BRPI0517024A - conjugados com atividade antiinflamatória - Google Patents
conjugados com atividade antiinflamatóriaInfo
- Publication number
- BRPI0517024A BRPI0517024A BRPI0517024-9A BRPI0517024A BRPI0517024A BR PI0517024 A BRPI0517024 A BR PI0517024A BR PI0517024 A BRPI0517024 A BR PI0517024A BR PI0517024 A BRPI0517024 A BR PI0517024A
- Authority
- BR
- Brazil
- Prior art keywords
- inflammatory activity
- steroid
- xiii
- nonsteroidal
- substructure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
CONJUGADOS COM ATIVIDADE ANTIINFLAMATóRIA A presente invenção refere-se a novos Compostos representados pela Fórmula I: onde M representa uma subunidade macrolida da subestrutura VIII: L representa a cadeia da subestrutura IX ou XIII: Z representa a subunidade esteróide ou não esteroidal derivada de drogas esteróides ou não esteroidais (NSAID) com atividade antiinflamatória. A presente invenção refere-se ainda aos sais farmaceuticamente aceitáveis e solvatos de tais Compostos preparados, a processos e intermediários para sua preparação, bem como a ação terapêutica melhorada e ao uso no tratamento de doenças e condições inflamatórias em humanos e animais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62315404P | 2004-10-27 | 2004-10-27 | |
PCT/IB2005/003213 WO2006046123A2 (en) | 2004-10-27 | 2005-10-27 | Conjugates with anti-inflammatory activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0517024A true BRPI0517024A (pt) | 2008-03-25 |
Family
ID=36097295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517024-9A BRPI0517024A (pt) | 2004-10-27 | 2005-10-27 | conjugados com atividade antiinflamatória |
Country Status (17)
Country | Link |
---|---|
US (1) | US20090048221A1 (pt) |
EP (2) | EP1805202B1 (pt) |
JP (1) | JP2008517993A (pt) |
KR (1) | KR20070083811A (pt) |
CN (1) | CN101090908A (pt) |
AT (1) | ATE453658T1 (pt) |
AU (1) | AU2005298312A1 (pt) |
BR (1) | BRPI0517024A (pt) |
CA (1) | CA2585711A1 (pt) |
DE (1) | DE602005018672D1 (pt) |
ES (1) | ES2337915T3 (pt) |
IL (1) | IL182694A0 (pt) |
MX (1) | MX2007005073A (pt) |
NO (1) | NO20072684L (pt) |
RU (1) | RU2007119577A (pt) |
WO (1) | WO2006046123A2 (pt) |
ZA (1) | ZA200702579B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2337915T3 (es) * | 2004-10-27 | 2010-04-30 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Conjugados con adtividad antiinflamatoria. |
FR2909876A1 (fr) * | 2006-12-19 | 2008-06-20 | Galderma Res & Dev S N C Snc | Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques |
CN101708338B (zh) * | 2008-12-26 | 2014-06-04 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 含甾体结构的前药及其高度分散制剂 |
KR101245078B1 (ko) * | 2010-11-11 | 2013-03-18 | 부산대학교 산학협력단 | 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 |
CA2908620A1 (en) | 2013-04-10 | 2014-10-16 | Probiotic Pharmaceuticals Aps | Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect |
JP2020517748A (ja) | 2017-04-20 | 2020-06-18 | ライジング タイド ファウンデーション | 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体 |
US11427606B2 (en) | 2017-04-20 | 2022-08-30 | Rising Tide Foundation | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
RS64436B1 (sr) | 2018-09-14 | 2023-09-29 | Enlitisa Shanghai Pharmaceutical Co Ltd | Konjugati montelukasta i peptida |
CN111170959A (zh) * | 2019-12-30 | 2020-05-19 | 南开大学 | 一种大环内酯化合物的晶型及其制备方法与用途 |
CN112521398B (zh) * | 2020-07-30 | 2022-03-15 | 上海交通大学医学院附属仁济医院 | 一种海绵共附生菌来源开环重排甾体化合物及其制备方法与应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0257956B2 (en) | 1986-08-19 | 2000-11-22 | Genentech, Inc. | Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion |
DE3860503D1 (de) | 1987-09-03 | 1990-10-04 | Pliva Pharm & Chem Works | 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung. |
SE9100341D0 (sv) | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
SE9100342D0 (sv) | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroid esters |
GB9225923D0 (en) | 1992-12-11 | 1993-02-03 | Rhone Poulenc Rorer Ltd | New compositions of matter |
CA2149777C (en) | 1992-12-24 | 2004-05-25 | Michael John Ashton | New steroids |
WO1996004920A1 (fr) | 1994-08-12 | 1996-02-22 | Taisho Pharmaceutical Co., Ltd. | Inhibiteur de production de l'interleukine-5 |
KR970704455A (ko) | 1994-08-12 | 1997-09-06 | 우에하라 아끼라 | 인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor) |
DE19616573C2 (de) | 1996-04-25 | 1999-03-04 | Pari Gmbh | Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase |
JP3530004B2 (ja) | 1998-02-06 | 2004-05-24 | 株式会社日立ユニシアオートモティブ | 吸入式投薬器 |
WO2000025776A1 (en) | 1998-10-30 | 2000-05-11 | Nitromed, Inc. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
IT1306205B1 (it) | 1999-01-15 | 2001-05-30 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
HRP20000310A2 (en) | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
FI110835B (fi) | 2000-07-11 | 2003-03-31 | Radiolinja Ab | Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla |
HRP20010018A2 (en) * | 2001-01-09 | 2002-12-31 | Pliva D D | Novel anti-inflammatory compounds |
US20050171342A1 (en) | 2002-02-15 | 2005-08-04 | Michael Burnet | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
PL374646A1 (en) | 2002-07-08 | 2005-10-31 | Pliva-Istrazivacki Institutt D.O.O. | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
EP1551865B1 (en) | 2002-07-08 | 2009-04-22 | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. | Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules |
CA2489402A1 (en) | 2002-07-08 | 2004-01-15 | Pliva-Istrazivacki Institut D.O.O. | New compounds, compositions and methods for treatment of inflammatory diseases and conditions |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
BRPI0514254A (pt) * | 2004-08-12 | 2008-06-03 | Glaxosmithkline Zagreb | uso de conjugados célula-especìficos para o tratamento de doenças inflamatórias do trato gastrintestinal |
ES2337915T3 (es) * | 2004-10-27 | 2010-04-30 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Conjugados con adtividad antiinflamatoria. |
-
2005
- 2005-10-27 ES ES05824103T patent/ES2337915T3/es active Active
- 2005-10-27 AU AU2005298312A patent/AU2005298312A1/en not_active Abandoned
- 2005-10-27 RU RU2007119577/04A patent/RU2007119577A/ru not_active Application Discontinuation
- 2005-10-27 AT AT05824103T patent/ATE453658T1/de not_active IP Right Cessation
- 2005-10-27 DE DE602005018672T patent/DE602005018672D1/de active Active
- 2005-10-27 EP EP05824103A patent/EP1805202B1/en active Active
- 2005-10-27 EP EP09075144A patent/EP2196469A1/en not_active Withdrawn
- 2005-10-27 CN CNA2005800451452A patent/CN101090908A/zh active Pending
- 2005-10-27 US US11/718,505 patent/US20090048221A1/en not_active Abandoned
- 2005-10-27 WO PCT/IB2005/003213 patent/WO2006046123A2/en active Application Filing
- 2005-10-27 BR BRPI0517024-9A patent/BRPI0517024A/pt not_active IP Right Cessation
- 2005-10-27 KR KR1020077009486A patent/KR20070083811A/ko not_active Application Discontinuation
- 2005-10-27 JP JP2007538531A patent/JP2008517993A/ja not_active Withdrawn
- 2005-10-27 CA CA002585711A patent/CA2585711A1/en not_active Abandoned
- 2005-10-27 MX MX2007005073A patent/MX2007005073A/es unknown
-
2007
- 2007-03-28 ZA ZA200702579A patent/ZA200702579B/xx unknown
- 2007-04-19 IL IL182694A patent/IL182694A0/en unknown
- 2007-05-25 NO NO20072684A patent/NO20072684L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2005298312A1 (en) | 2006-05-04 |
EP1805202B1 (en) | 2009-12-30 |
NO20072684L (no) | 2007-07-11 |
CA2585711A1 (en) | 2006-05-04 |
CN101090908A (zh) | 2007-12-19 |
US20090048221A1 (en) | 2009-02-19 |
JP2008517993A (ja) | 2008-05-29 |
KR20070083811A (ko) | 2007-08-24 |
MX2007005073A (es) | 2007-06-25 |
ATE453658T1 (de) | 2010-01-15 |
ES2337915T3 (es) | 2010-04-30 |
WO2006046123A2 (en) | 2006-05-04 |
IL182694A0 (en) | 2007-09-20 |
ZA200702579B (en) | 2008-08-27 |
EP1805202A2 (en) | 2007-07-11 |
DE602005018672D1 (de) | 2010-02-11 |
RU2007119577A (ru) | 2008-12-10 |
EP2196469A1 (en) | 2010-06-16 |
WO2006046123A3 (en) | 2006-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |