/en not_active Expired - Lifetime
- 1992-02-14 JP JP4504615A patent/JP2825652B2/ja not_active Expired - Fee Related
- 1992-02-14 DK DK92905117.5T patent/DK0573473T3/da active
- 1992-02-14 IL IL10095292A patent/IL100952A/en not_active IP Right Cessation
- 1992-02-14 AT AT92905117T patent/ATE131478T1/de not_active IP Right Cessation
- 1992-02-14 US US08/098,297 patent/US5434168A/en not_active Expired - Fee Related
- 1992-02-14 IL IL11383792A patent/IL113837A/en active IP Right Grant
- 1992-02-14 WO PCT/EP1992/000356 patent/WO1992014731A1/en active IP Right Grant
- 1992-02-14 DE DE69206787T patent/DE69206787T2/de not_active Expired - Fee Related
- 1992-02-14 AU AU12085/92A patent/AU649788B2/en not_active Ceased
- 1992-02-14 CA CA002104000A patent/CA2104000A1/en not_active Abandoned
- 1992-02-14 EP EP92200417A patent/EP0501552A1/en active Pending
- 1992-02-14 RU RU95112519/04A patent/RU2106348C1/ru not_active IP Right Cessation
- 1992-02-14 RO RO93-01147A patent/RO112959B1/ro unknown
- 1992-02-14 PL PL92300354A patent/PL168791B1/pl unknown
- 1992-02-20 TW TW081101226A patent/TW218016B/zh active
- 1992-02-21 SK SK512-92A patent/SK278705B6/sk unknown
- 1992-02-21 MA MA22735A patent/MA22447A1/fr unknown
- 1992-02-21 CZ CS92512A patent/CZ284705B6/cs not_active IP Right Cessation
- 1992-02-24 DZ DZ920018A patent/DZ1560A1/fr active
- 1992-02-24 IE IE920575A patent/IE69567B1/en not_active IP Right Cessation
- 1992-02-24 MX MX9200777A patent/MX9200777A/es not_active IP Right Cessation
- 1992-02-24 ZA ZA921341A patent/ZA921341B/xx unknown
- 1992-02-25 TN TNTNSN92017A patent/TNSN92017A1/fr unknown
-
1993
- 1993-08-23 KR KR1019930702525A patent/KR0165901B1/ko not_active IP Right Cessation
- 1993-08-24 FI FI933719A patent/FI933719A/fi unknown
- 1993-08-24 BG BG98068A patent/BG62332B1/bg unknown
- 1993-08-24 NO NO933010A patent/NO300591B1/no unknown
-
1994
- 1994-11-21 EE EE9400339A patent/EE02983B1/xx unknown
-
1995
- 1995-03-24 US US08/410,549 patent/US5675027A/en not_active Expired - Fee Related
- 1995-05-24 IL IL11383795A patent/IL113837A0/xx unknown
- 1995-05-30 CN CN95105632A patent/CN1043609C/zh not_active Expired - Fee Related
- 1995-05-30 CN CN95105633A patent/CN1117048A/zh active Pending
- 1995-06-21 HU HU95P/P00319P patent/HU211560A9/hu unknown
-
1996
- 1996-01-17 GR GR960400093T patent/GR3018692T3/el unknown
- 1996-08-13 LV LVP-96-334A patent/LV11689B/en unknown
- 1996-09-12 HK HK172296A patent/HK172296A/xx not_active IP Right Cessation
-
1997
- 1997-03-07 CY CY192497A patent/CY1924A/xx unknown
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