SI9400107A - New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. - Google Patents

New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. Download PDF

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Publication number
SI9400107A
SI9400107A SI9400107A SI9400107A SI9400107A SI 9400107 A SI9400107 A SI 9400107A SI 9400107 A SI9400107 A SI 9400107A SI 9400107 A SI9400107 A SI 9400107A SI 9400107 A SI9400107 A SI 9400107A
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SI
Slovenia
Prior art keywords
clavulanic acid
water
organic phase
fermentation broth
ethyl acetate
Prior art date
Application number
SI9400107A
Other languages
English (en)
Slovenian (sl)
Inventor
Egidij Capuder
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20431337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9400107(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Priority to SI9400107A priority Critical patent/SI9400107A/sl
Priority to NZ279958A priority patent/NZ279958A/en
Priority to CZ962557A priority patent/CZ284117B6/cs
Priority to EP95909194A priority patent/EP0748387B1/en
Priority to DE69500925T priority patent/DE69500925T2/de
Priority to RO96-01735A priority patent/RO118760B1/ro
Priority to AT95909194T priority patent/ATE159549T1/de
Priority to HU9602351A priority patent/HUT74944A/hu
Priority to AU17241/95A priority patent/AU694176B2/en
Priority to US08/632,402 priority patent/US5780274A/en
Priority to CN95191927A priority patent/CN1055694C/zh
Priority to RU96121357/13A priority patent/RU2206613C2/ru
Priority to KR1019960704806A priority patent/KR100293172B1/ko
Priority to DK95909194.3T priority patent/DK0748387T3/da
Priority to PCT/SI1995/000002 priority patent/WO1995023870A1/en
Priority to SK1120-96A priority patent/SK279780B6/sk
Priority to ES95909194T priority patent/ES2108572T3/es
Priority to JP7522554A priority patent/JP2948661B2/ja
Priority to PL95316085A priority patent/PL180520B1/pl
Priority to CA002184619A priority patent/CA2184619A1/en
Priority to ZA951689A priority patent/ZA951689B/xx
Publication of SI9400107A publication Critical patent/SI9400107A/sl
Priority to NO19963628A priority patent/NO318374B1/no
Priority to FI963408A priority patent/FI963408A/fi
Priority to BG100816A priority patent/BG62213B1/bg
Priority to GR980400112T priority patent/GR3025942T3/el
Priority to US09/113,790 priority patent/US5985625A/en
Priority to US09/415,483 priority patent/US6207428B1/en
Priority to US09/754,231 priority patent/US6566106B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Seasonings (AREA)
SI9400107A 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. SI9400107A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SI9400107A SI9400107A (en) 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
CA002184619A CA2184619A1 (en) 1994-03-02 1995-02-23 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
KR1019960704806A KR100293172B1 (ko) 1994-03-02 1995-02-23 스트렙토마이세스sp. P6621 FERM P2804의 발효액으로부터 클라불란산과 제약학적으로 허용가능한 이들의 염을 단리하는 신규한 방법
PCT/SI1995/000002 WO1995023870A1 (en) 1994-03-02 1995-02-23 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
EP95909194A EP0748387B1 (en) 1994-03-02 1995-02-23 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
DE69500925T DE69500925T2 (de) 1994-03-02 1995-02-23 Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804
RO96-01735A RO118760B1 (ro) 1994-03-02 1995-02-23 Procedeu pentru izolarea acidului clavulanic şi a sărurilor acestuia, acceptabile farmaceutic, din bulionul de fermentaţie al streptomyces sp. p 6621 ferm p 2804
AT95909194T ATE159549T1 (de) 1994-03-02 1995-02-23 Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804
HU9602351A HUT74944A (en) 1994-03-02 1995-02-23 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
AU17241/95A AU694176B2 (en) 1994-03-02 1995-02-23 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
US08/632,402 US5780274A (en) 1994-03-02 1995-02-23 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804
CN95191927A CN1055694C (zh) 1994-03-02 1995-02-23 分离棒酸及其药学上可接受的盐的新方法
RU96121357/13A RU2206613C2 (ru) 1994-03-02 1995-02-23 Способ выделения клавулановой кислоты
NZ279958A NZ279958A (en) 1994-03-02 1995-02-23 Isolation of clavulanic acid from the fermentation broth of streptomyces sp p 6621
DK95909194.3T DK0748387T3 (da) 1994-03-02 1995-02-23 Fremgangsmåde til isolation af clavulansyre og farmaceutisk acceptable salte deraf fra fermenteringsvæsken af Streptomyces sp. P 6621 FERM P 2804
CZ962557A CZ284117B6 (cs) 1994-03-02 1995-02-23 Způsob izolace kyseliny klavulanové a jejich farmaceuticky přijatelných solí z fermentačního prostředí Streptomyces SP. P 6621 FERM P 2804
SK1120-96A SK279780B6 (sk) 1994-03-02 1995-02-23 Spôsob izolácie kyseliny klavulánovej a jej farmac
ES95909194T ES2108572T3 (es) 1994-03-02 1995-02-23 Procedimiento para el aislamiento de acido clavulanico y de sales farmaceuticamente aceptables de este a partir del caldo de fermentacion de streptomyces sp p 6621 ferm p 2804.
JP7522554A JP2948661B2 (ja) 1994-03-02 1995-02-23 ストレプトミセス ｓｐ． Ｐ ６６２１ ＦＥＲＭ Ｐ ２８０４の発酵培養液からクラブラン酸及びその薬剤学的に応用可能な塩を分離する新規な方法
PL95316085A PL180520B1 (pl) 1994-03-02 1995-02-23 Sposób wyodrebniania kwasu klawulanowego z brzeczki fermentacyjnej po fermentacji z uzyciem mikroorganizmu wytwarzajacego kwas klawulanowy PL PL PL PL PL PL PL
ZA951689A ZA951689B (en) 1994-03-02 1995-03-01 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp P 6621 FERM P 2804
NO19963628A NO318374B1 (no) 1994-03-02 1996-08-30 Fremgangsmate for isolering av klavulansyre fra et vandig fermenteringsmedium
FI963408A FI963408A (fi) 1994-03-02 1996-09-02 Uusi menetelmä klavulaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen eristämiseksi Streptomyces sp. P 6621 FERM 2804 fermentointiliemestä
BG100816A BG62213B1 (bg) 1994-03-02 1996-09-02 Нов метод за изолиране на клавуланова киселина и нейнитефармацевтично приемливи соли от ферментационна хранителна среда наstreptomyces sp. p 6621 ferm p 2804
GR980400112T GR3025942T3 (en) 1994-03-02 1998-01-16 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
US09/113,790 US5985625A (en) 1994-03-02 1998-07-10 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804
US09/415,483 US6207428B1 (en) 1994-03-02 1999-10-08 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804
US09/754,231 US6566106B2 (en) 1994-03-02 2001-01-03 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9400107A SI9400107A (en) 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.

Publications (1)

Publication Number Publication Date
SI9400107A true SI9400107A (en) 1995-10-31

Family

ID=20431337

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9400107A SI9400107A (en) 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.

Country Status (25)

Country Link
US (4) US5780274A (no)
EP (1) EP0748387B1 (no)
JP (1) JP2948661B2 (no)
KR (1) KR100293172B1 (no)
CN (1) CN1055694C (no)
AT (1) ATE159549T1 (no)
AU (1) AU694176B2 (no)
BG (1) BG62213B1 (no)
CA (1) CA2184619A1 (no)
CZ (1) CZ284117B6 (no)
DE (1) DE69500925T2 (no)
DK (1) DK0748387T3 (no)
ES (1) ES2108572T3 (no)
FI (1) FI963408A (no)
GR (1) GR3025942T3 (no)
HU (1) HUT74944A (no)
NO (1) NO318374B1 (no)
NZ (1) NZ279958A (no)
PL (1) PL180520B1 (no)
RO (1) RO118760B1 (no)
RU (1) RU2206613C2 (no)
SI (1) SI9400107A (no)
SK (1) SK279780B6 (no)
WO (1) WO1995023870A1 (no)
ZA (1) ZA951689B (no)

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SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
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SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
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AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
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KR100768476B1 (ko) 2005-11-24 2007-10-18 한국해양연구원 항암물질을 생산하는 방선균 스트렙토마이세스 속 균주,이의 분리방법, 이로부터 반고형 추출물을 제조하는 방법,이로부터 유래한 반고형 추출물 및 이를 이용한 항암제조성물
CN102838624B (zh) * 2012-09-07 2014-10-29 安徽普朗膜技术有限公司 一种从发酵液中纯化克拉维酸的方法
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NO963628D0 (no) 1996-08-30
CA2184619A1 (en) 1995-09-08
WO1995023870A1 (en) 1995-09-08
FI963408A0 (fi) 1996-09-02
US5985625A (en) 1999-11-16
EP0748387A1 (en) 1996-12-18
CZ255796A3 (en) 1996-12-11
KR970701786A (ko) 1997-04-12
KR100293172B1 (ko) 2001-06-15
HUT74944A (en) 1997-03-28
DE69500925D1 (de) 1997-11-27
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CN1055694C (zh) 2000-08-23
US6566106B2 (en) 2003-05-20
NO318374B1 (no) 2005-03-14
PL180520B1 (pl) 2001-02-28
RO118760B1 (ro) 2003-10-30
US20010007761A1 (en) 2001-07-12
FI963408A (fi) 1996-10-30
ATE159549T1 (de) 1997-11-15
US5780274A (en) 1998-07-14
AU1724195A (en) 1995-09-18
BG100816A (en) 1997-10-31
US6207428B1 (en) 2001-03-27
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