EE03111B1 - Glükokortikosteroidi epimeerid, nende valmistamise protsessid ja neid sisaldavad ravimpreparaadid - Google Patents

Glükokortikosteroidi epimeerid, nende valmistamise protsessid ja neid sisaldavad ravimpreparaadid

Info

Publication number
EE03111B1
EE03111B1 EE9400349A EE9400349A EE03111B1 EE 03111 B1 EE03111 B1 EE 03111B1 EE 9400349 A EE9400349 A EE 9400349A EE 9400349 A EE9400349 A EE 9400349A EE 03111 B1 EE03111 B1 EE 03111B1
Authority
EE
Estonia
Prior art keywords
glucocorticosteroid
epimers
processes
preparation
pharmaceutical preparations
Prior art date
Application number
EE9400349A
Other languages
English (en)
Inventor
Andersson Paul
Axelsson Bengt
Brattsand Ralph
Thaln Arne
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE03111B1 publication Critical patent/EE03111B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
EE9400349A 1991-02-04 1994-11-03 Glükokortikosteroidi epimeerid, nende valmistamise protsessid ja neid sisaldavad ravimpreparaadid EE03111B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100341A SE9100341D0 (sv) 1991-02-04 1991-02-04 Novel steroids

Publications (1)

Publication Number Publication Date
EE03111B1 true EE03111B1 (et) 1998-08-17

Family

ID=20381806

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400349A EE03111B1 (et) 1991-02-04 1994-11-03 Glükokortikosteroidi epimeerid, nende valmistamise protsessid ja neid sisaldavad ravimpreparaadid

Country Status (40)

Country Link
US (2) US5674861A (et)
EP (1) EP0570454B1 (et)
JP (1) JPH06505232A (et)
KR (1) KR100216720B1 (et)
CN (3) CN1034868C (et)
AP (1) AP366A (et)
AT (1) ATE178611T1 (et)
BG (1) BG62211B1 (et)
CA (1) CA2103924A1 (et)
CZ (1) CZ281685B6 (et)
DE (1) DE69228870T2 (et)
DK (1) DK0570454T3 (et)
DZ (1) DZ1553A1 (et)
EE (1) EE03111B1 (et)
ES (1) ES2133315T3 (et)
FI (1) FI933450A (et)
GR (1) GR3030657T3 (et)
HK (1) HK1010733A1 (et)
HU (1) HU218275B (et)
IE (1) IE920166A1 (et)
IL (1) IL100532A (et)
IS (1) IS1601B (et)
MA (1) MA22406A1 (et)
MX (1) MX9200324A (et)
NO (1) NO304073B1 (et)
NZ (1) NZ241210A (et)
PH (1) PH31284A (et)
PL (1) PL170000B1 (et)
PT (1) PT100086B (et)
RO (1) RO111195B1 (et)
RU (1) RU2111212C1 (et)
SE (1) SE9100341D0 (et)
SG (1) SG52557A1 (et)
SI (1) SI9210065B (et)
SK (1) SK281801B6 (et)
TN (1) TNSN92007A1 (et)
UA (1) UA41267C2 (et)
WO (1) WO1992013872A1 (et)
YU (1) YU48892B (et)
ZA (1) ZA92233B (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
SE9700135D0 (sv) 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
IT1291288B1 (it) * 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
GB0009607D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medical compositions
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
GB0110411D0 (en) * 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
BR0212767A (pt) * 2001-09-25 2004-10-13 Pharmacia & Upjohn Comapny Transacetalização estereosseletiva de acetonida esteriodal c-22
EP1551865B1 (en) 2002-07-08 2009-04-22 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules
CA2489402A1 (en) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
AU2003265576A1 (en) * 2002-08-23 2004-03-11 The Mclean Hospital Corporation Corticosteroid conjugates and uses thereof
TW200417371A (en) * 2003-02-21 2004-09-16 Upjohn Co A continuous process for the production of R-rofleponide
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
US20080207577A1 (en) * 2005-07-11 2008-08-28 Astrazeneca Ab Combination I
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378110B (et) * 1972-05-19 1975-08-18 Bofors Ab
SE378109B (et) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
CN1060471A (zh) * 1985-04-04 1992-04-22 得拉科公司 新的16，17-缩醛取代雄甾烷-17β-酮类的制备方法
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
HU203562B (en) * 1989-03-09 1991-08-28 Richter Gedeon Vegyeszet Process for producing new steroide diols and pharmaceutical compositions containing them
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters

Also Published As

Publication number Publication date
EP0570454B1 (en) 1999-04-07
HK1010733A1 (en) 1999-06-25
MA22406A1 (fr) 1992-10-01
PH31284A (en) 1998-07-06
PT100086A (pt) 1994-05-31
DE69228870D1 (de) 1999-05-12
DK0570454T3 (da) 1999-10-18
CN1140178A (zh) 1997-01-15
SK79693A3 (en) 1994-03-09
IS3808A (is) 1992-08-05
SG52557A1 (en) 1998-09-28
CN1140059A (zh) 1997-01-15
PT100086B (pt) 1999-06-30
ES2133315T3 (es) 1999-09-16
IE920166A1 (en) 1992-08-12
SK281801B6 (sk) 2001-08-06
US5674861A (en) 1997-10-07
CZ281685B6 (cs) 1996-12-11
IL100532A (en) 1996-05-14
ATE178611T1 (de) 1999-04-15
AP366A (en) 1994-10-21
CN1058724C (zh) 2000-11-22
EP0570454A1 (en) 1993-11-24
MX9200324A (es) 1992-09-01
HU9302244D0 (en) 1993-10-28
NO932761L (no) 1993-08-02
GR3030657T3 (en) 1999-10-29
DZ1553A1 (fr) 2002-02-17
CN1064079A (zh) 1992-09-02
FI933450A0 (fi) 1993-08-03
IS1601B (is) 1996-10-18
YU48892B (sh) 2002-10-18
KR100216720B1 (ko) 1999-10-01
JPH06505232A (ja) 1994-06-16
WO1992013872A1 (en) 1992-08-20
DE69228870T2 (de) 1999-08-19
ZA92233B (en) 1992-10-28
AU661471B2 (en) 1995-07-27
UA41267C2 (uk) 2001-09-17
IL100532A0 (en) 1992-09-06
AU1230792A (en) 1992-09-07
AP9200353A0 (en) 1992-01-31
NO932761D0 (no) 1993-08-02
TNSN92007A1 (fr) 1993-06-08
BG62211B1 (bg) 1999-05-31
SI9210065A (en) 1995-02-28
CN1052155C (zh) 2000-05-10
RO111195B1 (ro) 1996-07-30
CN1034868C (zh) 1997-05-14
NZ241210A (en) 1993-08-26
FI933450A (fi) 1993-08-03
RU2111212C1 (ru) 1998-05-20
YU6592A (sh) 1995-01-31
BG97971A (bg) 1994-04-29
CZ149693A3 (en) 1994-03-16
NO304073B1 (no) 1998-10-19
PL170000B1 (pl) 1996-10-31
CA2103924A1 (en) 1992-08-05
HU218275B (en) 2000-07-28
SE9100341D0 (sv) 1991-02-04
US5939409A (en) 1999-08-17
SI9210065B (en) 2001-12-31
HUT64973A (en) 1994-03-28

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KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

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MM4A Lapsed by not paying the annual fees

Effective date: 20031103