BG62213B1 - Нов метод за изолиране на клавуланова киселина и нейнитефармацевтично приемливи соли от ферментационна хранителна среда наstreptomyces sp. p 6621 ferm p 2804 - Google Patents

Нов метод за изолиране на клавуланова киселина и нейнитефармацевтично приемливи соли от ферментационна хранителна среда наstreptomyces sp. p 6621 ferm p 2804 Download PDF

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Publication number
BG62213B1
BG62213B1 BG100816A BG10081696A BG62213B1 BG 62213 B1 BG62213 B1 BG 62213B1 BG 100816 A BG100816 A BG 100816A BG 10081696 A BG10081696 A BG 10081696A BG 62213 B1 BG62213 B1 BG 62213B1
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BG
Bulgaria
Prior art keywords
clavulanic acid
water
fermentation
microfiltration
phase
Prior art date
Application number
BG100816A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100816A (en
Inventor
Egidij Capuder
Original Assignee
Lek Pharmaceutical And Chemical Co. D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20431337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62213(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Pharmaceutical And Chemical Co. D.D. filed Critical Lek Pharmaceutical And Chemical Co. D.D.
Publication of BG100816A publication Critical patent/BG100816A/xx
Publication of BG62213B1 publication Critical patent/BG62213B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Seasonings (AREA)
BG100816A 1994-03-02 1996-09-02 Нов метод за изолиране на клавуланова киселина и нейнитефармацевтично приемливи соли от ферментационна хранителна среда наstreptomyces sp. p 6621 ferm p 2804 BG62213B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9400107A SI9400107A (en) 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
PCT/SI1995/000002 WO1995023870A1 (en) 1994-03-02 1995-02-23 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804

Publications (2)

Publication Number Publication Date
BG100816A BG100816A (en) 1997-10-31
BG62213B1 true BG62213B1 (bg) 1999-05-31

Family

ID=20431337

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100816A BG62213B1 (bg) 1994-03-02 1996-09-02 Нов метод за изолиране на клавуланова киселина и нейнитефармацевтично приемливи соли от ферментационна хранителна среда наstreptomyces sp. p 6621 ferm p 2804

Country Status (25)

Country Link
US (4) US5780274A (no)
EP (1) EP0748387B1 (no)
JP (1) JP2948661B2 (no)
KR (1) KR100293172B1 (no)
CN (1) CN1055694C (no)
AT (1) ATE159549T1 (no)
AU (1) AU694176B2 (no)
BG (1) BG62213B1 (no)
CA (1) CA2184619A1 (no)
CZ (1) CZ284117B6 (no)
DE (1) DE69500925T2 (no)
DK (1) DK0748387T3 (no)
ES (1) ES2108572T3 (no)
FI (1) FI963408A (no)
GR (1) GR3025942T3 (no)
HU (1) HUT74944A (no)
NO (1) NO318374B1 (no)
NZ (1) NZ279958A (no)
PL (1) PL180520B1 (no)
RO (1) RO118760B1 (no)
RU (1) RU2206613C2 (no)
SI (1) SI9400107A (no)
SK (1) SK279780B6 (no)
WO (1) WO1995023870A1 (no)
ZA (1) ZA951689B (no)

Families Citing this family (21)

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AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500074A (en) † 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
CN1238776A (zh) * 1996-11-11 1999-12-15 吉斯特-布罗卡迪斯有限公司 制备棒酸盐和酯的方法
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
ATE187498T1 (de) 1997-03-24 1999-12-15 Cipan Comp Ind Prod Verfahren zur isolierung eines pharmazeutisch verträglichen alkalimetallsalzes der clavulansäure
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
EP1165049B2 (en) * 1999-04-01 2011-07-06 DSM IP Assets B.V. Agglomerates by crystallisation
CA2408853C (en) 2000-05-13 2012-01-10 Smithkline Beecham P.L.C. Process
GB0022841D0 (en) * 2000-09-18 2000-11-01 Smithkline Beecham Plc Process
KR100443082B1 (ko) * 2002-10-18 2004-08-04 삼성전자주식회사 반도체 장치의 트랜지스터 제조 방법
KR100768476B1 (ko) 2005-11-24 2007-10-18 한국해양연구원 항암물질을 생산하는 방선균 스트렙토마이세스 속 균주,이의 분리방법, 이로부터 반고형 추출물을 제조하는 방법,이로부터 유래한 반고형 추출물 및 이를 이용한 항암제조성물
CN102838624B (zh) * 2012-09-07 2014-10-29 安徽普朗膜技术有限公司 一种从发酵液中纯化克拉维酸的方法
CN104910194A (zh) * 2015-05-28 2015-09-16 高希章 一种克拉维酸钾的制备方法及其复方制剂

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Also Published As

Publication number Publication date
US6566106B2 (en) 2003-05-20
BG100816A (en) 1997-10-31
FI963408A0 (fi) 1996-09-02
EP0748387B1 (en) 1997-10-22
US20010007761A1 (en) 2001-07-12
ZA951689B (en) 1995-12-11
HU9602351D0 (en) 1996-10-28
PL180520B1 (pl) 2001-02-28
JP2948661B2 (ja) 1999-09-13
JPH09504702A (ja) 1997-05-13
US5780274A (en) 1998-07-14
CN1055694C (zh) 2000-08-23
SK112096A3 (en) 1997-02-05
GR3025942T3 (en) 1998-04-30
NO318374B1 (no) 2005-03-14
AU1724195A (en) 1995-09-18
DE69500925D1 (de) 1997-11-27
NZ279958A (en) 1997-04-24
KR100293172B1 (ko) 2001-06-15
NO963628D0 (no) 1996-08-30
SK279780B6 (sk) 1999-03-12
ES2108572T3 (es) 1997-12-16
ATE159549T1 (de) 1997-11-15
CN1143388A (zh) 1997-02-19
AU694176B2 (en) 1998-07-16
DK0748387T3 (da) 1998-05-25
CZ284117B6 (cs) 1998-08-12
US6207428B1 (en) 2001-03-27
CA2184619A1 (en) 1995-09-08
SI9400107A (en) 1995-10-31
RO118760B1 (ro) 2003-10-30
US5985625A (en) 1999-11-16
DE69500925T2 (de) 1998-02-12
RU2206613C2 (ru) 2003-06-20
WO1995023870A1 (en) 1995-09-08
EP0748387A1 (en) 1996-12-18
CZ255796A3 (en) 1996-12-11
HUT74944A (en) 1997-03-28
PL316085A1 (en) 1996-12-23
FI963408A (fi) 1996-10-30
KR970701786A (ko) 1997-04-12
NO963628L (no) 1996-10-17

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