GR3030657T3 - Novel steroids - Google Patents

Novel steroids

Info

Publication number
GR3030657T3
GR3030657T3 GR990401743T GR990401743T GR3030657T3 GR 3030657 T3 GR3030657 T3 GR 3030657T3 GR 990401743 T GR990401743 T GR 990401743T GR 990401743 T GR990401743 T GR 990401743T GR 3030657 T3 GR3030657 T3 GR 3030657T3
Authority
GR
Greece
Prior art keywords
novel steroids
steroids
novel
Prior art date
Application number
GR990401743T
Other languages
English (en)
Inventor
Paul Andersson
Bengt Axelsson
Ralph Brattsand
Arne Thalen
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of GR3030657T3 publication Critical patent/GR3030657T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GR990401743T 1991-02-04 1999-06-30 Novel steroids GR3030657T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9100341A SE9100341D0 (sv) 1991-02-04 1991-02-04 Novel steroids
PCT/SE1992/000055 WO1992013872A1 (en) 1991-02-04 1992-01-29 Novel steroids

Publications (1)

Publication Number Publication Date
GR3030657T3 true GR3030657T3 (en) 1999-10-29

Family

ID=20381806

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401743T GR3030657T3 (en) 1991-02-04 1999-06-30 Novel steroids

Country Status (40)

Country Link
US (2) US5674861A (el)
EP (1) EP0570454B1 (el)
JP (1) JPH06505232A (el)
KR (1) KR100216720B1 (el)
CN (3) CN1034868C (el)
AP (1) AP366A (el)
AT (1) ATE178611T1 (el)
BG (1) BG62211B1 (el)
CA (1) CA2103924A1 (el)
CZ (1) CZ281685B6 (el)
DE (1) DE69228870T2 (el)
DK (1) DK0570454T3 (el)
DZ (1) DZ1553A1 (el)
EE (1) EE03111B1 (el)
ES (1) ES2133315T3 (el)
FI (1) FI933450A (el)
GR (1) GR3030657T3 (el)
HK (1) HK1010733A1 (el)
HU (1) HU218275B (el)
IE (1) IE920166A1 (el)
IL (1) IL100532A (el)
IS (1) IS1601B (el)
MA (1) MA22406A1 (el)
MX (1) MX9200324A (el)
NO (1) NO304073B1 (el)
NZ (1) NZ241210A (el)
PH (1) PH31284A (el)
PL (1) PL170000B1 (el)
PT (1) PT100086B (el)
RO (1) RO111195B1 (el)
RU (1) RU2111212C1 (el)
SE (1) SE9100341D0 (el)
SG (1) SG52557A1 (el)
SI (1) SI9210065B (el)
SK (1) SK281801B6 (el)
TN (1) TNSN92007A1 (el)
UA (1) UA41267C2 (el)
WO (1) WO1992013872A1 (el)
YU (1) YU48892B (el)
ZA (1) ZA92233B (el)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009607D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medical compositions
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
GB0110411D0 (en) * 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
CA2459880A1 (en) * 2001-09-25 2003-04-03 Pharmacia And Upjohn Company Stereoselective transacetalization of steroidal c-22 acetonide
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
US20040157810A1 (en) * 2002-08-23 2004-08-12 Teicher Martin H. Corticosteroid conjugates and uses thereof
TW200417371A (en) * 2003-02-21 2004-09-16 Upjohn Co A continuous process for the production of R-rofleponide
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
CA2585711A1 (en) 2004-10-27 2006-05-04 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugates with anti-inflammatory activity
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
EP1906960A4 (en) * 2005-07-11 2010-03-10 Astrazeneca Ab NEW COMBINATION 1
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378110B (el) * 1972-05-19 1975-08-18 Bofors Ab
SE378109B (el) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
CN1060471A (zh) * 1985-04-04 1992-04-22 得拉科公司 新的16，17-缩醛取代雄甾烷-17β-酮类的制备方法
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
HU203562B (en) * 1989-03-09 1991-08-28 Richter Gedeon Vegyeszet Process for producing new steroide diols and pharmaceutical compositions containing them
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters

Also Published As

Publication number Publication date
ATE178611T1 (de) 1999-04-15
DE69228870D1 (de) 1999-05-12
IE920166A1 (en) 1992-08-12
KR100216720B1 (ko) 1999-10-01
JPH06505232A (ja) 1994-06-16
PT100086B (pt) 1999-06-30
HUT64973A (en) 1994-03-28
SI9210065B (en) 2001-12-31
DZ1553A1 (fr) 2002-02-17
NO932761D0 (no) 1993-08-02
FI933450A0 (fi) 1993-08-03
PH31284A (en) 1998-07-06
WO1992013872A1 (en) 1992-08-20
SK79693A3 (en) 1994-03-09
HU9302244D0 (en) 1993-10-28
CA2103924A1 (en) 1992-08-05
CN1052155C (zh) 2000-05-10
CN1058724C (zh) 2000-11-22
EP0570454A1 (en) 1993-11-24
NO932761L (no) 1993-08-02
CN1034868C (zh) 1997-05-14
DK0570454T3 (da) 1999-10-18
AP366A (en) 1994-10-21
US5674861A (en) 1997-10-07
CN1064079A (zh) 1992-09-02
NO304073B1 (no) 1998-10-19
YU6592A (sh) 1995-01-31
ES2133315T3 (es) 1999-09-16
HU218275B (en) 2000-07-28
UA41267C2 (uk) 2001-09-17
BG62211B1 (bg) 1999-05-31
AU661471B2 (en) 1995-07-27
FI933450A (fi) 1993-08-03
IS1601B (is) 1996-10-18
CZ149693A3 (en) 1994-03-16
RU2111212C1 (ru) 1998-05-20
CN1140178A (zh) 1997-01-15
SK281801B6 (sk) 2001-08-06
AU1230792A (en) 1992-09-07
CZ281685B6 (cs) 1996-12-11
IL100532A0 (en) 1992-09-06
AP9200353A0 (en) 1992-01-31
MX9200324A (es) 1992-09-01
MA22406A1 (fr) 1992-10-01
BG97971A (bg) 1994-04-29
US5939409A (en) 1999-08-17
HK1010733A1 (en) 1999-06-25
SE9100341D0 (sv) 1991-02-04
IS3808A (is) 1992-08-05
ZA92233B (en) 1992-10-28
EP0570454B1 (en) 1999-04-07
YU48892B (sh) 2002-10-18
SG52557A1 (en) 1998-09-28
DE69228870T2 (de) 1999-08-19
CN1140059A (zh) 1997-01-15
TNSN92007A1 (fr) 1993-06-08
IL100532A (en) 1996-05-14
SI9210065A (en) 1995-02-28
PL170000B1 (pl) 1996-10-31
PT100086A (pt) 1994-05-31
EE03111B1 (et) 1998-08-17
NZ241210A (en) 1993-08-26
RO111195B1 (ro) 1996-07-30

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