NO20072684L - Konjugater med anti-inflammatorisk aktivitet - Google Patents

Konjugater med anti-inflammatorisk aktivitet

Info

Publication number
NO20072684L
NO20072684L NO20072684A NO20072684A NO20072684L NO 20072684 L NO20072684 L NO 20072684L NO 20072684 A NO20072684 A NO 20072684A NO 20072684 A NO20072684 A NO 20072684A NO 20072684 L NO20072684 L NO 20072684L
Authority
NO
Norway
Prior art keywords
inflammatory activity
steroid
xiii
nonsteroidal
substructure
Prior art date
Application number
NO20072684A
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Linda Tomaskovic
Stribor Markovic
Visnja Poljak
Gordana Sijan
Selvira Selmani
Original Assignee
Glaxosmithkline Zagreb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb
Publication of NO20072684L publication Critical patent/NO20072684L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det foreliggende oppfinnelsen vedrører nye forbindelser representert ved formel 1: hvor m representerer en makrolid subenhet av substrukturen VIII: L representerer kjeden i substrukturen IX eller XIII: -X1-(CH2)m-Q-(CH2)n-X2- IX -X1-(CH2)m-V-(CH2)p-Q-(CH2)n-X2- XIII Z representerer steroidet eller den ikke-steroide subenheten som er utledet fra steroide eller ikke-steroide (NSAID) medikamenter med antiinflammatorisk aktivitet. Den foreliggende oppfinnelsen vedrører også farmasøytisk akseptable salter og oppløsninger av slike tillagede forbindelser, til prosess og intermediater for deres tillaging, så vel som den forbedrede terapeutiske virkningen og anvendelsen i behandlingen av inflammatoriske sykdommer og tilstander hos mennesker og dyr.
NO20072684A 2004-10-27 2007-05-25 Konjugater med anti-inflammatorisk aktivitet NO20072684L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62315404P 2004-10-27 2004-10-27
PCT/IB2005/003213 WO2006046123A2 (en) 2004-10-27 2005-10-27 Conjugates with anti-inflammatory activity

Publications (1)

Publication Number Publication Date
NO20072684L true NO20072684L (no) 2007-07-11

Family

ID=36097295

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072684A NO20072684L (no) 2004-10-27 2007-05-25 Konjugater med anti-inflammatorisk aktivitet

Country Status (17)

Country Link
US (1) US20090048221A1 (no)
EP (2) EP1805202B1 (no)
JP (1) JP2008517993A (no)
KR (1) KR20070083811A (no)
CN (1) CN101090908A (no)
AT (1) ATE453658T1 (no)
AU (1) AU2005298312A1 (no)
BR (1) BRPI0517024A (no)
CA (1) CA2585711A1 (no)
DE (1) DE602005018672D1 (no)
ES (1) ES2337915T3 (no)
IL (1) IL182694A0 (no)
MX (1) MX2007005073A (no)
NO (1) NO20072684L (no)
RU (1) RU2007119577A (no)
WO (1) WO2006046123A2 (no)
ZA (1) ZA200702579B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007005073A (es) * 2004-10-27 2007-06-25 Glaxosmithkline Zagreb Conjugados con actividad antiinflamtoria.
FR2909876A1 (fr) * 2006-12-19 2008-06-20 Galderma Res & Dev S N C Snc Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques
CN101708338B (zh) * 2008-12-26 2014-06-04 中国人民解放军军事医学科学院放射与辐射医学研究所 含甾体结构的前药及其高度分散制剂
KR101245078B1 (ko) * 2010-11-11 2013-03-18 부산대학교 산학협력단 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물
US20160031925A1 (en) 2013-04-10 2016-02-04 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
CN110799516A (zh) 2017-04-20 2020-02-14 来兴泰德基金会 作为抗癌剂的包含鏻离子的阿奇霉素衍生物
US11427606B2 (en) 2017-04-20 2022-08-30 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
EP4253404A3 (en) 2018-09-14 2023-12-13 EnliTISA (Shanghai) Pharmaceutical Co., Ltd. Conjugates of montelukast and peptides
CN111170959A (zh) * 2019-12-30 2020-05-19 南开大学 一种大环内酯化合物的晶型及其制备方法与用途
CN112521398B (zh) * 2020-07-30 2022-03-15 上海交通大学医学院附属仁济医院 一种海绵共附生菌来源开环重排甾体化合物及其制备方法与应用

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EP0257956B2 (en) 1986-08-19 2000-11-22 Genentech, Inc. Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion
EP0283055B1 (en) 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. 10-dihydro-10-deoxo-11-azaerythronolide-a-compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
ES2107806T3 (es) 1992-12-24 1997-12-01 Rhone Poulenc Rorer Ltd Nuevos esteroides.
EP0775489A4 (en) 1994-08-12 1998-05-06 Taisho Pharmaceutical Co Ltd INTERLEUKIN-5 PRODUCTION INHIBITOR
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JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
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HRP20000310A2 (en) 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
FI110835B (fi) 2000-07-11 2003-03-31 Radiolinja Ab Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
EP1483277A4 (en) * 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
AU2003255849A1 (en) 2002-07-08 2004-01-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
ATE429441T1 (de) * 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
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MX2007005073A (es) * 2004-10-27 2007-06-25 Glaxosmithkline Zagreb Conjugados con actividad antiinflamtoria.

Also Published As

Publication number Publication date
EP2196469A1 (en) 2010-06-16
MX2007005073A (es) 2007-06-25
RU2007119577A (ru) 2008-12-10
IL182694A0 (en) 2007-09-20
ATE453658T1 (de) 2010-01-15
BRPI0517024A (pt) 2008-03-25
WO2006046123A3 (en) 2006-07-06
ZA200702579B (en) 2008-08-27
CA2585711A1 (en) 2006-05-04
EP1805202B1 (en) 2009-12-30
AU2005298312A1 (en) 2006-05-04
DE602005018672D1 (de) 2010-02-11
US20090048221A1 (en) 2009-02-19
JP2008517993A (ja) 2008-05-29
ES2337915T3 (es) 2010-04-30
EP1805202A2 (en) 2007-07-11
CN101090908A (zh) 2007-12-19
WO2006046123A2 (en) 2006-05-04
KR20070083811A (ko) 2007-08-24

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