BG62211B1 - Нови стероиди - Google Patents

Нови стероиди Download PDF

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Publication number
BG62211B1
BG62211B1 BG97971A BG9797193A BG62211B1 BG 62211 B1 BG62211 B1 BG 62211B1 BG 97971 A BG97971 A BG 97971A BG 9797193 A BG9797193 A BG 9797193A BG 62211 B1 BG62211 B1 BG 62211B1
Authority
BG
Bulgaria
Prior art keywords
compound
formula
dione
epimer
compound according
Prior art date
Application number
BG97971A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG97971A (bg
Inventor
Paul Andersson
Bengt Axelsson
Ralph Brattsand
Arne Thalen
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of BG97971A publication Critical patent/BG97971A/bg
Publication of BG62211B1 publication Critical patent/BG62211B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG97971A 1991-02-04 1993-07-20 Нови стероиди BG62211B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9100341A SE9100341D0 (sv) 1991-02-04 1991-02-04 Novel steroids
PCT/SE1992/000055 WO1992013872A1 (en) 1991-02-04 1992-01-29 Novel steroids

Publications (2)

Publication Number Publication Date
BG97971A BG97971A (bg) 1994-04-29
BG62211B1 true BG62211B1 (bg) 1999-05-31

Family

ID=20381806

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97971A BG62211B1 (bg) 1991-02-04 1993-07-20 Нови стероиди

Country Status (39)

Country Link
US (2) US5674861A (cs)
EP (1) EP0570454B1 (cs)
JP (1) JPH06505232A (cs)
KR (1) KR100216720B1 (cs)
CN (3) CN1034868C (cs)
AP (1) AP366A (cs)
AT (1) ATE178611T1 (cs)
BG (1) BG62211B1 (cs)
CA (1) CA2103924A1 (cs)
CZ (1) CZ281685B6 (cs)
DE (1) DE69228870T2 (cs)
DK (1) DK0570454T3 (cs)
DZ (1) DZ1553A1 (cs)
EE (1) EE03111B1 (cs)
ES (1) ES2133315T3 (cs)
FI (1) FI933450A7 (cs)
GR (1) GR3030657T3 (cs)
HU (1) HU218275B (cs)
IE (1) IE920166A1 (cs)
IL (1) IL100532A (cs)
IS (1) IS1601B (cs)
MA (1) MA22406A1 (cs)
MX (1) MX9200324A (cs)
NO (1) NO304073B1 (cs)
NZ (1) NZ241210A (cs)
PH (1) PH31284A (cs)
PL (1) PL170000B1 (cs)
PT (1) PT100086B (cs)
RO (1) RO111195B1 (cs)
RU (1) RU2111212C1 (cs)
SE (1) SE9100341D0 (cs)
SG (1) SG52557A1 (cs)
SI (1) SI9210065B (cs)
SK (1) SK281801B6 (cs)
TN (1) TNSN92007A1 (cs)
UA (1) UA41267C2 (cs)
WO (1) WO1992013872A1 (cs)
YU (1) YU48892B (cs)
ZA (1) ZA92233B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
JP3366640B2 (ja) * 1993-01-08 2003-01-14 アストラ・アクチエボラーグ 新規な結腸−または回腸−特異的ステロイド誘導体
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5983956A (en) 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009607D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medical compositions
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
GB0110411D0 (en) * 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
CA2459880A1 (en) * 2001-09-25 2003-04-03 Pharmacia And Upjohn Company Stereoselective transacetalization of steroidal c-22 acetonide
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
RS20050006A (sr) 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., NOVA JEDINjENjA, KOMPOZICIJE KAO NOSAČI ZA STEROIDNE/NE- STEROIDNE- ANTI-INFLAMATORNE, ANTINEOPLASTIČNE I ANTIVIRALNE AKTIVNE MOLEKULE
AU2003265576A1 (en) * 2002-08-23 2004-03-11 The Mclean Hospital Corporation Corticosteroid conjugates and uses thereof
TW200417371A (en) * 2003-02-21 2004-09-16 Upjohn Co A continuous process for the production of R-rofleponide
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
RU2253453C1 (ru) * 2004-03-15 2005-06-10 Общество с ограниченной ответственностью "ЮНАЛ" Противовоспалительная и антиаллергическая композиция
BRPI0517024A (pt) 2004-10-27 2008-03-25 Glaxosmithkline Zagreb conjugados com atividade antiinflamatória
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
WO2007008155A1 (en) * 2005-07-11 2007-01-18 Astrazeneca Ab New combination 1
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378110B (cs) * 1972-05-19 1975-08-18 Bofors Ab
SE378109B (cs) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
CN1060471A (zh) * 1985-04-04 1992-04-22 得拉科公司 新的16，17-缩醛取代雄甾烷-17β-酮类的制备方法
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
HU203562B (en) * 1989-03-09 1991-08-28 Richter Gedeon Vegyeszet Process for producing new steroide diols and pharmaceutical compositions containing them
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters

Also Published As

Publication number Publication date
AU661471B2 (en) 1995-07-27
CZ281685B6 (cs) 1996-12-11
NO304073B1 (no) 1998-10-19
AU1230792A (en) 1992-09-07
NO932761D0 (no) 1993-08-02
CN1064079A (zh) 1992-09-02
RU2111212C1 (ru) 1998-05-20
SK79693A3 (en) 1994-03-09
IE920166A1 (en) 1992-08-12
CN1140178A (zh) 1997-01-15
SG52557A1 (en) 1998-09-28
IL100532A0 (en) 1992-09-06
CN1058724C (zh) 2000-11-22
CA2103924A1 (en) 1992-08-05
PT100086A (pt) 1994-05-31
TNSN92007A1 (fr) 1993-06-08
RO111195B1 (ro) 1996-07-30
EE03111B1 (et) 1998-08-17
IS3808A (is) 1992-08-05
EP0570454A1 (en) 1993-11-24
NO932761L (no) 1993-08-02
ES2133315T3 (es) 1999-09-16
NZ241210A (en) 1993-08-26
GR3030657T3 (en) 1999-10-29
DE69228870T2 (de) 1999-08-19
FI933450L (fi) 1993-08-03
SE9100341D0 (sv) 1991-02-04
YU48892B (sh) 2002-10-18
BG97971A (bg) 1994-04-29
PT100086B (pt) 1999-06-30
AP9200353A0 (en) 1992-01-31
WO1992013872A1 (en) 1992-08-20
YU6592A (sh) 1995-01-31
SI9210065A (en) 1995-02-28
IS1601B (is) 1996-10-18
DK0570454T3 (da) 1999-10-18
DE69228870D1 (de) 1999-05-12
PL170000B1 (pl) 1996-10-31
ATE178611T1 (de) 1999-04-15
MX9200324A (es) 1992-09-01
US5674861A (en) 1997-10-07
PH31284A (en) 1998-07-06
HU218275B (en) 2000-07-28
ZA92233B (en) 1992-10-28
US5939409A (en) 1999-08-17
CN1034868C (zh) 1997-05-14
HUT64973A (en) 1994-03-28
HK1010733A1 (en) 1999-06-25
DZ1553A1 (fr) 2002-02-17
KR100216720B1 (ko) 1999-10-01
CN1140059A (zh) 1997-01-15
IL100532A (en) 1996-05-14
SI9210065B (en) 2001-12-31
EP0570454B1 (en) 1999-04-07
FI933450A0 (fi) 1993-08-03
HU9302244D0 (en) 1993-10-28
CZ149693A3 (en) 1994-03-16
UA41267C2 (uk) 2001-09-17
AP366A (en) 1994-10-21
JPH06505232A (ja) 1994-06-16
CN1052155C (zh) 2000-05-10
FI933450A7 (fi) 1993-08-03
MA22406A1 (fr) 1992-10-01
SK281801B6 (sk) 2001-08-06

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