PT100086A - Epimeros de esteroides de 16alfa, 17alfa-butilidenodioxi-11beta, 21-di-hidroxipregn-4-eno-3,20-diona fluoro-substituidos - Google Patents
Epimeros de esteroides de 16alfa, 17alfa-butilidenodioxi-11beta, 21-di-hidroxipregn-4-eno-3,20-diona fluoro-substituidosInfo
- Publication number
- PT100086A PT100086A PT100086A PT10008692A PT100086A PT 100086 A PT100086 A PT 100086A PT 100086 A PT100086 A PT 100086A PT 10008692 A PT10008692 A PT 10008692A PT 100086 A PT100086 A PT 100086A
- Authority
- PT
- Portugal
- Prior art keywords
- epoxes
- dihydroxyprepen
- butilidenodioxi
- 16alfa
- 17alfa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9100341A SE9100341D0 (sv) | 1991-02-04 | 1991-02-04 | Novel steroids |
Publications (2)
Publication Number | Publication Date |
---|---|
PT100086A true PT100086A (pt) | 1994-05-31 |
PT100086B PT100086B (pt) | 1999-06-30 |
Family
ID=20381806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT100086A PT100086B (pt) | 1991-02-04 | 1992-02-03 | Epimeros de esteroides de 16alfa, 17alfa-butilidenodioxi-11beta, 21-di-hidroxipregn-4-eno-3,20-diona fluoro-substituidos |
Country Status (40)
Country | Link |
---|---|
US (2) | US5674861A (pt) |
EP (1) | EP0570454B1 (pt) |
JP (1) | JPH06505232A (pt) |
KR (1) | KR100216720B1 (pt) |
CN (3) | CN1034868C (pt) |
AP (1) | AP366A (pt) |
AT (1) | ATE178611T1 (pt) |
BG (1) | BG62211B1 (pt) |
CA (1) | CA2103924A1 (pt) |
CZ (1) | CZ281685B6 (pt) |
DE (1) | DE69228870T2 (pt) |
DK (1) | DK0570454T3 (pt) |
DZ (1) | DZ1553A1 (pt) |
EE (1) | EE03111B1 (pt) |
ES (1) | ES2133315T3 (pt) |
FI (1) | FI933450A0 (pt) |
GR (1) | GR3030657T3 (pt) |
HK (1) | HK1010733A1 (pt) |
HU (1) | HU218275B (pt) |
IE (1) | IE920166A1 (pt) |
IL (1) | IL100532A (pt) |
IS (1) | IS1601B (pt) |
MA (1) | MA22406A1 (pt) |
MX (1) | MX9200324A (pt) |
NO (1) | NO304073B1 (pt) |
NZ (1) | NZ241210A (pt) |
PH (1) | PH31284A (pt) |
PL (1) | PL170000B1 (pt) |
PT (1) | PT100086B (pt) |
RO (1) | RO111195B1 (pt) |
RU (1) | RU2111212C1 (pt) |
SE (1) | SE9100341D0 (pt) |
SG (1) | SG52557A1 (pt) |
SI (1) | SI9210065B (pt) |
SK (1) | SK281801B6 (pt) |
TN (1) | TNSN92007A1 (pt) |
UA (1) | UA41267C2 (pt) |
WO (1) | WO1992013872A1 (pt) |
YU (1) | YU48892B (pt) |
ZA (1) | ZA92233B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
CA2152374A1 (en) * | 1993-01-08 | 1994-07-21 | Ralph Lennart Brattsand | Novel colon- or ileum-specific steroid derivatives |
US5983956A (en) | 1994-10-03 | 1999-11-16 | Astra Aktiebolag | Formulation for inhalation |
US5980949A (en) * | 1994-10-03 | 1999-11-09 | Astra Aktiebolag | Formulation for inhalation |
GB9423919D0 (en) * | 1994-11-26 | 1995-01-11 | Rhone Poulenc Rorer Ltd | Chemical process |
SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
SE9700133D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
IT1291288B1 (it) | 1997-04-30 | 1999-01-07 | Farmabios Srl | Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22. |
WO1999061055A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
GB0009607D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medical compositions |
GB0009592D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory combinations |
HRP20010018A2 (en) | 2001-01-09 | 2002-12-31 | Pliva D D | Novel anti-inflammatory compounds |
GB0110411D0 (en) * | 2001-04-27 | 2001-06-20 | Astrazeneca Ab | Chemical process |
BR0212767A (pt) * | 2001-09-25 | 2004-10-13 | Pharmacia & Upjohn Comapny | Transacetalização estereosseletiva de acetonida esteriodal c-22 |
CN100577681C (zh) | 2002-07-08 | 2010-01-06 | 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 | 用于治疗炎性疾病和病症的新化合物、组合物和方法 |
WO2004005313A2 (en) | 2002-07-08 | 2004-01-15 | Pliva - Istrazivacki Institut D.O.O. | Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules |
AU2003265576A1 (en) * | 2002-08-23 | 2004-03-11 | The Mclean Hospital Corporation | Corticosteroid conjugates and uses thereof |
TW200417371A (en) * | 2003-02-21 | 2004-09-16 | Upjohn Co | A continuous process for the production of R-rofleponide |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
HRP20030603A2 (en) | 2003-07-25 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Substituted furochromene compounds of antiinflammatory action |
HRP20030604A2 (en) | 2003-07-25 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | Substituted furochromenes, preparation thereof andtheir antiinflammatory action |
DE602005018672D1 (de) | 2004-10-27 | 2010-02-11 | Glaxosmithkline Zagreb | Konjugate mit entzündungshemmender aktivität |
CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
WO2007008155A1 (en) * | 2005-07-11 | 2007-01-18 | Astrazeneca Ab | New combination 1 |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
US20080200441A1 (en) * | 2007-02-14 | 2008-08-21 | University Of Southern California | Estrogen receptor modulators associated pharmaceutical compositions and methods of use |
NZ594310A (en) | 2009-02-20 | 2014-02-28 | To Bbb Holding B V | Glutathione-based drug delivery system |
MX2011011833A (es) | 2009-05-06 | 2012-01-27 | Lab Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas. |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3126375A (en) * | 1964-03-24 | Chioacyl | ||
US3048581A (en) * | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
US3357974A (en) * | 1965-12-28 | 1967-12-12 | Merck & Co Inc | Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones |
US3758686A (en) * | 1971-12-07 | 1973-09-11 | American Cyanamid Co | Method of using steroid acetonides |
SE378109B (pt) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
SE378110B (pt) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
US4749649A (en) * | 1983-05-16 | 1988-06-07 | The Upjohn Company | Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen |
IT1196142B (it) * | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
SE8403905D0 (sv) * | 1984-07-30 | 1984-07-30 | Draco Ab | Liposomes and steroid esters |
CN1060471A (zh) * | 1985-04-04 | 1992-04-22 | 得拉科公司 | 新的16,17-缩醛取代雄甾烷-17β-酮类的制备方法 |
SE8604059D0 (sv) * | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
HU203562B (en) * | 1989-03-09 | 1991-08-28 | Richter Gedeon Vegyeszet | Process for producing new steroide diols and pharmaceutical compositions containing them |
HU203769B (en) * | 1989-03-09 | 1991-09-30 | Richter Gedeon Vegyeszet | Process for producing new steroide derivatives and pharmaceutical compositions containing them |
PL164294B1 (pl) * | 1990-12-20 | 1994-07-29 | Inst Farmaceutyczny | Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL |
SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
SE9100342D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroid esters |
-
1991
- 1991-02-04 SE SE9100341A patent/SE9100341D0/xx unknown
- 1991-12-26 IL IL10053291A patent/IL100532A/en not_active IP Right Cessation
-
1992
- 1992-01-06 NZ NZ241210A patent/NZ241210A/xx unknown
- 1992-01-10 PH PH43757A patent/PH31284A/en unknown
- 1992-01-13 ZA ZA92233A patent/ZA92233B/xx unknown
- 1992-01-21 IE IE016692A patent/IE920166A1/en unknown
- 1992-01-22 SI SI9210065A patent/SI9210065B/sl unknown
- 1992-01-22 YU YU6592A patent/YU48892B/sh unknown
- 1992-01-22 DZ DZ920005A patent/DZ1553A1/fr active
- 1992-01-27 AP APAP/P/1992/000353A patent/AP366A/en active
- 1992-01-27 MX MX9200324A patent/MX9200324A/es unknown
- 1992-01-29 RU RU93053630A patent/RU2111212C1/ru active
- 1992-01-29 SG SG1996005993A patent/SG52557A1/en unknown
- 1992-01-29 DE DE69228870T patent/DE69228870T2/de not_active Expired - Fee Related
- 1992-01-29 JP JP4504216A patent/JPH06505232A/ja active Pending
- 1992-01-29 DK DK92904566T patent/DK0570454T3/da active
- 1992-01-29 HU HU9302244A patent/HU218275B/hu not_active IP Right Cessation
- 1992-01-29 AT AT92904566T patent/ATE178611T1/de not_active IP Right Cessation
- 1992-01-29 CZ CS931496A patent/CZ281685B6/cs not_active IP Right Cessation
- 1992-01-29 RO RO93-01095A patent/RO111195B1/ro unknown
- 1992-01-29 UA UA93004261A patent/UA41267C2/uk unknown
- 1992-01-29 US US08/094,207 patent/US5674861A/en not_active Expired - Fee Related
- 1992-01-29 SK SK796-93A patent/SK281801B6/sk unknown
- 1992-01-29 KR KR1019930702298A patent/KR100216720B1/ko not_active IP Right Cessation
- 1992-01-29 WO PCT/SE1992/000055 patent/WO1992013872A1/en active IP Right Grant
- 1992-01-29 PL PL92300350A patent/PL170000B1/pl unknown
- 1992-01-29 ES ES92904566T patent/ES2133315T3/es not_active Expired - Lifetime
- 1992-01-29 EP EP92904566A patent/EP0570454B1/en not_active Expired - Lifetime
- 1992-01-29 CA CA002103924A patent/CA2103924A1/en not_active Abandoned
- 1992-02-03 IS IS3808A patent/IS1601B/is unknown
- 1992-02-03 PT PT100086A patent/PT100086B/pt not_active IP Right Cessation
- 1992-02-03 CN CN92100800A patent/CN1034868C/zh not_active Expired - Fee Related
- 1992-02-03 MA MA22692A patent/MA22406A1/fr unknown
- 1992-02-04 TN TNTNSN92007A patent/TNSN92007A1/fr unknown
-
1993
- 1993-07-20 BG BG97971A patent/BG62211B1/bg unknown
- 1993-08-02 NO NO932761A patent/NO304073B1/no not_active IP Right Cessation
- 1993-08-03 FI FI933450A patent/FI933450A0/fi unknown
-
1994
- 1994-11-03 EE EE9400349A patent/EE03111B1/xx not_active IP Right Cessation
-
1996
- 1996-04-30 CN CN96100576A patent/CN1052155C/zh not_active Expired - Fee Related
- 1996-04-30 CN CN96100575A patent/CN1058724C/zh not_active Expired - Fee Related
-
1997
- 1997-10-07 US US08/944,676 patent/US5939409A/en not_active Expired - Fee Related
-
1998
- 1998-10-29 HK HK98111582A patent/HK1010733A1/xx not_active IP Right Cessation
-
1999
- 1999-06-30 GR GR990401743T patent/GR3030657T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19931027 |
|
FG3A | Patent granted, date of granting |
Effective date: 19990317 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20030930 |